Normal and abnormal lung development in mouse - PAPSA 2012

73 Pages·2012·6.13 MB·English

Normal and abnormal lung development
in mouse and man
Robbert Rottier
Dick Tibboel
[email protected]
Erasmus MC – Sophia Children’s Hospital
Department of Pediatric Surgery
Rotterdam, The Netherlands
Topics of this presentation
- General introduction early lung development
- Role of Sox2 in lung development
- Hif2α and type II cell differentiation
- Pulmonary hypertension of the newborn
Embryonic origin of the lung
?
Cardoso, 2006
Regionalization of the primitive gut
Wells and Melton, 2000
Specification of prospective lung field
Signals emanate from the heart ...
Serls et al., 2005
Specification of prospective lung field
Desai et al., 2006
Lung bud induction
Tbx4 misexpression
Ectopic bud formation
Fgf10 induction !
Tbx4 induces buds from the gut and local Fgf10
Sakiyama et al., 2003
Regionalization of lung bud
Morrisey and Hogan, 2010
Lung development
?
Primitive gut towards complex lung?
Processes during lung development
growth
differentiation
alveolar
morphogenesis
saccular
embryogenesis
canalicular
pseudoglandular
embryonic
gestational time