Nanotechnology Driven Herbal Medicine for Burns: From Concept to Application

195 Pages·2021·22.371 MB·English

by  Md. Abul Barkat, Sarwar Beg, Farhan Jalees Ahmad

Nanotechnology Driven Herbal
Medicine for Burns: From
Concept to Application
Edited by
Md. Abul Barkat
Department of Pharmaceutics,
College of Pharmacy, University of Hafr Al-Batin,
Al Jamiah, Hafr Al Batin, 39524,
Saudi Arabia
Sarwar Beg
AMS-DBT Newton International Fellow,
School of Pharmacy and Biomedical Sciences,
University of Central Lancashire,
UK
&
Farhan Jalees Ahmad
Nanomedicine Research Lab,
Department of Pharmaceutics,
School of Pharmaceutical Education and Research,
Jamia Hamdard,
New Delhi,
India
Nanotechnology Driven Herbal Medicine for Burns:
From Concept to Application
Editors: Md. Abul Barkat, Sarwar Beg and Farhan Jalees Ahmad
ISBN (Online): 978-981-5039-59-7
ISBN (Print): 978-981-5039-60-3
ISBN (Paperback): 978-981-5039-61-0
© 2022, Bentham Books imprint.
Published by Bentham Science Publishers Pte. Ltd. Singapore. All Rights Reserved.
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CONTENTS
FOREWORD ........................................................................................................................................... i
PREFACE ................................................................................................................................................ ii
LIST OF CONTRIBUTORS .................................................................................................................. iv
CHAPTER 1 CURRENT STATUS AND FUTURE OUTLOOK OF NANOTECHNOLOGY-
BASED THERAPEUTIC TREATMENT MODALITIES FOR BURN WOUND
(cid:3)
MANAGEMENT(cid:3)....................................................................................................................................... 1
Rana Mazumder and Subhabrota Majumdar
INTRODUCTION .......................................................................................................................... 2
Skin ......................................................................................................................................... 3
Physiology for Burn Wounds .................................................................................................. 3
Burn Wound Healing .............................................................................................................. 6
NANOMEDICINE AND ADVANCEMENT IN THERAPY FOR BURN WOUND
MANAGEMENT ............................................................................................................................ 7
Metallic Nanoparticles ............................................................................................................ 7
Polymeric Nanoparticles ......................................................................................................... 7
Liposomal Nanoparticles ........................................................................................................ 8
Nanoemulsion ......................................................................................................................... 8
Nanogels ................................................................................................................................. 9
Wound Dressings .................................................................................................................... 9
Tissue Engineering .................................................................................................................. 9
Nanostructured Topical Drug Delivery Recent Advancement as Burn Wound Therapy ....... 10
CONCLUDING REMARKS AND FUTURE PROSPECT ........................................................ 12
CONSENT FOR PUBLICATION ................................................................................................ 12
CONFLICT OF INTEREST ......................................................................................................... 12
ACKNOWLEDGEMENTS ........................................................................................................... 13
REFERENCES ............................................................................................................................... 13
CHAPTER 2 NANOTECHNOLOGY- MEDIATED DELIVERY OF PHYTOMEDICINE FOR
BURN WOUND HEALING ................................................................................................................... 21
Mohammed Aslam, Mohammad Zaki Ahmad, Abdul Aleem Mohammed, Harshita,
Md. Abul Barkat and Javed Ahmad
INTRODUCTION .......................................................................................................................... 22
SIGNIFICANCE OF NANOTECHNOLOGY-MEDIATED DELIVERY OF
PHYTOMEDICINE ....................................................................................................................... 23
DELIVERY OF PHYTOMEDICINE EXPLOITING NANOTECHNOLOGY IN BURN
WOUND HEALING ....................................................................................................................... 25
Berberine ................................................................................................................................. 28
Bromelain ................................................................................................................................ 29
Silymarin ................................................................................................................................. 30
Madecassoside ........................................................................................................................ 30
Resveratrol .............................................................................................................................. 31
Epigallocatechin ...................................................................................................................... 31
Curcumin ................................................................................................................................. 32
Aloe vera ................................................................................................................................. 33
CONCLUSION ............................................................................................................................... 35
CONSENT FOR PUBLICATION ................................................................................................ 35
CONFLICT OF INTEREST ......................................................................................................... 35
ACKNOWLEDGEMENTS ........................................................................................................... 35
REFERENCES .............................................................................................................................. 35
CHAPTER 3 PLANT MEDIATED GREEN SYNTHESIS OF SILVER NANOPARTICLES
FOR BURN WOUND INFECTIONS .................................................................................................... 40
Katayoon Kalantar, Alireza Kalantari and Thomas J. Webster
INTRODUCTION .......................................................................................................................... 40
Plant-Based Synthesis of Ag-NPs ........................................................................................... 42
Mechanism of Plant-Mediated Synthesis of Ag-NPs ............................................................. 45
Ag-NP Characterization Techniques ...................................................................................... 46
Cytotoxicity of Plant-Mediated Ag-NPs ................................................................................. 47
Antimicrobial Activities of Plant-Mediated Ag-NPs .............................................................. 47
Wound Healing Process .......................................................................................................... 48
Wound Healing Applications of Ag-NPs ............................................................................... 49
