Nomenclature, Methodology and Results of Clinical Trials in Acute Leukemias PDF
Preview Nomenclature, Methodology and Results of Clinical Trials in Acute Leukemias
Recent Results in Cancer Research Fortschritte der Krebsforschung Progres dans les recherches sur Ie cancer 43 Edited by V.G. All/rey, New York • M.Allgower,Basel· K.H.Bauer,Heidelberg I. Berenblum, Rehovoth • F. Bergel, Jersey • J. Bernard, Paris W. Bernhard, Villejui/ • N. N. Blokhin, Moskva· H. E. Bock, Tiibingen W. Braun, New Brunswick· P. Bucalossi, Milano· A. V. Chaklin, Moskva M. Chorazy, Gliwice • G. J. Cunningham, Richmond· M. Dargent, Lyon G. Della Porta, Milano· P. Denoix, Villejui/ • R. Dulbecco, La Jolla H. Eagle, New York· R. Eker, Oslo· R. A. Good, Minneapolis P. Grabar, Paris· H. Hamperl, Bonn' R. J. C. Harris, Salisbury E. Hecker, Heidelberg· R. Herbeuval, Nancy' J. Higginson, Lyon W. C. Hueper, Fort Myers· H. Isliker, Lausanne· J. Kieler, Kebenhavn G. Klein, Stockholm· H. Koprowski, Philadelphia L. G. Koss, New York· G. Martz, Zurich· G. Mathe, Villejui/ O. Muhlbock, Amsterdam· W. Nakahara, Tokyo· L. J. Old, New York V. R. Potter, Madison· A. B. Sabin, Washington' L. Sachs, Rehovoth E. A. Saxen, Helsinki' C. G. Schmidt, Essen· S. Spiegelman, New York W. Szybalski, Madison· H. Tagnon, Bruxelles • R. M. Taylor, Toronto A. Tissieres, Geneve • E. Uehlinger, Zurich· R. W. Wissler, Chicago T. Yoshida, Tokyo Editor in chief P. Rentchnick, Geneve Nomenclature, Methodology and Results of Clinical Trials in Acute Leukemias Edited by G. Mathe· P. Pouillart· L. Schwarzenberg With 79 Figures Springer-Verlag Berlin Heidelberg New York 1973 Workshop held June 19 and 20, 1972 at the Centre National de la Recherche Scientifique (C.N.R.S.), 15, quai Anatole France, 75007 Paris, France co-sponsored by Institut de Cancerologie et d'Immunogenetique (LC.LG.) Institut National de la Sante et de la Recherche Medicale (LN.S.E.R.M.) European Organization for Research on Treatment of Cancer (E.O.R.T.C.) National Cancer Institute (N.C.L) Sponsored by the Swiss League against Cancer ISBN-13:978-3 -642-80778-7 e-ISBN-13:978-3 -642-80776-3 DOl: 10.1007/978-3-642-80776-3 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by photocopying mamine or similar means, and storage in data banks. Under § 54 of the German Copyright Law where copies are made for other than private use, a fee is payable to the publisher, the amount of the fee to be determined by agreement with the publisher. @ by Springer-Verlag Berlin· Heidelberg 1973. Library of Congress Catalog Card Number 73-9197. Softcover reprint of the hardcover 1s t edition 1973 The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and there fore free for general use. Typesetting, Nomenclature, Methodology and Results of Clinical Trials in Acute Leukemias Edited by G. Mathe· P. Pouillan· L. Schwarzenberg With 79 Figures Springer-Verlag New York Heidelberg Berlin 1973 Workshop held June 19 and 20, 1972 at the Centre National de la Recherche Scientifique (C.N.R.S.), 15, quai Anatole France, 75007 Paris, France co-sponsored by Institut de Cancerologie et d'Immunogenetique (LC.LG.) Institut National de la Sante et de la Recherche Medicale (LN.S.E.R.M.) European Organization for Research on Treatment of Cancer (E.O.R.T.C.) National Cancer Institute (N.C.L) Sponsored by the Swiss League against Cancer ISBN-13:978-3 -642-80778-7 e-ISBN-13:978-3 -642-80776-3 DOl: 10.1007/978-3-642-80776-3 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically those of translation, reprinting, re~use of illustrations, broadcasting, reproduction by photocopying machine or similar means, and storage in data banks. Under § 54 of the German Copyright Law where copies are made for other than private use, a fee is payable to the publisher, the amount of the fee to be determined by agreement with the puhlisher. @ by