New Trends in Genetic Risk Assessment PDF
Preview New Trends in Genetic Risk Assessment
Based on the Proceedings of the Fifth International Round Table of the Rhône-Poulenc Santé Foundation, Nice 1987 New Trends in Genetic Risk Assessment edited by G. JOLLES Rhône-Poulenc Santé Antony France and A. CORDIER Rhône-Poulenc Santé Vitry-sur-Seine France ACADEMIC PRESS Harcourt Brace Jovanovich, Publishers London San Diego New York Berkeley Boston Sydney Tokyo Toronto ACADEMIC PRESS LIMITED. 24/28 Oval Road, London NW1 7DX United States Edition Published by ACADEMIC PRESS INC. San Diego, CA 92101 All Chapters have Copyright © 1989 by ACADEMIC PRESS LTD. except Chapters 3 and 13 and Chapter 17 held by Gesellschaft für Strahlen (GSF) All rights reserved. No part of this book may be reproduced in any form by photostat, microfilm, or any other means, without written permission from the publishers British Library Cataloguing in Publication Data New Trends in Genetic Risk Assessment 1. Man. Mutagenic effects on chemicals I. Jolies, G. II. Cordier, Α. 573.2'292 ISBN 0-12-388176-5 Typeset by Photo graphics, Honiton, Devon and printed in Great Britain by Cambridge University Press, Cambridge Contributors AI Achkar, W. Commissariat à l'Energie Atomique, Institut de Protection et de Sûreté Nucléaire, Département de Protection Sanitaire, BP N° 6, 92260 Fontenay-aux-Roses Cedex, France. Albertini, R.J. University of Vermont, Genetics Laboratory, 32 Ν. Pro- spect Street, Burlington, VT 05409, USA. Arlett, C.F. University of Sussex, MRC Cell Mutation Unit, Falmer, Brighton, Sussex BN1 9RR, Great Britain. Ashby, J. Imperial Chemical Industries PLC, Central Toxicology Labora- tory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, Great Britain. Athwal, R.S. New Jersey Medical School, Department of Microbiology and Molecular Genetics, 185 South Orange Avenue, Newark, NJ 07103, USA. Benzi, R. University of Sussex, Centre for Medical Research, Falmer, Brighton, Sussex BN1 9RR, Great Britain. Branscomb, E.W. University of California, Lawrence Livermore National Laboratory, Biomedical Sciences Division, PO Box 5507 L-452, Livermore, CA 94550, USA. Bridges, B.A. University of Sussex, MRC Cell Mutation Unit, Falmer, Brighton, Sussex BN1 9RR, Great Britain. vi Contributors Brusick, D. Hazleton Laboratories America Inc., Molecular Toxicology Division, 5516 Nicholson Lane, Kensington, MD 20895, USA. Cole, H. University of Sussex, Centre for Medical Research, Falmer, Brighton, Sussex BN1 9RR, Great Britain. Cole, J. University of Sussex, MRC Cell Mutation Unit, Falmer, Brighton, Sussex BN1 9RR, Great Britain. Cordier, A. Rhône-Poulenc Santé, Centre de Recherches de Vitry, Département de Toxicologie, 13 quai Jules Guesde, 94403 Vitry sur Seine Cedex, France. Dean, P.N. University of California, Lawrence Livermore National Laboratory, Biomedical Sciences Division, PO Box 5507, Livermore, CA 94550, USA. Diot, M.C Institut de Recherches Scientifiques sur le Cancer, CNRS, Département de Toxicologie, 7 rue Guy Môquet, BP 8, 94802 Villejuif Cedex, France. Dirheimer, G. Institut de Biologie Moléculaire et Cellulaire, CNRS, 15 rue René Descartes, 67084 Strasbourg Cedex, France. Dutrillaux, B. Institut Curie, Section de Biologie, CNRS UA 620, 26 rue d'Ulm, 75231 Paris Cedex 05, France. Ehling, U.H. Gesellschaft für Strahlen und Umweltforschung MBH, Institut für Säugetiergenetik, 8042 Neuherberg, Federal Republic of Germany. Ehrenberg, L. Stockholm University, Department of Radiobiology, 106 91 Stockholm, Sweden. Ennever, F.K. Case Western Reserve University, School of Medicine, Department of Environmental Health Sciences, Cleveland, OH 44106, USA. Evenson, D.P. South Dakota State University, Department of Chemistry, Animal Science Complex, Box 2170, Brookings SD 57007-1217, USA. Contributors vii Fuscoe, J.C. University of California, Lawrence Livermore National