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Non-Steroidal Anti-Inflammatory Drugs in Water: Emerging Contaminants and Ecological Impact PDF

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The Handbook of Environmental Chemistry 96 Series Editors: Damià Barceló · Andrey G. Kostianoy Leobardo Manuel Gómez-Oliván  Editor Non-Steroidal Anti-Inflammatory Drugs in Water Emerging Contaminants and Ecological Impact The Handbook of Environmental Chemistry Volume 96 Founding Editor: Otto Hutzinger (cid:1) Series Editors: Damia Barcelo´ (cid:129) Andrey G. Kostianoy Editorial Board Members: Jacob de Boer, Philippe Garrigues, Ji-Dong Gu, KevinC.Jones,ThomasP.Knepper,AbdelazimM.Negm, Alice Newton, Duc Long Nghiem, Sergi Garcia-Segura Inoverthreedecades,TheHandbookofEnvironmentalChemistryhasestablished itselfasthepremierreferencesource,providingsoundandsolidknowledgeabout environmentaltopicsfromachemicalperspective.Writtenbyleadingexpertswith practical experience in the field, the series continues to be essential reading for environmental scientists as well as for environmental managers and decision- makersinindustry,government,agenciesandpublic-interestgroups. Two distinguished Series Editors, internationally renowned volume editors as wellasaprestigiousEditorialBoardsafeguardpublicationofvolumesaccordingto highscientificstandards. Presenting a wide spectrum of viewpoints and approaches in topical volumes, thescopeoftheseriescoverstopicssuchas • localandglobalchangesofnaturalenvironmentandclimate • anthropogenicimpactontheenvironment • water,airandsoilpollution • remediationandwastecharacterization • environmentalcontaminants • biogeochemistryandgeoecology • chemicalreactionsandprocesses • chemical and biological transformations as well as physical transport of chemicalsintheenvironment • environmentalmodeling Aparticularfocusoftheseriesliesonmethodologicaladvancesinenvironmen- talanalyticalchemistry. TheHandbookofEnvironmentalChemistryisavailablebothinprintandonline via http://link.springer.com/bookseries/698. Articles are published online as soon astheyhavebeenreviewedandapprovedforpublication. Meeting the needs of the scientific community, publication of volumes in subserieshasbeendiscontinuedtoachieveabroaderscopefortheseriesasawhole. Non-Steroidal Anti-Inflammatory Drugs in Water Emerging Contaminants and Ecological Impact Volume Editor: Leobardo Manuel Gómez-Oliván With contributions by L. Aranda-Lara (cid:1) D. Arizmendi-Cotero (cid:1) J. Blasco (cid:1) S. E. Brewer (cid:1) L. C. Can-Ubando (cid:1) J. D. Cardoso-Vera (cid:1) L. I. Castro-Pastrana (cid:1) M. Cerro-Lo´pez (cid:1) J. J. Cisneros (cid:1) A. S. Commault (cid:1) G. A. Elizalde-Vela´zquez (cid:1) M. Galar-Mart´ınez (cid:1) O. D. Garc´ıa (cid:1) S. Garc´ıa-Medina (cid:1) R. M. Go´mez-Espinosa (cid:1) L. M. Go´mez-Oliva´n (cid:1) M. Hampel (cid:1) M. D. Herna´ndez-Navarro (cid:1) K. Isaac-Olive´ (cid:1) H. Islas-Flores (cid:1) G. L. Manzanares-Leal (cid:1) S. L. Mart´ınez-Vargas (cid:1) A. Mej´ıa-Garc´ıa (cid:1) M. A. Me´ndez-Rojas (cid:1) A. Mendoza (cid:1) E. Morales-Avila (cid:1) P. Moreno-Pe´rez (cid:1) M. P. A. Moreno-Pe´rez (cid:1) R.Natividad(cid:1)A.E.Navarro-Fro´meta(cid:1)L.D.Nghiem(cid:1)L.N.Nguyen(cid:1) K. A. Novoa (cid:1) B. Nunes (cid:1) S. Oh (cid:1) E. Olive´-Alvarez (cid:1) J.M.Ortega-Olvera(cid:1)E.Palacios-Rosas(cid:1) M.Parolini(cid:1) I.Pe´rez-Alvarez(cid:1) J. L. Pe´rez-Mazariego (cid:1) R. Pe´rez-Paste´n Borja (cid:1) M. Ramesh (cid:1) N. Ram´ırez-Dura´n (cid:1) R. Romero (cid:1) A. H. Sandoval-Trujillo (cid:1) H. Sandoval-Trujillo (cid:1) N. SanJuan-Reyes (cid:1) G. U. Semblante (cid:1) S. Siddeswaran (cid:1) D. Sutherland (cid:1) M. L. Toledo-Wall (cid:1) C. Trombini (cid:1) S. Umamaheswari Editor LeobardoManuelGo´mez-Oliva´n EnvironmentalToxicologyLab,FacultyofChemistry AutonomousUniversityoftheStateofMexico Toluca,EstadodeMe´xico,Mexico ISSN1867-979X ISSN1616-864X (electronic) TheHandbookofEnvironmentalChemistry ISBN978-3-030-56293-9 ISBN978-3-030-56294-6 (eBook) https://doi.org/10.1007/978-3-030-56294-6 ©SpringerNatureSwitzerlandAG2020 Thisworkissubjecttocopyright.AllrightsarereservedbythePublisher,whetherthewholeorpartof the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation,broadcasting,reproductiononmicrofilmsorinanyotherphysicalway,andtransmissionor informationstorageandretrieval,electronicadaptation,computersoftware,orbysimilarordissimilar methodologynowknownorhereafterdeveloped. