Michael Friebe Editor Novel Innovation Design for the Future of Health Entrepreneurial Concepts for Patient Empowerment and Health Democratization Novel Innovation Design for the Future of Health Michael Friebe Editor Novel Innovation Design for the Future of Health Entrepreneurial Concepts for Patient Empowerment and Health Democratization Editor MichaelFriebe IDTMRecklinghausen, Otto-von-GuerickeUniversity Magdeburg,Germany ISBN978-3-031-08190-3 ISBN978-3-031-08191-0 (eBook) https://doi.org/10.1007/978-3-031-08191-0 #TheEditor(s)(ifapplicable)andTheAuthor(s),underexclusivelicensetoSpringerNatureSwitzerland AG2022 Thisworkissubjecttocopyright.AllrightsaresolelyandexclusivelylicensedbythePublisher,whether thewholeorpartofthematerialisconcerned,specificallytherightsoftranslation,reprinting,reuseof illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similarordissimilarmethodologynowknownorhereafterdeveloped. Theuseofgeneraldescriptivenames,registerednames,trademarks,servicemarks,etc.inthispublication doesnotimply,evenintheabsenceofaspecificstatement,thatsuchnamesareexemptfromtherelevant protectivelawsandregulationsandthereforefreeforgeneraluse. The publisher, the authors, and the editorsare safeto assume that the adviceand informationin this bookarebelievedtobetrueandaccurateatthedateofpublication.Neitherthepublishernortheauthorsor theeditorsgiveawarranty,expressedorimplied,withrespecttothematerialcontainedhereinorforany errorsoromissionsthatmayhavebeenmade.Thepublisherremainsneutralwithregardtojurisdictional claimsinpublishedmapsandinstitutionalaffiliations. ThisSpringerimprintispublishedbytheregisteredcompanySpringerNatureSwitzerlandAG Theregisteredcompanyaddressis:Gewerbestrasse11,6330Cham,Switzerland This book is dedicated to my parents and YOU “You know the greatest danger facing us is ourselves, an irrational fear of the unknown. But there’s no such thing as the unknown — only things temporarily hidden, temporarily not understood.” —Captain James T. Kirk This is a short but also difficult page. Nobody typicallyreadstheDEDICATIONandnobody really remembers who was listed here. But it is a page that the author writes last and—considering the amount of text—spends the most time on. This book in essence is mainly dedicated to YOU, who holds it right now as a real physical book or as a digital version. The reason? Well, YOU must be someone who wants to create health-related innovation and has a purpose. And YOU see that there are a lot of global challenges related to WELL BEING and GOOD HEALTH that cannot be solved with the current focus of healthcare provision and the currently applied methodologies and mindsets. And of course this book is also dedicated to theonesthatareclosetome,thathavehelped and supported me for decades, that have stimulatedme,andthathavechallengedmein my private and professional life. I really appreciate and love you ... I may not havetoldyouyetornotoftenenoughandIam sorry for that. You know me and you accept me that way. Please stick around and help me! Thank You! —Michael Friebe Foreword Let’sputthepowerofexponentialtechnologiesintopatient’shandsandrevolution- izehowwelive. Weareedgingclosertowardsadramaticallyextendedhealthspan. Where“100yearsoldcanbecomethenew60” —PeterDiamandis,MD Rethink Health Innovation Generation with Exponential Technology Convergence Acceleratingadvancementofexponentialtechnologiesisactuallyoldnews. So,what’sthenewnewsin2022andusefulforhealthinnovators? That formerly independent waves of exponentially accelerating technology are beginning to converge with other independent waves of exponentially accelerating technology. In other words, these waves are starting to overlap—stacking atop one another, producing tsunami-sized behemoths that threaten to wash away (read: “reinvent”) almosteveryindustryintheirpath. For example, the speed of drug development is accelerating—not only because biotechnology(sequencing,CRISPR,etc.)isprogressingatanexponentialrate,but becauseAI,quantumcomputing,andotherexponentialsareconvergingonthefield. Whenaninnovationcreatesanewmarketandwashesawayanexistingone,we use the term “disruptive innovation,” such as when silicon chips replaced vacuum tubesatthebeginningofthedigitalage.Thatwasadisruptiveinnovation. Itisprettyclearthatnoindustryisimmunetothesedevelopments. Why would that therefore not be true for the healthcare business? Big data + machine and federated learning, novel sensors, 5G, gene information, and 3D