New Concepts in Alzheimer’s Disease

329 Pages·1986·30.85 MB·English

by  M. Briley

NEW CONCEPTS IN ALZHEIMER'S DISEASE
Pierre Fabre Monograph Series
Series Editors:
M. BRILEY, j. P. COUZINIER, P. LENOBLE and
j. TISNE-VERSAILLES
Centre de Recherche Pierre Fabre
Avenue Jean Moulin 17
811 00 Castres Cedex
France
PIERRE FABRE MONOGRAPH SERIES
VOLUME 1
NEW CONCEPTS IN
ALZHEIMER'S DISEASE
Edited by
M. BRILEY
Departement de Pharmacologie Biochimique
Centre de Recherche Pierre Fabre
Avenue Jean Moulin 17
811 00 Castres Cedex
France
A.KATO
Departement de Pharmacologie
Centre Medical Universitaire
1211 Geneva
Switzerland
M. WEBER
Laboratoire de Pharmacologie et de Toxicologie Fondamentales
Route de Narbonne 205
31400 Toulouse
France
M
© The Editors and the Contributors 1986
Softcover reprint of the hardcover 1st edition 1986 978-0-333-41356-2
All rights reserved. No reproduction, copy or transmission
of this publication may be made without written permission.
No paragraph of this publication may be reproduced, copied
or transmitted save with written permission or in accordance
with the provisions of the Copyright Act 1956 (as amended).
Any person who does any unauthorised act in relation to
this publication may be liable to criminal prosecution and
civil claims for damages.
First published 1986
Published by
THE MACMILLAN PRESS LTD
Houndmills, Basingstoke, Hampshire RG21 2XS
and London
Companies and representatives
throughout the world
British Library Cataloguing in Publication Data
New concepts in Alzheimer's disease.-(Pierre
Fabre monograph series; v. 1)
1. Alzheimer's disease
I. Briley, M. II. Kato, A. C. III. Weber, M.
IV. Series
618.97'68983 RC523
ISBN 978-1-349-08641-2 ISBN 978-1-349-08639-9 (eBook)
DOI 10.1007/978-1-349-08639-9
Contents
The contributors ix
Preface to the Series xxi
Preface xxiii
New concepts in relation to the pathophysiology of Alzheimer's
disease A. N. Davison 1
2 The 'autocannibalism' of choline-containing membrane phospholipids
in the pathogenesis of Alzheimer's disease R. J. Wurtman,
J. K. Blusztajn and J.-C. Maire 17
3 Future prospects offered by positron emission tomography for the
study of Alzheimer's disease J. C. Baron 23
4 The neuronal cytoskeleton and neurofibrillary tangles
B. H. Anderton, J.-P. Brion, J. Flament-Durand, M. C. Haugh, J. Kahn,
C. C. J. Miller, A. Probst and J. Ulrich 35
5 Neurochemical and behavioural effects following lesions of the
nucleus basalis in the rat G. Pepeu, F. Casamenti, F. Pedata,
F. Orzi, G. Diana and E. Palumbo 53
6 In search of possible markers and models in Alzheimer's disease.
M. Briley, M. Brown, P. Chopin, X. Heral and C. Moret 63
7 Neurotransmitter systems in Alzheimer's disease
S. De St Hilaire-Kafi, C. Bouras and J. Constantinidis 73
8 Serotonin neurones and receptors in Alzheimer's disease
D. N. Middlemiss, D. M. Bowen and A. M. Palmer 89
9 Two drug binding sites on muscarinic receptors N. J. M. Birdsall,
E. C. Hulme, W. Kromer, B. S. Peck, J. M. Stockton and M. J. Zigmond 103
vi CONTENTS
10 Soluble and membrane-bound forms of choline-o-acetyltransferase
activity in the purely cholinergic neurons of Torpedo. L. Eder-Coll~
S. Amato andY. Froment 122
11 Regulation and biosynthesis of cholinesterases in the human brain
H. Soreq and H. Zakut 140
12 An immunohistochemical study comparing selected features of the
anatomy of cholinergic innervation in the cerebral cortex of six
