New Concepts of Antiviral Therapy PDF
Preview New Concepts of Antiviral Therapy
NEW CONCEPTS OF ANTIVIRAL THERAPY New Concepts of Antiviral Therapy Edited by ELKE BOGNER Friedrich-Alexander Universität Erlangen-Nürnberg, Institut für Klinische und Molekulare Virologie, Erlangen, Germany and ANDREAS HOLZENBURG Texas A&M University, Microscopy and Imaging Centre, College Station, U.S.A. A C.I.P. Catalogue record for this book is available from the Library of Congress. ISBN-10 0-387-31046-0 (HB) ISBN-13 978-0-387-31046-6 (HB) ISBN-10 0-387-31047-9 (e-books) ISBN-13 978-0-387-31047-3 (e-books) Published by Springer, P.O. Box 17, 3300 AADordrecht, The Netherlands. www.springer.com Printed on acid-free paper All Rights Reserved © 2006 Springer No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Printed in the Netherlands. Dedication This Book is dedicated to our parents and our colleagues Dr. Ernst Kuechler & Dr. Susanna Prös ch who passed away in 2005 Contents Contributors xi Preface xvii Acknowledgements xix Part 1. Concepts of therapy for RNA viruses ________________________________________________________ 1.1 Therapeutic vaccination in chronic 3 hepadnavirus infection by Michael Roggendorf and Mengji Lu 1.2 Characterization of targets for antiviral therapy 21 of Flaviviridae infections by Peter Borowski 1.3 Inhibition of Hepatitis C virus by nucleic acid-based 47 antiviral approaches by Michael Frese and Ralf Bartenschlager 1.4 Inhibitors of respiratory viruses 87 by Ernst Kuechler and Joachim Seipelt 1.5 Anti-viral approaches against influenza viruses 115 by Stephan Pleschka, Stephan Ludwig, Thorsten Wolff and Oliver Planz 1.6 A new approach to an Influenza virus live vaccine: 169 Modification of cleavage site of the haemagglutini n by reverse genetics by Jürgen Stech, Holger Garn and Hans-Dieter Klenk 1.7 New concepts in anti-HIV therapies 189 by Justin Stebbing, Mark Bower and Brian Gazzard 1.8 Evaluation of current strategies to inhibit HIV 213 entry, integration and maturation by Jaqueline D. Reeves, Stephen D. Barr and Stephan Pöhlmann viii Contents 1.9 Managing antiretroviral resistance 255 by Barbara Schmidt, Monika Tschoschner, Hauke Walter and Klaus Korn Part 2. Concepts of therapy for DNA viruses ________________________________________________________ 2.1 Selective inhibitors of the replication of poxviruses 283 by Johan Neyts and Erik de Clercq 2.2 Maribavir: A promising new antiherpes therapeutic 309 agent by Karen K. Biron 2.3 Benzimidazole-D-ribonucleosides as antiviral 337 agents that target HCMV terminase by John C. Drach, Leroy B. Townsend and Elke Bogner 2.4 Recent developments in anti-herpesviral therapy based 351 on protein kinase inhibitors by Thomas Herget and Manfred Marschall 2.5 Immune therapy against papillomavirus-related 373 tumors in humans by Lutz Gissmann Part 3. Concepts of therapy for emerging viruses ________________________________________________________ 3.1 The SARS Coronavirus receptor ACE 2 397 A potential target for antiviral therapy by Jens H. Kuhn, Sheli R. Radoshitzky, Wenhui Li, Swee Kee Wong, Hyeryun Choe and Michael Farzan 3.2 Therapy of Ebola and Marburg virus infections 419 by Mike Bray Contents ix Part 4. General concepts of therapy ________________________________________________________ 4.1 Proteasome inhibitors as complementary or 455 alternative antiviral therapeutics by Susanna Prösch and Marion Kaspari 4.2 Human monoclonal antibodies for prophylaxis and 479 therapy of viral infections by Jan ter Meulen and Jaap Goudsmit 4.3 Vector-based antiviral therapy 507 by Armin Ensser Index 533 ________________________________________________________ Contributors Dr. Stephen Barr Department of Microbiology, University of Pennsylvania, 3610 Hamilton