Neuroanatomy and physiology of abdominal vagal afferents

331 Pages·1992·122.995 MB·English

by  Barnes, Charles D., Ritter, Robert C., Ritter, Sue

Neuroanatomy
and
Physiology
of
Abdominal Vagal

Mferents

NeuroanatofllY

and
Physiology

of
Abdotninal Vagal

Mferents

Edited by
Sue Ritter

c.
Robert Ritter

Charles D. Barnes

Department ofVeterinary and Comparative Anatomy,

Pharmacology and Physiology

College of Veterinary Medicine

Washington State University

Pullman, Washington

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Neuroanatomy and Physiology ofA bdominal Vagal Afferents v
CONTENTS

About the Editors ............................................................................................ vii

Contributors ..................................................................................................... ix

Preface ...........................................................................•............................. xiii

Acknowledgments ........................................................................................... xiv

CHAPTER l
COMPARATIVE ANATOMY OF MEDULLARY VAGAL NERVE
NUCLEI
Thomas E. Finger ..................................................................................... I
CHAPTER 2
VISCEROTOPIC REPRESENTATION OF THE ALIMENTARY
TRACT IN THE DORSAL AND VENTRAL VAGAL COMPLEXES
IN THE RAT
Steven M. Altschuler, Linda Rinaman and Richard R. Mise/is ............. 21

CHAPTER 3
THE DORSAL VAGAL COMPLEX FORMS A SENSORY -MOTOR
LATTICE: THE CIRCUITRY OF GASTROINTESTINAL REFLEXES
Terry L. Powley, Hans-Rudolf Berthoud, Edward A. Fox
and Watson Laughton ........................................................................... 55

CHAPTER 4
CENTRAL CONNECTIONS OF THE NUCLEI OF THE VAGUS NERVE
Ronald A. Leslie, D. John M. Reynolds and /.N.C. Lawes ...................81
CHAPTER 5
CENTRAL REGULATION OF BRAIN STEM GASTRIC VAGO-VAGAL
CONTROL CIRCUITS
R.C. Rogers and Gerlinda E. Hermann ................................................. 99
CHAPTER 6
VAGAL AFFERENT INNERVATION OF THE ENTERIC NERVOUS
SYSTEM
Catia Sternini ........................................................................................ 135
vi Neuroanatomy and Physiology of Abdominal Vagal Afferents
CHAPTER 7
VAGAL RECEPTOR TRANSPORT
Timothy H. Moran and Paul R. McHugh ............................................ 157
CHAPTER 8
VAGAL AFFERENT MECHANISMS OF MECHANO- AND
CHEMORECEPTION
David Grundy ....................................................................................... 179
CHAPTER 9
VAGAL AFFERENT INNERVATION AND THE REGULATION OF
GASTRIC MOTOR FUNCTION
Helen E. Raybould ................................................................................ 193
CHAPTER 10
PARTICIPATION OF VAGAL SENSORY NEURONS IN
PUTATIVE SATIETY SIGNALS FROM THE UPPER
GASTROINTESTINAL TRACT
Robert C. Ritter, Lynne Brenner and Daniel P. Yox ........................... 221

CHAPTER 11
COOPERATION OF VAGAL AND CENTRAL NEURAL SYSTEMS
IN MONITORING METABOLIC EVENTS CONTROLLING
FEEDING BEHAVIOR
Sue Ritter, Noel Y. Calingasan, Bruce Hutton and Thu T. Dinh ........ 249

CHAPTER 12
A PROTECTIVE ROLE FOR VAGAL AFFERENTS: AN HYPOTHESIS
P.L.R. Andrews and /.N.C. Lawes ........................................................ 279
Index .............................................................................................................. 303
Neuroanatomy and Physiology of Abdominal Vagal Afferents vii
ABOUT THE EDITORS

