Table Of Content

AUTHOR INDEX Abou-Donia M. B. 191 Edelman G. M. 97 Johnson B. G. 41] Agnati L. F. 347 Edvinsson L. 571 Johnston G. A. R. 63 Aguilar J. S. 39 Enomoto R. 55 Johns A. 575 Aimoto S. 525 Eta E. 559 Jones C. R. 507 Akiyama H. 535 Jordan S. J. 373 Alafuzoff I. 389, 399 Fanger B. O. 185 Joubert R. 275 Albrecht J. 125 Ferraguti F. 347 Aldegunde M. 199 Fonseca M. I. 39 Kadowitz P. J. 547 Allan R. D. 63 Fosbraey P. 265 Kamio Y. 257 Aumelas A. 471 Fowler C. J. 389 Kashiwabara T. 535 French M. C. 265 Kataoka Y. 503 Friedman M. 191 Kato H. 257 de Backer J. P. 137 Fuxe K. 347 Kato T. 257 Balcar V. J. 43 Kishikawa T. 257 Barraco R. A. 243 Garcia-Peregrin E. 171 Kitamura Y. 331 Barry R. 291 Garlind A. 389 Knapp R. J. 405 Basset P. 131 Gautron J.-P. 221 Kobayashi Y. 525 Bauer K. 221 Ghosh J. J. 107 Koizumi S. 503 Beart P. M. 75 Bergstrom L. 399 Giachetti A. 565 Kondo T. 525 van Giersbergen P. L. M. 167 Kordon C. 221 Berthault P. 471 Giroux M. L. 405 Koshiya N. 519 Bettuzzi S. 347 Giuliani S. 565 Kouda T. 55 Bladier D. 275 Goswami S. 107 Kuhn D. M. 33 Blanco I. 237 Goudou D. 97 Kumada M. 519 Blondet B. 425 Gozlan H. | Kuwaki T. 519 Boichot E. 477 Grahame-Smith D. G. 69 K yogoku Y. 525 Bortmann P. 491 Braquet P. 477, 481 Groome N. 291 Guard S. 149 La M. 465 Brisac A.-M. 553 Lagente V. 477, 481 Bucher B. 455 Hallén A. 515 Lapadula D. M. 191 Buck S. H. 167 Hamano S. 283 Laporte A.-M. | Burcher E. 167 Hamon M. | Le Caer J. P. 275 Hardy J. 373 Lecci A. 565 Cardell L. O. 571 Harvey J. M. 69 Le-Nguyen D. 471 Caron M. 275 Heim C. 175 Leslie R. A. 69 Carrington C. D. 191 Hemsén A. 515 Levi de Stein M. 39 Castillo M. 171 Higashida H. 419 Lieu A. T. 461 Champeroux P. 553 Hiley C. R. 445 Liu X. 27 Cheng H. C. 497 Hoflack J. 491 Louis J.C. 131 Chiche L. 471 Hojo H. 525 Lucacchini A. 51 Cincotta M. 75 Hoyer D. 17 Lundberg J. M. 515 Collier B. 115 Hu S. 541 Lynch M. 373 Collins M. J. 439 Humbert T. 367 Commissiong J. W. 249 Maggi C. A. 565 Corti A. 347 Iglesias J. 171 Magistretti P. J. 303 Cowburn R. F. 389 Ikeda M. 405 Magnier A. 553 Ikenaka K. 525 Mahe E. 471 Dage R. C. 497 Imai S. 331 Malatynska E. 405 Dashwood M. R. 439 Imazawa M. 357 Markefski M. 323 Daval G. 1 Inagaki Y. 535 Martel E. 553 De Robertis E. 39 Ingletti M. C. 347 Martin F. 199 Devesly P. 575 Ito J. 257 Martini C. 51 Dickenson H. W. 63 Iwamatsu A. 535 Mége R.-M. 97 Dilsaver S. C. 405 Melki J. 425 Douglas S. A. 445 Jacobson K. A. 207 Mencia-Huerta J.-M. 477, 481 Dreyfus P. 425 Jefferys J. G. R. 373 Mengod G. 17 Duke R. K. 63 Jeng A. Y. 541 Mercer L. D. 75 Dulak L. 191 Ji X.-D. 207 Mikoshiba K. 525 Index Miller K. 85 Rand M. J. 465 Tassin A.-M. 97 Minkes R. K. 547 Reid J. J. 461 Tenenhouse A. 249 Mitchell P. 373 Revel M. O. 131 Teo W. L. 353 Miyamoto K. 357 Rewers-Felkins K. 575 Teraoka K. 283 Morgan R. C. 75 Reynolds D. J. M. 69 Terui N. 519 Morita A. 535 Richard S. 553 Theodoropoulos S. 439 Morita K. 283 Richards M. H. 507 Tiley C. 373 Moroder L. 525 Rieger F. 97, 425 Toda T. 257 Mulder A. H. 215 Rodriguez J. 237 Toledo A. 237 Rodriguez R. 237 Touvay C. 477, 481 Nabeshima T. 55 Rosenthal L. P. 115 Triggle C. R. 559 Nakajima K. 357 Rossier J. 275 Nilsson L. 399 Rovero P. 565 Uddman R. 571 Nishikori K. 535 Rubanyi G. M. 575 Ueki S. 503 Nishimura S. 525 Niwa M. 503 Vauquelin G. 137 Sabria J. 237 Nomizu M. 535 Verge D. | Safar M. 553 Nomura Y. 331 Vieira R. 199 Sakai T. 419 Norenberg M. D. 125 Vincendon G. 131 Sasaki S. 257 Nozawa Y. 419 Volkmann I. 399 Sato A. 525 de Vos H. 137 Sattelle D. B. 341 Ogita K. 55 Vrana K. E. 27 Saudek V. 491 O’Hara L. 373 Savage P. 541 Ohkawara A. 55 Wade A. C. 185 Scates P. W. 381 Ohta H. 535 Wadsworth J. 373 Schaad N. C. 303 Oka M. 283 Waeber C. 17 Scheer H. W. 115 Okano Y. 419 Walter G. A. 243 Schoepp D. D. 411 O'Neill C. 389 Warner M. 249 Schorderet M. 303 Osborne N. N. 175 Watson S. P. 149 Sepulveda M.