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Naunyn - Schmiedeberg's Archives of Pharmacology 1992: Vol 346 Table of Contents PDF

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Naunyn- Schmiedeberg ‘Archives of Pharmacology Volume 346 1992 Editors L. Ahtee, Helsinki P. Honerjager, Minchen B. A.Peskar, Bochum O. E. Brodde, Essen K. H. Jakobs, Essen K. Resch, Hannover G. M. Drew, Ware/UK H. Kilbinger, Mainz T. H. Svensson, Stockholm M.Gothert, Bonn H. Marquardt, Hamburg P. Waldmeier, Basel K.-H. Graefe, Wurzburg E. Muscholl, Mainz P. A. van Zwieten, Amsterdam G. Hertting, Freiburg i. Br. Managing Editor K. Starke, Freiburg i. Br. Advisory Editors W. Bernauer, Freiburg i. Br. P. Holzer, Graz W. Osswald, Porto H. Betz, Frankfurt/Main D. Hoyer, Basel U. Otten, Basel J. Bockaert, Montpellier P. Illes, Freiburg i. Br. D. Palm, Frankfurt/Main H. Bonisch, Bonn J.L.Imbs, Strasbourg U. Panten, Gottingen A. F. Brading, Oxford H. G. Joost, Aachen A. Philippu, Innsbruck H. Coper, Berlin |. Jurna, Homburg/Saar U. Quast, Basel W. Feniuk, Ware G. F. Kahl, Gottingen M. Raiteri, Genova U. Forstermann, Chicago A. J. Kaumann, Cambridge H. P. Rang, London J.R. Fozard, Basel W. Knepel, Gottingen E. Schlicker, Bonn B. Fredholm, Stockholm K. Kuschinsky, Marburg W. Schmitz, Hamburg H. Fuder, Mainz M. Laubie, Suresnes G. Scholtysik, Bern G. Gro&, Ludwigshafen K. Loffelholz, Mainz K. Schror, Dusseldorf E. Habermann, Giessen W. Loscher, Hannover W. Schutz, Wien W. Haefely, Basel F. Markwardt, Erfurt G. Schultz, Berlin M. Hamon, Paris D. K. Meyer, Freiburg i. Br. R. Schulz, Munchen G. Hausler, Darmstadt H. Mohler, Zurich U. Schwabe, Heidelberg P. Heistracher, Wien S. R. Nahorski, Leicester A. Stier, Gottingen A. Herz, Munchen H. Nawrath, Mainz A. Wellstein, Bethesda P. Hjemdahl, Stockholm K. J. Netter, Marburg/Lahn F. J. Wiebel, Neuherberg F. Hofmann, Munchen L. Oreland, Uppsala A.M. Zharkovsky, Tartu Springer International Naunyn-Schmiedeberg’s Archives of Pharmacology Submission of a manuscript implies: that the work described has not been published before (except in the form of an abstract or as part of a published lecture, review, or thesis) ;t hat it is not under consideration for publication elsewhere; that its publication has been approved by all coauthors, if any, as well as by the responsible authorities at the institute where the work has been carried out; that, if and when the manuscript is accepted for publication, the authors agree to automatic transfer of the copyright to the (publisher, society) ; and that the manuscript will not be published elsewhere in any language without the consent of the copyright holders. All articles published in this journal are protected by copyright, which covers the exclusive rights to reproduce and distribute the article (e.g., as offprints), as well as all translation rights. No material published in this journal may be reproduced photographically or stored on microfilm, in electronic data bases, video disks, etc., without first obtaining written permission from the publisher. The use of general descriptive names, trade names, trademarks, etc., in this publication, even if not specifically identified, does not imply that these names are not protected by the relevant laws and regulations. While the advice and information in this journal is believed to be true and accurate at the date of its going to press, neither the authors, the editors, nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Special regulations for