Neuronal Grafting and Alzheimer’s Disease PDF
Preview Neuronal Grafting and Alzheimer’s Disease
RESEARCH AND PERSPECTIVES IN ALZHEIMER'S DISEASE Fondation Ipsen Editor Yves Christen, Fondation Ipsen, Paris (France) Editorial Board Yves Agid, H6pital Pitie Salpetriere, Paris (France) Albert Aguayo, The Montreal General Hospital, Montreal (Canada) Brian H. Anderton, St George's Hospital Medical School, London (GB) Raymond T. Bartus, Cortex, Irvine (USA) Floyd Bloom, Scripps Clinic and Research Foundation, La Jolla (USA) Fran~ois Boller, Inserm U324, Paris (France) Peter Davies, Albert Einstein College of Medicine New-York (USA) Andre Delacourte, Inserm U16, Lille (France) Steven Ferris, New-York University Medical Center, New-York (USA) Jean-Fran~ois Foncin, H6pital Salpetriere, Paris (France) Fran~ois Forette, H6pital Broca, Paris (France) Fred Gage, University of California, La Jolla (USA) Carleton D. Gajdusek, National Institute of Health, Bethesda (USA) George G. Glenner, University of California, La Jolla (USA) Dmitry Goldgaber, National Institute of Health, Bethesda (USA) John Hardy, St Mary's Hospital, Medical School, London (GB) Jean-Jacques Hauw, H6pital Pitie Salpetriere, Paris (France) Claude Kordon, Inserm U159, Paris (France) Yvon Lamour, Inserm U161, Paris (France) Jacques Mallet, CNRS, Gif-sur-Yvette (France) Colin L. Masters, Royal Perth Hospital, Perth (Australia) Stanley I. Rapoport, National Institute on Aging, Bethesda (USA) Andre Rascal, H6pital Purpan, Toulouse (France) Barry Reisberg, New-York University Medical Center, New-York (USA) Dennis J. Selkoe, Harvard Medical School Center for Neurological Diseases and Brigham and Women's Hospital, Boston (USA) Michael L. Shelanski, Columbia University, New-York (USA) J ean-Louis Signa ret, H6pital Salpetriere, Paris (France) Pierre-Marie Sinet, H6pital Necker, Paris (France) Peter St George Hyslop, Massachussetts General Hospital, Boston (USA) Henry Wisniewski, Institute for Basic Research in Developmental Disabilities, Staten Island (USA) Edouard Zarijian, Centre Hospitalier Universitaire, Caen (France). F. Gage A. Privat Y. Christen (Eds.) Neuronal Grafting and Alzheimer's Disease Springer-Verlag Berlin Heidelberg New York London Paris Tokyo Hong Kong Gage, F. H., Dr. Neurosciences, School of Medicine M. 024 University of California La Jolla, CA 92093, USA Privat, A., Dr. Laboratoire de Neurobiologie Institut de Biologie Boulevard Henri IV F-34060 Montpellier Christen, Yves, Dr. Fondation IPSEN pour la Recherche Therapeutique 30, rue Cambronne F-75737 Paris Cedex ISBN-13: 978-3-642-48371-4 e-ISBN-13: 978-3-642-48369-1 DOl: 10.1007/978-3-642-48369-1 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in other ways, and storage in data banks. Duplication of this publication or parts thereof is only permitted under the provisions of the German Copyright Law of September 9,1965, in its version of June 24,1985, and a copy- right feet must always be paid. Violations fall under the prosecution act of the German Copyright Law. © Springer-Verlag Berlin Heidelberg 1989 Softcover reprint of the hardcover 1st edition 1989 The use of general descriptive names, trade names, trade marks, etc. in this publication, even if the former are not especially identified, is not to be taken as a sign that such names, as under- stood by the Trade Marks and Merchandise Marks Act, may accordingly be used freely by anyone. Product Liability: The publisher can give no guarantee for information about drug dosage and application thereof contained in this book. In every individual case the respective user must check its accuracy by consulting other pharmaceutical literature. 