New Look to Phytomedicine : Advancements in Herbal Products as Novel Drug Leads PDF
Preview New Look to Phytomedicine : Advancements in Herbal Products as Novel Drug Leads
New Look to Phytomedicine This pageintentionallyleftblank New Look to Phytomedicine Advancements in Herbal Products as Novel Drug Leads Editedby MOHD SAJJAD AHMAD KHAN Department of Basic Sciences,College of Medicine, Imam Abdulrahman Bin FaisalUniversity, Dammam, Kingdom of Saudi Arabia IQBAL AHMAD Department of Agricultural Microbiology, Aligarh Muslim University, Aligarh,India DEBPRASAD CHATTOPADHYAY ScientistG & Director, ICMR-NationalInstitute of TraditionalMedicine, Nehru Nagar, Belagavi,Karnataka, India AcademicPressisanimprintofElsevier 125LondonWall,LondonEC2Y5AS,UnitedKingdom 525BStreet,Suite1650,SanDiego,CA92101,UnitedStates 50HampshireStreet,5thFloor,Cambridge,MA02139,UnitedStates TheBoulevard,LangfordLane,Kidlington,OxfordOX51GB,UnitedKingdom Copyrightr2019ElsevierInc.Allrightsreserved. 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Practitionersandresearchersmustalwaysrelyontheirownexperienceandknowledgeinevaluating andusinganyinformation,methods,compounds,orexperimentsdescribedherein.Inusingsuch informationormethodstheyshouldbemindfuloftheirownsafetyandthesafetyofothers,including partiesforwhomtheyhaveaprofessionalresponsibility. Tothefullestextentofthelaw,neitherthePublishernortheauthors,contributors,oreditors,assume anyliabilityforanyinjuryand/ordamagetopersonsorpropertyasamatterofproductsliability, negligenceorotherwise,orfromanyuseoroperationofanymethods,products,instructions,orideas containedinthematerialherein. BritishLibraryCataloguing-in-PublicationData AcataloguerecordforthisbookisavailablefromtheBritishLibrary LibraryofCongressCataloging-in-PublicationData AcatalogrecordforthisbookisavailablefromtheLibraryofCongress ISBN:978-0-12-814619-4 ForInformationonallAcademicPresspublications visitourwebsiteathttps://www.elsevier.com/books-and-journals Publisher:MicaHaley AcquisitionEditor:Erin-HillParks EditorialProjectManager:MeganAshdown ProductionProjectManager:PoulouseJoseph CoverDesigner:MatthewLimbert TypesetbyMPSLimited,Chennai,India CONTENTS ListofContributors xv Preface xxi Section 1 Introduction to Herbal Therapeutics 1 1. Herbal Medicine: Current Trendsand Future Prospects 3 MohdSajjadAhmadKhanandIqbalAhmad 1.1 Introduction 3 1.2 HerbalMedicine:DefinitionandItsProspects 4 1.3 CurrentStatusofHerbalMedicine:SourceofModernMedicine FromHigherPlants 6 1.4 FutureProspectsofHerbalMedicine 7 1.5 Conclusion 10 Acknowledgment 11 References 11 2. Diversity of Bioactive Compounds andTheir Therapeutic Potential 15 MohdMusheerAltaf,MohdSajjadAhmadKhanandIqbalAhmad 2.1 Introduction 15 2.2 ClassificationandMajorRepresentativeofActiveCompounds 16 2.3 MajorBiologicalActivitiesofPhyto-Compounds:Occurrence andMechanisms 20 2.4 AsAntioxidants 21 2.5 AsAnticancer 22 2.6 AsAntimicrobial 23 2.7 AsAntiulcer 24 2.8 AsAntidiabetic 24 2.9 AsAntiinflammatory 24 2.10 MultifunctionalTargets 25 2.11 ApproachesforDrugDiscoveryFromPhyto-Compounds 27 2.12 ChallengesintheDiscoveryofNewPhyto-Compounds 28 2.13 ConclusionandFutureProspects 31 References 31 v vi Contents 3. EthnomedicinalWisdom: AnApproach for Antiviral Drug Development 35 AnanyaDasMahapatra,PriyankaBhowmik,AnweshaBanerjee, ApurbaDas,DurbadalOjhaandDebprasadChattopadhyay 3.1 Ethnomedicine:ABoon 35 3.2 EthnomedicinalWisdomofDiverseCommunities 36 3.3 EthnomedicineinIndianContext 38 3.4 ViralDiseases—AGlobalHealthConcern 39 3.5 EthnomedicineandVirus 40 3.6 ModeofActionofPlant-DerivedAntiviralAgents 42 3.7 MechanismofActionofPlant-DerivedAntiviralAgents 43 3.8 AntiviralEthno-PharmacologyofMajorClassesofCompounds 45 3.9 ChallengesforEthnomedicinesasAntivirals 52 3.10 Conclusion 54 References 54 FurtherReading 61 4. Plant-Derived Prebiotics and Its Health Benefits 63 AbdullahSafarAlthubiani,SalehBakheetAl-Ghamdi,Samreen, FaizanAbulQais,MohammadShavezKhan,IqbalAhmad andHeshamA.Malak 4.1 Introduction 63 4.2 SourcesofPrebiotics 67 4.3 ModeofActionofPrebiotics 69 4.4 ChemicalNatureandTypeofPrebiotics 71 4.5 ExtraintestinalEffectsofPrebiotics 76 4.6 SignificanceofPlant-BasedPrebioticsinDifferentDiseases/Clinical ApplicationsinHumans 78 4.7 ConclusionandFutureDirections 81 References 82 