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publicationdoesnotimply,evenintheabsenceofaspecificstatement,thatsuchnamesareexempt fromtherelevantprotectivelawsandregulationsandthereforefreeforgeneraluse. Thepublisher,theauthors,andtheeditorsaresafetoassumethattheadviceandinformationinthisbook arebelievedtobetrueandaccurateatthedateofpublication.Neitherthepublishernortheauthorsorthe editorsgiveawarranty,expressedorimplied,withrespecttothematerialcontainedhereinorforany errorsoromissionsthatmayhavebeenmade.Thepublisherremainsneutralwithregardtojurisdictional claimsinpublishedmapsandinstitutionalaffiliations. ThisSpringerimprintispublishedbytheregisteredcompanySpringerNatureSwitzerlandAG. Theregisteredcompanyaddressis:Gewerbestrasse11,6330Cham,Switzerland Series Editors Prof. Dr. Dami(cid:1)a Barcelo´ Prof. Dr. Andrey G. Kostianoy Department of EnvironmentalChemistry ShirshovInstituteofOceanology IDAEA-CSIC RussianAcademyofSciences C/Jordi Girona18–26 36,NakhimovskyPr. 08034Barcelona, Spain 117997Moscow,Russia and and Catalan InstituteforWaterResearch (ICRA) S.Yu.WitteMoscowUniversity H20Building Moscow,Russia Scientific and Technological Parkof the [email protected] University ofGirona Emili Grahit,101 17003Girona, Spain [email protected] Editorial Board Members Prof. Dr. Jacob de Boer VUUniversityAmsterdam, Amsterdam, The Netherlands Prof. Dr. Philippe Garrigues Universite´ de Bordeaux,Talence Cedex,France Prof. Dr. Ji-Dong Gu Guangdong Technion-Israel Instituteof Technology, Shantou,Guangdong,China Prof. Dr. Kevin C. Jones Lancaster University, Lancaster, UK Prof. Dr. Thomas P. Knepper Hochschule Fresenius,Idstein, Hessen,Germany Prof. Dr. Abdelazim M. Negm Zagazig University, Zagazig,Egypt Prof. Dr. Alice Newton Universityof Algarve, Faro,Portugal Prof. Dr. Duc Long Nghiem Universityof TechnologySydney, Broadway, NSW,Australia Prof. Dr. Sergi Garcia-Segura ArizonaState University, Tempe, AZ,USA Series Preface Withremarkablevision,Prof. OttoHutzingerinitiatedTheHandbook ofEnviron- mentalChemistry in1980andbecamethe foundingEditor-in-Chief.Atthattime, environmental chemistry was an emerging field, aiming at a complete description of the Earth’s environment, encompassing the physical, chemical, biological, and geologicaltransformationsofchemicalsubstancesoccurringonalocalaswellasa global scale. Environmental chemistry was intended to provide an account of the impact of man’s activities on the natural environment by describing observed changes. Whileaconsiderableamountofknowledgehasbeenaccumulatedoverthelast four decades, as reflected in the more than 150 volumes of The Handbook of Environmental Chemistry, there are still many scientific and policy challenges ahead due to the complexity and interdisciplinary nature of the field. The series will therefore continue to provide compilations of current knowledge. Contribu- tions are written by leading experts with practical experience in their fields. The Handbook of Environmental Chemistry grows with the increases in our scientific understanding, and provides a valuable source not only for scientists but also for environmental managers and decision-makers. Today, the series covers a broad rangeofenvironmentaltopicsfromachemicalperspective,includingmethodolog- icaladvancesinenvironmentalanalyticalchemistry. Inrecentyears,therehasbeenagrowingtendencytoincludesubjectmatterof societal relevance in the broad view of environmental chemistry. Topics include life cycle analysis, environmental management, sustainable development, and socio-economic, legal and even political problems, among others. While these topics are of great importance for the development and acceptance of The Hand- bookofEnvironmentalChemistry,thepublisherandEditors-in-Chiefhavedecided tokeepthehandbookessentiallyasourceofinformationon“hardsciences”witha particular emphasis on chemistry, but also covering biology, geology, hydrology andengineeringasappliedtoenvironmentalsciences. Thevolumesoftheseriesarewrittenatanadvancedlevel,addressingtheneeds