2127/3140/543210 - Printed on acid-free paper Preface This volume contains the proceedings of the third Colloque Medecine et Recherche organized by the Fondation Ipsen pour la Recherche Therapeutique and devoted to Alzheimer's disease. After Immunology and Alzheimer's disease (Angers, September 14,1987) and Genetics and Alzheimer's disease (Paris, March 25,1988), this meeting was dedicated to an other up-to-date, and even futurist, topic: Neuronal grafting and Alzheimer's disease. It was held in Montpellier, an historical city, and under the patronage of one of the oldest School of Medicine of the world. For the last few months, a large number of experimental works and even of clinical trials on neuronal grafting have been carried out. As far as clinical studies are concerned, results remain highly controversial. Most of them concern Parkin- son's disease but for some scientists, neuronal grafting could be a cure for other neurodegenerative diseases, including Alzheimer's disease (and also Hun- tington's disease) but, at this point, there are only a few experimental data (perhaps not really related to the disease) on animal models and hypothesis. So the main aim of the Montpellier's meeting was not, indeed, to give a definitive answer to these questions. The following Colloque Mectecine et Recherche of this series was organized in Toulouse on March 24,1989, and was dedicated to the biological markers of Alz- heimer's disease. Yves Christen Vice-President of the Fondation Ipsen pour la Recherche TMrapeutique Acknowledgments: The editors wish to express their gratitude to Dean Claude Solassol for giving the patronage of the faculty of medicine of Montpellier, Mrs Mary Lynn Gage for her editorial assistance, Mrs Jacqueline Mervaillie for the organization of the meeting and Yves Agid and Jean-Didier Vincent for their col- laboration as chairmen for the meeting. Contents Neuronal Grafting and Alzheimer's Disease: Introduction F. H. Gage, A. Privat, and Y. Christen . . . . . . . . 1 Nigral and Striatal Grafts to the Lesioned Neostriatum: Models of Graft Function A. Bjorklund, O. /sacson, P. Brundin, and S. B. Dunnett 4 Intracerebral Grafts of Dopaminergic Neurons: A Discussion of Their Functional Effects and Mechanisms of Action 1. P. Herman, K. Choulli, N. Abrous, and M. Le Moal . . . . . . . 21 Purkinje Cell Replacement by Intracerebellar Neuronal Implants in an Animal Model of Heredodegenerative Ataxia: An Overview C. Sotelo ............................... 34 Spontaneous Remyelination and Intracerebral Grafting of Myelinating Cells in Mammals M. Gumpel, O. Gout, andA. Gansmuller ................. 43 Synaptic Plasticityvs Pathology in Alzheimer's Disease: Implications for Transplantation C. W. Cotman . . . . . . . . . . . . . . . . . . . . . . 54 Host Immune Responses to Neural Transplantation: A Possible Model for Autoimmune Diseases ofthe Central Nervous System R. D. Lund, K. Rao, and T. 1. Gill . . . . . . . . . . . . . . . . . . . 63 NGF in CNS: Sites of Synthesis and Effects of Novel Ways to Administer NGF on Intrinsic Cholinergic Neurons and Grafts of Cholinergic Neurons and Their Target Areas L. Olson, C. Ayer-LeLievre, T. Ebendal, M. Eriksdotter-Nilsson, P. Ern/ors, P. Mouton, H. Persson, and 1. Stromberg ..... 73 Short-Term Memory in Rodent Models of Ageing: Effects of Cortical Cholinergic Grafts S. B. Dunnett . . . . . . . . . . . . . . . . . . . . . . . . . . . . 