Neurobiology and Cell Physiology of Chemoreception PDF
Preview Neurobiology and Cell Physiology of Chemoreception
NEUROBIOLOGY AND CELL PHYSIOLOGY OF CHEMORECEPTION ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY Editorial Board: NATHAN BACK. State University of New York at Buffalo IRUN R. COHEN. The Weizmann Institute of Science DAVID KRITCHEVSKY. Wistar Institute ABEL LAJTHA. N. S. Kline Institute for Psychiatric Research RODOLFO PAOLEm. University of Milan Recent Volumes in this Series Volume 330 THE UNDERLYING MOLECULAR. CELLULAR. AND IMMUNOLOGICAL FACTORS IN CANCER AND AGING Edited by Stringner Sue Yang and Huber R. Warner Volume 331 FRONTIERS IN CEREBRAL VASCULAR BIOLOGY: Transport and Its Regulation Edited by Lester R. Drewes and A. Lorris Betz Volume 332 MECHANISM OF MYOFILAMENT SLIDING IN MUSCLE CONTRACTION Edited by Haruo Sugi and Gerald H. Pollack Volume 333 OPTICAL IMAGING OF BRAIN FUNCTION AND METABOLISM Edited by Ulrich Dirnagl. Arno Villringer. and Karl M. Einhliupl Volume 334 NEW CONCEPTS IN THE PATHOGENESIS OF NIDDM Edited by Claes Goran Ostenson. Suad Efendic. and Mladen Vranic Volume 335 DRUGS OF ABUSE. IMMUNITY. AND AIDS Edited by Herman Friedman. Thomas W. Klein. and Steven Specter Volume 336 ANCA-ASSOCIATED VASCULITIDES: Immunological and Clinical Aspects Edited by Wolfgang L. Gross Volume 337 NEUROBIOLOGY AND CELL PHYSIOLOGY OF CHEMORECEPTION Edited by P. G. Data, H. Acker, and S. Lahiri Volume 338 CHEMISTRY AND BIOLOGY OF PTERIDINES AND FOLATES Edited by June E. Ayling. M. Gopal Nair, and Charles M. Baugh A Continuation Order Plan is available for this series. A continuation order will bring deli very of each new volume immediately upon publication. Volumes are billed only upon actual shipment. For further information please contact the publisher. NEUROBIOLOGY AND CELL PHYSIOLOGY OF CHEMORECEPTION Edited by P. G. Data Universita degli Studi "G. D' Annunzio" Chieti, Ital y H. Acker Max-Planck-Institut für Molekulare Physiologie Dortmund, Germany and s. Lahiri University of Pennsylvania Philadelphia, Pennsylvania, U. S. A. SPRINGER-SCIENCE+BUSINESS MEDIA, LLC Llbrary of Congress Ca~aloglng-ln-Publlca~ion Da~a Neurobiology and cell physiology of chemoreception I edited by P.G. Data, H. Acker, and S. Lahiri. p. cm. -- (Advances in experimental medicine and biology v. 337> "Proceedings of an International Symposium on Arterial Chemoreception, held June 24-28, 1991, in Chieti, Italy"--Copr. p. Includes bibliographical references and index. ISBN 978-1-4613-6290-6 ISBN 978-1-4615-2966-8 (eBook) DOI 10.1007/978-1-4615-2966-8 1. Carotid body--Congresses. 2. Chemoreceptors--Congresses. I. Data, Pier Georgio. 11. Acker, H. (Helmut>, 1939- 111. Lahiri, Sukhamay. IV. International Symposium on Arterial Chemoreception (1991 Chieti, Italyl V. Series. OP368.8.N48 1993 612.4'92--dc20 93-29402 CIP Proceedings of an International Symposium on Arterial Chemoreception, held June 24-28, 1991, in Chieti, Italy ISBN 978-1-4613-6290-6 © 1993 Springer Science+Business Media New Y ork Originally pub1ished by Plenum Press, New Y ork in 1993 Softcover reprint ofthe hardcover 1st edition 1993 All rights reserved No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise, without written permission from the Publisher PREFACE This volume records the papers presented in Chieti, Italy, at the 1991 meeting of the International Society for Arterial Chemoreception (ISAC). This was the eleventh of a series of assemblies held since 1959. This field of research, which examines the critical function and mechanisms of O and pHIPC0 sensitive cells in 2 2 the body, is unique in that it encompasses diverse biological and medical areas. The reader of this book will note chapters concerning modem techniques like in situ hybridization; analysis of cell membrane channels and intracellular ion movements; immunohistochemistry of