New Aspects of Storage and Release Mechanisms of Catecholamines

313 Pages·1970·11.014 MB·English

by  G. Kroneberg (auth.), Professor Dr. Hans-Joachim Schümann, Professor Dr. Günter Kroneberg (eds.)

Bayer-Symposium II
New Aspects of
Storage and Release Mechanisms
of Catecholamines
Edited by
H. J. Schiimann . G. Kroneberg
With 116 Figures
Springer-Verlag Berlin· Heidelberg. New York 1970
Professor Dr. Hans·Joachim Schumann, Direktor des Pharmakologischen Institutes
am Klinikum Essen der Ruhruniversitat Bochum, 4300 Essen-Holsterhausen
Professor Dr. Gunter Kroneberg, Vorstand des Institutes fur Pharmakologie
der Farbenfabriken Bayer AG., 5600 Wuppertal-Elberfeld
The editors are indebted to Miss M. L. Chamberlain and Dr. K. Brandau
for their valuable assistance
Bayer-Symposium II
held at Grosse Ledder near Cologne, Germany
October 9th-12th, 1969
ISBN 978-3-642-49465-9 ISBN 978-3-642-49747-6 (eBook)
DOI 10.1007/978-3-642-49747-6
This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned,
specifically those of translation, reprinting, re-use of illustrations, broadcasting. reproduction by photocopying
machine or similar means, and storage in data banks.
Under § 54 of the German Copyright Law where copies are made for other than private use, a fee is payable to
the publisher, the amount of the fee to be determined by agreement with the publisher.
© by Springer-Verlag Berlin· Heidelberg 1970. Library of Congress Catalog Card Number 70·123307.
Softcover reprint of tbe hardcover 1st edition 1970
The use of general descriptive names, trade names, trade marks, etc. in this publication, even If the former are
not especially identified, is not to be taken as a sign that such names, as understood by the Trade Marks and Mer
chandise Marks Act, may accordingly be used freely by anyone. Title No. 3392.
Bayer-Symposium II
New Aspects of
Storage and Release Mechanisms
of Catecholamines
Edited by
H. J. Schumann· G. Kroneberg
With 116 Figures
Springer-Verlag New York· Heidelberg. Berlin 1970
Professor Dr. Hans·Joachim Schumann, Direktor des Pharmakologischen Institutes
am Klinikum Essen der Ruhruniversitat Bochum, 4300 Essen-Holsterhausen
Professor Dr. Gunter Kroneberg, Vorstand des Institutes fur Pharmakologie
der Farbenfabriken Bayer AG., 5600 Wuppertal-Elberfeld
The editors are indebted to Miss M. L. Chamberlain and Dr. K. Brandau
for their valuable assistance
Bayer-Symposium II
held at Grosse Ledder near Cologne, Germany
October 9th-12th, 1969
ISBN 978-3-642-49465-9 ISBN 978-3-642-49747-6 (eBook)
DOl 10.1007/978-3-642-49747-6
This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned,
specifically those of translation, reprinting, re-use of illustrations, broadcasting. reproduction by photocopying
machine or similar means, and storage in data banks.
Under § 54 of the German Copyright Law where copies are made for other than private use, a fee is payable to
the publisher, the amount of the fee to be determined by agreement with the publisher.
© by Springer-Verlag Berlin· Heidelberg 1970. Library of Congress Catalog Card Number 70·123307.
Softcover reprint of tbe hardcover 1st edition 1970
The use of general descriptive names, trade names, trade marks, etc. in this publication, even If the former are
not especially identified, is not to be taken as a sign that such names, as understood by the Trade Marks and Mer
chandise Marks Act, may accordingly be used freely by anyone. Title No. 3392.
Contents
Welcome: G. KRONEBERG . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
Opening Remarks: H. J. SCHUMANN... . . . .. .. .. . . . .. . ..... ...... ..... 2
Session 1
Origin and Axonal Transport of Adrenergic Nerve Granules
(Chairman: U. S. VON EULER)
Studies on the Origin of the Granulated and Non-granulated Vesicles:
A. PELLEGRINO DE IRALDI and E. DE ROBERTIS. With 10 Figures ..... 4
Discussion ........................................................ 17
The Effects of Drugs on Axonal Transport of Amine Storage Granules:
A. DAHLSTROM. With 8 Figures ................................... 20
Discussion ........................................................ 36
Invited Comment: L. B. GEFFEN .................................... 38
Discussion ........................................................ 41
Session 2a
Mechanism of Transmitter Release with Special Reference
to the Problem of Exocytosis (I)
(Chairman: E. DE ROBERTIS)
Opening Remarks: E. DE ROBERTIS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 44
