Table Of Content

AUTHOR INDEX Agnati L. F. 261, 271 Fabiano C. 313 Le H. H. 433 AguirreJ .A . 261 Faff-Michalak L. 573 Leavitt B. R. 113 Akers R. F. 549 Finiels-Marlier F. 93 Lee E. H. Y. 363 Albrecht J. 573 Fiori A. 45 Lee R. Y. 433 Al-Deen I. H. S. 605 Fowler C. J. 171 Le Gal la Salle G. 355 Andbjer B. 262 Franck J. 221 Le Grevés P. 341 Araki W. 537 Frankhuijzen A. L. 543 Lekman A. 505 Fredman P. 227 Le Peuch C. 93 Bachelard H. S. 495 Fried G. 221 Loctin F. 559 Bailly Y. 425 Fuxe K. 261, 271 Lorentz J.-G. 297 Barbeito L. 593 Lovenberg W. 327 Barnes N. M. 389 Gaitonde M. K. 151, 159 Liibbert H. 433 Belhage B. 475 Garcia L. 51 Liimmen G. 437 Benfenati F. 271 Ghazi H. 407 Luo D. 483 Benjannet S. 103 Gianoulakis C. 103 Benyhe S. 349 Girod R. 559 Maddison J. E. 511 Bernik D. L. 611 Glaser T. 437 Mansson J.-E. 227 Birman S. 87 Gothert M. 437 Matthiessen L. 425, 453 Boni C. 453 Gottfries J. 227 Mattson M. P. 17 Borsodi A. 349 Gozlan H. 413 MayoJ . 61 Bosin T. R. 531 Grieve A. 467 Maysinger D. 113 Bourde O. 25 Griffiths R. 467 Mbikay M. 103 Brodin E. 221 Gudehithlu K. P. 243 Medina J. H. 567 Brooks K. J. 495 Meier E. | Bruinvels A. 397 Hadjiconstantinou M. 243 Mengod G. 433 Hagberg B. 505 Meunier F.-M. 87 Cain S. T. 549 Hamon M. 413, 425, 453 Miller R. C. 327 Cangiano C. 45 Hansson E. 227 MinamiN. 81 Cardelli P. 45 Hartline D. K. 281, 297 Miquel M.-C. 453 Cascino A. 45 Hauser K. F. 17 Morel N. 355 Ceci F. 45 Hertz L. | Morita K. 71, 81 Chaki S. 335 Hibert M. 397 Mulder A. H. 543 Challiss R. A. J. 207 Hirouchi M. 375 Muramatsu M. 335 Hoflack J. 397 Murray E. 151, 159 Cheng C. H. K. 389 Holman R. B. 367 Chretien M. 103 Nahorski S. R. 207 Commissiong J. W. 445 lentile R. 313 Nakamura S. 537 Costall B. 389 Itoh Y. 135 Naylor R. J. 389 Cross A. J. 159 Cupo A. 483 Neff N. H. 243 Jacobowitz D. M. 517 Neise A. 437 Jansen F. P. 543 Newcomb R. W. 281, 297 Dalia D. A. 243 Johnston G. A. R. 511 Nicolet M. 51 Damgaard I. 475 Nishibori M. 135 Daval G. 425, 453 Kasper G. C. 531 Nomura Y. 247, 255 Dawson R. M. 125 Kaufman H. 601 Nordmann J. J. 297 Depaulis A. 297 Kauppinen R. A. 495 Nquyen H. 433 Dohi T. 71,81 Kia H. K. 425 Dopico A. M. 61 Kilpatrick G. J. 389 Obata K. 213 Doucet E. 453 Kim M. R. 523 Ohkuma S. 375 Dowling M. H. 125 Kimura J. 537 Oishi R. 135 Drian M.-J. 93 Kitamura Y. 247 Okuyama S. 335 Duchemin A.-M. 243 Kitayama S. 71, 81 O'Regan S. 87 Dunant Y. 559 Kuhn D. M. 39 Osborne N. N. 407 Dunlop D. S. 601 Kumagai C. 255 Otomo S. 335 Dunlop J. 467 Kuriyama K. 319, 375 Palacios J. M. 433 El Mestikawy S. 413, 453 Laborde C. 593 Pena C. 567 Eneroth P. 261 Lajtha A. 601 Piva M. A. 567 Index Poretski M. 125 Shaw G. G. 605 Tyers M. B. 389 Privat A. 93 Shibata O. 327 Pujol J.-F. 25 Siciliano J. 593 Ueda K. 537 Sok D.-E. 523 Ueha T. 319 Reed J. K. 581 de Souza L. R. 581 Usuki-Ito C. 335 Riad M. 413 Squires R. 475 Richards M. H. 327 Staufenbiel M. 433 Varga E. 349 Rieger F. 51 Steinbach J. 235 Veeranna 33 Rios H. 61 Stell W. K. 483 Verdiére-Sahuqué M. 51 Rivas E. A. 611 Stewart M. G. 143 Verge D. 413, 425, 453 Rodriguez de Lores Arnaiz G. 611 Strom R. 45 Villageois A. 51 Rossi Fanelli F. 45 Svennerholm L. 227, 505 Roth G. A. 213 Synguelakis M. 355 Warner M. 445 Routtenberg A. 549 Sziics M. 349 Watson W.E. J. 511 Widdowson P. S. 367 Saederup E. 475 Takei M. 247 Williams S. R. 495 Saeki K. 135 Tanaka §S. 537 Winsky L. 517 Sakurada T. 341 Taranath Shetty K. 33 Wolf W. A. 39 Sbia M. 355 Tenenhouse A. 445 Wollemann M. 349 Schlicker E. 437 Terenius L. 221, 341 Wysmyk-Cybula U. 573 Schliebs R. 143, 235 Tiger G. 171 Schmitt P. 25 Tinner B. 261 Yonemitsu O. 247 Schoffelmeer A. N. M. 543 Tohda M. 255 Schousboe A. 1, 467, 475 Trumpp-Kallmeyer S. 397 Zhao X.