Springer-Verlag Berlin' Heidelberg 1973. Library of Congress Catalog Card Number 73-9197. Sol'tcover reprint of the hardcover 1st edition 1973 The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and there fore free for general use. Typesetting, Nomenclature, Methodology and Results of Clinical Trials in Acute Leukemias Edited by G. Mathe· P. Pouillart· L. Schwarzenberg With 79 Figures 1973 William Heinemann Medical Books Ltd., London Springer-Verlag Berlin. Heidelberg. New York Workshop held June 19 and 20, 1972 at the Centre National de la Recherche Scientifique (C.N.R.S.), 15, quai Anatole France, 75007 Paris, France co-sponsored by Institut de Cancerologie et d'Immunogenetique (LC.LG.) Institut National de la Sante et de la Recherche Medicale (LN.S.E.R.M.) European Organization for Research on Treatment of Cancer (E.O.R.T.C.) National Cancer Institute (N.C.L) Sponsored by the Swiss League against Cancer ISBN-13:978-3 -642-80778-7 e-ISBN-13:978-3 -642-80776-3 DOl: 10.1007/978-3-642-80776-3 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by photocopying mamine or similar means, and storage in data banks. Under § 54 of the German Copyright Law where copies are made for other than private use, a fee is payable to the publisher, the amount of the fee to be determined by agreement with the publisher. @ by Springer-Verlag Berlin· Heidelberg 1973. Library of Congress Catalog Card Number 73-9197. Softcover reprint of the hardcover 1st edition 1973 The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and there fore free for general use. Typesetting, Contents MATHE, G.: General Introduction. 1 First Session - Nomenclature and Classification PERRY, S.: Introduction to Nomenclature and Classification of Acute Leukemias 3 MATHE, G., POUILLART, P., WEINER, R., HAYAT, M., STERESCO, M., LAFLEUR, M.: Classification and Subclassification of Acute Leukemias Correlated with Clinical Expression, Therapeutic Sensitivity and Prognosis 6 BEARD, M. E. J.: Classification of Acute Leukemias Using Romanowsky, Sudan Bla&: and Periodic Acid Schiff Stains 21 BENNETT, J. M., KLEMPERER, M. R., SEGEL, G. B.: Survival Prediction Based on Morphology of Lymphoblasts 23 LEE, S. L., GLIDEWELL, 0.: Cytology and Survival in Acute Lymphatic Leukemia of Children . . . . . 28 RAPPAPORT, H.: Histologic Criteria for Diagnosis and Classification of Acute Leukemias 35 FLANDRIN, G., DANIEL, M. T.: Practical Value of Cytochemical Studies for the Classification in Acute Leukemias 43 LOFFLER, H.: Indications and Limits of Cytochemistry in Acute Leukemia 57 BESSIS, M.: Cytologic Diagnosis of Leukemias by Electron Microscopy . 63 PAINTRAND, M., DANTCHEV, D., MATHE, G.: Electron Microscopic Aspects of Cells in the Four Subvarieties of Acute Lymphoid Leukemia 71 GAVOSTO, F.: Observations on the Kinetics of Acute Lymphoblastic Leukemia in Relation to its Division into Subvarieties . 76 FREI, III, E., HART, J. S.: Cytokinetic Studies and Treatment Response in Adult Acute Leukemia . . . . . 81 POUILLART, P.: Contribution of Cultures in Agar to the Classification of Acute Leukemias: Preliminary Results . 88 COWAN, D. H., MESSNER, H. A., SENN, J. S., MCCULLOCH, E. A.: The Hetero- geneity of Cell Culture Findings in Patients with Acute Myeloblastic Leukemia 92 c., HALL, T. KESSEL, D., NAHAS, A., HACKER, B.: Biochemical Techniques for Classification of Leukemic Cell Types . 97 PERRY, S.: Conclusions of the Working Session on Nomenclature and Classifica- tion 105 Second Session - Methodology of Clinical Trials CARTER, S. K.: Introduction to Methodology of Clinical Trials in the Varieties of Acute Leukemia; Defining the Numerator and Denominator in Leukemic Trials. 107 VI Contents MATHE, G., WEINER, R.: Criteria for Short-Term Results in the Treatment of Acute Leukemia 110 KARON, M.: Problems in the Evaluation of Long-Term Results . 