peptides, hormones, and the corresponding receptors of chemoreceptor cells; and systemic analysis of reflex pathways involving chemoreceptor cells and their meaning in health and disease. This broad spectrum will appeal to readers interested in the chemoreceptor field, as well as young scientists seeking a scientific field where not only structural analysis but also a sense for functional connections is required. In recognition of the importance of the contribution of a new scientific generation to this field, ISAC awarded the prestigious F. de Castro-C. Heymans E. Neil prize to A. G6rlach, a young scientist. Also at this meeting, the Ferdinando Data Foundation Award, for helping scientists from non-developed countries to pursue their interest in chemoreception, was initiated. ISAC held plenary lectures in honor of C. Eyzaguirre and R. Forster, both of whom have contributed greatly to research in the chemoreceptor field. We are grateful for the generous financial support offered by the University of Chieti, C.N.R. (the National Council of Research), the Abruzzo Regional Government, and the Ministry of University and Scientific and Technological Research (Italy). The skillful assistance of Plenum Press, the Publisher of the papers presented, is appreciated. Grateful thanks go to the staff of the Physiological Institute of Chieti University (Italy) for the most taxing of duties, preparation of the manuscripts and assistance in editing this book. We hope that this volume will meet with good reception from the growing number of scientists who are interested in the fascinating field of chemoreception and chemoreceptor reflex mechanisms. The Editors v CONTENTS SECTION I Morphology, Cyto- and Immunochemistry 1 Vascular Analysis of the Carotid Body in the Spontaneously Hypertensive Rat ................................... 3 I.A. Clarke, M. de Burgh Daly and H.W. Ead 2 Role of the Carotid Sinus Nerve and of Dopamine in the Biochemical Response of Sympathetic Tissues to Long-Term Hypoxia ....... 9 Y. Dalmaz, 1.M. Pequignot, 1.M. Cottet-Emard, A. Vouillarmet and L. Peyrin 3 The Effects of Almitrine on eH]5HT and [1251] Endothelin Binding to Central and Peripheral Receptors: An In Vitro Autoradiographic Study in the Cat .................................. 17 M.R. Dashwood, D.S. McQueen, R.M. Sykes, I.R. Muddle, M. de Burgh Daly, Y. Evrard and K.M. Spyer 4 Immunocytochemical and Neurochemical Aspects of Sympathetic Ganglion Chemosensitivity . . . . . . . . . . . . . . . . . . . . . . . . . .. 25 B. Dinger, Z.-Z. Wang, 1. Chen, W.-I. Wang, G. Hanson, L.J. Stensaas and S.J. Fidone 5 Neuronal and Neuroendocrine Markers in the Human Carotid Body in Health and Disease .............................. 31 1.-0. Habeck and W. Kummer 6 The Effects of Chronic Hypoxaemia upon the Structure of the Human Carotid Body ............................... 37 1.-0. Habeck, D.J. Pallot and A. Abramovici 7 Dopaminergic and Peptidergic Sensory Innervation of the Rat Carotid Body: Organization and Development ............. 43 D.M. Katz, I.C.W. Finley and 1. Polak 8 Effects of Cell-Free Perfusion and Almitrine Bismesylate on the Ultrastructure of Type-l Cell Mitochondria in the Cat Carotid Body .................................... 51 M. Kennedy, S. Giles, R.G. O'Regan, S. Feely and Y. Evrard 9 Multi-Unit Compartmentation of the Carotid Body Chemoreceptor by Perineurial Cell Sheaths: Immunohistochemistry and Freeze-Fracture Study .............................. 61 H. Kondo and M. Yamamoto 10 Light and Electronmicroscopical Immunohistochemical Investigation of the Innervation of the Human Carotid Body .. . . . . . . . . . .. 67 W. Kummer and 1.-0. Habeck vii 11 Serotonin (5-Hydroxytryptamine) Expression in Pulmonary Neuro-Endocrine Cells (NE) and a Netumor Cell Line . . . . . . .. 73 C. Newman, D. Wang and E. Cutz 12 Effects of Hypoxia on Cultured Chemoreceptors of the Rat Carotid Body: DNA Synthesis and Mitotic Activity in Glomus Cells ... 