Neoplastic Diseases of the Blood PDF
Preview Neoplastic Diseases of the Blood
Neoplastic Diseases of the Blood Peter H. Wiernik (cid:129) John M. Goldman Janice P. Dutcher (cid:129) Robert A. Kyle Editors Neoplastic Diseases of the Blood Fifth Edition Editors Peter H. Wiernik, MD John M. Goldman, DM, FRCP, FMedSci Beth Israel Hospital, Cancer Center Department of Hematology St. Lukes–Roosevelt Hospital Center Imperial College of London New York, NY, USA London, UK Janice P. Dutcher, MD Robert A. Kyle, MD Continuum Cancer Centers Division of Hematology Department of Medicine Mayo Clinic St. Luke’s–Roosevelt Hospital Center Rochester, MN, USA New York, NY, USA ISBN 978-1-4614-3763-5 ISBN 978-1-4614-3764-2 (eBook) DOI 10.1007/978-1-4614-3764-2 Springer New York Heidelberg Dordrecht London Library of Congress Control Number: 2012944838 © Springer Science+Business Media New York 2013 1st edition: © Churchill Livingstone 1985 2nd edition: © Churchill Livingstone 1991 3rd edition: © Churchill Livingstone 1996 4th edition: © Cambridge University Press 2003 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, speci fi cally the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on micro fil ms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifi c ally for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a speci fi c statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com) We dedicate the fi fth edition of this book to our families; to hundreds of fellows we have trained, many of whom have subsequently gone on to lead major cancer research and treatment programs in several continents; and to thousands of patients we have had the privilege to care for and learn from over the decades. Preface The fi fth edition of N eoplastic Diseases of the Blood is long overdue because tremendous progress in our understanding of the nature of hematologic malignancies and their treatment has come to light since the fourth edition of this work appeared in 2003. Molecular character- istics of these diseases that have major impact on prognosis and, sometimes, choice of treat- ment have been identi fi ed with ever-increasing frequency. In the fourth edition, imatinib was only brie fl y mentioned, and agents such as newer thymidine kinase inhibitors, lenalidomide, and bortezomib do not even appear in the index. This fi fth edition is current and up to date, drawing heavily on recent references, and is designed, as were the previous editions, to be a readable, encyclopedic resource for established hematologists and oncologists as well as for trainees in our disciplines. The chapter structure of the book follows closely that of previous editions with some excep- tions. Various aspects of chronic lymphocytic and chronic myelocytic leukemia are dealt with in separate chapters rather than together as in previous editions. This change has allowed us to include additional authors. A new chapter on the etiology of acute myeloid leukemia has also been added instead of including this information in other chapters. In the supportive care sec- tion, the chapters on stem cell processing and banking have been eliminated, and this informa- tion is now contained in other chapters. More than 130 authors from 5 continents, many new to this edition, have contributed their expertise to this work. This edition is also divided into five sections like the earlier editions, each section being assigned to an editor: Chronic Leukemias and Related Disorders (John M. Goldman), Acute Leukemias (Peter H. Wiernik), Myeloma and Related Disorders (Robert A. Kyle), Lymphomas (Peter H. Wiernik), and Supportive Care (Janice P. Dutcher). Our sincere hope is that patients with hematologic malignancies will directly bene fi t from this new edition. This hope drove us to take on and complete in a timely fashion the huge task, that is, the creation of this edition. We thank the publisher, Springer Science+Business Media, for invaluable assistance during all phases of the development of this work. Special thanks to Liz Corra for her day-to-day highly professional work with all the authors and especially for keeping us on schedule. She was instrumental in bringing this project to completion. New York, NY, USA Peter H. Wiernik London, UK John M. Goldman New York, NY, USA Janice P. Dutcher Rochester, MN, USA Robert A. Kyle vii viii Preface Peter H. Wiernik John M. Goldman Janice P. Dutcher Robert A. Kyle Contents Part I Chronic Leukemias and Related Disorders 1 A History of the Chronic Leukemias ...................................................................... 3 John M. Goldman and Myrtle Y. Gordon 2 Etiology and Epidemiology of Chronic Myeloid Leukemia ................................. 11 Maren Rohrbacher and Joerg Hasford 3 Pathology of the Chronic Myeloid Leukemias ...................................................... 19 Barbara J. Bain 4 Molecular Biology and Cytogenetics of Chronic Myeloid Leukemia .................. 29 Alfonso Quintás Cardama, Hagop Kantarjian, and Jorge Cortes 5 Diagnosis and Treatment of Chronic Myeloid Leukemia .................................... 45 Stephen G. O’Brien and John M. Goldman 6 Etiology and Epidemiology of CLL ........................................................................ 63 Dalemari Crowther-Swanepoel, Daniel Catovsky, and Richard S. Houlston 7 Histopathology, Morphology and Immunophenotyping of CLL ......................... 71 Abraham M. Varghese, Andy C. Rawstron, Roger G. Owen, and Peter Hillmen 8 Molecular Biology and Cytogenetics of Chronic Lymphocytic Leukemia .................................................................................................................. 91 David Oscier, Anne Gardiner, and Jonathan C. Strefford 9 Treatment of Chronic Lymphocytic Leukemia and Related Disorders .............. 103 Gautam Borthakur and Susan O’Brien 10 Hairy Cell Leukemia ................................................................................................ 121 Sejal A. Jhatakia, Darren S. Sigal, and Alan Saven 11 The Pathogenesis, Diagnosis, and Treatment of Polycythaemia Vera ................. 135 Mark A. Dawson and Brian J.P. Huntly 12 Diagnosis and Treatment of Essential Thrombocythemia and Primary Myelofibrosis ...................................................................................... 155 John T. Reilly ix
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