New Developments in Biosciences: Their Implications for Laboratory Animal Science: Proceedings of the Third Symposium of the Federation of European Laboratory Animal Science Associations, held in Amsterdam, The Netherlands, 1–5 June 1987

457 Pages·1987·9.01 MB·English

by  R. J. Samsom (auth.)

NEW DEVELOPMENTS IN BIOSCIENCES:
THEIR IMPLICATIONS FOR LABORATORY ANIMAL SCIENCE
New Developments
in Biosctences:
Their Implications for
Laboratory Animal Science
Proceedings of the Third Symposium of
the Federation of European Laboratory Animal Science Associations,
held in Amsterdam, The Netherlands, 1-5 June 1987
edited by
Anton C. Beynen
Department of Laboratory Animal Science, Faculty of Veterinary Medicine,
University of Utrecht, Utrecht, The Netherlands
and
Henk A. Solleveld
Preclinical Research and Development, Smith Kline & French Laboratories,
Philadelphia, Pennsylvania, U.S.A.
1988
MARTINUS NIJHOFF PUBLISHERS
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DORDRECHT I BOSTON I LANCASTER
Distributors
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for all other countries: Kluwer Academic Publishers Group, Distribution Center, P.O. Box 322,
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Library of Congress Cataloging in Publication Data
Federation of European Laboratory Animal Science Associations.
Symposium (3rd 1987, Amsterdam. Netherlands>
New developments In blosclences their Implications for
laboratory animal science proceedings of the Third Symposium of
the Federation of European Laboratory Animal Science Associations,
held In Amsterdam, The Netherlands. 1-5 ~une 1987 I edited by Anton
C. Beynen. Henk A. Solleveld.
p. cm.
ISBN-13: 978-94-010-7973-0 e-ISBN-13: 978-94-009-3281-4
DOl: 10.1007/978-94-009-3281-4
1. Laboratory anlmals--Congresses. 2. Zoology, Experlmental-
-Congresses. I. Beynen, Anton C., 1953- II. Solleveld, H. A.
III. T1tle.
Qi..,55.F43 1987
591' .07·24--dcI9 87-28193
CIP
Copyright
@ 1988 by Martinus Nijhoff Publishers, Dordrecht.
Softcover reprint of the hardcover 1st edition 1988
All rights reserved. No part of this publication may be reproduced, stored in a retrieval system,
or transmitted in any form or by any means, mechanical, photocopying, recording, or otherwise,
without the prior written permission of the publishers,
Martinus Nijhoff Publishers, P.O. Box 163,3300 AD Dordrecht, The Netherlands.
v
Preface
This volume includes chapters originally presented at the 3rd FELASA
Symposium, held in Amsterdam, June 1-5, 1987. Special topics were "Immune
Deficiency Syndromes in Man and Animals", "DNA Technology and Laboratory
Animal Science", "Interactions of Behaviour, Housing and Welfare", and
"Laboratory Animals as Models in Biomedical Research". In addition, there
was a great number of presentations concerning other aspects of
laboratory animal science.
We would like to thank the following persons for organizing the
Symposium.
Mrs. M.A.G. Kuipers, M.Sc., President FELASA
Mrs. V. Baumans, D.V.M., Ph.D., Secretary FELASA
P. de Vrey, D.V.M., Treasurer
Mrs. I. Zaalmink, Organizing and Scientific Secretariat.
The editors would also like to express their gratitude to all the
participants and authors for their contribution to this succesful
symposium.
A.C. Beynen, Ph.D., Secretary Scientific Committee
H.A. Solleveld, Ph.D., Chairman Scientific Committee
FELASA
Federation of European Laboratory Animal Science Associations
Gesellschaft fUr Versuchstierkunde/Society for Laboratory Animal Science
Laboratory Animal Science Association
Nederlandse Vereniging voor Proefdierkunde
Scandinavian Federation for Laboratory Animal Science
Societe Fran9aise d'Experimentation Animale
VII
CONTENTS
Contributors ....................................................... xiii
OPENING ADDRESS: THE FUTURE OF LABORATORY ANIMAL USE
R.J. Samsom ....................................................... .