79 C.A. Nurse and C. Vollmer 13 Localization of Dopamine D2 Receptor mRNA in the Rabbit Carotid Body and Petrosal Ganglion by in situ Hybridization . . . . . . . .. 85 A. Schamel and A. Vema 14 Noradrenergic Glomus Cells in the Carotid Body: An Autoradiographic and Immunocytochemical Study in the Rabbit and Rat. . . . . . .. 93 A. Vema, A. Schamel and J.-M. Pequignot n SECTION Molecular Biology, Biophysics and Biochemistry 15 The Modulation of Intracellular pH in Carotid Body Glomus Cells by Extracellular pH and pC02 ...•..................• 103 KJ. Buckler, R.D. Vaughan-Jones, C. Peers, D. Lagadic-Gossman and P.C.G. Nye 16 Evidence for Glucose Uptake in the Rabbit Carotid Body. . . . . . . . . .. 111 M.A. Delpiano 17 Effects of Inorganic Calcium Channel Blockers on Carotid Chemosensory Responses in the Cat ................... 117 C. Di Giulio, A. Mokashi, W.-X. Huang, L. Morelli and P.G. Data 18 Those Strange Glomus Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 123 C. Eyzaguirre 19 Carotid Body Neurotransmission ...... . . . . . . . . . . . . . . . . . . . . .. 131 R.S. Fitzgerald and M. Shirahata 20 Carbonic Anhydrase and the Carotid Body . . . . . . . . . . . . . . . . . . . .. 137 R.E. Forster II 21 Ca2+ Dynamics in Chemoreceptor Cells: An Overview . . . . . . . . . . . .. 149 C. Gonzalez, J.R. L6pez-L6pez, A. Obeso, A. Rocher and J. Garcia-Sancho 22 Spectrophotometric Analysis of Heme Proteins in Oxygen Sensing Cell Systems. . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 157 A. Gorlach, B. Bolling, E. Dufau, G. Holtermann and H. Acker viii 23 Neurochemical and Molecular Biological Aspects on the Resetting of the Arterial Chemoreceptors in the Newborn Rat. . . . . . . .. 165 H. Holgert, T. Hertzberg, A. Dagerlind, T. Hokfelt and H. Lagercrantz 24 Carbonic Anhydrase and Carotid Body Chemoreception in the Presence and Absence of CO2-HC03- ................. _ 171 R lturriaga and S. Lahiri 25 Role of Ion-Exchangers in the Cat Carotid Body Chemotransduction . " 177 S. Lahiri and R. Iturriaga 26 Dopamine Metabolism in the Rabbit Carotid Body in vitro: Effect of Hypoxia and Hypercapnia. . . . . . . . . . . . . . . . . . .. 183 L.-M. Leitner 27 P02-Dependence of Phospholipase C in the Cat Carotid Body ....... 191 M. Pokorski and R Strosznajder 28 Optical Measurements of Micro-Vascular Oxygen Pressure and Intracellular pH in the Cat Carotid Body: Testing Hypotheses of Oxygen Chemoreception. . . . . . . . . . . . . . . .. 197 W.L. Rumsey, R. Iturriaga, D. Spergel, S. Lahiri and D.F. Wilson 29 Elevation of Cytosolic Calcium Induced by pH Changes in Cultured Carotid Body Glomus Cells ................. " 205 M. Sato, K. Y oshizaki and H. Koyano 30 Role of Carbon Dioxide for Hypoxic Chemotransduction of the Cat Carotid Body ................................ 213 M. Shirahata and RS. Fitzgerald 31 Metabolic Substrate Dependence of Carotid Chemosensory Responses to Stop-Flow Evoked Hypoxia and to Nicotine .... 221 D. Spergel 32 Effects of Chemosensory Stimulation Membrane Currents Recorded with the Perforated-Patch Method from Cultured Rat Glomus Cells ................................... 227 A. Stea, S.A. Alexander and C.A. Nurse 33 Carbonic Anhydrase Near Central Chemoreceptors ............... 235 R.W. Torrance 34 Update on the Bicarbonate Hypothesis . . . . . . . . . . . . . . . . . . . . . . .. 241 RW. Torrance, E.M. Bartels and A.J. McLaren 35 Regulation of Intracellular pH in Type I Cells of the Neonatal Rat Carotid Body. . . . . . . . . . . . . . . . . . . . . . . . .. 251 R.D. Vaughan-Jones, KJ. Buckler, C. Peers and P.C.G. Nye ix SECTION III Neurotransmitter 36 Noradrenergic Inhibition of the Goat Carotid Body ............... 259 G. Bisgard, M. Warner, J. Pizarro, W. Niu and G. Mitchell 37 Role of Substance P in Rat Carotid Body Responses to Hypoxia and Capsaicin ............................ 