113 BERGSAGEL, D. E., COWAN, D. H.: Attempts at Standardization of Methods and Expression of Results. 121 c.: PIKE, M. The Analysis of Clinical Trials in Leukemia . 126 Third Session - Actuarial Results c., DOWLING, JR., M. D., HAGHBIN, M., GEE, T. S., CUNNINGHAM, B., TAN, C. T. CLARKSON, B. D., BURCHENAL, J. H.: Comparative Results Obtained in the Treatment of Acute Leukemia 133 BORELLA, L., GREEN, A. A., AUR, R. J. A., SIMONE, J. V., PINKEL, D.: Clinical and Immunological Recovery of Children with Acute Lymphocytic Leukemia Admitted to "Total Therapy" Studies . 145 BERNARD, J., BOIRON, M., JACQUILLAT, CL., W"IL, M.: Recent Results in Acute Leukemias at the Hospital Saint-Louis . 151 JACQUILLAT, CL., WElL, M., GEMON, M.-F., IZRAEL, V., BOIRON, M., BERNARD, J.: A New Agent Active in the Treatment of Acute Myeloblastic Leukemia: 22050 R. P. . 155 SCHWARZENBERG, L., MATHE, G., POUILLART, P., WEINER, R., HAYAT, M., AMIEL, J. L., JASMIN, c., ROSENFELD, c., DE VASSAL, F., SCHNEIDER, M., CATTAN, A.: Comparative Results Obtained in the Treatment of Acute Lymphoid Leu- kemia, Acute Myeloid Leukemia and Acute Monocytoid Leukemia. 160 Preliminary Results of a Trial on Acute Myeloid Leukemia Comparing the Effect of Cytosine Arabinoside, the Combination of Cytosine Arabinoside and Thioguanine and the Combination of Cytosine Arabinoside and Dauno rubicine by "Leukemia and Hematosarcoma" Cooperative Group of the EORTC . 165 List of Participants AMIEL, J. L., Unite Fred-Siguier de Development Therapeutique, Institut de Cancero logie et d'Immunogenetique, Hopital Paul-Brousse, 14-16, Avenue Paul-Vaillant Couturier, 94800 Villejuif, France AUR, R. J. A., St. Jude Children's Research Hospital, 332 North Lauderale, Memphis, TN 38101, USA BEARD, M. E. J., Department of Haematology, St. Bartholomew's Hospital, London, E. C.l, UK BENNETT, J. M., Departments of Medicine and Pediatrics, The University of Rochester, School of Medicine and Dentistry, Division of Oncology and the Highland Hospital of Rochester, Rochester, NY, USA BERGSAGEL, D. E., Princess Margaret Hospital, 500 Sherbourne Street, Toronto 5, Canada BERNARD, J., Institut de Recherches sur les Leucemies, Hopital Saint-Louis, 2, place du Docteur A. Fournier, 75010 Paris, France BESSIS, M., Institut de Pathologie Cellulaire, Hopital de Bic&tre, Universite de Paris, 75 Paris, France BOIRON, M., Institut de Recherches sur les Maladies du Sang, Hopital Saint-Louis, 2, place de Docteur A. Fournier, 75010 Paris, France BORELLA, L., St. Jude Children's Research Hospital, 332 North Lauderale, Memphis, TN 38101, USA BURCHENAL, J. H., Sloan-Kettering Institute for Cancer Research, Division of Chemo therapy Research, Memorial Hospital for Cancer and Allied Diseases and Cornell University Medical College, New York, NY, USA CARTER, S. K., National Cancer Institute, N. I. H., Bethesda, MD 20014, USA CATTAN, A., C.R.L.C., 45 rue Coqnacq Jay, 51100 Reims, France CLARKSON, B. D., Sloan-Kettering Institute for Cancer Research, Division of Chemo therapy Research, Memorial Hospital for Cancer and Allied Diseases and Cornell University Medical College, New York, NY, USA COWAN, D. H., Department of Medicine, Princess Margaret Hospital and the Ontario Cancer Institute and Sunnybrook Hospital and the University of Toronto, Toronto, Canada CUNNINGHAM, B., Sloan-Kettering Institute for Cancer Research, Division of Chemo therapy Research, Memorial Hospital for Cancer and Allied Diseases and Cornell University Medical College, New York, NY, USA DANIEL, M. T., Institut de Recherches sur les Leucemies et les Maladies du Sang, Hopi tal Saint-Louis, 2, place de Docteur A. Fournier, 75010 Paris, France DANTCHEV, D., Institut de Cancerologie et d'Immunogenetique, Hopital Paul-Brousse, 14-16, Avenue Paul-Vaillant-Courturier, 94800 Villejuif, France
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