photocopies in the USA Photocopies may be made for personal or in-house use beyond the limitations stipulated under Section 107 or 108 of U.S. Copyright Law, provided a fee is paid. All fees should be paid to the Copyright Clearance Center, Inc., 21 Congress Street, Salem, MA 01970, USA, stating the ISSN 0028-1298, the volume, and the first and last page numbers of each article copied. The copyright owner's consent does not include copying for general distribution, promotion, new works, or resale. In these cases, specific written permission must first be obtained from the publisher. Springer-Verlag Berlin Heidelberg New York Printed in Germany by Wiesbadener Graphische Betriebe GmbH, W-6200 Wiesbaden © Springer-Verlag Heidelberg 1992 Contents of volume 346 No. 1 published on July 17, 1992 T. Griesbacher: Kinin-induced relaxations of the rat duodenum 102 H. Prast, A. Philippu: Release of endogenous acetylcholine U. Martin, S. Fischer, U. Kohnert, U. Opitz, in the hypothalamus of conscious rats 1 R. Rudolph, G. Sponer, A. Stern, K. Strein: Pharmacokinetic and thrombolytic properties of P. A. Pierce, J. Y. Kim, S. J. Peroutka: Molecular unglycosylated recombinant tissue-type plasminogen structural basis of ligand selectivity for 5-HT2 versus 5-HTi¢ activator (BM 06.021) produced in Escherichia coli 108 cortical receptors 4 R. P. Garay, C. Rosati, C. Nazaret, A. Esanu,T . Tarrade, H. Nissbrandt, N. Waters, S. Hjorth: The influence of P. Braquet: Cicletanine sulfate: inhibition of anion transport serotoninergic drugs on dopaminergic neurotransmission in systems and natriuretic activity 114 rat substantia nigra, striatum and limbic forebrain in vivo 12 L. J. Bryan-Lluka, S. R. O'Donnell: Dopamine and adrenaline, but not isoprenaline, are substrates for uptake and metabolism in isolated perfused lungs of rats 20 S. Dhein, S. Titzer, M. Wallstein, A. Miller, R. Gerwin, No. 2 published on August 13, 1992 B. Panzner, W. Klaus: Celiprolol exerts microvascular dilatation by activation of B2-adrenoceptors 27 D. Kelder, S. B. Ross: Long lasting attenuation of 8-OH- F. P. Monnet, P. Blier, G.D ebonnel, C. de Montigny: DPAT-induced corticosterone secretion after a single Modulation by sigma ligands of N-methyl- D-aspartate- injection of a 5-HT,, receptor agonist 121 induced [*H]noradrenaline release in the rat hippocampus: G-protein dependency 32 J.R. Raymond, F. J. Albers, J. P. Middleton: Functional expression of human 5-HT,, receptors and differential H. Yokoyama, K. Onodera, K. Maeyama, K. Yanai, coupling to second messengers in CHO cells 127 K. linuma, L. Tuomisto, T. Watanabe: Histamine levels and clonic convulsions of electrically-induced seizure in S. B. Ross, L. Rényi, D. Kelder: N-Methyl-D-aspartate 7 the effects of «-fluoromethylhistidine and metoprine receptor antagonists counteract the long lasting 5-HT1, receptor-induced attenuation of postsynaptic responses in the ratin vivo 138 G. J. Molderings, G. Wei&enborn, E. Schlicker, J. Likungu, M. Gothert: Inhibition of noradrenaline release R. M. Eglen, G. C. Harris, H. Cox, A. O. Sullivan, from the sympathetic nerves of the human saphenous vein by E. Stefanich, R. L. Whiting: Characterization of the presynaptic histamine H3 receptors 46 interaction of the cervane alkaloid, imperialine, at muscarinic receptors in vitro 144 K. Yanai, K. Maeyama, N. Nakahata, H. Nakanishi, T. Watanabe: Calcium mobilization and its desensitization A. Ekman, E. Eriksson: Effects of N-ethoxycarbonyl-2- induced by endothelins