265 P.A. Cragg, Y.R. Kou and N.R. Prabhakar 38 Carotid Sinus Nerve Inhibition Mediated by Atrial Natriuretic Peptide . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 271 SJ. Fidone, Z.-Z. Wang, J. Chen, L. He, W.-J. Wang, B. Dinger and L.J. Stensaas 39 Neurotransmitters and Second Messenger Systems in the Carotid Body ................................... 279 M.T. Perez-Garcia, A. Gomez-Nino, L. Almaraz and C. Gonzalez 40 Does Adenosine Stimulate Rat Carotid Body Chemoreceptors? 289 D.S. McQueen 41 Effects of Haloperidol on Cat Carotid Body Chemoreception in Vitro ....................................... 295 L. Morelli, R. lturriaga, D. Spergel and P.G. Data 42 Effect of Arterial Chemoreceptor Stimulation: Role of Norepinephrine in Hypoxic Chemotransmission ........... 301 N.R. Prabhakar, Y.-R. Kou, P.A. Cragg and N.S. Chemiack SECTION IV Reflex Mechanism 43 Carotid Body Denervation and Pulmonary Vascular Resistance in the Rat . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 309 D. Bee and D. Pallot 44 Effects of Chemoreceptor Stimulation by Almitrine Bismesylate on Renal Function in Conscious Rats . . . . . . . . . . . . . . . . . .. 315 R. Behm, U. Franz, W.H. de Muinck Keizer, H. Mewes, R. Rettig and T. Unger 45 Carbon Dioxide-Sensitive Laryngeal Receptors and their Reflex Effects . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 323 A.J. Bradford, R.G. O'Regan, P. Nolan and D. McKeogh 46 Ventilatory Response at the Onset of Exercise: An Update of the Neurohumoral Theory. . . . . . . . . . . . . . . . . . . . . . . .. 327 P. Cerretelli, L. Xi, F. Schena, C. Marconi, B. Grassi, G. Ferretti and M. Meyer x 47 Carotid Chemoreceptor Reflex Cardioinhibitory Responses: Comparison of their Modulation by Central Inspiratory Neuronal Activity and Activity of Pulmonary Stretch Afferents . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 333 M. de Burgh Daly 48 The Modulation of Peripheral Chemoreceptor Input by Central Nervous System Hypoxia . . . . . . . . . . . . . . . . . . . . . . . . . .. 345 N.H. Edelman, J.E. Melton and J.A. Neubauer 49 Chemoreflexogenic Ventilatory Drive in Humans Adapted to Unusual Environments. . . . . . . . . . . . . . . . . . . . . . . . . . . .. 353 B. Grassi, G. Ferretti, M. Costa, C. Marconi and P. Cerretelli 50 Respiratory and Cardiovascular Activities in Carotid Body Resected Humans ................................ 359 Y. Honda and M. Tanaka 51 Effects of Oxygen Tests on the Ventilatory Resposes of the Cat and Rhesus Monkey to Changes in Arterial Potassium . . . . . .. 365 D.J. Paterson and P.C.G. Nye 52 Thermal Effects Upon the Chemosensory Drive of Ventilation 371 P. Zapata, C. Larrain, R. Fadic, B. Ramirez and H. Loyola SECTION V Developmental and Adaptative Physiology and Pharmacology 53 Carotid Chemosensory Response to Doxapram in the Newborn Kitten .. 381 A. Bairam, F. Marchal, B. Hannhart, J.-P. Crance and S. Lahiri 54 Carotid Chemoreceptor Responses to Hypoxia and Hypercapnia in Developing Kittens ............................. 387 J.L. Carroll and R.S. Fitzgerald 55 Presence of Chemosensitive SIF Cells in the Rat Sympathetic Ganglia: A Biochemical, Immunocytochemical and Pharmacological Study . . . . . . . . . . . . . . . . . . . . . . . . . . . .. 393 Y. Dalmaz, N. Borghini, J.M. Pequignot and L. Peyrin 56 Effects of Chronic Hypoxia and Cobalt on Macroprotein Pattern in the Rabbit Carotid Body and Superior Cervical Ganglion: Preliminary Observations ........................... 401 P.G. Data, G. Di Tano, G. Gigante, V. Biondelli, M. Iezzi, C. Di Giulio and L. Morelli 57 Time Course of the Response of Carotid Chemoreceptors to Sudden Rise of Inspired CO in the Newborn Kitten. . . . . . . . . . . . .. 407 2 B. Hannhart, A. Bairam and F. Marchal xi
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