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NCGR Bioinformatics Working Group PDF

31 Pages·2016·3.55 MB·English
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NCGR Advanced Bioinformatics Prepared for University of Alaska, Fairbanks and Anchorage January 28-29, 2016 Faye D. Schilkey Director of Strategic Projects and NM-INBRE Sequencing and Bioinformatics Core Agenda NCGR q  Education q  Research q  Sequencing Center q  Bioinformatics q  Understanding Projects at UA F & A q National Center for Genome Resources 501c(3) nonprofit research institute Applies bioinformatics, software engineering and next-generation sequencing to solve the preeminent challenges of 21st century biology NCGR History 1994 NCGR founded for discovery-driven q  computational biology and bioinformatics in support of the DOE Human Genome Project Created 1st relational human genome sequence database q  (GSDB) 1997-98 NCGR established and sold Molecular q  Informatics, now part of Celera Diagnostics 2000 NCGR’s completes new 32,000 square foot q  research facility NCGR History (cont.) 2000-2007 NCGR continues innovative q  bioinformatics tool development SYStem for Integrating heterogeneous bioinformatic q  resources (ISYS) Comparative Map and Trait Viewer (CMTV) q  A metabolic database and discovery tool (PathDB) q  A tool for Genomic Exploration and Survey of Immune q  Response (GEYSIR) The Arabidopsis Information Resource (TAIR) q  The Legume Information System (LIS) q NCGR History (cont.) 2007 NCGR creates NM Genome Sequencing Center q  Alpheus created to analyze Next Gen Sequencing (NGS) data q  2007 – date, Major sequencing & analysis projects q  NIH NM-INBRE §  Moore Foundation Marine Microbial Transcriptome §  Sequencing Project (MMETSP) NSF Medicago HapMap project §  Cacao Genome project funded by Mars, Inc. §  Development of a human carrier screening test §  NOAA – Deep Well Horizon §  2014 NCGR develops Bioinformatics-in-a-BoxTM q Faye D. Schilkey, BS Computer Engineering First Career: q  Software engineering in automotive (robotics) and aerospace (guidance and autopilot) systems Second Career (Big Data): q  IT / Software Engineering / Database development in n  Genomics and Bioinformatics (20 yrs) GSDB, ISYS, PathDB, GEYSIR n  PI/Director, NMINBRE Seq & Bioinformatics Core (10 yrs) n  Sequence Center operations, R&D, and product n  development (9 yrs) Leverage sequencing and bioinformatics techniques to n  solve biological questions Main elements of NCGR Bioinformatics Research Sequencing Education STEM / undergrad / grad INBRE/NCGR Researcher/student impact 2004-2015 period > 2500 researchers/students positively impacted through SBC activities 2015 2014 2013 Sequencing/bioinformatics for projects, pubs & grants (215) 2012 2011 College genomics/bioinformatics internships (125) r 2010 a Pre K - grade 12 genomics/bioinformatics education (722) e Y 2009 BioInformatics, Science and Technology Symposium-NMBIST (1080) 2008 College genomics/bioinformatics seminars (525) 2007 2006 2005 2004 0" 100" 200" 300" 400" 500" 600" 700" 800" Number of researchers and students impacted Research at NCGR •  Human health •  Plant science and nutrition •  > 200 publications AJ Brass Foundati on

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A tool for Genomic Exploration and Survey of Immune. Response (GEYSIR) INBRE/NCGR Researcher/student impact. 0". 100". 200" MJ126-NF4 (Actinobacteria having natural products: anti-bacteria/ viral/cancer) service projects featuring DNA and RNA sequencing spanning all kingdoms of life
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