Laboratory, Biomedical Sciences Division, PO Box 5507, Livermore, CA 94550, USA. Gebara, M. University of Sussex, MRC Cell Mutation Unit, Falmer, Brighton, Sussex BN1 9RR, Great Britain. Gerbault-Seureau, M. Institut Curie, Section de Biologie, UA 620 CNRS, 26 rue d'Ulm, 75231 Paris Cedex 05, France. Goerlich, O. Institut Pasteur, CNRS UA 271, INSERM U 163, Unité de Programmation Moléculaire et Toxicologie Génétique, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France. Gray, J.W. University of California, Lawrence Livermore National Laboratory, Biomedical Sciences Division, PO Box 5507, Livermore, CA 94550, USA. Green, M.H.L. University of Sussex, MRC Cell Mutation Unit, Falmer, Brighton, Sussex BN1 9RR, Great Britain. Gudi, R. New Jersey Medical School, Department of Microbiology and Molecular Genetics, 185 South Orange Avenue, Newark, NJ 07103, USA. Harcourt, S.A. University of Sussex, MRC Cell Mutation Unit, Falmer, Brighton, Sussex BN1 9RR, Great Britain. Henderson, L. Huntingdon Research Centre, Department of Mutagen- esis and Cell Biology, Huntingdon, Cambridgeshire PE18 6ES, Great Britain. Hoffschir, F. Commissariat à l'Energie Atomique, Institut de Protection et de Sûreté Nucléaire, Département de Protection Sanitaire, BP N° 6, 92260 Fontenay-aux-Roses Cedex, France. Hofnung, M. Institut Pasteur, CNRS UA 271, INSERM U 163, Unité de Programmation Moléculaire et Toxicologie Génétique, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France. James, M.R. Institut de Recherches Scientifiques sur le Cancer, 94802 Ville juif Cedex, France. viii Contributors James, S.E. University of Sussex, MRC Cell Mutation Unit, Falmer, Brighton, Sussex BN1 9RR, Great Britain. Klopman, G. Case Western Reserve University, School of Medicine, Department of Environmental Health Sciences, Cleveland, OH 44106, USA. Lamb, J.R. University of Sussex, MRC Cell Mutation Unit, Falmer, Brighton, Sussex BN1 9RR, Great Britain. Lehmann, A.R. University of Sussex, MRC Cell Mutation Unit, Falmer, Brighton, Sussex BN1 9RR, Great Britain. Leonard, A. Centre d'Etude de l'Energie Nucléaire, Département de Biologie, Boeretrang 200, 2400 Mol, Belgium. Lucas, J.N. University of California, Lawrence Livermore National Laboratory, Biomedical Sciences Division, PO Box 5507, Livermore, CA 94550, USA. Magdelenat, H. Institut Curie, Service de Radiopathologie, 26 rue d'Ulm, 75231 Paris Cedex 05, France. Melcion, C. Rhône-Poulenc Santé, Centre de Recherches de Vitry, Département de Toxicologie, 13 quai Jules Guesde, 94403 Vitry sur Seine Cedex, France. Mohrenweiser, H.W. University of California, Lawrence Livermore National Laboratory, Biomedical Sciences Division, PO Box 5507 L-452, Livermore, CA 94550, USA. Moustacchi, E. Institut Curie, Section de Biologie, 26 rue d'Ulm, 75231 Paris Cedex 05, France. Muleris, M. Institut Curie, Section de Biologie, UA 620 CNRS, 26 rue d'Ulm, 75231 Paris Cedex 05, France. Muriel, W.J. University of Sussex, MRC Cell Mutation Unit, Falmer, Brighton, Sussex BN1 9RR, Great Britain. Nicklas, J.A. University of Vermont, Genetics Laboratory, 32 N. Pro- spect Street, Burlington, VT 05409, USA. Contributors ix O'Neill, J.P. University of Vermont, Genetics Laboratory, 32 N. Pro- spect Street, Burlington, VT 05409, USA. Parry, E.M. University College of Swansea, School of Biological Sciences, Singleton Park, Swansea, Wales SA2 8PP, Great Britain. Parry, J.M. University College of Swansea, School of Biological Sciences, Singleton Park, Swansea, Wales SA2 8PP, Great Britain. Peters, D.C University of California, Lawrence Livermore National Laboratory, Biomedical Sciences Division, PO Box 5507, Livermore, CA 94550, USA. Phillips, D.H. Institute of Cancer Research, Chester Beatty Laboratories, Fulham Road, London SW3 6JB, Great Britain. Price, M.L. Brighton General Hospital, Dermatology Department, Elm Grove, Brighton, Sussex BN1 9RR, Great