Side Effects of Silver Use ....................................................................................................... 54
SUMMARY AND FUTURE PROSPECTS ........................................................................... 55
CONSENT FOR PUBLICATION ................................................................................................ 55
CONFLICT OF INTEREST ......................................................................................................... 55
ACKNOWLEDGEMENTS ........................................................................................................... 56
REFERENCES ............................................................................................................................... 56
CHAPTER 4 THERAPEUTIC PROSPECTIVE OF GREEN-SYNTHESIZED SILVER
NANOPARTICLES IN BURN WOUND MANAGEMENT ............................................................... 66
S. Sumathi
INTRODUCTION .......................................................................................................................... 66
Wound Healing ....................................................................................................................... 68
AgNPs as Antimicrobial Agents ............................................................................................. 70
Green Synthesis of AgNPs ...................................................................................................... 71
Characterization of AgNPs and its Applications .................................................................... 72
Plant Mediated Synthesis of AgNPs and its Wound Healing Activity ................................... 75
Microbial Organism Mediated AgNPs and its Wound Healing Activity ............................... 80
Mechanism of Action of Antibacterial Activity ..................................................................... 81
CONCLUDING REMARKS ......................................................................................................... 82
CONSENT FOR PUBLICATION ................................................................................................ 83
CONFLICT OF INTEREST ......................................................................................................... 83
ACKNOWLEDGEMENT ............................................................................................................. 83
REFERENCE .................................................................................................................................. 83
CHAPTER 5 PHYTOCHEMICAL-ASSISTED GOLD NANOPARTICLES FOR BURN
WOUND MANAGEMENT .................................................................................................................... 89
Abdelgadir A. Abdelgadir and Pooja A. Chawla
INTRODUCTION .......................................................................................................................... 89
GOLD NANOPARTICLES POTENTIAL THERAPEUTIC EFFECTS ON WOUND
HEALING ....................................................................................................................................... 90
GREEN SYNTHESIS OF GOLD NANOPARTICLES AND CHARACTERIZATION ........ 91
WOUND HEALING MECHANISM OF PHYTOCHEMICAL-ASSISTEDGOLD
NANOPARTICLES ........................................................................................................................ 95
In Vitro Studies ....................................................................................................................... 96
In Vivo Studies ....................................................................................................................... 98
CONCLUDING REMARKS ......................................................................................................... 99
CONSENT FOR PUBLICATION ................................................................................................ 100
CONFLICT OF INTEREST ......................................................................................................... 100
ACKNOWLEDGEMENTS ........................................................................................................... 100
REFERENCES ............................................................................................................................... 100
CHAPTER 6 THERAPEUTIC IMPORTANCE OF PHYTO-ASSISTED GREEN SYNTHESIS
OF ZINC OXIDE NANOPARTICLES IN BURN WOUND MANAGEMENT ............................... 105
Md. Abul Barkat
INTRODUCTION .......................................................................................................................... 105
Phyto-assisted Green Synthesis of Zinc Oxide Nanoparticles ................................................ 107
Therapeutic Potential of Phyto-assisted ZnONPs in Burn Wound ......................................... 109
CONCLUSION ............................................................................................................................... 112
CONSENT FOR PUBLICATION ................................................................................................ 113
CONFLICT OF INTEREST ......................................................................................................... 113
ACKNOWLEDGEMENT ............................................................................................................. 113
REFERENCES ............................................................................................................................... 113
CHAPTER 7 PLANT MEDIATED SYNTHESIS OF TITANIUM DIOXIDE
NANOPARTICLES FOR BURN WOUND MANAGEMENT ........................................................... 117
Abdelgadir A. Abdelgadir and Pooja A. Chawla
INTRODUCTION .......................................................................................................................... 117
NANOPARTICLE’S POTENTIAL THERAPEUTIC EFFECTS ON WOUND HEALING 118
GREEN SYNTHESIS OF TITANIUM DIOXIDE NANOPARTICLES AND
CHARACTERIZATION ............................................................................................................... 119
TITANIUM DIOXIDE PLANT-BASED NANOPARTICLES .................................................. 122
APPLICATIONS OF PLANT TITANIUM DIOXIDE NANOPARTICLES FOR WOUND
HEALING ....................................................................................................................................... 124
In vitro Studies ........................................................................................................................ 124
In vivo Studies ........................................................................................................................ 126
CONCLUDING REMARKS ........................................................................................................ 127
CONSENT FOR PUBLICATION ................................................................................................ 128
CONFLICT OF INTEREST ......................................................................................................... 128
ACKNOWLEDGEMENTS ........................................................................................................... 128
REFERENCES ............................................................................................................................... 128
CHAPTER 8 TOXICITY RELATED TO PHYTOCHEMICAL-ASSISTED METALLIC
NANOPARTICLES IN BURN WOUND MANAGEMENT ............................................................... 132
Lubna Abidin, Mohd. Mujeeb and Md. Abul Barkat
INTRODUCTION .......................................................................................................................... 132
CLASSIFICATION OF BURN WOUNDS .................................................................................. 134
THE RESTORATION CASCADE ............................................................................................... 136
