New Concepts in Alzheimer’s Disease PDF
Preview New Concepts in Alzheimer’s Disease
NEW CONCEPTS IN ALZHEIMER'S DISEASE Pierre Fabre Monograph Series Series Editors: M. BRILEY, j. P. COUZINIER, P. LENOBLE and j. TISNE-VERSAILLES Centre de Recherche Pierre Fabre Avenue Jean Moulin 17 811 00 Castres Cedex France PIERRE FABRE MONOGRAPH SERIES VOLUME 1 NEW CONCEPTS IN ALZHEIMER'S DISEASE Edited by M. BRILEY Departement de Pharmacologie Biochimique Centre de Recherche Pierre Fabre Avenue Jean Moulin 17 811 00 Castres Cedex France A.KATO Departement de Pharmacologie Centre Medical Universitaire 1211 Geneva Switzerland M. WEBER Laboratoire de Pharmacologie et de Toxicologie Fondamentales Route de Narbonne 205 31400 Toulouse France M © The Editors and the Contributors 1986 Softcover reprint of the hardcover 1st edition 1986 978-0-333-41356-2 All rights reserved. No reproduction, copy or transmission of this publication may be made without written permission. No paragraph of this publication may be reproduced, copied or transmitted save with written permission or in accordance with the provisions of the Copyright Act 1956 (as amended). Any person who does any unauthorised act in relation to this publication may be liable to criminal prosecution and civil claims for damages. First published 1986 Published by THE MACMILLAN PRESS LTD Houndmills, Basingstoke, Hampshire RG21 2XS and London Companies and representatives throughout the world British Library Cataloguing in Publication Data New concepts in Alzheimer's disease.-(Pierre Fabre monograph series; v. 1) 1. Alzheimer's disease I. Briley, M. II. Kato, A. C. III. Weber, M. IV. Series 618.97'68983 RC523 ISBN 978-1-349-08641-2 ISBN 978-1-349-08639-9 (eBook) DOI 10.1007/978-1-349-08639-9 Contents The contributors ix Preface to the Series xxi Preface xxiii New concepts in relation to the pathophysiology of Alzheimer's disease A. N. Davison 1 2 The 'autocannibalism' of choline-containing membrane phospholipids in the pathogenesis of Alzheimer's disease R. J. Wurtman, J. K. Blusztajn and J.-C. Maire 17 3 Future prospects offered by positron emission tomography for the study of Alzheimer's disease J. C. Baron 23 4 The neuronal cytoskeleton and neurofibrillary tangles B. H. Anderton, J.-P. Brion, J. Flament-Durand, M. C. Haugh, J. Kahn, C. C. J. Miller, A. Probst and J. Ulrich 35 5 Neurochemical and behavioural effects following lesions of the nucleus basalis in the rat G. Pepeu, F. Casamenti, F. Pedata, F. Orzi, G. Diana and E. Palumbo 53 6 In search of possible markers and models in Alzheimer's disease. M. Briley, M. Brown, P. Chopin, X. Heral and C. Moret 63 7 Neurotransmitter systems in Alzheimer's disease S. De St Hilaire-Kafi, C. Bouras and J. Constantinidis 73 8 Serotonin neurones and receptors in Alzheimer's disease D. N. Middlemiss, D. M. Bowen and A. M. Palmer 89 9 Two drug binding sites on muscarinic receptors N. J. M. Birdsall, E. C. Hulme, W. Kromer, B. S. Peck, J. M. Stockton and M. J. Zigmond 103 vi CONTENTS 10 Soluble and membrane-bound forms of choline-o-acetyltransferase activity in the purely cholinergic neurons of Torpedo. L. Eder-Coll~ S. Amato andY. Froment 122 11 Regulation and biosynthesis of cholinesterases in the human brain H. Soreq and H. Zakut 140 12 An immunohistochemical study comparing selected features of the anatomy of cholinergic innervation in the cerebral cortex of six mammalian species