Novel approaches in prognosis and personalized treatment of cancer

192 Pages·2012·6.58 MB·English

Expression of nuclear FIH independently predicts overall survival of clear cellrenal cell carcinoma patients Chapter 3 1
evoN l apprao hc e s
ni pr sisongo
a dn peranos ezil d
treatem tn fo ac ecn r
Joost eV rmaat 20 1 2
2 Part I Molecular prognosticators
Expression of nuclear FIH independently predicts overall survival of clear cellrenal cell carcinoma patients Chapter 3 3
evoN l apprao hc e s
ni pr sisongo
a dn peranos ezil d
treatem tn fo ac ecn r

Joost eV rmaat 20 1 2
4 Part I Molecular prognosticators
oN ev l approaceh s
in prognosis
an d personaliez d
treatem nt o f cancer

Thesis with summary in Dutch, Utrecht University, The Netherlands
Proefschrift met Nederlandse samenvatting, Universiteit Utrecht
Joost Vermaat

ISBN/EAN: 978-94-6169-236-8
revoC ngised a dn al tuo-y :yb
W. de Jong
Prtni de :yb
Optima Grafsche Communicatie, Rotterdam

eh T rp tni gni fo t sih t siseh aw s an� aicn yl ropus t de :yb
Stichting Het Scholten-Cordes Fonds, Tridelta Development Ltd, Von Hippel Lindau Belangenvereniging,
J. E. Jurriaanse Stichting, Maatschap Interne Geneeskunde van het St. Antoniusziekenhuis Nieuwegein,
Janssen Biologics BV, Amgen BV, Novartis Oncology, Bayer BV, Pfzer Oncology, Boehringer Ingelheim BV,
Roche Nederland BV, GlaxoSmithKline BV, Sanof Aventis, ChipSoft en Vermaat Groep BV

Copyright © 2012 J.S.P. Vermaat, the Netherlands.
All rights reserved. No part of this thesis may be reproduced or transmitted,
in any form or by any means without prior permission of the author.
Expression of nuclear FIH independently predicts overall survival of clear cellrenal cell carcinoma patients Chapter 3 5
evoN l apprao hc e s ni pr sisongo
a dn peranos ezil d treatem tn fo ac ecn r

eiN ewu eb an ed regni n av n
presongo e n eg peranos esil ered
eb haedn gnil av n ak ekn r
em( t ee n as em avn tt gni ni het eN ed ral )sdn
rP eo hcsf rtfi
ter verkrijging van de graad van doctor aan de Universiteit Utrecht
op gezag van de rector magnifcus, prof. dr. G.J. van der Zwaan
ingevolge het besluit van het college van promoties in het openbaar
te verdedigen op donderda g 1 0 mei 02 21 des middasg te 1.4 5 uur

door
anoJ tha n tS epha sun hP pili p su eV ram at
geboren op 11 maart 1980 te Veenendaal
6 Part I Molecular prognosticators
Prtomo ro
rP o .f rd . .E.E oV est
Expression of nuclear FIH independently predicts overall survival of clear cellrenal cell carcinoma patients Chapter 3 7
rP omotiecommissie
rP .fo rd . .H.J eB enji n
rP .fo rd . .E.E Cpu pe n
rP .fo rd . .H. P av n eiD ts
rP .fo rd . .G.A.B.J aH aen n
rP .fo rd . . P.J.G poK s

aP ranimfen
C .A. av n tnA ew rpe n a dn .G Cro en esil
8 Part I Molecular prognosticators
aT elb fo tnoC tne s
C hapter 1 eG neral introud ction 1
C hapter 2 uO tline o f teh teh sis 12

PA R T I M O L E C U L A R P R O G N O S T I C A T O R S
C hapter 3 pxE ression o f nuclear FI H ined pened ntl y preid cts oev rall 7 2
suriv av l o f clear cell renal cell carcinoam patients

Chapter 4 eR gulation o f 1F2E yb teh ov n iH ppeliL- nad u tuom r suppressor 45
protein preid cts suriv av l in renal cell cancer patients
PA R T I I P R O T E O M I C S

C hapter 5 ow T p- rotein signature o f noev l serological am rek rs apolipoprotein 2A- 6 9
an d seru m alym oi d alpah preid cts prognosis in patients iw t h
em tastatic renal cell cancer an d ipm roev s teh currentl y use d
prognostic suriv av l om ed ls

C hapter 6 aV liad tion o f seru m alym oi d alpah as an ined pened nt ib oam rek r 9 1
of r progression rf ee - an d oev rall suriv av l in em tastatic renal cell
cancer patients
Expression of nuclear FIH independently predicts overall survival of clear cellrenal cell carcinoma patients Chapter 3 9

P A R T I I I M I T O X
C hapter 7 Cri aluc t gni ec rf-l ee tim hco rdno ai l D AN a s prtsongo ci tub ton 1 1 1
pretcid evi am rek r rof av r suoi tpy e s fo ac ecn r

P A R T I V G E N O M I C S
C hapter 8 rP ami r y roloc etc a l ac ecn r s a dn theri esbus euq tn hepat ci em tats aes s 31
are eg en taci yl efid retn : pmi acil t snoi rof es el tc noi fo patei tn s rof
tareg te d treatem tn
C hapter 9 eG en ra l noisucsid a dn tuf ru e perps etc evi s 1 5 5
Dutch summary / Nederlandse samenvatting 1 6 9
Contributing Authors 7 7 1
Acknowledgements / Dankwoord 18 1
List of Publications 18 5
Curriculum Vitae 18 9
1 0 Part I Molecular prognosticators