Walk, Philadelphia, PA 19104, USA Dr. Ralf Bartenschlager Department for Molecular Virology, Hygiene Institute, University of Heidelberg, Im Neuenheimer Feld 345, 69120 Heidelberg, Germany Dr. Karen K. Biron International Clinical Virology, GlaxoSmithKline R&D, Research Triangle Park, NC 27709, USA Dr. Elke Bogner Institut für Molekulare und Klinische Virologie, Universität Erlangen-Nürnberg, Schloßgarten 4, 91054 Erlangen, Germany Dr. Peter Borowski Abteilung für Virologie, Bernhard-Nocht-Institut für Tropenmedizin, Bernhard-Nocht-Str. 74, 20359 Hamburg, Germany Dr. Mark Bower The Chelsea and Westminster Hospital, 369 Fulham Road, London, SW10 9NH, UK Dr. Mike Bray Biodefense Clinical Research Branch, Office of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, Maryland 20892, USA xii Contributors Dr. Hyeryun Choe Department of Pediatrics, Children’s Hospital, Harvard Medical School, Boston, MA 01772-9102, USA Dr. Erik De Clercq Laboratory of Virology, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium Dr. John C. Drach Department of Biologic and Materials Sciences, School of Dentistry and Interdepartmental Graduate Program in Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, USA Dr. Armin Ensser Institut für Molekulare und Klinische Virologie, Universität Erlangen-Nürnberg, Schloßgarten 4, 91054 Erlangen, Germany Dr. Michael Farzan Department of Microbiology and Molecular genetics, Harvard Medical School, New England Primate Research Center, Southborough, MA 01772-9102, USA Dr. Michael Frese Department for Molecular Virology, Hygiene Institute, University of Heidelberg, Im Neuenheimer Feld 345, 69120 Heidelberg, Germany Dr. Holger Garn Institut für Klinische Chemie und Molekulare Diagnostik, Philipps-Universität Marburg, 35033 Marburg, Germany Dr. Brian Gazzard The Chelsea and Westminster Hospital, 369 Fulham Road, London, SW10 9NH, United Kingdom Dr. Lutz Gissmann Deutsches Krebsforschungszentrum Heidelberg, Schwerpunkt Infektionen und Krebs, In Neuenheimer Feld 280, 69120 Heidelberg, Germany Dr. Jaap Goudsmit CRUCELL Holland B.V., Archimedesweg 4, 2301 CA Leiden, The Netherlands Dr. Thomas Herget Merck KGaA Darmstadt, Frankfurter Str. 250/C 10/351, 64293 Darmstadt, Germany Contributors xiii Marion Kaspari Institute of Virology, Charité – University of Medicine Berlin, Schumannstr. 20/21, 10117 Berlin, Germany Dr. Hans-Dieter Klenk Institut für Virologie, Philipps-Universität Marburg, Robert-Koch-Str. 17, 35037 Marburg, Germany Dr. Klaus Korn Institut für Molekulare und Klinische Virologie, Universität Erlangen-Nürnberg, Schloßgarten 4, 91054 Erlangen, Germany Dr. Ernst Kuechler† Max. F. Perutz Laboratories, University Departments at the Vienna Biocenter, Department of Medical Biochemistry. Medical University Vienna, Dr. Bohrgasse 9/3, 1030 Vienna, Austria; died March 5th 2005 Dr. Jens Kuhn Department of Microbiology and Molecular genetics, Harvard Medical School, New England Primate Research Center, Southborough, MA 01772-9102, USA and Department of Biology, Chemistry, Pharmacy, Freie Universität Berlin, Berlin, Germany Dr. Stephan Ludwig Institute of Molecular Virology (IMV), ZMBE, Westfälische-Wilhelms-Universität , Von-Esmarch Str. 56, D-48149 Münster, Germany Dr. Wenhui Li Department of Microbiology and Molecular genetics, Harvard Medical School, New England Primate Research Center, Southborough, MA 01772-9102, USA Dr. Mengji Lu Universitätsklinikum Essen, Hufelandstr. 55, 45122 Essen, Germany Dr. Manfred Marschall Institut für Molekulare und Klinische Virologie, Universität Erlangen-Nürnberg, Schloßgarten 4, 91054 Erlangen, Germany Dr. Jan ter Meulen CRUCELL Holland B.V., Archimedesweg 4, 2301 CA Leiden, The Netherlands
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