and sarafotoxin in human ethoxy-1,2-dihydroquinoline on the prolactin suppression astrocytoma cells (1321N1): Comparison of histamine- induced by a series of full and partial dopamine D2 receptor induced calcium mobilization 51 agonists in male rats 152 E. Panula-Lehto, M. Makinen, L. Ahtee: Effects of H. Russ, M. Gliese, J. Sonna, E. Schomig: The taurine, homotaurine and GABA on hypothalamic and striatal extraneuronal transport mechanism for noradrenaline dopamine metabolism 57 (uptake2) avidly transports 1-methyl-4-phenylpyridinium (MPP*) 158 A. Lorenzen, S. Griin, H. Vogt, U. Schwabe: Identification of novel high affinity adenosine binding protein V. Marino, I. S. de la Lande, D. A. S. Parker, J. Dally, from bovine striatum 63 S. Wing: Extraneuronal uptake of noradrenaline in rabbit dental pulp: evidence of identity with uptake, 166 T. Sakurada, Y. Manome, K. Katsumata, H. Uchiumi, K. Tan-No, S. Sakurada, K. Kisara: Naloxone-reversible M. Msghina, C. Mermet, F. Gonon, L. Stjarne: effect of spantide on the spinally mediated behavioural Electrophysiological and electrochemical analysis of the ar, induced by neurokinin-2 and -3 receptor agonists secretion of ATP and noradrenaline from the sympathetic 6 nerves in rat tail arterty: effects of a2-adrenoceptor agonists and antagonists and noradrenaline reuptake blockers 173 Y. Uezono, A. Wada, N. Yanagihara, H. Kobayashi, T. Mizuki, T. Terao, Y. Koda, F. Izumi: Veratridine causes |. von Kiigelgen, L. Spath, K. Starke: Stable adenine the Ca?* -dependent increase in diacylglycerol formation and nucleotides inhibit [*H]-noradrenaline release in rabbit brain translocation of protein kinase C to membranes in cultured cortex slices by direct action at presynaptic adenosine bovine adrenal medullary cells 76 A,-receptors 187 U. Jahnel, H. Jakob, H. Nawrath: Electrophysiologic and O. Nagano, F. F. Foldes, H. Nakatsuka, D. Reich, inotropic effects of «-adrenoceptor stimulation in human Y. Ohta, B. Sperlagh, E. S. Vizi: Presynaptic A, -purino- isolated atrial heart muscle 82 ceptor-mediated inhibitory effects of adenosine and its stable analogues on the mouse hemidiaphragm preparation 197 U. Jahnel, H. Nawrath, R.-C. Shieh, V. K. Sharma, D. J. Williford, S.-S. Sheu: Modulation of cytosolic free J. Michael-Hepp, B. Blum, H. Bénisch: Characterization calcium concentration by «,-adrenoceptors in rat atrial cells of the [H]-desipramine binding site of the bovine adreno- medullary plasma membrane 203 T. Ishibashi, M. Hamaguchi, S. Imai: Vasodilating M. C. Koss, J. A. Hey: Activation of histamine H3 receptors properties of KRN2391: structural basis of a new pyridine- produces presynaptic inhibition of neurally evoked cat type potassium channel opener with a nitrate moiety 94 nictitating membrane responses in vivo 208 IV K. Krejcy, G. Krumpl, H. Todt, G. Raberger: Lidocaine T. Griesbacher, J. Donnerer, F. J. Legat, F. Lembeck: has a narrow antiarrhythmic dose range against ventricular CP-96,345, a non-peptide antagonist of substance P: arrhythmias induced by programmed electrical stimulation in Il. Actions on substance P-induced hypotension and conscious postinfarction dogs 213 bronchoconstriction, and on depressor reflexes in mammals 323 U. Holzer-Petsche: Blood pressure and gastric motor responses to bradykinin and hydrochloric acid injected into J. Donnerer, U. Stark, H. A. Tritthart, F. Lembeck: somatic or visceral tissues 219 CP-96,345, a non-peptide antagonist of substance P: Ill. Cardiovascular effects in mammals unrelated to actions on A. Schmoldt, |. Blomer, A. Johannes: Hydroxysteroid substance P receptors 328 sulfotransferase and a specific UDP-glucuronosyltransferase are involved in the metabolism of digitoxin in man 226 M. T. Lin, C. F. Su: Spinal 5-HT pathways and the antinociception induced by intramedullary clonidine in rats 333 Short communications R. Raddino, E. Poli, E. Pasini, R. Ferrari: Effects of the D. Nolte, A. Lorenzen, H.