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342 Pages·1981·7.34 MB·English
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New Trends in Allergy Edited by J. Ring and G. Burg With a Foreword by O. Braun-Falco With 106 Figures Springer-Verlag Berlin Heidelberg New York 1981 Privatdozent Dr. Johannes Ring Prof. Dr. Gunter Burg, Dermatologisehe Klinik und Poliklinik der Ludwig-Maximilians-Universitat, (Head: Prof. Dr. Dr. he. O. Braun-Falco) Frauenlobstr. 9, 0-8000 Munehen 2 ISBN-13: 978-3-540-10346-2 e-ISBN-13: 978-3-642-67807-3 DOl: 10.1007/978-3-642-67807-3 Library of Congress Cataloging in Publication Data. Main entry under title: New trends in allergy. Bibliography: p. Includes index. 1. Allergy. I. Ring, Johannes. II. Burg, Giinter. RC584.N48 616.97 81-4924 ISBN 0-387-10346-5 (U.S.) AACR2 This work is subject to copyright. All rights are reserved, whether the whole or part of the ma terial is concerned, specifically those of translation, reprinting, re-use of illustrations, broad casting, reproduction by photocopying machine or similar means, and storage in data banks. Under § 54 of the German Copyright Law where copies are made for other than private use a fee is payable to "Verwertungsgesellschaft Wort", Munich. © Springer-Verlag Berlin Heidelberg 1981 The use of general descriptive names, trade names, trade marks, etc. in this publication, even if the former are not especially identified, is not to be taken as a sign that such names, as understood by the Trade Marks and Merchandise Marks Act, may accordingly be used freely by anyone. Composition: R. & J. Blank, Composer-& Fotosatzstudio GmbH, Miinchen 2127/3321-543210 Contents Foreword O. Braun-Falco. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . X The Mast Cell The Mast Cell: Morphology and Ontogeny L.-D. Leder. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Mast Cell Activation and Secretion S.T. Holgate, R.A. Lewis and K.F. Austen 9 Mast Cell Granule Induced Late Phase Responses (LPR) in Rat Skin: Effect of Corticosteroids (CCS). Partial Purification of Infiltration Inducing Factors H. Oertel ........................................... 20 The IgE Receptor W. Konig, K. Theobald, G. Moller, P. Pfeiffer andA. Bohn ........................................ 21 Releasability - a New Dimension in Basophil and Mast Cell Reactivity M.C. Conroy ........................................ 40 In Vitro Sensitization of Rat Mast Cells by Human Serum IgE Tested by Histamine Release R.Sonak............................................ 46 Stress and Histamine H.-J. Reimann, H.J. Meyer and P. Wendt 50 Vasoactive Mediators Release of Proinflammatory Peptides by Complement in Prophyrin-induced Photosensitivity 1. Gigli and H.W. Lim ................................ 58 V Contents Interaction of DNA with the Early Components of Complement M. Meurer and I. Gigli . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 69 Pharmacological Regulation of Histamine Release in Skin M.W. Greaves, A. Kobza Black and S. Yamamoto 70 Kallikreins, Kinins and Allergy W. Miiller-Esterl and H. Fritz ......................... 81 Induction of Late Cutaneous Reactions (LCR) by Skin Blister Fluid (SBF) from Allergen-Tested and Normal Skin W.DorschandJ.Ring ................................ 91 Kallikrein Activity in Skin Blister Fluid from Allergen-induced Dual Skin Reactions W. Dorsch and R. Geiger ............................. 95 Diagnostics Variations of the Radioallergosorbent Test for Measurement of IgE Antibody Levels, Allergens and Blocking Antibody Activity G.J.GleichandJ.W.Yunginger ....................... 98 Drug Influences upon Skin Test Reactivity E. Schopf .................. " .. . . . . . ... . . . . .. .. .. . . . . 108 Immunological Work up G.BurgandT.Rehle ................................. 115 Immunohistologic Diagnosis with Protein A - Peroxidase in Allergic Vasculitis T.H. Trost, M. Noack and H. Pullmann . . . . . . . . . . . . . . . . . . 