New Trends in Allergy

342 Pages·1981·7.34 MB·English

by  L.-D. Leder (auth.)

New Trends in Allergy
Edited by
J. Ring and G. Burg
With a Foreword by O. Braun-Falco
With 106 Figures
Springer-Verlag
Berlin Heidelberg New York 1981
Privatdozent Dr. Johannes Ring
Prof. Dr. Gunter Burg,
Dermatologisehe Klinik und Poliklinik der
Ludwig-Maximilians-Universitat,
(Head: Prof. Dr. Dr. he. O. Braun-Falco)
Frauenlobstr. 9,
0-8000 Munehen 2
ISBN-13: 978-3-540-10346-2 e-ISBN-13: 978-3-642-67807-3
DOl: 10.1007/978-3-642-67807-3
Library of Congress Cataloging in Publication Data. Main entry under title:
New trends in allergy. Bibliography: p. Includes index. 1. Allergy. I. Ring, Johannes.
II. Burg, Giinter. RC584.N48 616.97 81-4924 ISBN 0-387-10346-5 (U.S.) AACR2
This work is subject to copyright. All rights are reserved, whether the whole or part of the ma
terial is concerned, specifically those of translation, reprinting, re-use of illustrations, broad
casting, reproduction by photocopying machine or similar means, and storage in data banks.
Under § 54 of the German Copyright Law where copies are made for other than private use a
fee is payable to "Verwertungsgesellschaft Wort", Munich.
© Springer-Verlag Berlin Heidelberg 1981
The use of general descriptive names, trade names, trade marks, etc. in this publication, even
if the former are not especially identified, is not to be taken as a sign that such names, as
understood by the Trade Marks and Merchandise Marks Act, may accordingly be used freely
by anyone.
Composition: R. & J. Blank, Composer-& Fotosatzstudio GmbH, Miinchen
2127/3321-543210
Contents
Foreword
O. Braun-Falco. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . X
The Mast Cell
The Mast Cell: Morphology and Ontogeny
L.-D. Leder. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2
Mast Cell Activation and Secretion
S.T. Holgate, R.A. Lewis and K.F. Austen 9
Mast Cell Granule Induced Late Phase Responses (LPR)
in Rat Skin: Effect of Corticosteroids (CCS).
Partial Purification of Infiltration Inducing Factors
H. Oertel ........................................... 20
The IgE Receptor
W. Konig, K. Theobald, G. Moller, P. Pfeiffer
andA. Bohn ........................................ 21
Releasability - a New Dimension in Basophil and
Mast Cell Reactivity
M.C. Conroy ........................................ 40
In Vitro Sensitization of Rat Mast Cells by Human Serum
IgE Tested by Histamine Release
R.Sonak............................................ 46
Stress and Histamine
H.-J. Reimann, H.J. Meyer and P. Wendt 50
Vasoactive Mediators
Release of Proinflammatory Peptides by Complement in
Prophyrin-induced Photosensitivity
1. Gigli and H.W. Lim ................................ 58
V
Contents
Interaction of DNA with the Early Components
of Complement
M. Meurer and I. Gigli . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 69
Pharmacological Regulation of Histamine Release in Skin
M.W. Greaves, A. Kobza Black and S. Yamamoto 70
Kallikreins, Kinins and Allergy
W. Miiller-Esterl and H. Fritz ......................... 81
Induction of Late Cutaneous Reactions (LCR) by Skin
Blister Fluid (SBF) from Allergen-Tested and Normal Skin
W.DorschandJ.Ring ................................ 91
Kallikrein Activity in Skin Blister Fluid from
Allergen-induced Dual Skin Reactions
W. Dorsch and R. Geiger ............................. 95
Diagnostics
Variations of the Radioallergosorbent Test for
Measurement of IgE Antibody Levels, Allergens and
Blocking Antibody Activity
G.J.GleichandJ.W.Yunginger ....................... 98
Drug Influences upon Skin Test Reactivity
E. Schopf .................. " .. . . . . . ... . . . . .. .. .. . . . . 108
Immunological Work up
G.BurgandT.Rehle ................................. 115
Immunohistologic Diagnosis with Protein A - Peroxidase
in Allergic Vasculitis