THE ACQUIRED IMMUNEDEFICIENCY SYNDROME IN MAN
D.W. van Bekkum .................................................... 7
FELINE ACQUIRED IMMUNODEFICIENCY SYNDROMES
M.C. Horzinek ...................................................... 11
IMMUNE DEFICIENCY SYNDROME IN RODENTS: THE NUDE RAT
H. van Loveren, H.J. Schuurman and J.G. Vos ........................ 17
ANIMAL WELFARE - COMMON INTEREST
M. Luukkainen and E. Hirsjarvi ..................................... 29
LABORATORY ANIMAL ....... SCIENCE - SERVICE - USE
K.J. Obrink, M. Waller and L. Wass ................................. 31
LABORATORY ANIMAL SCIENCE IN CZECHOSLOVAKIA
P. Kl!r ............................................................ 35
ON THE ETHOLOGY OF PAIN, ITS EXPERIENCE AND EXPRESSION
J.A.R.A.M. van Hooff ............................................... 41
PAIN IN NEONATES
B.P. Cats.......................................................... 47
ENDORPHINS AND PAIN
J .M. van Ree ....................................................... 53
EFFECTS OF EXOGENOUS PAIN RELIEVING SUBSTANCES ON EXPERIMENTAL
RESULTS
A.M.L. van Delft,.................................................. 59
VETERINARY CARE AT THE PRIMATE CENTER TNO
P.M.C.A. van Eerd .................................................. 63
DEVELOPING HOUSING FACILITIES FOR RHESUS MONKEYS: PREVENTION OF
ABNORMAL BEHAVIOUR
C. Goosen .......................................................... 67
MICROBIOLOGICAL QUALITY ASSURANCE AND QUALITY ASSESSMENT OF
LABORATORY ANIMALS
R. Boot............................................................ 71
CENTRALISATION - DECENTRALISATION: FAILURE - SUCCESS
J.A.P. van Hoof .................................................... 75
VIII
THE EFFECT OF HOMOGENIZATION AND PASTEURIZATION ON THE ALLERGENICITY
OF BOVINE MILK ANALYSED BY A MURINE ANAPHYLACTIC SHOCK MODEL
O.M. Poulsen and J. Hau ..... ,...................................... 81
MURINE PASSIVE CUTANEOUS ANAPHYLAXIS TEST (PCA) FOR THE "ALL OR NONE"
DETERMINATION OF ALLERGENICITY OF BOVINE WHEY PROTEINS AND PEPTIDES
O.M. Poulsen and J. Hau ............................................ 87
PHENOTYPIC AND PATHO-MORPHOLOGICAL CHARACTERISTICS IN A HALF-SIB
FAMILY OF TRANSGENIC MICE CARRYING FOREIGN MT-HGH GENES
G. Brem and R. Wanke ............................................... 93
THE HOUSING AND HANDLING OF MARMOSETS AND TAMAR INS INFECTED WITH
AIDS AND OTHER RETROVIRUSES
L. Francis, R.T. Moore, R.T. Raymond and A. Baskerville ............ 99
LONG-TERM OBSERVATION OF LITTER INTERVALS IN PERMANENTLY MONOGAMOUS
MATED Han:NMRI MICE
K. G. Rapp and R. Kluge ............................................. 105
GENITAL INFLAMMATION IN MALE MICE. A MICROBIOLOGICAL STUDY
I. Kunstfr ......................................................... 111
MICROBIAL ASSESSMENT OF A SINGLE FUMIGATION BY FORMALDEHYDE OF A
MULTI-LEVEL ANIMAL FACILITY
M.R. Gamble and J.R. Needham....................................... 117
MECHANISMS OF NATURAL SELECTION MAINTAINING IN GROUPS OF HIGHLY
STANDARDIZED MICE AND RATS, INFLUENCE ON INFECTION RESISTANCE
K. Gartner, F. Iglauer, K. Mensing and R. Velleuer ................. 121
PROVOCATION OF LATENT INFECTIONS
N.-C. Juhr ..........................•.............................. 127
INTRODUCTION TO RECOMBINANT DNA TECHNOLOGY
J. Vijg ....................... ..................................... 133
DNA HYBRIDIZATION AS A TOOL IN DIAGNOSING INFECTIOUS DISEASES.