-I. 341 Wetherell J. R. 265 Sharif N. A. 89 Pacini R. 51 White H. L. 381 Sieklucka M. 175 Palacios J. M. 17 Whiting R. L. 89 Singh I. S. 107 Parker-Botelho L. H. 575 Winblad B. 389, 399 Sizun P. 471 Pattou E. 221 Wolf G. 323 Smits R. P. J. M. 215 Paya D. 455 Wolf W. A. 33 Sontag K. H. 175 Payton M. 291 Wong P. T.-H. 353 Stiles G. L. 207 Pelton J. T. 485, 491 Wong-Dusting H. K. 465 Stoclet J.-C. 455 Perly B. 471 Stoeckel M. E. 507 Pernow J. 515 Yacoub M. H. 439 Suzuki T. 55 Phillis J. W. 243 Yamamura H. I. 405 Sykes R. M. 439 Pingon-Raymond M. 425 Yamashita K. 507 Poduslo S. E. 85 Yoneda Y. 55 Polasek P. M. 243 Takashima H. 525 Pons F. 477, 481 Tamaoki H. 525 Zafra M. F. 171 Prehar S. 439 Tanaka R. 257 Zini I. 347 Tao F. 419 Zoli M. 347 Radja F. | Tapia-Arancibia L. 367 Zwiller J. 131 SUBJECT INDEX acetylcholine release - effect of various substances, 115 acetylcholine release - from synaptosomes, 115 acetylcholinesterase activity - reduced in Wobbler mutant mouse, 425 acetylcholinesterase - content in the CNS, 265 14C-acrylamide - binding to CNS, 191 A,-adenosine receptor - xanthine amine congener is a ligand, 207 S-adenosyl methionine - effect on a,-receptors, 39 adenylyl cyclase activity - characterization and distribution, 389 adenylyl cyclase activity - in human brain, 389 a,-adrenoreceptors - effect of S-adenosyl methionine, 39 a,-adrenoceptor antagonist - Efaroxan, 137 aluminium chloride - effect on release of taurine and GABA, 125 2-amino-3-phosphonopropionic acid - inhibits metabotrophic excitatory amino acids, 411 ammonia influence on NAD(P)H, 323 3H-AMPA binding to synaptic membranes, 75 3H-AMPA lack of effect of barbiturates on binding, 75 3H-AMPA = [3H]a-amino-3-hydroxy-5-methylisoxazole-4-propionic acid anoxic stress - effect of diazepam treatment, 107 apamin - neurotoxin mast cell degranulating peptide, 525 arachidonic acid - effect on guanylate cyclase, 131 aromatic acid decarboxylases, 27 astrocytes - release of GABA and taurine, 125 ATP - cytoplasmic levels, 283 ATP - influence on catecholamine synthesis, 283 autoradiography of 5-HT receptors, 17 autoradiography of 5-HT, receptors, 69 autoradiography of serotonin receptors, 1 autoradiography - of !125I-endothelin binding, 439 barbiturates - lack of effects on 3H-AMPA binding, 75 benzodiazepine antagonist - Ro15-1788, 405 benzodiazepine antagonist - interaction with GABA, 405 Big-endothelin-1 - bronchopulmonary and pressor effects, 481 binding sites - of *H-tryptophan, 347 binding - of 5-HT ligands, 331 binding - of endothelin to various tissues of hypertensive rats, 541 binding of endothelin-1, 507 binding of !25I-Bolton Hunter substance P, 399 binding of 14C-acrylamide to CNS, 191 binding of *H-endothelin to coronary tissue, 439 binding - of 3?H-glutamate, 341 binding - of 3?H-xanthine amine congener, 207 125[T-Bolton Hunter substance P binding sites - in human brain, 399 B,-bradykinin receptors - in CNS and peripheral tissues, 89 bradykinin - stimulates phosphoinositide turnover, 419 bronchopulmonary effects - by Big-endothelin-1, 481 bronchopulmonary response - effect of endothelin-1 and phosphoramidon, 477 2,3-butanedione inactivates binding