Nanotechnology for Oral Drug Delivery: From Concept to Applications PDF
Preview Nanotechnology for Oral Drug Delivery: From Concept to Applications
NANOTECHNOLOGY FOR ORAL DRUG DELIVERY NANOTECHNOLOGY FOR ORAL DRUG DELIVERY From Concept to Applications Edited by JOÃO PEDRO MARTINS Drug Research Program, Division of PharmaceuticalChemistry and Technology,FacultyofPharmacy,UniversityofHelsinki,Helsinki,Finland HE(cid:1)LDER A. SANTOS FullProfessor,Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Facultyof Pharmacy, University of Helsinki, Helsinki, Finland FullProfessor,Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland AcademicPressisanimprintofElsevier 125LondonWall,LondonEC2Y5AS,UnitedKingdom 525BStreet,Suite1650,SanDiego,CA92101,UnitedStates 50HampshireStreet,5thFloor,Cambridge,MA02139,UnitedStates TheBoulevard,LangfordLane,Kidlington,OxfordOX51GB,UnitedKingdom ©2020ElsevierInc.Allrightsreserved. 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Practitionersandresearchersmustalwaysrelyontheirownexperienceandknowledgeinevaluatingandusingany information,methods,compounds,orexperimentsdescribedherein.Inusingsuchinformationormethodsthey shouldbemindfuloftheirownsafetyandthesafetyofothers,includingpartiesforwhomtheyhaveaprofessional responsibility. Tothefullestextentofthelaw,neitherthePublishernortheauthors,contributors,oreditors,assumeanyliability foranyinjuryand/ordamagetopersonsorpropertyasamatterofproductsliability,negligenceorotherwise,orfrom anyuseoroperationofanymethods,products,instructions,orideascontainedinthematerialherein. LibraryofCongressCataloging-in-PublicationData AcatalogrecordforthisbookisavailablefromtheLibraryofCongress BritishLibraryCataloguing-in-PublicationData AcataloguerecordforthisbookisavailablefromtheBritishLibrary ISBN:978-0-12-818038-9 ForinformationonallAcademicPresspublications visitourwebsiteathttps://www.elsevier.com/books-and-journals Publisher:Wolff,Andre AcquisitionsEditor:Hill-Parks,Erin EditorialProjectManager:Young,SamW ProductionProjectManager:Raviraj,Selvaraj CoverDesigner:Pearson,Victoria TypesetbySPiGlobal,India Contributors Beatrice Albertini Departmentof Pharmacy and BioTechnology, University of Bologna, Bologna, Italy Andreia Almeida i3S—Instituto deInvestigac¸a˜oe Inovac¸a˜oem Sau´de; Instituto de Ci^encias Biom(cid:2)edicasAbel Salazar, Universidade do Porto, Porto, Portugal Mar´ıaJos(cid:2)eAlonso CenterforResearchinMolecularandChronicDiseases(CIMUS);DepartmentofPharmaceutics andPharmaceuticalTechnology,SchoolofPharmacy,CampusVida,UniversityofSantiagode Compostela,Santiago de Compostela, Spain Manuel Arruebo Departmentof Chemical Engineering, Aragon Institute of Nanoscience (INA), Universityof Zaragozaand Instituto de Ciencia de Materiales deArago´n (ICMA),Universidad de Zaragoza-CSIC, Zaragoza; NetworkingResearch Center on Bioengineering, Biomaterials and Nanomedicine, CIBER-BBN, Madrid, Spain Cla´udia Azevedo i3S—Instituto deInvestigac¸a˜oe Inovac¸a˜oem Sau´de; Instituto de Ci^encias Biom(cid:2)edicasAbel Salazar, Universidade do Porto, Porto, Portugal Abdul W. Basit UCLSchool of Pharmacy,University College London,London, United Kingdom Serena Bertoni Departmentof Pharmacy and BioTechnology, University of Bologna, Bologna, Italy Johan Peter Boetker Departmentof Pharmacy,Facultyof Healthand Medical Sciences, Universityof Copenhagen, Copenhagen, Denmark Maria Cristina Bonferoni Departmentof Drug Sciences, University of Pavia, Pavia,Italy