COMPARISON WITH OTHER METHODS.
A.D.M.E. Osterhaus................................................. 143
EMBRYO TRANSFER AND MANIPULATION
R.L. Gardner....................................................... 147
STRAIN PRESERVATION OF RODENT EMBRYOS. POSSIBILITIES AND LIMITATIONS
H.J. Hedrich and I.C. Reetz........................................ 163
THE GENERATION OF TRANSGENIC ANIMALS AND THEIR USE IN FUNDAMENTAL
RESEARCH
A. Berns ........................................................... 175
ON THE INHERITANCE OF BLOOD CHARACTERS IN MICE
R. Kluge, K.G. Rapp and K. Burow................................... 185
IX
INVESTIGATING GENETIC VARIABILITY BETWEEN THE MHS HYPERTENSIVE
STRAIN OF RATS AND ITS NORMOTENSIVE CONTROL, MNS
B.R. Barber, L. Torielli, M. Ferrandi, P. Ferrari, S. Salardi,
P. Parenti and L. Duzzi ............................................ 191
GENE MAPPING AND LINKAGE HOMOLOGY
L.F.M. van Zutphen and M.G.C.W. den Bieman ......................... 197
A NEW METHOD TO PRODUCE ARTIFICIAL MONOZYGOTIC TWINS IN MICE
P. Agrawala, E. Baunack and J. Hahn ................................ 203
GENETIC ANALYSIS OF MULTI GENIC TRAITS USING THE RECOMBINANT CONGENIC
STRAINS
P. Demant, A.A.M. Hart and L.F.M. van Zutphen 209
ACUTE DERMAL TOXICITY: MORPHOLOGICAL RESPONSE OF THE HAIRLESS MICE
SKIN ORGAN CULTURE
W. Pitterman, F. Bartnik and K. KUnstler ........................... 215
THE DUTCH RABBIT IN TOXICITY TESTING. CHEMICAL-INDUCED CREATINE
KINASE RELEASE; A SPECIES- AND STRAIN-SPECIFIC RESPONSE?
T.D. Yih, A.J.M. Degen, J. Kamerman and H.F.P. Joosten 221
INTERTRIAL-INTERVAL IN THE "WATER ESCAPE TEST" IN MICE
H. Heinecke ........................................................ 225
BEHAVIOUR, HOUSING AND WELFARE OF NON-HUMAN PRIMATES
T.B. Poole ...................................... _.................. 231
HOUSING AND WELFARE OF LABORATORY RODENTS
G. Clough .......................................................... 239
HOUSING CONDITIONS AND EXPERIMENTAL RESULTS
W.H. Weihe......................................................... 245
BASIS OF THE EUROPEAN GUIDELINES: FACTS OR lNTUITION?
P. de Greeve 255
GNOTOBIOTIC ANIMALS IN NUTRITION RESEARCH
B. Ratcliffe....................................................... 267
ANIMAL MODELS FOR CHOLESTEROL METABOLISM STUDIES
A.C. Beynen ........................................................ 279
ANIMAL MODELS IN HEMOSTASIS AND THROMBOSIS
H.C. Rowsell....................................................... 289
MICE WITH ULCERATING LESIONS ON THE NOSE, LIMBS AND/OR TAIL
H. van Herck and V. Baumans ........................................ 295
SPONTANEOUS HYPERPLASIA OF THE ENDOMETRIUM IN THE RABBIT
P. Zwart ........................................................... 299
x
MONKEY GRAFFITY: ENVIRONMENTAL DEFICIENCY, BOREDOM OR ARTISTIC DRIVE?
D. Wesseling, V. Baumans and C. Goosen............................. 305
MARKING OF AFRICAN CLAWED TOADS (Xenopus laevis). IMPROVEMENT OF A
SKIN AUTOGRAFT TECHNIQUE
J.A. Loopstra, P. Zwart, R. Verhoeff-de Fremery and F.J.M.
