Neurologic complications of cancer therapy PDF
Preview Neurologic complications of cancer therapy
Neurologic Complications Wen Schiff Lee of Cancer Therapy N Patrick Y. Wen, MD • David Schiff, MD • Eudocia Quant Lee, MD, MPH e u r o Neurologic Complications of Cancer Therapy provides comprehensive coverage of the l o recognition and management of neurologic symptoms related to cancer therapy including g neurologic complications of treatments utilizing novel targeted therapies as well as traditional i c chemotherapies, surgery, and radiation therapy. C Neurologic Part One of the book focuses on systemic therapies. In the first half of this section, systemic o therapies are organized by class of agent and include discussion of supportive therapies, m immunosuppressants, and corticosteroids. The second half of Part One is organized according to adverse event, which is particularly valuable to clinicians, allowing them to consult by symptom p in cases where multiple agents have been administered and the source of the complication l Complications of i is uncertain. Part Two of the book examines neurologic complications of radiation therapy, c a organized according to location within the nervous system. Parts Three and Four address t neurologic complications of surgery and hematopoietic stem cell transplantation. i o n Cancer Therapy s Neurologic Complications of Cancer Therapy Features: o n A widely recognized team of editors f n Systemic therapy covered by therapeutic agent and by adverse event, C enabling a “problem-oriented” approach for the clinician a n Coverage of newer modalities including immunologic agents, biologics, and n Patrick Y. Wen • David Schiff • Eudocia Quant Lee targeted therapies c n Complete sections on complications of radiation therapy, surgery, high-dose e chemotherapy, and stem-cell transplantation r T About the Editors h e Patrick Y. Wen, MD, Director, Center for Neuro-Oncology, r Dana-Farber/Brigham and Women’s Cancer Center a David Schiff, MD, Co-Director, Neuro-Oncology Center, p University of Virginia Health System y Eudocia Quant Lee, MD, MPH, Instructor in Neurology, Center for Neuro-Oncology, Dana-Farber/Brigham and Recommended Women’s Cancer Center Shelving Category: Oncology 11 W. 42nd Street New York, NY 10036 9 781936 287079 www.demosmedpub.com Neurologic Complications of Cancer Therapy Neurologic Complications of Cancer Therapy Editors Patrick Y. Wen, MD Director Center for Neuro-Oncology Dana-Farber/Brigham and Women’s Cancer Center Boston, Massachusetts David Schiff , MD Co-Director Neuro-Oncology Center University of Virginia Health System Charlottesville, Virginia Eudocia Quant Lee, MD, MPH Instructor in Neurology Center for Neuro-Oncology Dana-Farber/Brigham and Women’s Cancer Center Boston, Massachusetts NEW YORK Visit our website at www.demosmedpub.com ISBN: 978-1-936287-07-9 ebook ISBN: 9781617050190 Acquisitions Editor: Richard Winters Compositor: Absolute Service, Inc. Printer: Hamilton Printing Company © 2012 Demos Medical Publishing, LLC. All rights reserved. Th is book is protected by copyright. No part of it may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior written permission of the publisher. M edicine is an ever-changing science. Research and clinical experience are continually expanding our knowledge, in particu- lar our understanding of proper treatment and drug therapy. Th e authors, editors, and publisher have made every eff ort to ensure that all information in this book is in accordance with the state of knowledge at the time of production of the book. Nevertheless, the authors, editors, and publisher are not responsible for errors or omissions or for any consequences from application of the information in this book and make no warranty, express or implied, with respect to the contents of the publication. Every reader should examine carefully the package inserts accompanying each drug and should carefully check whether the dosage schedules mentioned therein or the contraindications stated by the manufacturer diff er from the state- ments made in this book. Such examination is particularly important with drugs that are either rarely used or have been newly released on the market. Library of Congress Cataloging-in-Publication Data Neurologic complications of cancer therapy / [edited by] Patrick Y. Wen, David Schiff , Eudocia Quant Lee. p. ; cm. Includes bibliographical references and index. ISBN 978-1-936287-07-9 — ISBN 978-1-61705-019-0 (e-book) 1. Cancer—Treatment—Complications. 2. Cancer—Treatment. 3. Neurologic manifestations of general diseases. I. Wen, Patrick Y. II. Schiff , David, 1959- III. Quant Lee, Eudocia. [DNLM: 1. Neoplasms—complications. 2. Neoplasms—therapy. 3. Neurologic Manifestations. 