-H. 247 Seidah N. G. 103 Tsujimoto A. 71, 81 Zieher L. M. 61 SUBJECT INDEX N-acetyl-aspartyl-glutamate - effect of lesions on distribution, 593 N-acetyl-aspartyl-glutamate - in rat brain, 593 acetylcholine content - effect of 6-aminonicotinamide, 159 acetylcholine metabolism - effect on vesamicol, 559 acetylcholine release - from rat amygdala slices, 543 acetylcholine - elevation of [ca**],, 74 acetylcholinesterase binding sites - 125 acetylcholinesterase - glycolipid domain, 51 acetylcholinesterase - in Electric eel, 537 acetylcholinesterase - involvement of phosphatidylinositol, 51 acetylcholinesterase - protease activity, 537 adrenal chromaffin cells - release of catecholamines 71,81 age-related changes - in expression of glutamate transporter, 243 allergic encephalomyelitis - clinicopathological responses, 213 allergic encephalomyelitis - immunochemical responses, 213 allergic encephalomyelitis - in animals, 213 6-aminonicotinamide - effect on acetylcholine content, 159 amines - in neuronal differentiation, 2 amino acids - in neuronal differentiation, 2 ammonia - effect on energy metabolism and intracellular pH, 495 AMPA receptors - in chronic hepatic encephalopathy, 511 3H-AMPA binding - in cerebellum, 511 antibodies - to S-HT,, receptors, 413 antidepressants - effect on glutamatergic system, 247 antidepressants - effect upon 3H-MK-801 binding, 247 astrocytes - uptake of sulphur-containing amino acids, 467 astrocytes - effect of neurotransmitters, 6 astroglial cells - characterisation of gangliosides, 227 autophosphorylation - calmodulin-dependent protein kinase II, 271 aziridinium ion - cholinergic toxin, 113 binding of *H-minaprine to brain slices, 335 binding - of 3H-paroxetine, 42 1257_Rolton-Hunter-8-methoxy-2- (N-propyl-N-propylamino)tetralin - ligand to localise S-HT,. receptors, 426 n-butyl-B-carboline-3-carboxylate - uptake into cerebral cortex, 567 calcitonin gene-related peptide - fragmentation, 341 calcium binding protein - calretinin, 517 calcium - internal stores, 75 calcium/camodulin-dependent protein kinase II, 271 [Ca**], - elevation by various substances, 74 calmodulin-dependent protein kinase II - modulated by ganglioside GMI, 271 calretinin -"in rat brain, 517 calretinin - radioimmunoassay, 517 carbon dioxide - effect on inositol monophosphate levels, 327 castration - reduced mRNA pituitary protein 7B2, 103 catecholamine release - effect of C-AMP, 71 catecholamine release - from adrenal medulla, 71,81 catecholaminergic mechanisms - in hypothalamus, 261 cerebellum - localisation of 5-HT,, receptors, 425 Xl Index cerebellum - noradrenaline content, 61 choline acetyltransferase - subcellular distribution, 151 choline transport - in oocytes, 87 cholinergic receptors - in visual cortex, 143 cholinergic receptors - postnatal development, 143 cholinergic toxin - aziridinium ion, 113 cholinergic transmission - in Torpedo, 559 circadian variation - in spermine and spermidine, 605 convulsions - produced by kainic acid, 235 C-AMP formation - negatively coupled to S-HT,, receptors, 407 - facilitation of catecholamine release, 81 - in catecholamine release, 71 - inhibits Na*,+ K*-ATPase, 81 