Vervoordeldonk ..................................................... 311
CHANGES IN ENERGY INTAKE, BODY WEIGHT GAINS, AVERAGE FEED EFFICIENCY
AND SOME PLASMA HORMONE LEVELS IN DOGS FROM DIFFERENT ENVIRONMENTS
G. Kuhn and W. Hardegg ...................................... ~...... 317
SERUM CONCENTRATIONS OF VITAMINS A, D AND E OF GROWING BEAGLES FED
COMMERCIAL DOG AND FOX DIETS
H.-M. Voipio, T. Nevalainen and P. Maenpaa 325
INTEGRATION OF HGH GENE IN TRANSGENIC MICE AND TRANSMISSION TO NEXT
GENERATION
B. Brenig and G. Brem .............................................. 331
ATTEMPTS TO PRODUCE TRANSGENIC RABBITS CARRYING MTI-HGH RECOMBINANT
GENE
K. Ross, B. Brenig, J. Meyer and G. Brem ........................... 337
ELECTROFUSION OF EARLY MAMMALIAN EMBRYO CELLS
A. Clement, J. Meyer and G. Brem ................................... 343
PASSIVE INFRARED MOVEMENT DETECTOR, A NEW EQUIPME~T TO MONITOR MOTOR
ACTIVITY OF SMALL RODENTS IN NORMAL CAGES
H. Sigg and P. Tamborini ........................................... 349
ESTABLISHMENT OF A SPF POPULATION OF Cricetulus griseus
U. Marki, W. Rossbach and J. Leuenberger ........................... 353
CHRONIC PHLORIZIN INTOXICATION IN ADIPOSE MUTANT MICE C57BL/KS db/db
AND IN NORMAL CONTROLS
I. Ortlepp, K. Gartner, H. Sch5tz and A. Zogbaum ................... 359
PLASMA a-AMYLASE AND LIPASE ACTIVITIES IN DOGS WITH VARIATIONS IN FOOD
COMPOSITION AND AVAILABILITY
G. Kuhn and W. Hardegg ............................................. 365
LOCOMOTOR ACTIVITY OF A BEHAVIOR MUTANT IN NMRI MICE
C. Heckl-Ensslin and I. von Butler ................................. 373
THE APPLICATION OF EMBRYO TRANSFER AND CRYOPRESERVATION TO COMMERCIAL
LABORATORY ANIMAL BREEDING
F. Dagmes-Hansen ................................................... 375
SEROLOGICAL FOLLOWING OF A LABORATORY RAT BREEDING CONTAMINATED WITH
RESPIRATORY VIRUSES DURING 1981 - 1986
M. Pribylova, T. Svoboda and P. Klir ............................... 379
XI
ERADICATION OF ENCEPHALITOZOONOSIS IN RABBIT BREEDING COLONIES BY
CARBON IMMUNOASSAY
T. Waller .......................................................... 385
SPONTANEOUS MURINE HEMOSIDEROSIS, A MODEL FOR HUMAN HEMOCHROMATOSIS?
T.S. Veninga and H. Morse.......................................... 389
IN VITRO ADHESION OF K88 POSITIVE E. COLI TO INTESTINAL VILLI OF
JUST-WEANED PIGLETS
E. Cox, V. Cools and A. Houvenaghel ................................ 393
THE EFFECTS OF GENTLING ON OPEN-FIELD BEHAVIOUR OF RATS
P.A. Hirsj~rvi and M.A. Junnila .................................... 399
BLASTOMERE-KARYOTYPING: A DIRECT METHOD FOR PRODUCING MOUSE TRISOMY
16~DIPLOID AGGREGATION CHIMERAS AS AN ANIMAL MODEL OF HUMAN DOWN'S
SYNDROME
C. Bacchus and W. Buselmaier ....................................... 405
A PROPOSED SPECIES DIFFERENCE IN THE RENAL EXCRETION OF PERFLUORO
OCTANOIC ACID IN THE BEAGLE DOG AND RAT
H. Hanhij~rvi, M. Ylinen, T. Haaranen and T. NevalaLlen 409
MEASUREMENT OF ORTHOSTATIC RESPONSES IN CONSCIOUS DOGS
E. Ahonen, T. Nevalainen, E. L~nsimies, K. Tahvanainen,
J. Hartikainen and M. Hakum~ki ..................................... 413
ORAL 65Zn LOADING TEST IN RATS FED IRI-OB DIET WITH VARIOUS Zn
CONCENTRATIONS
J.P. van Wouwe, M. Veldhuizen and C.J.A. van den Hamer ............. 419
MORTALITY AND TUMOUR INCIDENCE OF BDII/HAN RATS
J. Kaspareit-Rittinghausen and F. Deerberg ......................... 425
ASSESSMENT OF DISCOMFORT INDUCED BY ORBITAL HiHCTURE IN RATS
A.C. Beynen, V. Baumans, J.W.M. Haas, K.K. van Hellemond, F.R.