Immunological Properties of Chromogranin: K. B. HELLE. With 5 Figures 45
Discussion ........................................................ 56
Immunohistochemical Localization of Chromogranins in Sheep Sympathetic
Neurons and their Release by Nerve Impulses: L. B. GEFFEN, B. G.
LIVETT, and R. A. RUSH. With 10 Figures ......................... 58
Discussion ........................................................ 72
VI Contents
Session 2b
Mechanism of Transmitter Release with Special Reference
to the Problem of Exocytosis (II)
(Chairman: P. HOLTZ)
Quantal Aspects of the Secretion of Catecholamine. . and Dopamine-(1-hydro
xylase from the Adrenal Medulla: N. KIRSHNER and O. H. VIVEROS. With
1 Figure .................................... " ... ..... . . .... . . . 78
Discussion ........................................................ 88
Some Aspects of the Quantal Release of the Adrenergic Transmitter:
B. FOLKOW and J. HAGGENDAL ................................... 91
Discussion ........................................................ 97
Some Further Aspects on the Release of the Adrenergic Transmitter:
J. HAGGENDAL. With 5 Figures ................................... 100
Discussion ........................................................ 109
Quantal or Graded Secretion of Adrenal Medullary Hormone and Sympathe-
tic Neurotransmitter: L. STJARNE. With 7 Figures .................. 112
Discussion ........................................................ 127
Session 3
Chemical Sympathectomy
(Chairman: P. HOLTZ)
Chemical Sympathectomy with 6-Hydroxydopamine: H. THOENEN, J. P.
TRANZEl~, and G. HAUSLER. With 10 Figures ....................... 130
Discussion ........................................................ 142
Session 4a
Effects of Drugs on Uptake and Release of Catecholamines (I)
(Chairman: H. BLASCHKO)
Effect of Some Metabolic Factors and Drugs on Uptake and Release of Cate
cholamines in vitro and in vivo: U. S. VON EULER. With 10 Figures. .. 144
Discussion ........................................................ 159
Saturation of the Uptake ofNo radrenaline as a Determinant of Pharmacologi
cal Effects: U. TRENDELENBURG, P. R. DRASKOCZY, K.-H. GRAEFE, andH.
HENNEMANN. With 2 Figures .................................... 161
Discussion ........................................................ 166
Contents VII
Cholinomimetic Drugs and Release of the Adrenergic Transmitter: E.
MUSCHOLL. With 8 Figures. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 168
Discussion ........................................................ 186
Session 4b
Effects of Drugs on Uptake and Release of Catecholamines (II)
(Chairman: A. CARLSSON)
Membrane Effects of Catecholamine Releasing Drugs: D. PALM, H. GROB
ECKER, and 1. J. BAK. With 8 Figures. . . . . . . . . . . . . . . . . . . . . . . . . . . .. 188
Discussion ........................................................ 198
Effect of Angiotensin on Noradrenaline Release of the Isolated Rabbit Heart:
H. J. SCHUMANN. With 8 Figures ................................. 202
Discussion ........................................................ 209
Neuronal and Hormonal Control of Tyrosine Hydroxylase and Phenyletha
nolamine N-methyltransferase Activity: J. AXELROD, R. A. MUELLER,
and H. THOENEN. With 4 Figures. . . . . . . .. . . ... ..... .. ...... .. . ... 212
Discussion ........................................................ 219
Session 4c
Effects of Drugs on Uptake and Release of Catecholamines (III)
(Chairman: J. AXELROD)
Effect of Drugs on Amine Uptake Mechanisms in the Brain: A. CARLSSON.
With 7 Figures ................................................. 223
Discussion ....................................................... 234
Release of Monoamines in the Central Nervous System: J. GLOWINSKI. With
3 Figures ...................................................... 237
Discussion ........................................................ 248
The Effect of Different Neuroleptic Drugs on the Monoamine Neurons of the
Rat Brain: H. CORRODI ........................................ 252
Discussion ........................................................ 256
Release of Catecholamines from the Hypothalamus by Drugs and Electrical
Stimulation: A. PHILIPPU. With 10 Figures ........................ 258
Discussion ........................................................ 267
VIII Contents
Session 5
(Chairman: H. J. SCHUMANN)
General Discussion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 270
Author Index 283
Subject Index 295