FurtherReading 87 Section 2A Biological Activity and Discovery of New Compounds From Herbs, Medicinal Plants, and Herbal Medicine 89 5. Moroccan Medicinal Plants as Antiinfective andAntioxidant Agents 91 MalikaAit-Sidi-Brahim,MohammedMarkoukandMustaphaLarhsini 5.1 Introduction 91 Contents vii 5.2 AntimicrobialActivityofMoroccanMedicinalPlants 93 5.3 AntimicrobialSynergeticInteractions 116 5.4 OtherActivities 124 5.5 AntioxidantActivity 126 5.6 Conclusion 136 References 137 6. Antiinflammatory Properties of Herbs in Oral Infection 143 SudhanshuSharma,VivekKumarSharma,SankalpMisra,GovindGupta, DeepakDiwvedi,BrahmaN.SinghandPuneetSinghChauhan 6.1 Introduction 143 6.2 Inflammation:OldFriendbutaDreadfulFoe 144 6.3 TypesofInflammation 144 6.4 InflammatoryMediators:KeyPlayersinInflammation 145 6.5 Antiinflammatory:ARetaliationProcess 146 6.6 OralCavity:ADynamicBattleGround 146 6.7 Phytoresources:NaturalCombatants 147 6.8 Conclusion 152 Acknowledgements 153 References 153 7. Bioactive Molecules,Pharmacology andFuture Research TrendsofGanoderma lucidium as a Cancer Chemotherapeutic Agent 159 TemitopeO.Lawal,SheilaM.Wicks,AngelaI.CalderonandGailB.Mahady 7.1 Introduction 159 7.2 BiologicallyActivePolysaccharidesofGanodermalucidum 160 7.3 BiologicallyActiveTriterpenesofGanodermalucidum 164 7.4 EffectsofGanodermaExtractsandBioactiveCompoundson OvarianandBreastCancers 165 7.5 EffectsofGanodermaPolysaccharidesandTriterpenesin ColorectalCancer 167 7.6 EffectsofGanodermaPreparationsonAsciticandHepatocellular Carcinomas 169 7.7 Leukemia,Fibrosarcoma,andAstrocytomaTumors 170 7.8 UseofChemometricsandBiochemometricstoIdentify AnticancerCompoundsinGanoderma 172 7.9 ConclusionsandFutureDirections/Prospects 174 References 175 viii Contents 8. Indian Berries and Their ActiveCompounds:Therapeutic Potential in Cancer Prevention 179 MohammadShavezKhan,FaizanAbulQaisandIqbalAhmad 8.1 Introduction 179 8.2 IndianBlackberry 181 8.3 IndianGooseberry 187 8.4 OtherImportantIndianBerriesofMedicinal/EdibleImportance 190 8.5 Conclusion 194 References 194 FurtherReading 201 9. Prospects of EssentialOils in Controlling Pathogenic Biofilm 203 HumaJafri,FirozAhmadAnsariandIqbalAhmad 9.1 Introduction 203 9.2 StrategiestoPrevent/EradicateBiofilm 208 9.3 PlantEssentialOils 211 9.4 AntibiofilmActivityofOtherEssentialOils 224 9.5 InVivoStudies 225 9.6 Conclusion 226 References 227 FurtherReading 236 10.Anticancer Phytocompounds: Experimental and ClinicalUpdates 237 FarrukhAqil,RadhaMunagala,AshishK.AgrawalandRameshGupta 10.1 CurrentProbleminCancerTherapy 238 10.2 PlantBioactivesinCancerPrevention/Therapy 240 10.3 Curcumin 241 10.4 GreenTeaPolyphenols 248 10.5 OtherChemopreventiveAgents 249 10.6 EmergingPhytocompounds 256 10.7 Conclusion 265 Acknowledgments 266 References 266 11.Plant-Derived Molecules in Managing HIV Infection 273 JayTrivedi,AnjaliTripathi,DebprasadChattopadhyayandDebashisMitra 11.1 DiscoveryofHIV 273 11.2 OriginofHIV 274 Contents ix 11.3 Epidemiology 275 11.4 Pathogenesis 275 11.5 Treatment 276 11.6 ConcludingRemarks 291 References 292 Section 2B Mechanism of Action Plant Derived Products/Medicine 299 12.Current Strategy to TargetBacterial Quorum Sensing andVirulence byPhytocompounds 301 FohadMaboodHusain,NasserA.Al-Shabib,SabaNoor, RaisAhmadKhan,MohammadShavezKhan,FirozAhmadAnsari, MohdShahnawazKhan,AltafKhanandIqbalAhmad 12.1 Introduction 301 12.2 DiscoveryandExplorationofQuorum-SensingInhibitors FromMedicinalPlants 307 12.3 PhytocompoundsIdentifiedasQuorum-SensingInhibitors 312 12.4 Conclusion 320 Acknowledgments 321 References 321 13.Understanding Biochemical andMolecular Mechanism of Complications of Glycation and Its Management byHerbal Medicine 331 FaizanAbulQais,MohammadShavezKhan,AbdullahSafarAlthubiani, SalehBakheetAl-GhamdiandIqbalAhmad 13.1 Introduction 331 13.2 Diabetes:AGlobalHealthProblem 332 13.3 AnOverviewofComplicationsAssociatedWithDiabetesand AdvancedGlycationEndProducts 335 13.4 BiochemicalMechanismofGlycation 335 13.5 MechanismsofComplicationsInducedbyGlycation 339 13.6 AccumulationofAdvancedGlycationEndProductsinDiabetesand ItsAssociatedComplications 340 13.7 ControlofDiabetesbyHerbalMedicineorPlants-BasedMedicines 345 13.8 Conclusion 354 Acknowledgment 354 References 354
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