Neuroreceptor Mechanisms in Brain

488 Pages·1991·13.309 MB·English

by  Shozo Kito, Rie Miyoshi (auth.), Shozo Kito, Tomio Segawa, Richard W. Olsen (eds.)

NEURORECEPTOR
MECHANISMS IN
BRAIN
ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY
Editorial Board:
NATHAN BACK, State University of New York at Buffalo
IRUN R. COHEN, The Weizmann Institute of Science
DAVID KRITCHEVSKY, Wistar Institute
ABEL LAJTHA, N.S. Kline Institute for Psychiatric Research
RODOLFO PAOLETTI, University of Milan
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NEURORECEPTOR
MECHANISMS IN
BRAIN
Edited hy
Shozo Kito
University of the Air
Chiba, Japan
Tomio Segawa
Hiroshima University School of Medicine
Hiroshima, Japan
and
Richard W. Olsen
University of California-Los Angeles School of Medicine
Los Angeles, California
PLENUM PRESS • NEW YORK AND LONDON
Library of Congress Cataloging in Publication Data
International Symposium on Neurotransmitter Receptors (3rd: 1990: Hiroshima-shi, Japan)
Neuroreceptor mechanisms in brain I edited by Shozo Kito, Tomio Segawa, and Richard
W. Olsen.
p. cm. -(Advances in experimental medicine and biology; v. 287)
"Proceedings of. the Third International Symposium on Neurotransmitter Receptors, held
February 5-8,1990, in Hiroshima, Japan"-T.p. verso.
Includes bibliographical references.
Includes index.
ISBN-13: 978-1-4684-5909-8
1. Neurotransmitter receptors-Congresses. 2. Brain-Congresses. I. Kite, Sheze, date.
II. Segawa, Tomio, 1927 - . III. Olsen, Richard W. IV. Title. V. Series.
[DNLM: 1. Brain-physiology-congresses. 2. Receptors, Synaptic-physiology
congresses. WI AD559 v. 287 I WL 300 I61243n 1990)
QP364.7.I59 1990
612.8'22-dc20
DNLM/DLC 91-3019
for Ubrary of Congress CIP
Proceedings of the Third International Symposium on Neurotransmitter Receptors,
held February 5-8, 1990, in Hiroshima, Japan
ISBN-13: 978-1-4684-5909-8 e-ISBN-13: 978-1-4684-5907-4
DOl: 10.1007/978-1-4684-5907-4
© 1991 Plenum Press, New York
Softcover reprint of the hardcover 1st edition 1991
A Division of Plenum Publishing Corporation
233 Spring Street, New York, N.Y. 10013
All rights reserved
No part of this book may be reproduced, stored in a retrieval system, or transmitted
in any form or by any means, electronic, mechanical, photocopying, microfilming,
recording, or otherwise, without written permission from the Publisher
FOREWORD
The Third International Symposium on Neurotransmitter Receptors was
held in Hiroshima at a time when the entire field of neurotransmitter
receptors in the brain is progressing at an unprecedented pace. The sym
posium also marked my retirement as Professor and Chairman of the Third
Department of Internal Medicine, Hiroshima University School of Medicine,
and a new beginning as a Professor of the University of the Air.
The symposium was remarkably successful, and there were enthusiastic
responses from scientists allover the world, proving that the meeting was
timely. The selected papers contained in this volume constitute a state
of-the-art survey of the most advanced aspects of neurotransmitter recep
tor mechanisms in the brain.
lowe thanks for the great success of the symposium to Prof. Richard
Olsen of UCLA, Prof. Tomio Segawa of Hiroshima University, Prof. Kinya
Kuriyama of Kyoto Prefectural University of Medicine, and Prof. Masaya
Tohyama of Osaka University. I express my sincere gratitude to many
friends for making this publication possible. I especially thank Dr. Rie
Miyoshi, whose devoted efforts as secretary-general were vital to the
success of the symposium. Dr. Miyoshi is currently an instructor in the
Department of Pharmacology at Tokyo Women's Medical College. I would also
like to acknowledge the excellent secretarial work of Misses Ritsuko Sato
and Yuko Wakita.
My appointment to the University of the Air affords me access to a
well-equipped laboratory for basic biological research. I hope that my
concentration on receptor studies over the next several years will make it
possible for me to organize the Fourth International Symposium on Neuro
transmitter Receptors, probably not at Hiroshima, but at the University of
the Air, which is located close to the Tokyo metropolitan area.
Finally, this symposium was financially supported by the Japanese
Ministry of Science, Culture, and Education.
Shozo Kito
v
PREFACE
The Third International Symposium on Neurotransmitter
Receptors, held in Hiroshima, Fabruary 5-8, 1990, continues
the tradition of the first two such symposia held in 1983
and 1987, also published by Plenum Press. However, the
fame of these meetings has obviously been growing, as
indicated by both the large number of abstracts received and
the great number of countries represented by the attending
neuroscientists.