development - of neurotransmitter signals, 1 development - of neurotransmitters signals, 17 development - of Raphé neurones, 93 diacylglycerol - second messenger, 171 dibutyryl C-AMP - effect on morphology of cells, 255 dopamine release - effect of substance P, 367 dopamine release - from striatum, 367 dynorphin converting enzyme, 221 ecto-ATPase activity - in PC12 cells, 581 electromotoneuron - tubulin localisation, 355 encephalopathy - 2-oxglutarate dehydrogenase activity in subcellular sites of CNS, 578 encephalopathy - kainate and AMPA receptors in cerebellum, 511 energy metabolism - effect of ammonia, 495 ethanol - effect on GABA, receptor, 319 N-ethylmaleimide - stimulates serotonin and S¢Rp* uptake, 531 expression of sodium dependent choline transport, 87 forskolin - elevation of [Ca**],, 74 GABA receptors - 475 GABA, receptor complex, 319 GABA, receptor - effect of ethanol, 319 GABA, receptor - mRNA, 373 GABA, receptors - in cultures of cerebellar granule cells, 475 GABA, receptors - of high and low affinity, 475 GABA, receptors - regulate transmitter release, 475 GABA, - receptor a, subunit, 373 gallamine - competition for acetylcholinesterase binding sites, 125 ganglioside pattern - in Rett Syndrome, 505 gangliosides GMI - modulates calmodulin-dependent protein kinase Eby 2 hk gangliosides - in cerebellum of humans, 505 gangliosides - lacto series, 227 gangliosides - of astroglial cells, 227 gas chromatography-mass spectrometry - of neurotransmitter contents, 445 glucose-6-phosphate dehydrgenase - subcellular distribution, 151 glutamate transporter - age related change, 243 glutamatergic system - effect of antidepressants, 247 glycolipid - and acetylcholinesterase, 51 GR67330 - 5-HT, receptor ligand, 389 Index granule cells in culture - GABA, receptor-types, 475 granules - transport, 281 hemicholinium mustard, 113 hemicholinium mustard - effect nullified by monosialganglioside GM2, 113 histamine-N-methyltransferase + purification and characterisation, 135 histamine - inhibits release of serotonin and noradrenaline, 437 hypothalamic catecholaminergic mechanisms, 261 5-HT receptors - modelling studies, 397 5-HT,, receptor antibodies, 413 receptors - autoradiographic localisation, 453 receptors - in cerebellum, 425 receptors - in rabbit retina, 407 receptors - localisation, 425 S-HT, receptors - localisation by in situ hybridization, 453 S-HT,. receptors - mRNA, 453 receptors - negatively coupled to C-AMP formation, 407 receptors - visualisation with antibodies, 413 receptor - mRNA localisation, 433 agonists - effect on transporter, 39 receptors - conformation/activity relationship, 397 receptor-subtype - mRNAs, 433 transporter, 39 receptors - in ileum and brain, 389 - receptors, 389 immunoautoradiogaphy - of 5S-HT,, receptors, 413 in_situ hybridization - localisation of 5-HT,, receptors, 453 inositol 1,4,5-triphosphate - second messenger, 171 inositol monophosphate levels - effect of CO, and low potassium, 327 inositol phospholipid breakdown, 207 inositol phospholipid turnover, 171 intracellular pH - effect of ammonia, 495 kainate receptors - in cerebellum of drugs with chronic hepatic encephalopathy, 511 3H-kainate binding - in cerebellum, 511 kainic acid-induced convulsions, 235 kainic acid-induced convulsions - affect phorbol ester binding and protein phosphorylation, 235 Kappa opioid receptor - in frog brain, 349 phosphatidylserine, tyrosine hydroxyl ntidepressant 