NEUROSCIENCE BASICS This pageintentionallyleftblank NEUROSCIENCE BASICS ’ A Guide to the Brain s Involvement in Everyday Activities JENNIFER L. LARIMORE Agnes Scott College,Decatur, Georgia, UnitedStates AcademicPressisanimprintofElsevier 125LondonWall,LondonEC2Y5AS,UnitedKingdom 525BStreet,Suite1800,SanDiego,CA92101-4495,UnitedStates 50HampshireStreet,5thFloor,Cambridge,MA02139,UnitedStates TheBoulevard,LangfordLane,Kidlington,OxfordOX51GB,UnitedKingdom Copyrightr2017JenniferL.Larimore.PublishedbyElsevierInc.Allrightsreserved. Nopartofthispublicationmaybereproducedortransmittedinanyformorbyanymeans, electronicormechanical,includingphotocopying,recording,oranyinformationstorageand retrievalsystem,withoutpermissioninwritingfromthepublisher.Detailsonhowtoseek permission,furtherinformationaboutthePublisher’spermissionspoliciesandourarrangements withorganizationssuchastheCopyrightClearanceCenterandtheCopyrightLicensing Agency,canbefoundatourwebsite:www.elsevier.com/permissions. Thisbookandtheindividualcontributionscontainedinitareprotectedundercopyrightbythe Publisher(otherthanasmaybenotedherein). Notices Knowledgeandbestpracticeinthisfieldareconstantlychanging.Asnewresearchand experiencebroadenourunderstanding,changesinresearchmethods,professionalpractices,or medicaltreatmentmaybecomenecessary. Practitionersandresearchersmustalwaysrelyontheirownexperienceandknowledgein evaluatingandusinganyinformation,methods,compounds,orexperimentsdescribedherein. Inusingsuchinformationormethodstheyshouldbemindfuloftheirownsafetyandthesafety ofothers,includingpartiesforwhomtheyhaveaprofessionalresponsibility. Tothefullestextentofthelaw,neitherthePublishernortheauthors,contributors,oreditors, assumeanyliabilityforanyinjuryand/ordamagetopersonsorpropertyasamatterofproducts liability,negligenceorotherwise,orfromanyuseoroperationofanymethods,products, instructions,orideascontainedinthematerialherein. BritishLibraryCataloguing-in-PublicationData AcataloguerecordforthisbookisavailablefromtheBritishLibrary LibraryofCongressCataloging-in-PublicationData AcatalogrecordforthisbookisavailablefromtheLibraryofCongress ISBN:978-0-12-811016-4 ForInformationonallAcademicPresspublications visitourwebsiteathttps://www.elsevier.com/books-and-journals Publisher:NikkiLevy AcquisitionEditor:NatalieFarra EditorialProjectManager:KathyPadilla ProductionProjectManager:LauraJackson Designer:VictoriaPearsonEsser TypesetbyMPSLimited,Chennai,India DEDICATION This book is dedicated to my students who challenge me to be a better professor, to the lab mates and colleagues who have challenged me to be a better neuroscientist, my family who has supported and enhanced my education, my daughters who remind me of what really matters in life, and to my husband for the endless support and love through my career. Thank you all! This page intentionallyleftblank CONTENTS Preface xi 1. How to Build a Human Brain 1 Summary 1 1.1 WhatIstheBrain? 2 1.2 OverviewofBrainDevelopment 2 1.3 BrainDevelopmentSteps 3 1.4 WhatPurposeDoesHumanChildhoodServe?BacktotheSandbox 7 1.5 OrganizationoftheNervousSystem 8 1.6 WhatHappensWhentheBrainIsDamagedorDevelopmentDoesn’tGo AccordingtothePlan? 11 1.7 Conclusions 16 Bibliography 17 2. 6:00a.m. Timeto Start the Day! How Our Senses Help UsWakeup! 19 Summary 19 2.1 Cells101 20 2.2 HistoryofCellTheory 22 2.3 SupportCells 23 2.4 ThinkingCells(Neurons) 24 2.5 TheSensesandTheirCells 26 2.6 WhatHappensWhenSensationisAltered? 34 2.7 WhatHappensWhenCellsDoNotFunctionProperly? 35 2.8 Conclusion 38 Bibliography 38 3. 6:35a.m. Timeto Run—How Does the BrainTell Our Muscles to Move? 39 Summary 39 3.1 HowDoestheBrainMovetheBody? 40 3.2 BackgroundInformationfortheActionPotential 43 3.3 ChemistryandUnbalancedIons 44 3.4 HistoryoftheActionPotential:GiantSquids! 47 3.5 ChemicalMessagesAssociatedWithExercise 47 vii viii Contents 3.6 WhatHappensWhentheMessageforMovementIsn’tCommunicated? 48 3.7 Conclusion 51 Bibliography 52 4. 9:00 a.m. Lions and Tigers andBears,OhMy! Oh Wait, No, It’sJust Work! 53 Summary 53 4.1 Stress 54 4.2 BackgroundInformationAboutNeurotransmitters 55 4.3 TypesofChemicalMessages(Neurotransmitters) 56 4.4 LockandKey 57 4.5 StoppingtheChemicalMessages 58 4.6 TypesofCommunications 58 4.7 WhatHappensWhenChemicalMessagesAreMessedUp? 60 4.8 Conclusion 63 Bibliography 64 5. 10:00 a.m. StaffMeeting Aboutthe New Thing and How We Have to Learn It to Do Our Job! 65 Summary 65 5.1 TypesofLearningandMemory 65 5.2 MovingtheChannels 68 5.3 LearningandMemoryResearch 68 5.4 HowAgingImpactsLearningandMemory 72 5.5 WhatDisordersImpactLearningandMemory? 73 5.6 Conclusion 75 Bibliography 75 6. 11:30 a.m. Hanger: (n) Hunger-Induced Anger 77 Summary 77 6.1 Hunger 77 6.2 Blood(cid:1)BrainBarrier 78 6.3 BrainFood 79 6.4 WhyDoestheBrainWantUstoEat? 80 6.5 WhatHappensWhenThereIsTooLittleBloodorTooMuchDopamine? 81 6.6 Conclusion 84 Bibliography 84 7. 1:00 p.m. Mid-Afternoon Blues 87 Summary 87 7.1 HumanMoodsandHumanBehavior 87 Contents ix 7.2 Taxonomy—TheClassificationofOrganisms 88 7.3 HumanEvolution 91 7.4 WhatWeretheDrivingForcesforHumanBrainEvolution? 93 7.5 HumanEmotions,Behaviors,andMoods 94 7.6 DisordersWithDisruptedEmotions 97 7.7 Conclusion 100 Bibliography 100 8. 10:00 p.m. Counting Sheep 103 Summary 103 8.1 Biorhythms 103 8.2 CircadianRhythms 104 8.3 Sleep 105 8.4 Dreams 106 8.5 SleepResearchImplications—Neuroethics 107 8.6 WhatHappensWhenSleepIsDisrupted? 109 8.7 Conclusion 110 Bibliography 110 Index 113
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