Marcos Luciano Bruschi LaboratoryofResearchandDevelopmentofDrugDeliverySystems,DepartmentofPharmacy, State University of Maringa,Maringa,Parana, Brazil J(cid:2)essica Bassi daSilva LaboratoryofResearchandDevelopmentofDrugDeliverySystems,DepartmentofPharmacy, State University of Maringa,Maringa,Parana, Brazil Henry P.Diehl Departmentof Pharmaceutical Chemistry,TheUniversity of Kansas, Lawrence,KS, United States Franca Ferrari Departmentof Drug Sciences, University of Pavia, Pavia,Italy xi xii Contributors Mo´nica P.A.Ferreira DrugResearchProgram, Division of Pharmaceutical Chemistry and Technology,Faculty of Pharmacy, University of Helsinki, Helsinki, Finland Natalja Genina Departmentof Pharmacy,Faculty of HealthandMedical Sciences, Universityof Copenhagen, Copenhagen, Denmark Nazende Gu€nday Tu€reli € MyBiotech GmbH, Uberherrn, Germany Jouni Hirvonen DrugResearchProgram, Division of Pharmaceutical Chemistry and Technology,Faculty of Pharmacy, University of Helsinki, Helsinki, Finland Tushar Kumeria School of Pharmacy,TheUniversity of Queensland; Translational Research Institute,Mater Research Institute-The University of Queensland, Brisbane, QLD, Australia Robert Langer DepartmentofChemicalEngineering,MassachusettsInstituteofTechnology,Cambridge,MA, UnitedStates Mar´ıaVictoriaLozano CellularNeurobiologyandMolecularChemistryoftheCentralNervousSystemGroup,Faculty of Pharmacy; Regional Centre of Biomedical Research (CRIB), Universityof Castilla-La Mancha (UCLM), Albacete,Spain Maria Helena Macedo i3S—Instituto de Investigac¸a˜o e Inovac¸a˜oem Sau´de;Instituto de Ci^enciasBiom(cid:2)edicas Abel Salazar, Universidade do Porto, Porto, Portugal Joa˜o Pedro Martins DrugResearchProgram, Division of Pharmaceutical Chemistry and Technology,Faculty of Pharmacy, University of Helsinki, Helsinki, Finland Chiara Mazzoni Departmentof HealthTechnology, Technical University of Denmark, Lyngby, Denmark Line HagnerNielsen Departmentof HealthTechnology, Technical University of Denmark, Lyngby, Denmark Nadia Passerini Departmentof Pharmacy and BioTechnology, Universityof Bologna, Bologna, Italy Amirali Popat School of Pharmacy,TheUniversity of Queensland; Translational Research Institute,Mater Research Institute-The University of Queensland, Brisbane, QLD, Australia Vivitri D. Prasasty Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia, Jakarta,Indonesia Veronique Pr(cid:2)eat Advanced DrugDelivery and Biomaterials,Louvain DrugResearchInstitute, Universit(cid:2)e catholique deLouvain, Brussels, Belgium Contributors xiii Jukka Rantanen Departmentof Pharmacy,Facultyof Healthand Medical Sciences, Universityof Copenhagen, Copenhagen, Denmark PrarthanaRewatkar School of Pharmacy, TheUniversity of Queensland, Brisbane,QLD,Australia Silvia Rossi Departmentof Drug Sciences, University of Pavia, Pavia,Italy Marco Ruggeri Departmentof Drug Sciences, University of Pavia, Pavia,Italy Giuseppina Sandri Departmentof Drug Sciences, University of Pavia, Pavia,Italy Manuel J.Santander-Ortega CellularNeurobiologyandMolecularChemistryoftheCentralNervousSystemGroup,Faculty of Pharmacy;Regional Centre of Biomedical Research (CRIB), University of Castilla-La Mancha (UCLM), Albacete,Spain H(cid:2)elderA. Santos FullProfessor,DrugResearchProgram,DivisionofPharmaceuticalChemistryandTechnology, Faculty of Pharmacy;FullProfessor, Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland Bruno Sarmento i3S—Instituto deInvestigac¸a˜oe Inovac¸a˜oem