of [35s]t- butylbicylophosphorothionate, 51 [35S]t-butylbicylophosphorothionate - binding inactivated by 2,3-butanedione, 51 calcium fluxes - by endothelin-2, 575 calcium mobilization - by endothelin-2, 575 calcium - intracellular levels in synaptosomes, 115 [3H] (+)-3-(2-carboxypiperazin-4-YL) propyl-1-phosphonate - effect of SH-reactive agents on binding, 55 carotid arteries - occlusion, 175 catecholamine synthesis - in adrenal chromaffin cells, 283 catecholamine synthesis - influence of ATP, 283 cerebrospinal fluid - myelin basic products, 291 cerebrospinal fluid - purine levels, 243 charybdotoxin - neurotoxin mast cell degranulating peptide, 525 chloride uptake - effect of GABA and Ro15-1788, 405 cholesterogenic enzymes, 171 chromaffin cells - catecholamine synthesis, 283 cocaine - and serotonin, 33 cocaine - serotonin uptake, 33 coiled coils - in aromatic acid decarboxylases, 27 damselfly - metabolism of 5-HT, 199 diabetic rat - effect of endothelin-1 an atria, 461 diazapam - effect on GABAergic system, 107 diazepam treatment - effect of anoxic stress, 107 dihydropyridine-sensitive calcium channels - activation induces somatostatin release, 367 down-regulation - of protein kinase C, 419 Efaroxan - selective a,-antagonist, 137 eicosanoids - role in CNS, 303 endocytosis - cis-platinum-encapsulating liposome, 257 Index 125T-endothelin binding sites - to human coronary tissue, 439 endothelin binding - to various tissues from hypertensive rats, 541 endothelin receptors - two types in arteries, 571 endothelin (16-21) - effect on blood pressure and micturition reflex, 565 endothelin - a neurotoxic factor, 503 endothelin - effect on vascular and non-vascular smooth muscle, 559 endothelin - formation, release, 515 endothelin - involvement of hypoglycemic/ischemic brain injury, 503 endothelin - neurotoxin mast cell degranulating peptide, 525 endothelins - effect on cardiovascular and pulmonary responses, 547 endothelin-1 - binding sites and stimulation of inositol monophosphates, 507 endothelin-1 - effect of intravenous perfusion, 445 endothelin-1 - effect on atria from diabetic rat, 461 endothelin-1 effect on blood pressure and micturition reflex, 565 endothelin-1 - effect on ear arteries, 465 endothelin-1 - fluorescent studies, 485 endothelin-1 - in pressor response, 553 endothelin-1 modulates cardiorespiratory control of the CNS, 519 endothelin-1 modulates 3H-noradrenaline release, 455 endothelin-1 potentiates the effect of phosphoramidon, 477 endothelin-1 receptor binding, 535 endothelin-2 - mobilization of intracellular calcium and stimulation of calcium fluxes, 575 endothelin-3 - effect on »lood pressure and micturition reflex, 565 endothelin-3 - 'H NMR studies, 491 endothelin-like peptides, 515 endothelium-denuded arteries - effect of endothelin-1, 465 endothelium-intact arteries - effect of endothelin-1, 465 N-ethylmaleimide - effect on 5-HT receptors, 331 excitatory amino acid agonists - effect on phosphoinositide hydrolysis, 411 fluorescent studies - of endothelin-1, 485 GABA release - effect of aluminium chloride, 125 GABA release - from astrocytes, 125 GABA release - from TTX-induced chronic epileptic foci, 373 GABA release - in seizures, 373 GABA uptake - ZAPA a substrate, 63 GABA - ex vivo release, 373 GABA - interaction with benzodiazepine, 405 GABAergic system - effect of diazepam, 107 GABA, receptor, 405 B-galactoside - amino acid sequence, 275 B-galactoside - lectin in brain, 275 gastrin - competes with somatostatin for binding to 120 