The topics covered in this publication of the pro
ceedings include structural and functional studies on some
well-characterized receptor proteins, and characterization
of receptor-coupling mechanisms, receptor interactions, and
receptor regulation, with concentration on the central
nervous system. Techniques described include now-classical
molecular pharmacology through imaging of second messengers
in cells and in intact brain to the most sophisticated use
of recombinant DNA technology. Readers will no doubt find
these representative chapters at the cutting edge of
neuroscience.
Speaking on behalf of the participants at the Hiroshima
symposium, I would like to thank Professor Kito sincerely
and warmly for providing this excellent scientific program
in the midst of an extremely friendly and enjoyable visit to
Japan. I hope that there will be more such occasions.
Richard W. Olsen
vii
CONTENTS
Effect of Neuropeptides on Classic Types of Neurotransmission
in the Rat Central Nervous System
S. Kito and R. Hiyoshi ...•......................................
Solubilization and Characterization of Substance PReceptors
in the Central Nervous System
T. Segawa and Y. Nakata......................................... 13
Evidence for Cardiovascular Roles of Tachykinin Peptides
in the Brain of the Rat
H. Kamiya, Y. Takano, and A. Nagashima.......................... 27
Functions of a Co-Transmitter, Calcitonin Gene-Related Peptide,
on the Neuromuscular Junction
S. Uchida, K. Takami, H. Kobayashi, K. Hashimoto, and
N. Matsumoto................................................. 39
Pharmacological Characterization of Sigma Binding Sites
in Guinea Pig Brain Membranes
E.W. Karbon and S.J. Enna....................................... 51
Transmitter-Activated Ion Channels as the Target of Chemical Agents
T. Narahashi.................................................... 61
Chemical Kinetic Investigations of the Channel-Opening Process of
Neurotransmitter Receptors
N. Matsubara, A.P. Billington, H.C. Chen, A.P. Guzikowski,
K.W. Johnson, D. Ramesh, M.T. Sweet, and G.P. Hess........... 75
Primary Structure and Functional Expression of the Inositol
1,4,5-Trisphosphate Receptor, P400
K. Mikoshiba, T. Furuichi, N. Maeda, S. Yoshikawa,
A. Miyawaki, M. Niinobe, and K. Wada......................... 83
Inositol 1,4,5-Trisphosphate Activates Ca2+ Channels in the Plasma
Membranes of Rat Brain Nerve Terminals
M. Satoh, H. Ueda, S. Tamura, Y. Yoshihara, and
N. Fukushima................................................. 97
Formation of Inositol Polyphosphates in Cultured Adrenal
Chromaffin Cells
N. Sasakawa, T. Nakaki, and R. Kato............................. ill
Effects of Oxygen Depletion on Phosphoinositide Breakdown in
Rat Brain Slices
H. Ninomiya, T. Taniguchi, and M. Fujiwara ...................... 125
ix
Expression of G-Protein ~-Subunit cDNA
T. Nukada....................................................... 141
Serotonin Receptor Subtypes in Brain: Ligand Binding Properties
and Coupling with G Proteins
Y. Nomura, Y. Kitamura, M. Tohda, S. Imai, T. Katada,
and M. Ui.................................................... 151
A Cerebral Endogenous Factor Regulates the Activity of the
Serotonergic Receptors Mudulating the Neuronal Release of
Acetylcholine
G. Fillion, P. Barone, I. Cloez, M.P. Fillion, C. Harel,
O. Massot, J.C. Rousselle, and E. Zifa ....................... 165
Serotonin Receptor Heterogeneity and the Role of Potassium Channels
in Neuronal Excitability
J.S. Kelly, P. Larkman, N.J. Penington, D.G. Rainnie,
H. McAllister-Williams, and J. Hodgkiss ...................... 177
Modulatory Actions of Norepinephrine on Neural Circuits
D.J. Woodward, H.C. Moises, B.D. Waterhouse, H.H. Yeh,
and J .E. Cheun............................................... 193
Genetic Analysis of the ~-Adrenergic Receptor
C.D. Strader and R.A.F. Dixon ................................... 209
Reversal of Nigrostriatal-Lesion-Induced Receptor Alterations by
Grafting of Fetal Mesencephalic Dopaminergic Neurons
J.K. Wamsley, T.M. Dawson, V.L. Dawson, M.A. Hunt, L.J. Fisher,
and F.H. Gage ................................................ 221
Octopamine: An Endogenous Blocker of Dopamine D-1 Receptors
J.T. Cheng and J.T. Tsai ........................................ 237
Depression of NMDA-Evoked Acetylcholine Release by Endogenous
Adenosine in Striatum Slices
E. Porsche and T. Schwan........................................ 241
Imaging of Dopamine D1 and D2 Receptors by a High Resolution