397 actions, 1 iediated events, Index modulation - of receptor mediated events, 207 monoamines - effect on astrocytes, 6 monocular deprivation - effect on muscarinic receptors in visual cortex, 143 monosialganglioside GMI - protects lesions produced by hemicholinium mustard, 113 MRNA for pituitary protein 7B2 - reduced by castration, 103 mRNA - for 5-HT,, receptors, 453 mRNA - for pituitary protein 7B2, 103 mRNA - of GABA, receptors, 373 mRNAs - of different 5-HT receptor-types, 433 uw-opioid receptor activator - inhibits release of acetylcholine, 543 w-opioid receptor activator - inhibits release of noradrenaline, 543 w-opioid receptors - modulation of neurotransmitter release, 543 opioid receptopr - in frog brain, 349 muscarinic receptors - in visual cortex, 143 muscarinic receptors - postnatal development, 143 NAAG - see N-acetyl-aspartyl-glutamate, 593 Na’, K*-ATPase - inhibition by C-AMP, 81 neurones - effect of protein kinase C, 93 neuroendocrine functions - involvement of neuropeptide Y, 261 neurohypophysis - oxytocin-neurophysin processing2,97 neuronal cultures - uptake of sulphur-containing amino acids, 467 neuropeptide converting enzymes, 221 neuropeptide Y receptors, 261 neuropeptide Y receptors - involvement in hypothalamic catecholamine systems, 261 neuropeptide Y receptors - involvement in neuroendocrine functions, 261 neurophysin - processing in neurohypophysis, 297 neurotransmitter content - gas chromatography/mass spectrometry, 445 neurotransmitters - as development signals, 1 neurotransmitters - quantification, 445 NG 108-15 cells - effect of dibutyryl C-AMP and phorbol esters, 255 nimodipine - in studies on serotonin and noradrenaline release, 437 NMR - ammonia neurotoxicity, 495 noradrenaline release - from rat amygdala slices, 543 noradrenaline release - inhibition by 5-HT and histamine, 437 noradrenaline - content in postnatal period, 61 noradrenaline - in cerebellum, 61 noradrenaline - induced by x-irradiation, 61 p-nitrophenyl phosphorylcholine-hydrolysing phosphodiesterase - released by phospholipase C, 523 nuclear magnetic resonance spectroscopy - see NMR, 495 ontogeny - of thiamine pyophosphatase, 33 opioid receptors - effect of 5’-guanylimidodiphosphate, 349 2-oxoglutarate dehydrogenase activity - effect of ammonia, 573 2-oxoglutarate dehydrogenase activity - in cerebellum from encephalopathy rats, 573 2-oxoglutarate dehydrogenase activity - in subcellular sites of cerebellum, 573 Index oxytocin - processing in neurohypophysis, 297 paroxatine - binding, 42 PC12 cells - ecto ATP-ase activity and phosphorylation, 581 peptide - processing, release, compartmentation, 281 phorbol ester binding - effect of kainic acid-induced convulsions, 235 phorbol ester binding - to protein kinase C, 235 phorbol esters - effect on morphology of cells, 255 phorbol esters - effect on serotonin uptake, 99 phosphatidylinositol - involvement in acetylcholinesterase, 51 phosphatidylserine liposomes - fusion with synaptosomes, 611 phosphoglucose isomerase - subcellular distribution - 151 6-phosphogluconate dehydrogenase - subcellular distribution, 151 phosphoinositide cycle, 171 phospholipase C - releases enzyme, 523 phosphorylation - efect of kainic acid-induced convulsions, 235 pituiary protein 7B2 - mRNA, 103 polyamine interconversion - effect of methylglioxal bis[guanylhydrazone], 313 polyamine - interconversion in retina, 313 polyamines circadian variations, 