-A. Lehr, F. J. Zimmer, novel calcium channel blocker, anipamil, on the isolated rabbit K-N. Klotz, K. Messmer: Reduction of postischemic heart. Comparison with verapamil and gallopamil 339 leukocyte-endothelium interaction by adenosine via A2 receptor 234 J. Gédicke, S. Herzig, A. Mescheder, K. Mohr, F. Steinke: Enantioselectivity of asocainol studied at different E. Abe, S. Murai, Y. Masuda, H. Saito, T. Itoh: Reversal conditions: a novel approach to check the feasibility of by 3,3’,5-triido-L-thyronine of the working memory deficit, molecular models of antiarrhythmic drug action 345 and the decrease in acetylcholine, glutamate and y-amino- ae induced by ethylcholine aziridinium ion in P. Walday, E. Fyllingen, P. Aas: Effect of calcium mice antagonists (w-conotoxin GVIA, verapamil, gallopamil, diltiazem) on bronchial smooth muscle contractions induced by soman 352 No. 3 published on September 1, 1992 Short communications A. T. Bruinvels, H. Lery, J. Nozulak, J. M. Palacios, D. Sanders, E. Habermann: Evidence for a link between D. Hoyer: 5-HT;p binding sites in various species: similar specific proteolysis and inhibition of [*H]-noradrenaline pharmacological profile in dog, monkey, calf, guinea-pig and release by the light chain of tetanus toxin 358 human brain membranes 243 B. K. Evans, R. Mason, V. G. Wilson: Evidence for direct D. Hoyer, H. Lery, C. Waeber, A. T. Bruinvels, vasoconstrictor activity of melatonin in “pressurized” J. Nozulak, J. M. Palacios: “5-HT,,” or 5-HT;p sites? segments of isolated caudal artery from juvenile rats 362 Evidence for 5-HT,p binding sites in rabbit brain 249 H. W. G. M. Boddeke, M. Buttini, M. Lichtsteiner, A. Enz: M1 muscarinic receptors mediate intracellular calcium release in NB-OK1 human neuroblastoma cells 255 No. 4 published on October 5, 1992 E. Nissinen, |.-B. Lindén, E. Schultz, P. Pohto: Biochemical and pharmacological properties of a peripherally A. Varrault, J. Bockaert: Differential coupling of 5-HT,, acting catechol-O-methyltransferase inhibitor Entacapone receptors occupied by 5-HT or 8-OH-DPAT to adenylyl 262 cyclase 367 J. Patel, S. J. Trout, Z. L. Kruk: Regional differences in G. Brehm, R. Lindmar, K. Loffelholz: Inhibitory and evoked dopamine efflux in brain slices of rat anterior and excitatory muscarinic receptors modulating the release of posterior caudate putamen 267 acetylcholine from the postganglionic parasympathetic neuron of the chicken heart 375 S. Sarre, P. Herregodts, D. Deleu, A. Devrieze, N. De Klippel, G. Ebinger, Y. Michotte: N.A. Dorofeeva, S. A. Shelkovnikov, L. A. Starshinova, Biotransformation of L-DOPA in striatum and substantia nigra A. F. Danilov, J. Nedoma, S. Tuéek: Quest for agonist of rats with a unilateral, nigrostriatal lesion: a microdialysis and antagonist selectivity at muscarinic receptors in guinea- study 277 pig smooth muscles and cardiac atria 383 D. Branco, M. Caramona, F. Martel, J. A. Ferreira de M.A. Casado, J. Marin, M. Salaices: Evidence for M, Almeida, W. Osswald: Predominance of oxidative muscarinic cholinoceptors