F. Eckenstein 157 13 Cell biology of forebrain cholinergic neurons: effect of NGF, triiodo- thyronine and gangliosides F. Hefti 169 14 Dissociated monolayer cultures of human spinal cord A. C Kato, L. Erkman and G. Touzeau 181 15 A glycoprotein from muscle-conditioned medium involved in the dif ferentiation of rat cholinergic neurons in culture: partial purification and regulation of neurotransmitter metabolism enzymes in central- nervous-system cultures M. C Giess, J. C Martinou, B. Raynaud, C De/teil, A. LeVan Thai, S. Vidal and M. Weber 190 16 Neurite-promoting factors for embryonic spinal neurons: studies on development in the chick and possible importance for the understand- ing of degenerative disorders of the nervous system T. Taguchi and C E. Henderson 203 17 Molecular biology as a possible approach to human inherited disorders L Oberle 216 18 Genetics of Alzheimer's disease: a large kindred with apparent Mendelian transmission; possible implications for a linkage study J.-F. Foncin, D. Salmon and A. C Bruni 242 19 DNA markers in familial Alzheimer's disease P. H. StGeorge-Hyslop, R. Tanzi, W. Hobbs, K. Gibbons, J. F. Gusella, L. Nee, R. Polinsky, J. Haines and P.M. Conneally 257 20 Behavioural recovery following 6-0HDA lesion of the nucleus accumbens and intra-accumbens implantation of dopaminergic grafts K. Choulli, J. P. Herman, D. Nadaud, K. Taghzouti, H. Simon and M. Le Moal 265 CONTENTS vii 21 Transplantation of 5-HT neurons to the adult rat brain A. Privat, H Mansour, M. Geffard and M. Lerner-Natoli 280 Index 301 The Contributors Amato, S. Department of Pharmacology University Medical Centre, University of Geneva 1211 Geneva 4 Switzerland Anderton, B. H. Department of Immunology StGeorge's Hospital Medical School Cranmer Terrace London SW17 ORE UK Baron, J. C. Service Hospitalier Frederic Jo liot CEA, Departement de Biologie 91406 Orsay France Birdsall, N.J. M. Division of Physical Biochemistry National Institute for Medical Research The Ridgeway, Mill Hill London NW7 1AA UK Blusztajn, J. K. Laboratory of Neuroendocrine Regulation Department of Nutrition and Food Sciences Massachusetts Institute of Technology 26245 Cambridge MA 02139 USA Bouras, C. Division of Morphological Psychopathology Institutions Universitaires de Psychiatrie 1225 Chene-Bourg Geneva Switzerland X THE CONTRIBUTORS Bowen, D. M. Department of Neurochemistry Institute of Neurology 33 John's Mews London WC1N 2NS UK Briley, M. Department of Biochemical Pharmacology Centre de Recherche Pierre Fabre 17, avenue Jean Moulin 81100 Castres Cedex France Brion, J.-P. Laboratoire d'Anatomie Pathologique et de Microscopie Electronique Universite Libre de Bruxelles Route de Lennik 808 1070 Brussels Belgium Brown, M. Department of Biochemical Pharmacology Centre de Recherche Pierre Fabre 17, avenue Jean Moulin 81100 Castres Cedex France Bruni, A. C. Servizio di Neurologia dell'Ospedale Civile Regione Calabria USLno. 17 Lamezia Terme Italy Casamenti, F. Department of Pharmacology and Toxicology University of Florence Viale Morgagni 65 50134 Florence Italy Chopin, P. Department of Biochemical Pharmacology Centre de Recherche Pierre Fabre 17, avenue Jean Moulin 81100 Castres Cedex France Choulli, K. Laboratoire de Psychobiologie des Comportements Adaptatifs INSERM-U. 259 Domaine de Carreire Rue Camille-St-Saens 33077 Bordeaux Cedex France
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