Britain. Prieur, M. Institut Curie, Section de Biologie, UA 620 CNRS, 26 rue d'Ulm, 75231 Paris Cedex 05, France. Prod'homme-Ricoul, M. Commissariat à l'Energie Atomique, Institut de Protection et de Sûreté Nucléaire, Département de Protection Sanitaire, BP N° 6, 92260 Fontenay-aux-Roses Cedex, France. Quillardet, P. Institut Pasteur, CNRS UA 271, INSERM U 163, Unité de Programmation Moléculaire et Toxicologie Génétique, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France. Radman, M. Institut Jacques Monod, Université Paris VII, Laboratoire de Mutagenèse, Tour 43, 2 place Jussieu, 75251 Paris Cedex 05, France. Rigaud, O. Commissariat à l'Energie Atomique, Institut de Protection et de Sûreté Nucléaire, Département de Protection Sanitaire, Services d'Hygiène Radiologique, BP No° 6, 92260 Fontenay-aux-Roses Cedex, France. Roe, F.J.C. 19 Marryat Road, Wimbledon Common, London SW19 5BB, Great Britain. χ Contributors Rosenkranz, H.S. Case Western Reserve University, School of Medicine, Department of Environmental Health Sciences, Cleveland, OH 44106, USA. Sabatier, L. Commissariat à l'Energie Atomique, Institut de Protection et de Sûreté Nucléaire, Département de Protection Sanitaire, BP N° 6, 92260 Fontenay-aux-Roses Cedex, France. Sala-Trepat, M. Institut Curie, Section de Biologie, 26 rue d'Ulm, 75231 Paris Cedex 05, France. Sandhu, S.S. United States Environmental Protection Agency, Genetic Toxicology Division, Health Effects Research Laboratory, Research Triangle Park, NC 27711, USA. Sankaranarayanan, K. State University of Leiden, Department of Radiation Genetics and Chemical Mutagenesis, Sylvius Laboratories, Wassenaarseweg 72, 2333 AL, Leiden, Netherlands. Sarasin, A. Institut de Recherches Scientifiques sur le Cancer, Labor- atoire de Mutagenèse Moléculaire, 7 rue Guy Môquet, BP 8, 94802 Ville juif Cedex, France. Steingrimsdottir, H. University of Sussex, MRC Cell Mutation Unit, Falmer, Brighton, Sussex BN1 9RR, Great Britain. Touati, E. Institut Pasteur, CNRS UA 271, INSERM U 163, Unité de Programmation Moléculaire et Toxicologie Génétique, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France. Trask, B.J. University of California, Lawrence Livermore National Laboratory, Biomedical Sciences Division, PO Box 5507, Livermore, CA 94550, USA. Van den Engh, G.J. University of California, Lawrence Livermore National Laboratory, Biomedical Sciences Division, PO Box 5507, Livermore, CA 94550, USA. Van Dilla, M.A. University of California, Lawrence Livermore National Laboratory, Biomedical Sciences Division, PO Box 5507, Livermore, CA 94550, USA. Viegas-Pequignot, E. Commissariat à l'Energie Atomique, Institut de Protection et de Sûreté Nucléaire, Département de Protection Sanitaire, BP N° 6, 92260 Fontenay-aux-Roses Cedex, France. Participants Averbeck, D. Institut Curie, Section de Biologie, 26 rue d'Ulm, 75231 Paris Cedex 05, France. Bichet, N. Sanofi, Direction des Recherches, Service de Toxicologie, Rue du Professeur J. Blayac, 34082 Montpellier Cedex, France. Bonneau, D. Rhône-Poulenc Santé, Centre de Recherches de Vitry, Département de Toxicologie, 13 quai Jules Guesde, 94403 Vitry sur Seine Cedex, France. Bost, P.E. Rhône-Poulenc Santé, Direction des Recherches, 20 avenue Raymond Aron, 92165 Antony Cedex, France. Cadet, J. Centre d'Etudes Nucléaires de Grenoble, Département de Recherches Fondamentales, Laboratoire de Chimie, 38041 Grenoble Cedex, France. C ail lard, L. Rhône-Poulenc SA, Service de Toxicologie Industrielle, 47 rue de Villiers, 92527 Neuilly sur Seine Cedex, France. Champey, Y. Rhône-Poulenc Santé, Direction Médicale et Scientifique, 20 avenue Raymond Aron, 92165 Antony Cedex, France. Chouroulinkov, I. Institut de Recherches Scientifiques sur le Cancer, CNRS, Département de Toxicologie, 7 rue Guy Môquet, BP 8, 94802 Ville juif Cedex, France.
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