mediating facilitation of deamination in the metabolism of exogenous noradrenaline noradrenaline release in guinea-pig carotid artery 391 by the normal and chemically denervated human uterine J. Grenhoff, T. H. Svensson: Nicotinic and muscarinic artery 286 components of rat brain dopamine synthesis stimulation S. A. Doggrell: An analysis of the inhibitory effects of induced by physostigmine 395 prazosin on the phenylephrine response curves of the rat L. J. Bryan-Lluka, H. E. Vuocolo: Evidence from guinea- aorta 294 pig trachealis that Uptake. of isoprenaline is enhanced by A. J. Balmforth, F. E. Parkinson, N. Altiok, B. B. hyperpolarization of the smooth muscle 399 Fredholm: Identification of a B2-bradykinin receptor linked R. Pekelmann Markus, M. Ch. Werneck de Avellar: to phospholipase C and inhibition of dopamine stimulated Effect of ageing on the number of neuronal noradrenaline cyclic AMP accumulation in the human astrocytoma cell line uptake sites in the rat vas deferens 405 D384 303 M. Haass, G. Richardt, A. Schomig: Potentiation of M. G. Kazanietz, M. A. Enero: Role of cyclic AMP in the potassium-evoked noradrenaline and neuropeptide Y co- release of noradrenaline from isolated rat atria. Effect of release by cardiac energy depletion: role of calcium channels pretreatment with clenbutero! 311 and sodium-proton exchange 410 F. J. Legat, T. Griesbacher, F. Lembeck: CP-96,345, a Y. Takata, J. Ozawa, H. Kato: Possible involvement of non-peptide antagonist of substance P: |. Effects on the both N- and L-type voltage-dependent Ca channels in actions mediated by substance P and related tachykinins on adrenergic neurotransmission of canine saphenous veins in the guinea-pig ileum and rabbit jejunum 315 low Ca?* plus tetraethylammonium medium 419 J. Harro, S. S. Jossan, L. Oreland: Changes in chole- M. Vincens, C. Shu, M. Fortin, D. Philibert, cystokinin receptor binding in rat brain after selective damage M. Gaillard-Moguilewsky : Comparison between the of locus coeruleus projections by DSP-4 treatment 425 interaction of steroids with [°°S]TBPS binding to cerebral cortical and to pituitary membranes: correlation with L. Rago, V. Saano, T. Auvinen, A. Adojaan, R. Holma, inhibition of prolactin release 523 M. M. Airaksinen: The effect of chronic treatment with peripheral benzodiazepine receptor ligands on behavior and M. Roenfeldt, H. Safayhi, H. P. T.A mmon: KCl-induced GABA, /benzodiazepine receptors in rat 432 insulin secretion from RINM5F cells is mediated through Ca?* influx along L-type Ca?* channels 527 G. Engberg, M. Hajés: Alcohol withdrawal reaction as a result of adaptive changes of excitatory amino acid receptors S. Lenzen, M. Mirzaie-Petri: Inhibition of aconitase by 437 alloxan and the differential modes of protection of glucose, 3-O-methyliglucose, and mannoheptulose 532 W. Fischer, R. Bodewei, G. Satzinger: Anticonvulsant F. Guthmann, B. Mayer, D. Koesling, W. R. Kukovetz, and sodium channel blocking effects of ralitoline in different E. Bohme: Characterization of soluble platelet guanylyl screening models 442 cyclase with peptide antibodies 537 B. Wagner, H.