mammalian species F. Eckenstein 157
13 Cell biology of forebrain cholinergic neurons: effect of NGF, triiodo-
thyronine and gangliosides F. Hefti 169
14 Dissociated monolayer cultures of human spinal cord A. C Kato,
L. Erkman and G. Touzeau 181
15 A glycoprotein from muscle-conditioned medium involved in the dif
ferentiation of rat cholinergic neurons in culture: partial purification
and regulation of neurotransmitter metabolism enzymes in central-
nervous-system cultures M. C Giess, J. C Martinou, B. Raynaud,
C De/teil, A. LeVan Thai, S. Vidal and M. Weber 190
16 Neurite-promoting factors for embryonic spinal neurons: studies on
development in the chick and possible importance for the understand-
ing of degenerative disorders of the nervous system T. Taguchi and
C E. Henderson 203
17 Molecular biology as a possible approach to human inherited disorders
L Oberle 216
18 Genetics of Alzheimer's disease: a large kindred with apparent
Mendelian transmission; possible implications for a linkage study
J.-F. Foncin, D. Salmon and A. C Bruni 242
19 DNA markers in familial Alzheimer's disease P. H. StGeorge-Hyslop,
R. Tanzi, W. Hobbs, K. Gibbons, J. F. Gusella, L. Nee, R. Polinsky,
J. Haines and P.M. Conneally 257
20 Behavioural recovery following 6-0HDA lesion of the nucleus
accumbens and intra-accumbens implantation of dopaminergic grafts
K. Choulli, J. P. Herman, D. Nadaud, K. Taghzouti, H. Simon and
M. Le Moal 265
CONTENTS vii
21 Transplantation of 5-HT neurons to the adult rat brain A. Privat,
H Mansour, M. Geffard and M. Lerner-Natoli 280
Index 301
The Contributors
Amato, S.
Department of Pharmacology
University Medical Centre, University of Geneva
1211 Geneva 4
Switzerland
Anderton, B. H.
Department of Immunology
StGeorge's Hospital Medical School
Cranmer Terrace
London SW17 ORE
UK
Baron, J. C.
Service Hospitalier Frederic Jo liot
CEA, Departement de Biologie
91406 Orsay
France
Birdsall, N.J. M.
Division of Physical Biochemistry
National Institute for Medical Research
The Ridgeway, Mill Hill
London NW7 1AA
UK
Blusztajn, J. K.
Laboratory of Neuroendocrine Regulation
Department of Nutrition and Food Sciences
Massachusetts Institute of Technology
26245 Cambridge
MA 02139
USA
Bouras, C.
Division of Morphological Psychopathology
Institutions Universitaires de Psychiatrie
1225 Chene-Bourg
Geneva
Switzerland
X THE CONTRIBUTORS
Bowen, D. M.
Department of Neurochemistry
Institute of Neurology
33 John's Mews
London WC1N 2NS
UK
Briley, M.
Department of Biochemical Pharmacology
Centre de Recherche Pierre Fabre
17, avenue Jean Moulin
81100 Castres Cedex
France
Brion, J.-P.
Laboratoire d'Anatomie Pathologique et de Microscopie Electronique
Universite Libre de Bruxelles
Route de Lennik 808
1070 Brussels
Belgium
Brown, M.
Department of Biochemical Pharmacology
Centre de Recherche Pierre Fabre
17, avenue Jean Moulin
81100 Castres Cedex
France
Bruni, A. C.
Servizio di Neurologia dell'Ospedale Civile
Regione Calabria
USLno. 17
Lamezia Terme
Italy
Casamenti, F.
Department of Pharmacology and Toxicology
University of Florence
Viale Morgagni 65
50134 Florence
Italy
Chopin, P.
Department of Biochemical Pharmacology
Centre de Recherche Pierre Fabre
17, avenue Jean Moulin
81100 Castres Cedex
France
Choulli, K.
Laboratoire de Psychobiologie des Comportements Adaptatifs
INSERM-U. 259
Domaine de Carreire
Rue Camille-St-Saens
33077 Bordeaux Cedex
France