85 VIII Contents Pathophysiology of the Subcortically Deafferented Hippocampus: Improvement and Deterioration of Function by Fetal Grafts G. Buzsaki and F. H. Gage . . . . . . . . . . . . . . . . . . .. ... 103 Can Fetal Cell Grafts be Expected to Ameliorate Symptoms of Human Neurodegenerative Disorders? Evidence from Animal Models T. J. Collier and J. R. Sladek Jr. ................... .. 120 Age-Related Changes in Rat Hippocampal Noradrenergic Transmission: Insights from In Oculo Transplants B. Hoffer, P. Bickford-Wimer, M. Eriksdotter-Nilsson, A. -CO Granholm, M. Palmer, G. Gerhardt, L. Olson, A. Seiger, and G. Rose ..... .. 130 Neural Grafts and Neurotransmitter Interactions in Cognitive Deficits M. Segal, G. Richter-Levin, V. Greenberger, and R. Shpiegelman .. . 141 Serotonin-Expressing Cells from Different Microregions of the Embryonic Rat Rhombencephalon: Behaviour in Cell Culture and in Transplants to the Adult Spinal Cord N. Konig, N. Rajaofetra, M. J. Drian, F. Favier, F. Sandillon, C. Fuentes, and A. Privat . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 150 Two Approaches for the Reversal of Phenobarbital-Induced Behavioral Birth Defects J. Yanai, F. Fares, M. Gavish, Z. Greenfeld, C. G. Pick, Y. Rogel-Fuchs, and D. Trombkal . . . . . . . . . . . . . . . . . . . . . . . . . . . . 165 Differential Neural Plasticity of Diffuse Monoaminergic and Point-to-Point Sensory Afferents as Demonstrated by Responses to Target Deprivation and Fetal Neural Transplants M. Peschanski, F. Nothias, 1. Dusart, B. Onteniente, M. Geffard, and O. Isacson ......................... . .... 177 Deleterious and "Overshoot" Effects of Intracerebral Transplants B. Will, J. -CO Cassel, and C. Kelche . 189 Subject Index . . . . . . . . . . . . 199 Contributors Abrous, N. INSERM U 259, Universite Bordeaux II., Domaine de Carreire, rue Camille Saint-Saens, 33077 Bordeaux, France Ayer-LeLievre, C. Department of Histology and Neurobiology, Karolinska Institute, P.O.Box 60400,10401 Stockholm, Sweden P. Bickford-Wimer Department of Pharmacology (C236) University of Colorado, Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA Bjorklund, A. Department of Medical Cell Research, Biskopsgatan 5, 22362 Lund, Sweden Brundin, P. Department of Medical Cell Research, University of Lund, Biskopsgatan 5,22362 Lund, Sweden Buzstiki, G. Department of Neurosciences M-024, University of California at San Diego, La Jolla, CA 92093, USA Cassel, J.-c. Departement de Neurophysiologie et de Biologie des Comportments, Centre de Neurochimie du C.N.R.S., 12 rue Goethe, 67000 Strasbourg, France Choulli, K. INSERM U 259, Universite Bordeaux II., Domaine de Carreire, rue Camille Saint-Saens, 33077 Bordeaux, France Christen, Y, Fondation Ipsen, 30 rue Cambronne 7574 Paris Cedex 15 Collier, T. J. Department of Neurobiology and Anatomy, University of Rochester, School of Medicine, Rochester, NY 14642, USA X Contributors Cotman, C. w. Department of Psychobiology , University of California, Irvine, CA 92717, USA Drian, M. J. INSERM U 249 et CNRS LP 8402, 34060 Montpellier, France Dunnett, S. B. Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK Dusart, I. INSERM U 161, 2 rue d'Alesia, Paris 75014, France Ebendal, T. Department of Developmental Biology, Biomedical Center, Uppsala University, 75123 Uppsala, Sweden Eriksdotter-Nilsson, M. Department of Histology and Neurobiology, Karolinska Institute, P.O.Box 60400,10401 Stockholm, Sweden Ern/ors, P. Department of Medical Chemistry Laboratory of Molecular Neurobiology, Karolinska Institute, P.O.Box 60400,10401 Stockholm, Sweden Fares, F. Rappaport Family Institute for Research in the Medical Sciences, Department of