Positron Emission Tomography
H. Shinotoh, A. Aotsuka, O. Inoue, K. Suzuki, H. Fukuda, M. Iyo,
T. Yamazaki, Y. Tateno, K. Hirayama, and N. Nohara ........... 249
The Nicotinic Acetylcholine Receptor Gene Family: Structure
of Nicotinic Receptors from Muscle and Neurons and Neuronal
~-Bungarotoxin-Binding Proteins
J. Lindstrom, R. Schoepfer, W. Conroy, P. Whiting, M. Das,
M. Saedi, and R. Anand....................................... 255
Regulation of the Nicotinic Acetylcholine Receptor by Serine and
Tyrosine Protein Kinases
R.L. Huganir.................................................... 279
Affinity Purification of Nicotinic Acetylcholine Receptor from
Rat Brain
H. Nakayama, J. Lindstrom, T. Nakashima, and Y. Kurogochi ....... 295
Differential Coupling of Subtypes of the Muscar;nic Receptor to
Signaling Mechanisms in Brain and Peripheral Tissues
F.J. Ehlert, F.M. Delen, S.H. Yun, and P. Tran .................. 301
x
The Molecular Properties of the Ml Muscarinic Receptor and its
Regulation of Cytosolic Calcium in a Eukaryotic Gene
Expression System
J. Lai, T.L. Smith, L. Mei, M. Ikeda, Y. Fujiwara, J. Gomez,
M. Halonen, W.R. Roeske, and H.I. Yamamura ...........•...•... 313
Molecular Mechanism Underlying the Occurrence of Supersensitivity
at Muscarinic Receptors: Analysis Using Cerebral Cortical
Neurons in Primary Culture
K. Kuriyama and S. Ohkuma....................................... 331
Super-Delayed Changes of Muscarinic Acetylcholine Receptor in the
Gerbil Hippocampus Following Transient Ischemia
N. Ogawa, K. Haba, M. Asanuma, K. Mizukawa, and A. Mori ......... 343
Intramembrane Particles in the Postsynaptic Membranes of the
S-, F-, and C-Type Synapses by Freeze-Fracturing, and
Deep-Etching Studies on the Xenopus Spinal Cord
H. Watanabe, H. Washioka, and A. Tonosaki ....................... 349
GABAA-Benzodiazepine Receptors: Demonstration of Pharmacological
Subtypes in the Brain
R.W. Olsen, M. Bureau, S. Endo, G. Smith, L. Deng, D. Sapp,
and A.J. Tobin............................................... 355
Structural, Developmental, and Functional Heterogeneity of Rat
GABA Receptors
A.J. Totin, M. Khrestchatisky, A.J. MacLennan, M.Y. Chiang,
N.J.K. Tillakaratne, W. Xu, M.B. Jackson, N. Brecha,
C. Sternini, and R.W. Olsen.................................. 365
Subunit and Subtype-Specific Antibodies to the GABA-A/Benzodiazepine
Receptor Complex
s. Endo and R.W. Olsen.......................................... 375
The Differential Expression Pattern of the mRNAs Encoding S
Subunits «(:31' (32 and (33) of GABAA Receptor in Rat Brain
J.H. Zhang, M. Sato, K. Noguchi, ana M. Tohyama ................. 381
"In Vivo" Inhibition of GABAergic Transmission Increases 35S_TBPS
Binding in the Rat Brain
G. Biggio, E. Sanna, M. Serra, G.P. Serra, and A. Concas ........ 391
123-I-Iomazenil-SPECT in Patien~~ with Focal Epilepsies -
A Comparative Study with mTc-HMPAO-SPECT, CT and MR
F.J. Ferstl, M. Cordes, I. Cordes, H. Henkes, W. Christe,
H. Eichstadt, G. Barzen, B. Schmitz, P.H. Hasler,
P.A. Schubiger, D. Schmidt, and R. Felix..................... 405
Expression of the GABAB Receptor in Xenopus Oocytes and
Desensitization oy Activation of Protein Kinase C
K. Taniyama, K. Takeda, H. Ando, and C. Tanaka .........•........ 413
Structure and Expression of Inhibitory Glycine Receptors
H. Betz, D. Langosch, W. Hoch, P. Prior, I. Pribilla,
J. Kuhse, V. Schmieden, M.-L. Malosio, B. Matzenbach,
F. Holzinger, A. Kuryatov, B. Schmitt, Y. Maulet, and
C.-M. Becker................................................. 421
xi
Heterogeneous Distribution of Glutamate Receptor Subtypes in
Hippocampus as Revealed by Calcium Fluorometry
Y. Kudo, E. Ito, and A. Ogura ................................... 431
Excitatory Amino Acid Receptors in the Xenopus Oocyte
Expression System
R. Dingledine, N.W. Kleckner, and C.J. McBain ................... 441
Novel Fourth Binding Sites of [3H] Spermidine within the NMDA
Receptor Complex
Y. Yoneda and K. Ogita.......................................... 455
Solubilization of the NMDA Receptor Ion Channel Complex
from Rat Brain
K. Ogita and Y. Yoneda.......................................... 477
NMDA Receptor Agonists: Relationships between Structure and
Biological Activity
B. Ebert, U. Madsen, T.N. Johansen, and P. Krogsgaard-Larsen .... 483
Contributors. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 489
Index. . . • . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 495