Table Of Content

Nutrition, Diet and Cancer Sharmila Shankar • Rakesh K. Srivastava Editors Nutrition, Diet and Cancer 123 Editors Assoc.Prof.SharmilaShankar Prof.Dr.RakeshK.Srivastava PathologyandLaboratoryMedicine PharmacologyandToxicology UniversityofKansasMedicalCenter TherapeuticsMedicine RainbowBlvd3901 UniversityofKansasMedicalCenter KansasCity,Kansas RainbowBlvd3901 USA KansasCity,Kansas USA ISBN978-94-007-2922-3 e-ISBN978-94-007-2923-0 DOI10.1007/978-94-007-2923-0 SpringerDordrechtHeidelbergLondonNewYork LibraryofCongressControlNumber:2012934829 ©SpringerScience+BusinessMediaB.V.2012 Nopartofthisworkmaybereproduced,storedinaretrievalsystem,ortransmittedinanyformorby anymeans,electronic,mechanical,photocopying,microfilming,recordingorotherwise,withoutwritten permissionfromthePublisher,withtheexceptionofanymaterialsuppliedspecificallyforthepurpose ofbeingenteredandexecutedonacomputersystem,forexclusiveusebythepurchaserofthework. Printedonacid-freepaper SpringerispartofSpringerScience+BusinessMedia(www.springer.com) Preface Basedonathoroughreviewofthescientificevidence,thisbookprovidesthemost authoritativeassessmentoftherelationshipbetweendietaryandnutritionalfactors and the incidence of cancer. It highlightsinterim dietary guidelinesthat are likely to reduce the risk of cancer as well as ensure good nutrition. The relationships amongnutrition,dietandcancerhaveadvancedinrecentyears,butmuchremains to be understood with respect to diet and dietary components in cancer risk and prevention. Continuing accumulation of scientific evidence provides clues about thatnutritionisoneofthemostimportantdeterminantsofhealthfortheindividual, and that specific nutrition habits of variouspopulationscan significantly decrease the overallrisk of cancer. Sequencing of the human genome has opened the door to an exciting new phase for nutritional science. Unraveling the effects of dietary components on genes and their encoded proteins as well as identifying genetic influences on dietary factors is essential for identifying those who will and will notbenefitfrominterventionstrategiesforcancerprevention.Otheremergingareas that require greater attention include understandingthe link between obesity, diet andcancer,theinteractionbetweendietandthemicrobiome,aswellashowdietary agentsmodulateinflammatoryprocesses.Importantly,nutrigenomicsapproachmay provideusefulbiomarkersofcancerprevention,earlydisease,ornutritionalstatus, aswellasidentifypotentialmoleculartargetsincancerprocessesthataremodulated bydietaryconstituentsand/ordietarypatterns. Scientific literatureon nutritionfor the cancerpreventionis inadequate.Whilst theimplicationsofreducedperformancestatusandpoornutritionalstatusoncancer outcomes are documented, there is still a lack of conclusive research data on the potentialeffectofimprovementinnutrition.Ourgoalisprovidethemostaccurate, up-to-date,andusefultextbookpossible.Theseambitiousgoalswouldnotbepos- siblewithoutcontributionoftheauthorswhichrepresentadiversegroupofexperts whohaveendeavoredtoprovideacomprehensiveperspectiveonthedietaryagents withnutrigenetics,nutritionalepigenomics,nutritionaltranscriptomics,proteomics, andmetabolomics,toallowresearchersanddieticianstoassimilatethesefactsinto cancerpreventionandtherapyalgorithms.Evidencecontinuestomountthatdietary componentsare importantdeterminantsof cancerrisk and tumorbehavior.As the v vi Preface era of molecular nutrition grows, a greater understanding about the role of foods and their componentson cancer risk and tumor behavior will surely unfold. Such informationwillprovideanewwayofunderstandingoftheroleofdietandnutrition inthedevelopmentofeffectivepreemptiveapproachestoreducethecancerburden. We would like to greatly appreciate and sincerely thank for the exceptional contributions of the authors, each of which reflects their commitment to the field ofnutrition,dietandcancer. TheUniversityofKansasCancerCenter SharmilaShankar,Ph.D TheUniversityofKansasMedicalCenter RakeshK.Srivastava,Ph.D KansasCity,Kansas Contents 1 AberrantSignalingPathwaysinCancer:Modulation bytheDietaryFlavonoid,Quercetin ..................................... 