605 postnatal development - of muscarinic receptors, 143 postnatal development - of pyruvate dehydrogenase, 549 post-translational processing of retinal proenkephalin, 483 potassium - elevation of [Ca**],, 74 potassium - effect on inositol monophosphate levels, 327 potassium channel - binding of minaprine, 335 proenkephalin - effect of light and dark in chicken retina, 483 proenkephalin - in light and dark adapted retinas, 483 protease activity - associated with acetycholinesterase, 537 protein kinase C - binding of phorbol esters, 235 protein kinase C - involvement in development of neurones, 93 protein synthesis - regulation, 601 pyruvate dehydrogenase - phosphorylation, 549 pyruvate dehydrogenase - postnatal development, 549 pyruvate dehydrogenase - subcellular, 151 R424722 - effect on tyrosine hydroxylase, 25 radioimmunoassay - of calretinin, 517 Raphé neurones - development, 93 Raphé neurones - in culture, 93 86Rpt uptake into platelets - stimulated by N-ethylmaleimide, 531 receptor crosstalk, 171 receptor desensitization, 171 receptor modelling - of 5-HT receptors, 397 receptors - 5-HT, subtype, 389 receptors - linked to inositol phospholipid breakdown, 171 receptors - linked to inositol phospholipid breakdown, 171 receptors - linked to inositolphospholipid breakdown, 207 release - of enzymes caused by phospholipase C, 523 retina - proenkephalin metabolism, 483 retina - polyamines, 313 Rett Syndrome - altered ganglioside patterns, 505 ribosome content - during development, 601 RU 24969 - action on 5-HT transporter, 39 secretory granules - transport, 281 Index sensorimotor cortex lesions - effect on distribution of N-acetyl- aspartyl-glutamate, 593 serotonin uptake - effect of phorbol esters, 99 serotonin receptor heterogeneity, 433 serotonin release - inhibition caused by serotonin and histamine, 437 serotonin uptake into platelets - stimulated by N-ethylmaleimide, 531 serotonin - inhibits release of serotonin and noradrenaline, 437 Signals - in development, 1 sodium-dependent choline transport, 87 spermidine content - circadian variation, 605 spermine concentration - circadian variation, 605 substance P endopeptidase, 221 substance P - effect on dopamine release, 367 sulphur-containing amino acids - 467 susbtance P - fragmentation, 341 synaptosomes - fusion with phosphatidylserine liposomes, 605 synthesis of retinal proenkephalin, 483 tacrine - competition for acetylcholinesterase binding sites, 125 temporal integration - of neurotransmitters, 17 tetrahydrobiopterin levels - effect of tryptophan, 363 TFMPP - effect on 5-HT transporter, 39 thiamine pyophosphatase - purification and distribution, 33 thiamine pyrophosphatase - in brain, 33 Torpedo - tubulin in electromotoneurons, 355 toxins - hemicholinium derivatives, 113 transketolase - subcellular distribution, 151 transport - of secretory granules, 281 transporter: = of 5-HT, SS tryptophan - effect on tetrahydrobiopterin levels, 363 tubulin - in electromotoneurones3,5 5 tyrosine hydroxylase - effect of R424722 tyrosine hydroxylase - in Locus coeruleus, 25 uptake - of n-butyl-fB-carboline-3-carboxylate, 567 uptake - of sulphur-containing amino acids, 467 vesamicol - effect on acetylcholine metabolism, 559 visual cortex muscarinic receptors - effect of monocular deprivation, 143 Xenopus oocytes - injection of poly A(+) mRNA, 243 x-irradiation - effect on noradrenalne content, 61 PRINTED BY BPCC-AUP ABERDEEN LTD