kDa protein, 185 3H-glutamate binding - to insect muscle membranes, 341 3H-glutamate binding - to synaptic membranes, 55 3H-glutamate -effect of SH-reactive agents on binding, 55 glutamate uptake - ionic requirements, 43 glutamate - uptake, 43 GTPYS - effect on phosphoinositide metabolism, 381 guanylate cyclase - effects of arachidonic acid and hydroperoxides, 131 G-proteins - associated with neurokinin receptors, 158 hippocampal slices - effect of neurotoxins, 323 hippocampus - neurotransmitter levels, 268 histamine - effect on noradrenaline release, 215 histamine - effect on ornithine decarboxylase activity, 237 histamine - effect on serotonin release, 215 hydroperoxides - effect on guanylate cyclase, 131 5-hydroxytryptamine receptor subtypes, 331 5-hydroxytryptamine receptors - effect of N-ethylmaleimide, 331 S-hydroxytryptamine - metabolism in damselfly, 199 5-HT, see also serotonin 5-HT receptors - autoradiography, 17 S-HT,, receptors, 2 5-HT,, receptors, 3 S-HT,,< receptors, 4 5-HT,,) receptors, 6 5-HT, receptors - different types, 17 5-HT, receptors, 8 5-HT, receptors, 9 5-HT, receptors - autoradiographic localisation, 69 hyperketonemia - lipid synthesis, 85 hypertensive rats - effect of endothelin-1, 553 hyperthyroidism - lipid synthesis, 85 hypocalcemic rat, 249 hypoglycemic injury - involvement of endothelin, 503 hypoxia - effect on CSF levels of purines, 243 Index hypoxic conditions - effect on NAD(P)H, 323 in situ hybridization - of ornithine decarboxylase, 347 inositol monophosphates - stimulation by endothelin-1, 507 inositol phosphates - and a,-receptors, 175 inositol phosphates - effect of carotid artery occlusion, 175 insect muscle - binding of *H-glutamate, 341 ionic requirements - in glutamate uptake, 43 ischemic injury - involvement of endothelin, 503 ketone bodies - precursors for lipid synthesis, 85 ketone bodies - used in brain during development, 85 lanthanides - effect on acetylcholine release and intracellular calcium levels, 115 a-latrotoxin - effect on acetylcholine release and intracellular calcium levels, 115 lectin - B-galactoside, 275 leucine zippers - in aromatic amino acid decarboxylase, 27 lipid synthesis - from ketone bodies, 85 luteinizing hormone-releasing hormone-like material - in frog CNS, 221 metabotrophic axcitatory amino acid receptors - inhibited by 2- amino-3-phosphonopropionic acid, 411 Multiple Sclerosis - myelin basic protein products in CSF, 291 muscle - effect of endothelin and sarafotoxin, 559 myelin basic protein catabolism, 291 myelin basic protein - catabolism, 291 myelin basic protein - in chick brain, 357 myelin - from chick, 357 myogenesis - distribution of N-CAM, 97 NAD(P)H - influence of ammonia, octanoate, quinolinate and hypoxia, 323 NCB-20 cells - down regulation of protein kinase C, 419 neuroblastoma cells, 257 neurokinin receptors, 152 neurotoxic factor - endothelin, 503 neurotoxin mast cell degranulating peptides, 525 neurotoxins - effect on hippocampal slices, 323 neurotransmitter levels - in hippocampus and striatum, 268 neurotransmitters - in vitamin D deficient hypocalcemic rat, 249 'H NMR - of endothelin-3, 491 "H NMR - studies on structure of sarafotoxin-S6b, 471 noradrenaline release - effect of histamine, 215 3H-noradrenaline release - modulated by endothelin-1, 455 normotensive rats - effect of endothelin-1, 553 nucleotides - effect on phosphoinositides, 381 N-CAM expression - modulation, 97 N-CAM - absent in Wobbler mutant mouse, 425 N-CAM - distribution during myogenesis, 