Pharmacology, Faculty of Medicine, Technion-Israel, Institute of Technology, Haifa, Israel Favier, F. Laboratoire Cytometrie Flux INSERM, 34060 Montpellier, France Fuentes, C. Laboratore de Neurophysiologie, U.S.T.L. Place E. Bataillon, 34060 Montpellier Cedex 1, France Gage, F. H. Department of Neurosciences M-024, University of California at San Diego, La Jolla, CA 92093, USA Gansmuller, A. INSERM U 134, Laboratoire de Neurobiologie cellulaire, moleculaire et clinique, 47 Boulevard de I'Hopital, Hopital de la Salpetriere, 75651 Paris Cedex 13, France Contributors XI Gavish, M. Rappaport Family Institute for Research in the Medical Sciences, Department of Pharmacology, Faculty of Medicine, Technion-Israel, Institute of Technology, Haifa, Israel Geffard, M. Institut de Biochimie Cellulaire et de Neurochimie, 33007 Bordeaux, France Gerhardt, G. Department of Pharmacology (C236), University of Colorado, Health Sciences Center, 4200 Ninth Avenue, Denver, CO 80262, USA Gill, T. J. University of Pittsburgh, School of Medicine, Pittsburgh, PA 15261, USA Gout, O. INSERM U 134, Laboratoire de Neurobiologie cellulaire, moh~culaire et clinique, 47 Boulevard de I'H6pital, H6pital de la Salpetriere, 75651 Paris Cedex 13, France Granholm, A.-c. Karolinska Institute, P.O. Box 60400,104 10 Stockholm, Sweden Greenberger, V. Center for Neurosciences, Weizmann Institute of Science, Rehovot, Israel Greenfeld, z. The Melvin A. and Eleanor Ross Laboratory for Studies in Neural Birth Defects, Department of Anatomy and Embryology, The Hebrew University- Hadassah Medical School, Box 1172, 91010 Jerusalem, Israel Gumpel, M. INSERM U 134, Laboratoire de Neurobiologie cellulaire, moleculaire et clinique, 47 Boulevard de l'H6pital, H6pital de la Salpetriere, 75651 Paris Cedex 13, France Herman, 1. P. INSERM U 259, Universite Bordeaux II., Domaine de Carreire, rue Camille Saint-Saens, 33077 Bordeaux, France Hoffer, B. Department of Pharmacology (C236), University of Colorado, Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA /sacson, O. Department of Anatomy, University of Cambridge, Downing Street, Cambridge CB2 3DY, UK XII Contributors Kelche, C. Departement de Neurophysiologie et de Biologie des Comportements, Centre de Neurochimie du C.N.R.S., 12 rue Goethe, 67000 Strasbourg, France Konig, N. Laboratore de Neurophysiologie, U.S.T.L., INSERM U249 et CNRS LP 8402 Place E. Bataillon, 34060 Montpellier Cedex 1, France LeMoal, M. INSERM U 259, Universite Bordeaux II., Domaine de Carreire, rue Camille Saint-Saens, 33077 Bordeaux, France Lund, R. D. University of Pittsburgh, School of Medicine, Pittsburgh, PA 15261, USA Mouton, P. Department of Histology and Neurobiology, Karolinska Institute, P.O.Box 60400,10401 Stockholm, Sweden Nothias, F. INSERM U 161, 2 rue d'Alesia, 75014 Paris, France Olson, L. Department of Histology and Neurobiology, Karolinska Institute, P.O.Box 60400, 104 01 Stockholm, Sweden Onteniente, B. Centre de Biochimie, Universite de Nice, 06034 Nice Cedex, France Palmer, M. Department of Pharmacology (C236) , University of Colorado, Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA Persson, H. Department of Medical Chemistry, Laboratory of Molecular Neurobiology, Karolinska Institute, P.O.Box 60400,10401 Stockholm, Sweden Peschanski, M. INSERM U 161, 2 rue d'Alesia, 75014 Paris, France Pick, C. G. The Melvin A. and Eleanor Ross Laboratory for Studies in Neural Birth Defects, Department of Anatomy and Embryology, The Hebrew University- Hadassah Medical School, Box 1172, 91010 Jerusalem, Israel
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