Dr. Sue Ritter, Ph.D., is Professor of Physiology and Pharmacology in the
Department of Veterinary and Comparative Anatomy, Pharmacology and Physi­
ology (VCAPP) in the College of Veterinary Medicine at Washington State
University.
Dr. Ritter graduated from Valparaiso University in 1968 with a BA in
psychology. In 1970 she earned an M.S. and in 1972 received the Ph.D. from
Bryn Mawr College in the area of psychopharmacology.
From 1972 to 1974 Dr. Ritter was a senior psychologist at Wyeth Labora­
tories in the Department of Psychopharmacology. She was appointed Assistant
Professor of Physiology in the College of Veterinary Medicine in 1974. She
advanced to Associate Professor of Physiology and Pharmacology in 1979 and
was made a full professor in 1986. She is director of veterinary neuroscience
teaching for the Department of VCAPP. In 1986 and 1987 she was a Fogarty
International Fellow and Visiting Professor of Gastroenterology at the London
Hospital Medical College of the University of London, England.
Dr. Ritter is a member of the Society for Neuroscience, the International
Brain Research Organization, the North American Society for the Study of
Obesity and the Society for the Study of Ingestive Behavior. She serves on the
editorial advisory board of Physiology and Behavior and has served as a
consultant and study section member for the National Institutes of Health. She
has been the recipient of research grants from the National Institutes of Health,
the American Heart Association and private foundations.
Dr. Ritter has authored more than 50 scientific papers and book chapters.
Her two most active areas of research are metabolic controls of food intake and
the use of specific toxins to study neuroanatomy.
Dr. Robert C. Ritter, VMD, Ph.D., is Professor of Physiology and Pharma­
cology in the Department of Veterinary and Comparative Anatomy, Pharmacol­
ogy and Physiology, in the College of Veterinary Medicine at Washington State
University.
Dr. Ritter graduated from Valparaiso University in 1967 with a B.S. in
biology. He received a doctorate in veterinary medicine from the University of
Pennsylvania in 1971. From 1971 to 1974 he was a postdoctoral fellow at the
Institute of Neurological Sciences at the University of Pennsylvania, from
which he received the Ph.D. in biology in 1974.
In 1974 Dr. Ritter became Assistant Professor of Veterinary Medicine in the
WOI Regional Program in Veterinary Medicine at the University of Idaho. He
was advanced to Associate Professor in 1979 and to Professor in 1984. In 1988
he was appointed Professor of Physiology and Pharmacology at the College of
Veterinary Medicine at Washington State University. Dr. Ritter is Chairman of
the Research Track in the veterinary curriculum. He was a Fogarty Interna­
tional Fellow and Visiting Professor of Gastroenterology at the London Hospi­
viii Neuroanatomy and Physiology of Abdominal Vagal Afferents
tal Medical College of the University of London, England, in 1986 and 1987.
He was recently named a Jacob Javits Neuroscience Investigator by the Na­
tional Institutes of Health.
Dr. Ritter is a member of the Society for Neuroscience, the International
Brain Research Organization, the North American Society for the Study of
Obesity, the Society for the Study of Ingestive Behavior and the Phi Kappa Phi
academic honor society. He serves on the editorial board of the American
Journal of Physiology and has served as consultant for the National Institutes
of Health. Dr. Ritter has received research grants from the National Institutes
of Health, National Institute of Alcohol, Drug Abuse and Mental Health, the
USDA and private foundations.
Dr. Ritter has authored more than 40 scientific papers and chapters. His
research focuses on neural and gastrointestinal interactions in the control of
food intake.
Dr. Charles D. Barnes, Ph.D., is Professor and Chairman ofthe Department
of Veterinary and Comparative Anatomy, Pharmacology and Physiology in the
College of Veterinary Medicine at Washington State University.
Dr. Barnes received his B.S. degree from Montana State University in 1958
with double majors in biology and physics. In 1961 he received an M.S. degree
in physiology and biophysics from the University of Washington, and in 1962
he earned his Ph.D. in physiology from the University of Iowa.
After two years as a postdoctoral fellow in the Department of Pharmacology
at the University of California at San Francisco, he became Assistant Professor
of Anatomy and Physiology at Indiana University in 1964. He advanced to
Associate Professor in 1968, and in 1971 became Professor of Life Sciences at
Indiana State University. In 1975 he was named Chairman of the Department
of Physiology at Texas Tech University College of Medicine, where he re­
mained until taking his present position in 1983.
Dr. Barnes is a member of the American Association for the Advancement
of Science, American Association of Anatomists, American Institute of Bio­
logical Sciences, American Physiological Society, American Association of
Veterinary Anatomists, American Society of Pharmacology and Experimental
Therapeutics, American Society of Veterinary Physiologists and Pharmacolo­
gists, Association of Veterinary Anatomy Chairpersons, Association of Chair­
men of Departments of Physiology, International Brain Research Organization,
Society for Experimental Biology and Medicine, Society for Neuroscience,
Society of General Physiologists, and the Western Pharmacological Society.
He has been the recipient of many research grants from the National Institutes
of Health and the National Science Foundation.
Dr. Barnes is the author of more than 150 papers and has been the author or
editor of 16 books. His current research interests relate to the modulation of
nervous system output by centers in the brainstem.
Neuroanatomy and Physiology of Abdominal Vagal Afferents ix
CONTRIBUTORS
(IN ORDER OF CHAPTER PRESENTATION)
THOMAS E. FINGER, Ph.D.
Professor
Department of Cellular and Structural Biology
University of Colorado Medical School
Denver. CO
STEVEN M. ALTSCHULER, M.D.
Acting Chief
Division of Gastroenterology Nutrition and Lipid-Heart Research
The Children's Hospital of Philadelphia
Assistant Professor of Pediatrics
University of Pennsylvania School of Medicine
Philadelphia, P A
LINDA RINAMAN, Ph.D.
Research Associate
Department of Behavioral Neuroscience
University of Pittsburgh
Pittsburgh. PA
RICHARD R. MISELIS, M.D.• Ph.D.
Professor of Animal Biology
University of Pennsylvania
Philadelphia, P A
TERRY L. POWLEY, Ph.D.
Professor
Department of Psychological Sciences
Purdue University
West Lafayette. IN
HANS-RUDOLF BERTHOUD, Ph.D.
Associate Professor
Anatomy Institute
University of Ziirich
Ziirich. Switzerland
EDWARD A. FOX, Ph.D.
Postdoctoral Fellow
Department of Neuropharmacology
The Scripps Research Institute
LaJolla, CA
WATSON LAUGHTON, Ph.D.
Scientific Writer
Immunobiology Research Institute
Annandale, NJ