Novel Insights on Chronic Kidney Disease, Acute Kidney Inj. ,Polycys. Kidn. Dis. PDF
Preview Novel Insights on Chronic Kidney Disease, Acute Kidney Inj. ,Polycys. Kidn. Dis.
NOVEL INSIGHTS ON CHRONIC KIDNEY DISEASE, ACUTE KIDNEY INJURY AND POLYCYSTIC KIDNEY DISEASE Edited by Soundarapandian Vijayakumar Novel Insights on Chronic Kidney Disease, Acute Kidney Injury and Polycystic Kidney Disease Edited by Soundarapandian Vijayakumar Published by InTech Janeza Trdine 9, 51000 Rijeka, Croatia Copyright © 2012 InTech All chapters are Open Access distributed under the Creative Commons Attribution 3.0 license, which allows users to download, copy and build upon published articles even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. After this work has been published by InTech, authors have the right to republish it, in whole or part, in any publication of which they are the author, and to make other personal use of the work. Any republication, referencing or personal use of the work must explicitly identify the original source. As for readers, this license allows users to download, copy and build upon published chapters even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. Notice Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published chapters. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials, instructions, methods or ideas contained in the book. Publishing Process Manager Petra Nenadic Technical Editor Teodora Smiljanic Cover Designer InTech Design Team First published February, 2012 Printed in Croatia A free online edition of this book is available at www.intechopen.com Additional hard copies can be obtained from [email protected] Novel Insights on Chronic Kidney Disease, Acute Kidney Injury and Polycystic Kidney Disease, Edited by Soundarapandian Vijayakumar p. cm. ISBN 978-953-51-0234-2 Contents Preface IX Part 1 Acute and Chronic Kidney Diseases 1 Chapter 1 Congenital Obstructive Nephropathy: Clinical Perspectives and Animal Models 3 Susan E. Ingraham and Kirk M. McHugh Chapter 2 Association Between Haemoglobin Variability and Clinical Outcomes in Chronic Kidney Disease 30 Roshini Malasingam, David W. Johnson and Sunil V. Badve Chapter 3 Complexity of Differentiating Cerebral-Renal Salt Wasting from SIADH, Emerging Importance of Determining Fractional Urate Excretion 41 John K. Maesaka, Louis Imbriano, Shayan Shirazian and Nobuyuki Miyawaki Chapter 4 Epidemiology, Causes and Outcome of Obstetric Acute Kidney Injury 67 Namrata Khanal, Ejaz Ahmed and Fazal Akhtar Part 2 Polycystic Kidney Diseases 85 Chapter 5 Extracellular Matrix Abnormalities in Polycystic Kidney Disease 87 Soundarapandian Vijayakumar Chapter 6 Angiogenesis and the Pathogenesis of Autosomal Dominant Polycystic Kidney Disease 93 Berenice Reed and Wei Wang VI Contents Part 3 The Renin-Angiotensin-Aldosterone Pathway 111 Chapter 7 The Renin-Angiotensin- ldosterone System in Dialysis Patients 113 Yoshiyuki Morishita and Eiji Kusano Chapter 8 Diagnosis and Treatment of Primary Aldosteronism 125 Ozlem Tiryaki and Celalettin Usalan Preface Chronic kidney disease (CKD) has been recently recognized by the United Nations as a major non-communicable disease that poses significant health burden to the world population. This book offers novel insights on topics such as congenital obstructive nephropathy, cerebral-renal salt wasting, and the role of hemoglobin variability in clinical outcomes of CKD which are not very often discussed in the literature. Two related topics, primary aldosteronism and the role of renin-angiotensin-aldosterone system in the development of hypertension in CKD patients are also discussed. Acute Kidney Injury (AKI), characterized by a rapid reduction in kidney function, is more common in hospitalized patients and is an independent risk factor for mortality. Dr. Khanal Namrata discusses the epidemiology, causes and outcome of obstetric acute kidney injury in this book. Polycystic Kidney Diseases (PKD) are a group of genetic diseases affecting nearly 12 million people worldwide and there has been a significant interest and progress in the understanding of these diseases. Two often overlooked topics, the role of extracellular matrix abnormalities in PKD cystogenesis and progression, and the role of angiogenesis in ADPKD pathogenesis provide critical insights into these topics. With comprehensive and insightful reviews by eminent clinicians and scientists in the field, this book is a valuable tool for nephrologists. Dr. S. Vijayakumar, Ph.D Pediatric Nephrology University of Rochester Medical Center USA
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