-G. Eichler, B. Scheider, B. Blochi- H. Wuorela, I. Porsti, P. Arvola, H. Makynen, Daum, B. Brenner, S. Gasic, K. Lechner, P. A. Kyrle: H. Vapaatalo: Three levels of dietary calcium-effects on Studies on the effect of two angiotensin-converting enzyme blood pressure and electrolyte balance in spontaneously inhibitors, captopril and cilazapril, on platelet and vascular hypertensive rats 542 prostaglandin metabolism in vivo 453 M. Fukuchi, T. Uematsu, S. Araki, M. Nakashima: S. M. Jacinto, B. S. Jandhyala: Evaluation of the effects Photochemically induced thrombosis of the rat coronary of felodipine, verapamil and hydralazine on the survival rate artery and functional evaluation of thrombus formation by of rats subjected to lethal effects of oxygen free radicals 457 occurrence of ventricular arrhythmias. Effects of acetylsalicylic acid and a thromboxan A2 synthetase inhibitor J. Cortijo, B. Sarria, C. Pedrés, M. Perpina, F. Paris, of thrombus formation 550 E. Morcillo: The relaxant effects of cromakalim(BRL 34915) on human isolated airway smooth muscle 462 H. Nakaya, Y. Hattori, M. Endou, S. Gandou, M. Kanno: Electrophysiologic and anticholinergic effects of pirmenol enantiomers in guinea-pig myocardium 555 Short communications J. Schneider, E. Beck, C. Heers, C. Conrad, B. Muhlibauer, H. Osswald: Feeding but not salt loading D. de Chaffoy de Courcelles, B. Wilffert, T. Peters: is the dominant factor controlling urinary dopamine excretion Cardiac effects of R 79595 and its isomers (R 80122 and in conscious rats 469 R 80123) in an acute heart failure model. A new class of E. P. Finta, J. T. Regenold, P. liles: Depression by cardiotonic agents with highly selective phosphodiesterase neuropeptide Y of noradrenergic inhibitory postsynaptic ||| inhibitory properties 563 potentials of locus coeruleus neurones 472 J. Cortijo, M. Gonzalez, J. L. Ortiz, E. Morcillo: Effects of low temperature and pharmacological interventions on the responses of the isolated guinea-pig trachea 573 C. Li Zhang, U. Heinemann: Effects of the triazole derivative loreclezole (R 72063) on stimulus induced ionic and field potential responses and on different patterns of No. 5 published on November 2, 1992 epileptiform activity induced by low magnesium in rat entorhinal cortex-hippocampal slices 581 T. Wieland, P. Gierschik, K. H. Jakobs: G protein- L. Velisek, H. Kubova, M. Pohl, L. Stankova, P. Mare&, mediated receptor-receptor interaction: studies with R. Schickerova: Pentylenetetrazol-induced seizures in rats: chemotactic receptors in membranes of human leukemia an ontogenetic study (HL 60) cells 475 U. Jahnel, J. Rupp, R. Ertl, H. Nawrath: Positive Short communications inotropic response to 5-HT in human atrial but not in ventricular heart muscle 482 A.A. Parsons, C. Stutchbury, P. Raval, A. J. Kaumann: Sumatriptan contracts large coronary arteries of beagle dogs R. G. Schoemaker, X. Y. Du, W. A. Bax, P. R. Saxena: through 5-HT,-like receptors 592 5-Hydroxytryptamine increases contractile force in porcine right atrium but not in left ventricle 486 A. Terzic, M. Pucéat, O. Clement-Chomienne, G. Vassort: Phenylephrine and ATP enhance an amiloride M. Wolzt, E. Schmidt, B. Wagner, S. Schuller- insensitive bicarbonate-dependent alkalinizing mechanism in Petrovic, P. A. Kyrle, H.-G. Eichler: Effects of serotonin rat single cardiomyocytes 597 and noradrenaline on superficiai hand veins in patients with primary hypertension and in healthy volunteers 490 K. F. Rhodes, J. Coleman, N. Lattimer: A component of 5-HT-evoked depolarization of the rat isolated vagus nerve is mediated by a putative 5-HT, receptor 496 M. T. Lin, M. T. Ho, M. S. Young: Stimulation of the No. 6 published on December 4, 1992 nigrostriatal dopamine system inhibits both heat production and heat loss mechanisms in rats 504 A. De Luca, V. Tortorella, D. Conte Camerino: Chloride channels of