1 RamamurthiVidyaPriyadarsiniandSiddavaramNagini 2 MicronutrientsandCancer:AddSpicetoYourLife................... 23 SahdeoPrasad,SubashC.Gupta,andBharatB.Aggarwal 3 ChemopreventionofProstateCancerwithCruciferous Vegetables:RoleofEpigenetics ........................................... 49 LauraM.Beaver,DavidE.Williams,RoderickH.Dashwood, andEmilyHo 4 Molecular Insight and Preclinical Perspective of Thymoquinone as Chemopreventive Agent andTherapeuticAdjunctinCancer...................................... 83 SanjeevBanerjee, MansiParasramka, FazlulH.Sarkar, andRamziM.Mohammad 5 DietaryBiofactorsintheManagement ofCancer:MythorReality? .............................................. 109 VidushiS.Neergheen-Bhujun, K.S.Kang, O.I.Aruoma, andT.Bahorun 6 NutritionalCompounds asChemopreventiveAgents byProteasomeInhibition.................................................. 129 KristinLandis-Piwowar, ElizabethSmerczak, JianZuo, andQ.PingDou 7 STATSignalinginCancerPrevention.................................... 149 Su-NiTang,SharmilaShankar,andRakeshK.Srivastava 8 ”•TCells,TeaandCancer................................................ 169 JingweiLu,VincentJ.Pompili,andHiranmoyDas vii viii Contents 9 PhytochemicalIntakeswithaMediterraneanDiet:Levels AchievablewithanExchangeList DietandPotential BiomarkersinBlood ....................................................... 185 ZoraDjuricPh.D. 10 PlantPolyphenolsandTheirRoleinCancerPrevention andChemotherapy......................................................... 209 SharmilaShankar, BrahmaN.Singh, andRakeshK.Srivastava 11 RoleofFoodMicro-moleculesinthePreventionofCancer ........... 235 LathaSabikhi, AlokJha, SudhirKumarTomer, andAshishKumarSingh 12 TheProtectiveRoleofZincinCancer: APotentialChemopreventiveAgent...................................... 255 BinBaoM.D.,Ph.D., AamirAhmadPh.D., AzfarSAzmiPh.D., ZhiweiWangPh.D., SanjeevBanerjeePh.D.,andFazlulH.SarkarPh.D. 13 Diet-InducedEpigeneticChangesandCancerPrevention: AMantraforHealthyLiving.............................................. 283 AjayGoelandGauravChaturvedi 14 WesternDiet-InducedPancreaticCancer ............................... 327 M.MuraAssifiandGuidoEibl 15 IntracellularSignalingNetworkasaPrimeChemotherapy TargetofGreenTeaCatechin,(–)-Epigallocatechin-3-gallate........ 339 BrahmaN.Singh, SharmilaShankar, andRakeshK.Srivastava 16 RoleofDietaryAntioxidantsinCancer.................................. 377 C.M.AjilaandS.K.Brar 17 Curcumin:Structure,BiologyandClinicalApplications.............. 413 SharmilaShankarandRakeshK.Srivastava 18 Obesity,CancerandPsychopathology:CanVegetarian DietBeofHelp?............................................................. 459 VikasKumar, AjitKumarThakur, andShyamSunderChatterjee 19 DietaryPhytochemicalsasEpigeneticModulatorsinCancer......... 493 VijayS.ThakurPh.D.andSanjayGuptaPh.D. 20 Modulation of the Nrf2 Signaling Pathway byChemopreventiveDietaryPhytoconstituents ........................ 521 AltafS.DarveshM.Pharm.,Ph.D.andAnupamBishayee Contents ix 21 RoleofFishOilfromGeneExpressiontoPharmacological EffectinCancerPrevention............................................... 541 MalayChatterjee, SubhadeepDas, MaryChatterjee, andKaushikRoy 22 AntioxidantSupplements:AnEvidence-BasedApproach toHealthBenefitsandRisks............................................... 557 GoranBjelakovic,DimitrinkaNikolova,andChristianGluud 23 NaturalAntioxidantsandTheirRoleinCancerPrevention .......... 563 AkankshaSingh, AkanshaJain, BirinchiKumarSarma, AlokJha,andH.B.Singh 24 DietaryandNon-dietaryPhytochemicalsinCancerControl.......... 585 DhanirTailorandRanaP.Singh Index............................................................................... 625