NANOPARTICLES IN BURN WOUND TREATMENT .......................................................... 137
PENETRATION OF PMNPS THROUGH DERMAL ROUTE ................................................ 138
Intracellular Pathway .............................................................................................................. 140
Intercellular Pathway .............................................................................................................. 140
Follicular Pathway .................................................................................................................. 140
TOXICITY CAUSED BY PMNPS IN BURN WOUNDS ........................................................... 141
Mechanism of PMNPs Toxicity .............................................................................................. 142
Production of ROS .................................................................................................................. 143
Inflammatory Cascade ............................................................................................................ 144
Genotoxicity ............................................................................................................................ 144
Autophagy ............................................................................................................................... 144
Apoptosis ................................................................................................................................ 145
Epigenetic Effects ................................................................................................................... 145
Phototoxicity ........................................................................................................................... 145
Neurotoxicity .......................................................................................................................... 146
Skin Sensitivity by Metallic NPs ............................................................................................ 146
CONCLUSION ............................................................................................................................... 146
CONSENT FOR PUBLICATION ................................................................................................ 147
CONFLICT OF INTEREST ......................................................................................................... 147
ACKNOWLEDGEMNT ................................................................................................................ 147
REFERENCES ............................................................................................................................... 147
CHAPTER 9 A NOVEL HERBAL INFORMATIC APPROACH FOR THE MANAGEMENT
OF SKIN BURN INJURY ...................................................................................................................... 152
Ankit Tanwar, Ruby Sharma, Ayesha Ali Zaidi, Deepti Sharma, Rashmi Wardhan
Raman Chawla, Himanshu Ojha, Rajesh Arora and Haider Ali Khan
INTRODUCTION .......................................................................................................................... 153
Types of Wounds and Their Healing Mechanism .................................................................. 153
Side Effects of Skin Burn Injury ............................................................................................. 155
Biomarkers of the Skin Wounds ............................................................................................. 156
METHODOLOGY ......................................................................................................................... 157
Classic Literature Surge Model .............................................................................................. 157
Evaluation of Relevance Factor Using ‘Keywords Hits’ Scoring Matrix Approach .............. 164
Binary Coefficients Matrix to Assess the Presence/Absence of a Bioactivity Parameter
(BAP) ...................................................................................................................................... 165
Weightage Matrix-Based Analysis ........................................................................................ 165
Fuzzy Set Optimization for the Decision Matrix .................................................................... 165
RESULTS ........................................................................................................................................ 166
Bioactivity Parameters Analysis Using the Classical Approach ............................................ 166
Keywords Hit Scoring Matrix Approach to Evaluate the Relevance Factor .......................... 166
Simple Additive Weighting Matrix ........................................................................................ 167
Decision Matrix-Based Optimization ..................................................................................... 167
DISCUSSION .................................................................................................................................. 168
CONCLUSION ............................................................................................................................... 169
CONSENT FOR PUBLICATION ................................................................................................ 169
CONFLICTS OF INTEREST ....................................................................................................... 169
ACKNOWLEDGEMENT ............................................................................................................. 169
REFERENCES ............................................................................................................................... 170
SUBJECT INDEX .................................................................................................................................... (cid:20)(cid:26)(cid:24)
i
FOREWORD
It gives me immense pleasure to write this foreword for the book titled Nanotechnology
driven Herbal Medicine For Burns: From Concept to Application. At the onset, I compliment
and congratulate the editors and authors of the book for their voluminous compilations on the
aforementioned title. I have gone through the chapters contributed to the book by
internationally acclaimed authors and researchers having expertise in nanotechnology and
nanomedicines for topical drug delivery applications. The chapters have been very aptly
selected, thus well justifying the theme of the book in general. Overall, the book can be
considered as an updated and extensive compilation of the Nanotechnology-driven
perspectives in phytomedicines for burn injuries treatment. The first chapter of this book
looks at issues of burn wound pathogenesis, infections and currently available therapies,
advancement in burn wound management. The other chapters highlight the importance of
phytotherapeutics-based metallic and non-metallic nanoparticles for burn wound
management.
Applications of phyto-based nanotherapeutics to address the issues of targeted therapy for
burn wound infections is a novel area in medical research, which makes this book a valuable
textual repertoire along with updated bibliography of references are the unique selling
features of the book. In my opinion, this book would be of immense use not only to
pharmaceutical scientists but also for physicians and clinicians who may like to get a better
understanding of phytonanomedicine applications in burn wound management.
Overall, this compilation represents a wonderful treatise based on expert experience with a
clear bearing on phytonanomedicine applications in burn therapy. In the end, I wish the
editors all the very best of their efforts for a successful completion of the book and anticipate
their activeness in bringing more such assignments in the near future.
Prof. Om Prakash Katare
University Institute of Pharmaceutical Sciences,
Punjab University, Sector 14, Chandigarh, 160 014,
India