ofbothresearchersandgraduatestudents,aswellasofpeopleoutsidethefieldof vii viii SeriesPreface “pure” chemistry, including those in industry, business, government, research establishments, and public interest groups. It would be very satisfying to see these volumes used as a basis for graduate courses in environmental chemistry. Withitshighstandardsofscientificqualityandclarity,TheHandbookofEnviron- mental Chemistry provides a solid basis from which scientists can share their knowledge on the different aspects of environmental problems, presenting a wide spectrumofviewpointsandapproaches. TheHandbookofEnvironmentalChemistryisavailablebothinprintandonline via www.springerlink.com/content/110354/. Articles are published online as soon as they have been approved for publication. Authors, Volume Editors and Editors-in-Chief are rewarded by the broad acceptance of The Handbook of Envi- ronmentalChemistrybythescientificcommunity,fromwhomsuggestionsfornew topicstotheEditors-in-Chiefarealwaysverywelcome. Dami(cid:1)aBarcelo´ AndreyG.Kostianoy SeriesEditors Preface Pharmaceuticals are designed to persist and perform their therapeutic action and, consequently,oncetheyentertheaquaticenvironment,theypersistinit,damaging thehealthoforganismslivingintheseecosystemsandevenhumanhealth.There- fore, these products are currently of worldwide environmental concern and have been called“emergingcontaminants”. Thelatterterm includesnon-steroidalanti- inflammatory drugs (NSAIDs), a heterogeneous group of pharmaceuticals with anti-inflammatory, analgesic and antipyretic properties, which act as selective inhibitors of the enzyme cyclooxygenase (COX), inhibiting cyclooxygenase-1 (COX-1)andcyclooxygenase-2(COX-2)whichareresponsiblefortheproduction ofprostaglandins,prostacyclinsandthromboxanes. SomeNSAIDsdonotdegradeintheenvironment,othersaredegradablebutata veryslowpaceandalthoughsomeothersarenotpersistentintheenvironment,they canbetransformedthroughnaturalprocesses.Thecontinuousintroductionofthis typeofproductsfromvarioussources(municipal,hospitalandindustrialeffluents) prolongsandmaintainsitspresenceinthewatersincreasinganypossibleimpacton aquaticlife. TheappearanceofNSAIDsinwaterrepresentsahighrisktotheenvironmentfor many reasons. The main one is that they contain active ingredients that were designed to induce specific pharmacological effects in humans but, when they dissolve in water, can reach non-target populations such as fish, amphipods, amphibians, among others, which produces toxicological effects. Diverse studies havereportedNSAID-inducedtoxicityinaquaticorganismssincetheseorganisms aremoresusceptibletotoxiceffectsduetotheircontinuedexposuretowastewater dischargesthroughoutthelifecycle. In the chapters included in this book are indicated data about fate, occurrence, toxicological findings identified by the presence of NSAIDs in various aquatic organisms of economic and ecological interest. Also are included avant-garde technologies for the removal of NSAIDs and the regulatory framework for the presenceofthesedrugsintheworld. ix x Preface The authors are well-known researchers from Mexico, Spain, Portugal, Italy, AustraliaandIndiaandmakeexhaustivereviewsandshowthefindingsidentifiedin their investigations related to NSAIDs occurrence, toxicity characterization using different biomarkers, as well as showing some technologies for the removal of NSAIDsandlegalframeworkoftheNSAIDsaroundtheworld.Thiscompilationof researchinworldcountriesallowsustohaveaveryspecificvisionofthespecific waterproblembyNSAIDsandconsidersolutionproposals. TheauthorsandIhopethatourbookcomplieswiththediverseandgeneralized expectations and needs for information about the contamination problem in the worldbyNSAIDs. Ithankalltheauthorsofthisbookfortheirprofessionalexpertiseandthorough- nessinwritinguptheirchapters;theUniversidadAuto´nomadelEstadodeMe´xico fortheunendingsupportithasshownasmyemployingentity;myresearchgroup; and my family, most especially my mother, Aida Oliva´n, and friends for the enthusiasmandsupporttheyhavealwaysshown. Toluca,Mexico LeobardoManuelGo´mez-Oliva´n

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Most books are stored in the elastic cloud where traffic is expensive. For this reason, we have a limit on daily download.