129 Thermographic Analysis of Skin Test Reactions by AGA Thermovision and Ikotherm (Zeiss) G. Stiittgen and U. Flesch ............................. 130 Relationship Between Skin Tests, Bronchial Provocation and RAST in Patients with Bronchial Asthma X. Baur, G. Fruhmann, G. Burg and V. von Liebe 134 Skin Tests and Dermatophagoides Allergy C. Scarpa and G. Talocchi ............................. 135 VI Contents Comparison Between Radioimmunoassay (RIA) and Enzyme Immunoassay (EIA) for the Determination of Serum Total IgE and IgE Antibodies G.M. Halpern, A. Bedossa and C. Levy ................. 137 Clinical Allergy Allergic Vasculitis H.H. Wolff and R. Scherer 140 Urticarial Vasculitis M. Meurer.. .. . . . . . . ... . .. . ... . . . .... . .. .. . . . . . .. . . . . 148 Photoallergy G. Plewig, E. H61z1e, E. Roser-MaaB and C. Hofmann 152 Localization of a Clinically Relevant Antigenic Determinant Within an Insect Hemoglobin (Erythrocruorin) of Chironomus (Sequence 58-98 of CIT VI) X. Baur, H. Aschauer, D. Ziegler and G. Braunitzer 170 Specific Serum Factors Mediate Responses to Pollen J.F.JonesandR.Lindberg ............................ 171 Risk-Factors for the Development of Pollinosis and Extrinsic Asthma G. Enders and G. Kunkel . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 172 Ragweed Pollen Allergy in Austria F. Horak, S. Jager and R. Turk ......................... 175 Allergy Caused by Internal Exposure to Copper (Copper-T-IUD) G. Forck ............................................ 178 Contact Dermatitis Langerhans Cells in Contact Hypersensitivity G. Stingl and W. Aberer . . . . .. . . .. .. ... . . . . . . . .. . . . . .. . 182 Vasoactive Mediators in Contact Sensitivity L. Polak and T. Rufli . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 187 Topography of Contact Dermatitis and Patch Testing H.-J. Bandmann and M. Agathos . . . . . . . . . . . . . . . . . . . . . . . 200 VII Contents The E.S.S. - Excited Skin Syndrome (Alias the" Angry Back") H.I. Maibach ........................................ 208 Atopic Dermatitis Histamine Release in Atopic Dermatitis of Childhood P. Y. Venencie, B. Lebel and J .H. Saurat . . . . . . . . . . . . . . . . . 224 T Cell Defects in Atopic Dermatitis: Therapeutic Consequences R. Jarisch . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 231 Atopic Dermatitis: a Disease of Immuno-vegetative (Autonomic) Dysregulation J. Ring.............................................. 237 Lymphocyte Function in Atopy: Regulatory Role of Beta-adrenergic Receptors A. Giannetti, V. Monafo, S. Seidenari, M. Cespa and A.M. Castellazzi ..................................... 250 Spontaneous Tritiated Thymidine Incorporation by Cells of the Dermal Infiltrate and by Peripheral Blood Lymphocytes in Atopic Dermatitis D. van Neste andJ.M. Lachapelle ...................... 251 Ascaris Suum Extract: Polyclonal Activator Properties as Possible Tools for Investigating in Vitro IgE Production in Humans L. Nespoli, R. Maccario, F. Ferrari, A. Vitiello, S. Siena and A. Giannetti ......................................... 254 Clinical Therapy Evaluation and Treatment of Insect Sting Allergy K.C. Schuberth, D.B.K. Golden, A. Kagey-Sobotka, M.D. Valentine and L.M. Lichtenstein .................. 260 Insect Venom Tolerance: IgG "Blocking" Antibodies and Sting Provocation G. Forck, H. Kastner, K.-J. Kalveram and C. Kalveram 269 VIn Contents Clinical Aspects and Therapy of Hereditary Angioneurotic Edema W. Opferkuch, P.M. Kovary, U. Jaeger, K. Echternacht Happle, W. Gronemeyer, C. Hammar, H. Niemczyk and C. Rieger . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 272 Modern Approaches to Treatment of Chronic Urticaria L. Juhlin. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 279 ALG Therapy in Horse IgG Sensitized Kidney Transplanted Patients H.F. Welter, C. Hammer and W. Land .................. 283 Hapten Inhibition of Dextran-induced Anaphylactoid Reactions: a Clinical Study H. Laubenthal, H. Hedin, W. Richter, K. Peter, C. Seemann and K. MeSmer ...................................... 