Sau´de, Universidade do Porto, Porto; CESPU, Instituto de Investigac¸a˜o eFormac¸a˜o Avanc¸ada em Ci^encias e Tecnologiasda Sau´de, Gandra, Portugal Victor Sebastian Departmentof Chemical Engineering, Aragon Institute of Nanoscience (INA), Universityof Zaragozaand Instituto de Ciencia de Materiales deArago´n (ICMA),Universidad de Zaragoza-CSIC, Zaragoza;Networking ResearchCenter onBioengineering, Biomaterials and Nanomedicine, CIBER-BBN,Madrid,Spain Katia P. Seremeta Departmentof Basic and AppliedSciences, National University of the Chaco Austral; National Scientific and Technical ResearchCouncil (CONICET), Pcia. Roque Sa´enzPen˜a, Chaco, Argentina Neha Shrestha Advanced Drug Delivery and Biomaterials, Louvain Drug Research Institute, Universit(cid:2)e catholique de Louvain, Brussels, Belgium Teruna J.Siahaan Departmentof Pharmaceutical Chemistry,TheUniversity of Kansas, Lawrence,KS, United States Alejandro Sosnik Laboratory of Pharmaceutical Nanomaterials Science, Departmentof Materials Science and Engineering, Technion-Israel Institute of Technology,Haifa,Israel xiv Contributors Sabrina Barbosa de SouzaFerreira LaboratoryofResearchandDevelopmentofDrugDeliverySystems,DepartmentofPharmacy, State Universityof Maringa, Maringa,Parana, Brazil Sarah J.Trenfield UCL School of Pharmacy,University College London,London, United Kingdom Akif EmreTu€reli € MyBiotech GmbH, Uberherrn, Germany Barbara Vigani Departmentof DrugSciences, University of Pavia, Pavia,Italy Aldyn Wildey Departmentof Pharmaceutical Chemistry,The University of Kansas, Lawrence, KS, UnitedStates Foreword Thisbookaddressestwoofthemostsignificantareasofdrugdeliverytoday—oraldrug deliveryandnanotechnology.Thebookboastsanumberofexcellentscientistsasauthors from around the world. It covers chemical, biological, and engineering aspects of oral drug delivery using micro and nano-particles. In particular,thebookcontainsanumberofchapterson thebiology andbarriersto oraldrugdelivery,aswellaswaystostudythem.Thesechaptersincludeanexamination oftheintestinalmucosaasabarriertodrugdeliveryaswellasthedevelopmentofthree- dimensionalintestinalmodelsandhowtousethesemodelstorealisticallyscreenfordrug permeability. A number of chapters focus on biomaterials. There are chapters on nanomaterials for oral drug administration, and on microadhesive and mucus penetrating particles. Other chapters discuss manufacturing considerations. For example, three-dimensional printing and spray drying are examined in detail, as are the use of different reactions in the synthesis of enteric drug carriers. Microdevices for oral drug delivery are also discussed. In addition, an industrial perspective is provided. Thebookhaschaptersexamininganumberofotherimportanttopics.Theseinclude chaptersonthesizeandshapeofparticulatecarriers,ontargetingsuchsystemstoincrease transport of orally administered drugs, and on other approaches for modifying drug release. Buccal drug delivery is also discussed. Finally, both in vitro and in vivo approaches for examining oral delivery of nanoparticles are provided. This book should be a useful reference to scientists in universities and companies alikewhoareworkingonoraldrugdeliveryandnanoparticulatesystems.Thisisanarea that is also expected to increase in importance in the future. Robert Langer MITDepartmentofChemicalEngineering,MassachusettsInstituteofTechnology, Cambridge, MA, United States xv
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