4. Th erapeutics— adverse eff ects. QZ 200] RC270.8.N45 2012 616.99'406—dc23 2011024254 Special discounts on bulk quantities of Demos Medical Publishing books are available to corporations, professional associa- tions, pharmaceutical companies, healthcare organizations, and other qualifying groups. For details, please contact: Special Sales Department Demos Medical Publishing 11 W. 42nd Street, 15th Floor New York, NY 10036 Phone: 800-532-8663 or 212-683-0072 Fax: 212-941-7842 E-mail: [email protected] Made in the United States of America 11 12 13 14 / 5 4 3 2 1 We would like to dedicate this work to our wonderful practice nurses, and especially in memory of Joan Riley, RN—a jewel from the north. Contents Preface ix Acknowledgments xi Contributors xiii PART ONE: NEUROLOGIC COMPLICATIONS OF SYSTEMIC THERAPIES ACCORDING TO AGENT 1. Neurologic Complications of Alkylating Agent Chemotherapy 3 Herbert B. Newton 2. Neurologic Complications of Antimetabolites 17 Ryan Merrell, Jörg Dietrich, and Tracy Batchelor 3. Neurologic Complications Associated with Plant Alkaloids 35 Abhishek Singla, Aditya Bardia, and Vinay Chaudhry 4. Neurologic Complications of Topoisomerase Inhibitors 49 April F. Eichler 5. Neurologic Complications of Epothilones and Amino Acid Degraders 63 April F. Eichler 6. Neurologic Complications of Corticosteroids 73 Erin M. Dunbar, Rizwan Kalani, and Santosh Kesari 7. Neurologic Complications of Immunomodulatory Agents 93 Stuart C. Apfel 8. Neurologic Complications of Immunosuppressive Drugs 107 Ramani Balu and Amy A.Pruitt 9. Neurologic Complications Associated with Biologic Agents 125 Aaron G. Mammoser and Morris D. Groves 10. Neurologic Complications of Targeted Th erapy 149 Eudocia Quant Lee, Andrew D. Norden, David Schiff , and Patrick Y. Wen 11. Neurologic Complications of Hormonal Chemotherapies 167 Wendy Sherman Sojka and Jeff rey Raizer viii CONTENTS 12. Neurologic Complications Associated with Supportive Th erapies 189 Jan Drappatz 13. Chemotherapy-Associated Cognitive Dysfunction 201 Jörg Dietrich and Alexander Pine 14. Central Nervous System Toxicity of Chemotherapy 213 Jerome J. Graber and Lisa M. DeAngelis 15. Neurologic Complications Aff ecting Peripheral Nerves 237 Guido Cavaletti and Paola Marmiroli 16. Neurologic Complications Aff ecting the Neuromuscular Junction 263 Kelly G. Gwathmey, Ted M. Burns, and Elliot L. Dimberg PART TWO: NEUROLOGIC COMPLICATIONS OF RADIATION THERAPY 17. Cellular Mechanisms of Radiation Injury to Cognition 291 Michelle Monje 18. Central Nervous System Complications of Radiation Th erapy 301 Damien Ricard, Dimitri Psimaras, Carole Soussain, Nadine Martin-Duverneuil, and Jean-Yves Delattre 19. Radiation-Induced Tumors 315 Hilary L. Somerset, B.K. Kleinschmidt-DeMasters, and Kevin O. Lillehei 20. Radiation Vasculopathy 331 Lisa R. Rogers 21. Radiation Myelopathy 341 Timothy E. Schultheiss 22. Radiation-Induced Peripheral Nerve Disorders 355 Odysseas Kargiotis and Athanasios P. Kyritsis PART THREE: NEUROLOGIC COMPLICATIONS OF SURGERY 23. Complications of Neurosurgical Oncology 371 Brian J. Williams, Robert G. Louis, and Mark E. Shaff rey PART FOUR: NEUROLOGIC COMPLICATIONS OF HEMATOPOIETIC STEM CELL TRANSPLANTATION 24. Common Neurologic Complications in Hematopoietic Stem Cell Transplant Patients 395 Eudocia Quant Lee and Patrick Y. Wen Index 411 Preface We are grateful and honored for this opportu- targeted therapies as well as traditional chemothera- nity to organize and edit a textbook on neu- pies, surgery, and radiation therapy. rologic complications of cancer therapy. Patients Th is textbook is truly a multi-disciplinary ef- with cancer are living longer due to earlier diagnosis fort as we were able to bring together experts from and remarkable improvements in treatments. Un- multiple fi elds. It is a timely and thorough review fortunately, neurologic complications from cancer of the neurologic complications of anti-cancer treat- therapies remain an important source of morbidity ments. In Part One, we focus on systemic therapies. and sometimes limit the administration of poten- In the fi rst half of this section, chapters are orga- tially benefi cial therapies. Since treatments for ther- nized according to classes of agents. We also include apy-induced neurotoxicity are limited, awareness of discussions on supportive therapies, immunosup- common neurologic complications is important to pressants, and corticosteroids. In the second half of minimize permanent damage. Part One, chapters are organized according to ad- Over the past decade, our understanding of the verse event. Part Two examines the neurologic com- molecular pathways important in cancer has dramat- plications of radiation therapy, organized according ically increased. Th is has led to a plethora of targeted to location within the nervous system. Neurologic agents against these abnormal pathways and has dra- complications of surgery and hematopoietic stem matically changed the treatment landscape for several cell transplantation are the main topics in Parts cancers, including chronic myelogenous leukemia Th ree and Four, respectively. and multiple myeloma. While the neurotoxicities Th is textbook has been written with practic- of radiation, surgery, and traditional cytotoxic che- ing physicians in mind. While some chapters con- motherapies are well described, less is known about tain discussions on pathophysiology, the main fo- the side-eff ect profi les of these novel agents. None cus is on clinical information. Our hope is that this of the available textbooks on cancer therapy address textbook can serve as a reference for neurologists, this issue. Th erefore, we decided to create a compre- neuro-oncologists, medical oncologists, radiation hensive textbook of neurologic complications due to oncologists, and neurosurgeons.
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