Stafleu and G. van Tintelen ........................................ 431
EFFECT OF MORPHINOMIMETICS IN DIFFERENT PAIN TESTS
K.M. Dhasmana, A.K. Banerjee and W. Rating ......................... 437
PREVENTION OF EARLY DEATHS IN MICE CONTAMINATED WITH GRAM NEGATIVE
ENTERIC BACTERIA AND FUNGUS FOLLOWING IRRADIATION
A.K. Banerjee, A.F. Angulo and J. Kong-A-San ....................... 443
DETECTION OF Mycoplasma neurolyticum IN A COLONY OF INBRED MICE:
CLINICALLY SILENT INFECTION
A.F. Angulo, A.K. Banerjee and A.A. Polak-Vogelzang 447
EFFECTS OF HANDLING AND TRANSPORTATION STRESS ON RODENTS
M. Landi, T. Bowman and S. Campbell................................ 449
XIII
CONTRIBUTORS*
P. Agrawala, Abteilung fUr experimentelle Fortpflanzungsbiologie, Klinik
fUr Gyn~kologie des Rindes, Tier~rtzlichen Hochschule Hannover, Hannover,
Federal Republic of Germany (203)
E. Ahonen, Department of Clinical Physiology, Kuopio University Central
Hospital, SF-70210 Kuopio, Finland (413)
A.F. Angulo, National Institute of Public Health and Environmental
Hygiene, P.O. Box 1, 3720 BA Bilthoven, The Netherlands (443, 447)
C. Bacchus, Institut fUr Humangenetik und Anthropologie, Universitat
Heidelberg, 1m Neuenheimer Feld 328, D-6900 Heidelberg, Federal Republic
of Germany (405)
A.K. Banerjee, Laboratory Animal Centre, Erasmus University, P.O. Box
1738, 3000 DR Rotterdam, The Netherlands (437, 443, 447)
B.R. Barber, Farmitalia Carlo Erba, Istituto Ricerche Nerviano, Milano,
Italy (191)
F. Bartnik, Henkel KGaA, Postfach 1100, D-4000 DUsseldorf 1, Federal
Republic of Germany (215)
A. Baskerville, PHLS, Centre for Applied Microbiology and Research,
Porton Down, Salisbury, Wiltshire, SP4 OJG, United Kingdom (99)
V. Baumans, Department of Laboratory Animal Science, Veterinary Faculty,
State University, P.O. Box 80.166, 3508 TD Utrecht, The Netherlands
(295, 305, 431)
E. Baunack, Zentrales Tierlaboratorium, Medizinische Hochschule Hannover,
Konstanty-Gutschow-Strasse 8, D-3000 Hannover 61, Federal Republic of
Germany (203)
D.W. van Bekkum, Radiobiological Institute TNO, P.O. Box 5815, 2280 HV
Rijswijk, The Netherlands (7)
A. Berns, Division of Molecular Genetics, Netherlands Cancer Institute,
Plesmanlaan 121, 1066 CX Amsterdam and Department of Biochemistry,
University of Amsterdam, Amsterdam, The Netherlands (175)
A.C. Beynen, Department of Laboratory Animal Science, Veterinary Faculty,
University of Utrecht, P.O. Box 80.166, 3508 TD Utrecht and Department
of Human Nutrition, Agricultural University, De Dreijen 12, 6703 BC
Wageningen, The Netherlands (279, 431)
M.G.C.W. den Bieman, Department of Laboratory Animal Science, Veterinary
Faculty, University of Utrecht, P.O. Box 80.166, 3508 TD Utrecht, The
Netherlands (197)
R. Boot, National Institute of Public Health and Environmental Hygiene,
P.O. Box 1, 3720 BA Bilthoven, The Netherlands (71)
*The number in parentheses is the opening page number of the
contributor's article.