97 octanoate - influence on NAD(P)H, 323 ornithine decarboxylase activity - effect of histamine, 237 ornithine decarboxylase mRNA levels, 347 ornithine decarboxylase mRNA levels - in situ hybridization, 347 phenolic derivatives - of phenylalanine, 171 phenylalanine - phenolic derivatives, 171 Phenylketonuria, 171 phorbol esters - effect on protein kinase C, 419 phosphoinositide hydrolysis - effect of excitatory amino acids, 411 phosphoinositide metabolism - effect of GTPXs and nucleotides, 381 phosphoinositide metabolism - in synaptosomes, 381 phosphoinositide pathway - with neurokinin receptors, 158 phosphoinositide turnover - by bradykinin, 419 phosphoramidon - effect on endothelin-1 response, 477 physostigmine-hyoscine pretreatment - neurochemical changes, 265 cis-platinum-encapsulating liposome - uptake by endocytosis in neuroblastoma cells, 257 potassium - effect on acetylcholine release and intracellular calcium levels, 115 pressor effects - by Big-endothelin-1, 481 pressor response - to endothelin-1, 553 proendothelin (1-38) - from humans, 445 proendothelin (1-39) - from porcine, 445 prostaglandins - role in CNS, 303 prostanoids - role in cell-cell interactions, 303 protein kinase C - down regulation, 419 purine concentrations - in CSF after hypoxia, 243 quinolinate - influence on NAD(P)H, 323 receptor binding - of endothelins, 535 receptor types - neurokinin, 152 receptor types - tachykinins, 149 a,-receptors - and inositol phosphates, 175 receptors - A,-adenosine type, 207 receptors - serotonin subtypes, 1 receptors - tachykinins, 167 mRNA levels - of ornithine decarboxylase, 347 Ro15-1788 - a benzodiazepine antagonist, 405 sarafotoxin 6b - effect on cardiovascular and pulmonary responses, 547 Index sarafotoxin - effect on vascular and non-vascular smooth muscle, 559 sarafotoxin-S6b - 'H NMR studies, 471 seizure - release of GABA, 373 serotonin, see also 5-HT or 5-hydroxytryptamine serotonin receptors - autoradiography, 1 serotonin receptors - different subtypes, 1 serotonin release - effect of histamine, 215 serotonin uptake - effect of cocaine, 33 serotonin - and cocaine, 33 SH-reactive agents - effect on binding of [3H]/{+)-3-(2- carboxypiperazin-4-YL) propyl-1-phosphonate, 55 SH-reactive agents - effect on *H-glutamate binding, 55 signalling mechanisms - involvement of tachykinins, 149 soman intoxication, 265 soman - production of neurochemical changes, 265 somatostatin release - involvement of dihydropyridine-sensitive calcium channels, 367 somatostatin - competes with gastrin for binding to 120 kDa protein, 185 striatum - neurotransmitter levels, 270 stroke - myelin basic protein products in CSF, 291 substance P - binding sites, 399 synaptosomes - intracellular calcium levels, 115 Synaptosomes - phosphoinositide metabolism, 381 tachykinins - receptor subtypes, 149 tachykinins - receptors, 167 taurine release - effect of aluminium chloride, 125 taurine release - from astrocytes, 125 Tetanus toxin-induced chronic epileptic foci - release of GABA, 373 3H-tryptophan - binding sites in brain, 347 uptake - of glutamate, 43 vitamin D deficient hypocalcemic rat - effect on neurotransmitters, 249 Wobbler mutant mouse - reduced acetylcholinesterase and lack of N-CAM, 425 3H-xanthine amine congener - binding, 207 xanthine amine congener - radioligand for A,-adenosine receptor, 207 ZAPA - substrate for GABA uptake, 63 ZAPA = Z-3[(aminoiminomethyl)thio]prop-2-enoic acid (hydroxyproline? )luteinizing hormone-releasing hormone a novel peptide, 221