skeletal muscle from developing, adult and aged H. Schworer, S. Katsoulis, W. Creutzfeldt, rats are differently affected by enantiomers of 2-(p- W. E. Schmidt: Pituitary adenylate cyclase activating chlorophenoxy) propionic acid 601 peptide, a novel VIP-like gut-brain peptide, relaxes the guinea-pig taenia caeci via apamin-sensitive potassium R. Lindmar, K. L6ffelholz: Phospholipase D in heart: basal channels 511 activity and stimulation by phorbol esters and aluminum fluoride 607 K. Nakazawa, H. Saito, N. Matsuki: Effects of calcitonin gene-related peptide (CGRP) on Ca?*-channel current of P. N. Patil: Reactivity of human iris-sphincter to muscarinic isolated smooth muscle cells from rat vas deferens 515 drugs in vitro 614 Vi P. N. Patil, T. F. Mauger: Cholinergic sensitivity of irides S. Dionisotti, C. Zocchi, K. Varani, P. A. Borea, E. from donors with various pathological conditions and lens Ongini: Effects of adenosine derivatives on human and rabbit implants 620 platelet aggregation. Correlation of adenosine receptor affinities and antiaggregatory activity 673 P. R. Saxena, C. M. Villalon, K. M. Dhasmana, P. D. Verdouw: 5-Hydroxytryptamine-induced increase in left 1. von Kiigelgen, L. Spath, K. Starke: Adenosine but not ventricular dP/dt,,., does not suggest the presence of an adenine nucleotide mediates tonic purinergic inhibition, ventricular 5-HT, receptors in the pig 629 as well as inhibition by glutamate, of noradrenaline release in rabbit brain cortex slices 677 B. H. C. Westerink, M. Santiago, J. B. De Vries: In vivo evidence for a concordant response of terminal and dendritic M. D. Barrachina, M. A. Martinez-Cuesta, dopamine release during intranigral infusion of drugs 637 A. Canet, J. V. Esplugues, J. Esplugues: Differential effects of locally-applied capsaicin on distension-stimulated R. Mancino, L. Cerulli, A. Ricci, F. Amenta: Direct gastric acid secretion in the anesthetized rat 685 demonstration of dopamine D, -like receptor sites in the ciliary T. Yamagishi, T. Yanagisawa, N. Taira: body of the rabbit eye by light microscope autoradiography K* channel openers, cromakalim and Ki4032, inhibit agonist- 644 induced Ca?* release in canine coronary artery 691 S. J. Bunn, K. J. O’Brien, T. L. Boyd, D. A. Powis: Pertussis toxin inhibits noradrenaline accumulation by bovine G. T. P. Saccone, Y.-F. Liu, A. Thune, adrenal medullary chromaffin cells 649 J. R. Harvey, R. A. Baker, J. Toouli: Erythromycin and motilin stimulate sphincter of Oddi motility and inhibit trans- A. J. Surman, S. A. Doggrell: Characterization of the sphincteric flow in the Australian antagonism with metoprolol, IC! 147,798, pindolol, possum 701 mepindolol and bopindolol on the responses of the rat left J.-P. Wang, M.-F. Hsu, S.-L. Raung, C.-C. Chen, J.-S. atria to isoprenaline 657 Kuo, C.-M. Teng: Anti-inflammatory and analgesic effects U. Jahnel, B. Kaufmann, M. Rombusch, of magnolol 707 H. Nawrath: Contribution of both a- and B-adreno- Contents of volume 346 |-XIil ceptors to the inotropic effects of catecholamines in the rabbit heart 665 Indexed in Current Contents Supplement 1 to Volume 346 (1992) Abstracts of the Autumn Meeting of the Deutsche Gesellschaft fiir Pharmakologie und Toxikologie, 6—9 September 1992, Graz, Austria R1 —R44 Supplement 2 to Volume 346 (1992) Abstracts of the Fourth Winter Meeting December 2—4, 1992, Hannover, and the First Microdialysis Symposium, 5 December 1992, Hannover R45—R76

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