printing will undoubtedly cause a disruption of how healthcare is seen and performed and also where it takes place. And with that disruption we will most likely see an adapted and completely changed health business model. More home care, more prevention and prediction, a higher health personalization, and an vviiii viii Foreword increasedparticipationoftheindividualwillhelptoidentifyandfixhealthproblems long before they are noticeable or even diagnosable. Do we then still need the amount of hospital beds that we have today? Do we still need the same sick-care financingthatcoversthetreatmentandtherapycost? And ultimately that should lead to developing new ways to fight diseases associatedwithagingleadingtoanincreasedhealthlongevity. As an entrepreneur, being able to see around the corner of tomorrow and being agileenoughtoadaptiscriticaltoyoursuccess. What you should remember as you think about how to leverage these new business models is that the rate at which technology is accelerating is itself accelerating. Yeteveninthisdynamicenvironment,countlessbusinessesarestillanchoredby amentalityofmaintaining—competingsolelyonoperationalexecution. Butasaninnovatorandentrepreneur,it’smorevitalthaneverthatyouleverage thesebusinessmodelsforsuccessinthedecadesahead. Each one is a revolutionary way of creating value—each is a force for acceleration. Allofthisrequires anovel lookoneducationandeducating,andthisbookwill possiblyhelptosolvesomeofthebigchallengesinandaroundglobalhealththrough creating awareness, helping to develop an exponential mind, and providing a valuabletoolsetforinnovators. PeterDiamandis,MDRecentlynamedbyFortuneasoneofthe“World’s50 GreatestLeaders,”PeterH.Diamandisisthefounderandexecutivechairman oftheXPRIZEFoundation,whichleadstheworldindesigningandoperating large-scaleincentivecompetitions.HeisalsotheexecutivefounderofSingu- larity University, a graduate-levelSiliconValleyinstitution that counsels the world's leaders on exponentially growing technologies. As an entrepreneur, Diamandis has started over 20 companies in the areas of longevity, space, venturecapital andeducation.He isco-founder ofBOLD CapitalPartners, a venture fund with $250M investing in exponential technologies, and co- (continued) Foreword ix founder and Vice Chairman of Celularity, Inc., a cellular therapeutics com- pany. He is also a New York Times Bestselling author of three books: Abundance—The Future Is Better Than You Think, BOLD—How to go Big, Create Wealth & Impact the World and The Future is Faster Than You Think.Contact:[email protected] XPRIZEFoundation PeterDiamandis CulverCity,CA,USA SINGULARITYUniversity SantaClara,CA,USA Foreword We have to challenge, disrupt, and find new solutions to make healthcare more affordable,moreaccessible,andultimatelymoreequitable. —Prof.ShafiAhmed,MD The Exciting Future of Surgery ... but that Is Not the Primary Concern of the Future of Health Istartedwritingthisforewordwithaperspectiveonthefutureofsurgery,asIama practicing surgeon. The new concept of digital surgery follows on from the longer journey of digital health, and it is incredible and reassuring to see the recent developments in this field globally with international teams solving important problems. Itissafetoassumethatsomeofthesewillactuallybetranslatedtothepatient’s bedside over the next few years. Augmented and virtual reality, combined with artificial intelligence, will help a surgeon plan and navigate a complex procedure moresafely.Semi-autonomoussurgeryisalmostatatouchingdistanceandbecom- ing a reality. The rapid expansion of surgical robots and improvements in connec- tivitymayguideustothepointofthesurgicalsingularityandtotheShangriLaofa fullyautonomousoperation. Isthatgoodorbad? Well,ifyouarguefromapatient’sperspective—andthatisthepointofviewthat one should always have—with a proven better accuracy and efficacy, that is fairly easytoanswer.However,wearenotquitethereyet,butIamofthefirmbeliefthatit willnottakemuchlonger.Fromaperspectiveofasurgeon,theremaybeaconcern thatitwillremovetheneedforsurgeons,butIamconvincedthatthesetechnologies will actually enhance and augment our work and remove variation and improve outcomes that are driven by data. There will always be a need for surgeons in decision making and judgment which are essential and require a myriad of skills includingempathyandcommunication.Surgeonswillbevitalinemergencycases, orforverycomplicatedproceduresthattheAI-poweredrobotisnotyettrainedfor xxii