T.H. Trost, M. Noack and H. Pullmann . . . . . . . . . . . . . . . . . . 129
Thermographic Analysis of Skin Test Reactions by AGA
Thermovision and Ikotherm (Zeiss)
G. Stiittgen and U. Flesch ............................. 130
Relationship Between Skin Tests, Bronchial Provocation
and RAST in Patients with Bronchial Asthma
X. Baur, G. Fruhmann, G. Burg and V. von Liebe 134
Skin Tests and Dermatophagoides Allergy
C. Scarpa and G. Talocchi ............................. 135
VI
Contents
Comparison Between Radioimmunoassay (RIA) and
Enzyme Immunoassay (EIA) for the Determination of
Serum Total IgE and IgE Antibodies
G.M. Halpern, A. Bedossa and C. Levy ................. 137
Clinical Allergy
Allergic Vasculitis
H.H. Wolff and R. Scherer 140
Urticarial Vasculitis
M. Meurer.. .. . . . . . . ... . .. . ... . . . .... . .. .. . . . . . .. . . . . 148
Photoallergy
G. Plewig, E. H61z1e, E. Roser-MaaB and C. Hofmann 152
Localization of a Clinically Relevant Antigenic Determinant
Within an Insect Hemoglobin (Erythrocruorin) of
Chironomus (Sequence 58-98 of CIT VI)
X. Baur, H. Aschauer, D. Ziegler and G. Braunitzer 170
Specific Serum Factors Mediate Responses to Pollen
J.F.JonesandR.Lindberg ............................ 171
Risk-Factors for the Development of Pollinosis
and Extrinsic Asthma
G. Enders and G. Kunkel . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 172
Ragweed Pollen Allergy in Austria
F. Horak, S. Jager and R. Turk ......................... 175
Allergy Caused by Internal Exposure to Copper
(Copper-T-IUD)
G. Forck ............................................ 178
Contact Dermatitis
Langerhans Cells in Contact Hypersensitivity
G. Stingl and W. Aberer . . . . .. . . .. .. ... . . . . . . . .. . . . . .. . 182
Vasoactive Mediators in Contact Sensitivity
L. Polak and T. Rufli . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 187
Topography of Contact Dermatitis and Patch Testing
H.-J. Bandmann and M. Agathos . . . . . . . . . . . . . . . . . . . . . . . 200
VII
Contents
The E.S.S. - Excited Skin Syndrome
(Alias the" Angry Back")
H.I. Maibach ........................................ 208
Atopic Dermatitis
Histamine Release in Atopic Dermatitis of Childhood
P. Y. Venencie, B. Lebel and J .H. Saurat . . . . . . . . . . . . . . . . . 224
T Cell Defects in Atopic Dermatitis:
Therapeutic Consequences
R. Jarisch . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 231
Atopic Dermatitis: a Disease of Immuno-vegetative
(Autonomic) Dysregulation
J. Ring.............................................. 237
Lymphocyte Function in Atopy: Regulatory Role of
Beta-adrenergic Receptors
A. Giannetti, V. Monafo, S. Seidenari, M. Cespa and
A.M. Castellazzi ..................................... 250
Spontaneous Tritiated Thymidine Incorporation by Cells of
the Dermal Infiltrate and by Peripheral Blood Lymphocytes
in Atopic Dermatitis
D. van Neste andJ.M. Lachapelle ...................... 251
Ascaris Suum Extract: Polyclonal Activator Properties as
Possible Tools for Investigating in Vitro IgE Production in
Humans
L. Nespoli, R. Maccario, F. Ferrari, A. Vitiello, S. Siena and
A. Giannetti ......................................... 254
Clinical Therapy
Evaluation and Treatment of Insect Sting Allergy
K.C. Schuberth, D.B.K. Golden, A. Kagey-Sobotka,
M.D. Valentine and L.M. Lichtenstein .................. 260
Insect Venom Tolerance: IgG "Blocking" Antibodies and
Sting Provocation
G. Forck, H. Kastner, K.-J. Kalveram and C. Kalveram 269
VIn
Contents
Clinical Aspects and Therapy of Hereditary Angioneurotic
Edema
W. Opferkuch, P.M. Kovary, U. Jaeger, K. Echternacht
Happle, W. Gronemeyer, C. Hammar, H. Niemczyk and
C. Rieger . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 272
Modern Approaches to Treatment of Chronic Urticaria
L. Juhlin. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 279
