Nuclear Medicine in Psychiatry

564 Pages·2004·19.38 MB·English

by  Kurt Audenaert

Nuclear Medicine in Psychiatry
Springer-Verlag Berlin Heidelberg GmbH

The Editors dedicate this book
To Professor Peter]. Ell for his outstanding life's work in
nuclear medicine, especially in functional brain imaging
To Professor Herman M. van Praag for his enduring effort
on pointing to the importance off unctional psychopathol
ogy to generations ofp sychiatrists
ANDREAS 0TTE, KURT AUDENAERT,
KATHELIJNE PEREMANS, KEES VAN HEERINGEN,
RUDI A. DIERCKX (EDS.)
•
clear Medici e n
Psyc iat y
With 79 figures and 33 tables
Springer
Prof. Dr. Andreas Otte Prof. Dr. Kees van Heeringen
Division of Nuclear Medicine University Department of Psychiatry
University Hospital Ghent University Hospital Ghent
De Pintelaan 185 De Pintelaan 185
9000 Gent, Belgium 9000 Gent, Belgium
Prof. Dr. Kurt Audenaert Prof. Dr. Rudi A. Dierckx
University Department of Psychiatry Division of Nuclear Medicine
University Hospital Ghent University Hospital Ghent
De Pintelaan 185 De Pintelaan 185
9000 Gent, Belgium 9000 Gent, Belgium
Dr. Kathelijne Peremans
Department of Medical Imaging
Faculty of Veterinary Medicine
Ghent University
Salisburylaan 133
9820 Merelbeke, Belgium
ISBN 978-3-642-62287-8 ISBN 978-3-642-18773-5 (eBook)
DOI 10.1007/978-3-642-18773-5
Library of Congress Cataloging-in-Publication Data
Nuclear medicine in psychatry I [edited by) Andreas Otte ... [eta!.). p.; em.
Includes bibliographical references and index.
1. Brain-Imaging. 2. Mental illness - Diagnosis. 3. Nuclear medicine. 4. Psychatry.I. Otte, Andreas P.,
1967-
[DNLM: 1. Mental Disorders-radionuclide imaging. 2. Nuclear Medicine. WM 141 N964 2004)
RC473.B7N83 2004 616.8'04754-dc22
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0 Springer-Verlag Berlin Heidelberg 2004
Softcover reprint of the hardcover 1st edition 2004
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In bunten Bildern wenig Klarheit,
Viel Irrtum und ein Funkchen Wahrheit,
So wird der beste Trank gebraut,
Der aile Welt erquickt und auferbaut.
In motley pictures little clarity,
Much error and a spark of verity,
Thus can the best of drinks be brewed
To cheer and edify the multitude.
Goethe, Faust I
Preface
In a most timely fashion the editors have assembled in this volume the combined
expertise of some 40 authors whose dedication to the investigation of psychiatric
disease through nuclear medicine technology has achieved international recogni
tion. It would have been hard to imagine some 10 or 15 years ago what impressive
advances would soon be made in understanding the underlying mechanisms of
psychiatric disease, in developing effective interventions and in monitoring drug
efficacy and mechanisms of action.
It is befitting of this progress that one of the first chapters in this volume dis
cusses the molecular aspects of psychiatry. Major developments have occurred in
this field, and further advances are expected. In a sign of modern times, psychi
atric disturbances of the child are also individually discussed. According to the
WHO (World Health Organization 2001), some 450 million people suffer from
mental and neurological disorders. As pointed out in a recent Lancet editorial
(Reynolds 2003 ), this equates to 12.3% of the global burden of disease, and within
the next 20 years the figure is likely to rise to a staggering 15%!
Progress in this specialized field reflects both the technological advances - in
instrumentation, data processing and modelling, and ligand development - and,
above all, the increased commitment of dedicated researchers. It is these scien
tists and doctors who are best placed to pose and test appropriate hypotheses,
to develop experimental protocols and to acquire and analyse the data obtained
from these complex technologies.
There is rapid change. New radio labelled ligands have appeared for the investi
gation of a number of neuroreceptor systems, pharmacological challenge has been
introduced into the investigative instrumentarium, parkinsonian syndromes are
now routinely investigated with nuclear medicine technologies, and the day may
not be far off when an effective imaging ligand will emerge for the investigation of
the extent and severity of the dementias (Alzheimer's in particular).
There is much to be explored-the tip of an enormous iceberg has just emerged.In
this volume the attentive reader will find much to impress andmuch to stimulate.W ith
due care, he or she will find the cracks in the iceberg that deserve further study and
scrutiny. A day hardly goes by without a clinician or a representative from indus
try describing scenarios in which a nuclear medicine approach would appear to
provide unique information not obtainable using other methodologies. There is
X Preface
great enthusiasm and dedication in this field, and hope that improved patient care
will ultimately be delivered.
Peter JEll,
MD MSc PD FRCR FRCP FMedSci
Institute of Nuclear Medicine, University College London, UK
References
Reynolds EH (2003) Brain and mind: a challengeforWHO. Lancet 361: 1924-1925
World Health Organization (2001) The World Health Report 2001. Mental health: new under
standing, new hope. WHO, Geneva
About this Book
A. 0TTE. K. AUDENAERT. K. PEREMANS. K. VAN HEERINGEN. R. DIERCKX
Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . XI
Technical Section . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . XII
Clinical Section . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . XII
Concluding Remarks . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . XIII
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . XIV
"Knowledge is knowing the Self.
Additional knowledge is a way to
Make us more humble and modest.
The one, who makes himself the lowest,
Knows everything,
And he gets access to the Universal
Consciousness of Eternal Life"
Proverb from India
Introduction
A book on a broad field such as nuclear medicine in psychiatry will always be
subject to limitations. These include technical limitations regarding space and
timely constraints with deadlines, which make editorial decisions necessary to
exclude chapters of interest in the field. Also, a book chapter can not always cover
all detailed aspects in the field in only the one chapter, and often other detailed
books exist on these special aspects. Although we have tried to make this book
comprehensive, there may be topics which are not or only generally addressed or
which are not explicitly dealt with in a separate chapter but included in a chapter
with a different title.
The index can, of course, be a useful tool to find such topics. The following brief
sections will provide further assistance, with explanations as to why particular
chapters were not included.