285 New Therapeutic Concepts (Experimental Studies) Regulation ofIgE Response by Antiidiotypes and Adjuvants A.L. de Weck ........................................ 288 Suppression of IgE Antibodies with Tolerogenic Derivatives of Allergens A.H. Sehon and W.Y. Lee ............................. 294 Specific IgE Anti-Timothy Immunosuppression by P4 Allergen Coupled to Poly (N-Vinylpyrrolidone) B.U.v.SpechtandN.Smorodinsky ..................... 308 Recent Studies with Human IgE Pentapeptide (HEPP) R.N. Hamburger..................................... 311 Decrease of Circulating Antibodies in Blood by Enteral Antigen Application J. Seifert, G. Enders, B. Eberle, J. Krumbach and W. Brendel. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 320 Epilogue Allergic, but to what? J. Ring.............................................. 324 Index of Authors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 328 Subject Index. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 329 IX Foreword From the first to the third of August, 1980, an international sym posium entitled "New Trends in Allergy" was held in Munich, sponsored by the Ludwig-Maximilian University, Munich, in cooperation with the German Society for Allergy and Immunity Research and the European Society for Dermatological Research. The symposium pursued two main goals: to bring allergy oriented colleagues from various specialties such as dermatology, otorhinolaryngology, pediatrics, internal medicine, immunology, and pulmonology together for interdisciplinary contacts and dis cussions; and to attract internationally known experts in an effort to disseminate information on new and fundamental develop ments in allergology. The fact that English has become the lingua franca at congresses for the exchange of ideas in medical specialties led to the decision to hold the symposium in English. In spite of the mild handicap this posed for some participants, it was also a major factor in the symposium's success. This book contains the papers delivered by the invited speakers together with the poster presentations. They cover both basic ex perimental research as well as clinical problems in allergology. Their arrangement here is necessarily slightly different from the order in which they were presented at the symposium. The main areas discussed in this book can be described as follows: mast cells; vasoactive mediators of allergic or immunologic reactions; diagnostic methods for the recognition of allergologic reactions; and problems in clinical allergology, in particular contact dermatitis and atopic dermatitis. Considerable space is devoted to clinical treatment as well as to recent therapeutic concepts derived from experimental studies. Of course, a book such as this cannot hope to capture the at mosphere of the symposium, especially since the discussions and pharmaceutic displays could not be included. It is astounding, how ever, just how much information the text does offer the reader seeking to acquaint himself with the latest developments in aller gology and immunology, insofar as they hold clinical or practical relevance for him. I would like to take this opportunity to thank my collaborators, Professor Dr. G. Burg and Privatdozent Dr. J. Ring, without whose x Foreword efforts this book would not have been possible, and to Springer Verlag for the book's rapid publication. May it find a wide audi ence, for it contains a wealth of practical information for colleagues in clinical and private practice. o. Braun-Falco, Miinchen XI

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From the first to the third of August, 1980, an international sym­ posium entitled "New Trends in Allergy" was held in Munich, sponsored by the Ludwig-Maximilian University, Munich, in cooperation with the German Society for Allergy and Immunity Research and the European Society for Dermatological
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