ALG Therapy in Horse IgG Sensitized Kidney Transplanted
Patients
H.F. Welter, C. Hammer and W. Land .................. 283
Hapten Inhibition of Dextran-induced Anaphylactoid
Reactions: a Clinical Study
H. Laubenthal, H. Hedin, W. Richter, K. Peter, C. Seemann
and K. MeSmer ...................................... 285
New Therapeutic Concepts (Experimental Studies)
Regulation ofIgE Response by Antiidiotypes and Adjuvants
A.L. de Weck ........................................ 288
Suppression of IgE Antibodies with Tolerogenic Derivatives
of Allergens
A.H. Sehon and W.Y. Lee ............................. 294
Specific IgE Anti-Timothy Immunosuppression by P4
Allergen Coupled to Poly (N-Vinylpyrrolidone)
B.U.v.SpechtandN.Smorodinsky ..................... 308
Recent Studies with Human IgE Pentapeptide (HEPP)
R.N. Hamburger..................................... 311
Decrease of Circulating Antibodies in Blood by Enteral
Antigen Application
J. Seifert, G. Enders, B. Eberle, J. Krumbach and
W. Brendel. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 320
Epilogue
Allergic, but to what?
J. Ring.............................................. 324
Index of Authors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 328
Subject Index. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 329
IX
Foreword
From the first to the third of August, 1980, an international sym
posium entitled "New Trends in Allergy" was held in Munich,
sponsored by the Ludwig-Maximilian University, Munich, in
cooperation with the German Society for Allergy and Immunity
Research and the European Society for Dermatological Research.
The symposium pursued two main goals: to bring allergy
oriented colleagues from various specialties such as dermatology,
otorhinolaryngology, pediatrics, internal medicine, immunology,
and pulmonology together for interdisciplinary contacts and dis
cussions; and to attract internationally known experts in an effort
to disseminate information on new and fundamental develop
ments in allergology. The fact that English has become the lingua
franca at congresses for the exchange of ideas in medical
specialties led to the decision to hold the symposium in English. In
spite of the mild handicap this posed for some participants, it was
also a major factor in the symposium's success.
This book contains the papers delivered by the invited speakers
together with the poster presentations. They cover both basic ex
perimental research as well as clinical problems in allergology.
Their arrangement here is necessarily slightly different from the
order in which they were presented at the symposium. The main
areas discussed in this book can be described as follows: mast cells;
vasoactive mediators of allergic or immunologic reactions;
diagnostic methods for the recognition of allergologic reactions;
and problems in clinical allergology, in particular contact dermatitis
and atopic dermatitis. Considerable space is devoted to clinical
treatment as well as to recent therapeutic concepts derived from
experimental studies.
Of course, a book such as this cannot hope to capture the at
mosphere of the symposium, especially since the discussions and
pharmaceutic displays could not be included. It is astounding, how
ever, just how much information the text does offer the reader
seeking to acquaint himself with the latest developments in aller
gology and immunology, insofar as they hold clinical or practical
relevance for him.
I would like to take this opportunity to thank my collaborators,
Professor Dr. G. Burg and Privatdozent Dr. J. Ring, without whose
x
Foreword
efforts this book would not have been possible, and to Springer
Verlag for the book's rapid publication. May it find a wide audi
ence, for it contains a wealth of practical information for colleagues
in clinical and private practice.
o. Braun-Falco, Miinchen
XI