Nanophytomedicine: Concept to Clinic

220 Pages·2020·4.459 MB·English

by  Sarwar Beg, Md Abul Barkat, Farhan Jalees Ahmad

Sarwar Beg
Md Abul Barkat
Farhan Jalees Ahmad  Editors
Nanophytomedicine
Concept to Clinic
Nanophytomedicine
(cid:129) (cid:129)
Sarwar Beg Md Abul Barkat
Farhan Jalees Ahmad
Editors
Nanophytomedicine
Concept to Clinic
Editors
SarwarBeg MdAbulBarkat
DepartmentofPharmaceutics,School DepartmentofPharmaceutics,College
ofPharmaceuticalEducationandResearch ofPharmacy
JamiaHamdard UniversityofHafrAl-Batin
NewDelhi,Delhi,India HafrAl-Batin,SaudiArabia
FarhanJaleesAhmad
DepartmentofPharmaceutics,School
ofPharmaceuticalEducationandResearch
JamiaHamdard
NewDelhi,Delhi,India
ISBN978-981-15-4908-3 ISBN978-981-15-4909-0 (eBook)
https://doi.org/10.1007/978-981-15-4909-0
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Contents
Nanotechnology-BasedPhytotherapeutics:CurrentStatus
andChallenges. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
MdAbulBarkat,Harshita,SabyaSachiDas,SarwarBeg,
andFarhanJ.Ahmad
NanophytomedicineMarket:GlobalOpportunityAnalysis
andIndustryForecast. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19
RahulShukla,KomalThok,ImtiyazAlam,andRaghurajSingh
EmergenceofNanophytomedicineinHealthCareSetting. . . . . . . . . . . 33
RahulShukla,SanchitaKakade,MayankHanda,andKanchanKohli
Nanophytomedicine:AnEffectiveWayforImprovingDrugDelivery
andBioavailabilityofHerbalMedicines. . . . . . . . . . . . . . . . . . . . . . . . . 55
MohammadZaidurRahmanSabujandNazrulIslam
Self-NanoemulsifyingDrugDeliverySystemforImprovingEfficacy
ofBioactivePhytochemicals. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 71
JavedAhmad,SaimaAmin,SanjeevSingh,GulamMustafa,
andMdAbulBarkat
PotentialofNano-StructuredDrugDeliverySystemforPhytomedicine
Delivery. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 89
VineetKumarRai,GhanshyamDasGupta,FaheemHyderPottoo,
andMd.AbulBarkat
InsightsofNanophytomedicinesasaCombinatorialTherapyinDisease
DiagnosisandTreatment. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 113
AkshayKumar,HimanshiWalia,FaheemHyderPottoo,
andMd.NoushadJaved
Pharmacokinetics,Interaction,andToxicologicalProfileof
Nanophytomedicine. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 133
VineetKumarRai,RajKumarNarang,FaheemHyderPottoo,
andMdAbulBarkat
vv
vi Contents
RecentAdvancementinClinicalApplicationofNanotechnological
ApproachedTargetedDeliveryofHerbalDrugs. . . . . . . . . . . . . . . . . . 151
MdNoushadJaved,EktaSinghDahiya,AbdallahMohammadIbrahim,
Md.SabirAlam,FirdosAlamKhan,andFaheemHyderPottoo
NanophytomedicineEthicalIssues,RegulatoryAspects,
andChallenges. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 173
RoohiMohi-ud-din,ReyazHassanMir,FaheemHyderPottoo,
GiftySawhney,MubashirHussainMasoodi,andZulfiqarAliBhat
NanomedicineBasedPhytoformulationinDiseaseDiagnosis
andTreatment. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 193
AlokSharma,KuldeepSinghYadav,FaheemHyderPottoo,
VineetKumarRai,andMd.AbulBarkat
About the Editors
Sarwar Beg is currently serving as an Assistant Professor at the Department of
Pharmaceutics,SchoolofPharmaceuticalEducationandResearch,JamiaHamdard,
NewDelhi,India.PriortojoiningJamiaHamdard,DrBegwasaResearchScientist
at Jubilant Generics Limited, Noida, India. He has over a decade of research
experience in the field of pharmaceutics, especially in the systematic development
andcharacterizationofdiversedrugdeliverysystemsemployingQualitybyDesign
paradigms like Design of Experiments and Multivariate Statistical Techniques. To
date he has authored over 170 publications in various peer-reviewed journals,
45 book chapters and 12 books, with H-index of 30 and 3500 citations. Dr Beg
has also participated in and presented his research work at several conferences in
India, China, Bangladesh, UAE, USA and Canada, and has several best paper
awardsandyoungscientistawardstohiscredit.
MdAbulBarkat iscurrentlyservingasanAssistantProfessorattheDepartmentof
Pharmaceutics, College of Pharmacy, University of Hafr Al Batin, Kingdom of
Saudi Arabia. He holds a Master’s degree in Pharmaceutical Sciences from Jamia
Hamdard University, New Delhi, India, and a PhD in Pharmaceutical Sciences
(Pharmaceutics) from the Integral University Lucknow, India. With more than
10yearsofteachingandresearchexperienceinthefieldofPharmaceuticalScience,
his researchinterests include thedevelopment andoptimizationof herbal/synthetic
based nanostructured delivery systems, controlled release drug delivery systems,
bio-enhanceddrugdeliverysystems,nanomaterialsandnanocompositesforavari-
ety of conditions like burns, cancer etc. To date he has authored more than
30 research and review publications in various peer-reviewed journals, 6 book
chaptersand7books.
Farhan Jalees Ahmad is currently serving as a Professor at the Department of
Pharmaceutics, School of Pharmaceutical Education and Research, and is Dean of
School of Interdisciplinary Sciences at Jamia Hamdard, New Delhi, India. An
internationally respected researcher in the area of Pharmaceutical Sciences with
M. Pharma and PhD (Medicine) degrees from Jamia Hamdard, he continues to
teach and leads a very productive research group, which has been extensively
vviiii
viii AbouttheEditors
supportedbynationalandinternationalfundingagencies.ProfAhmadhas28years
ofexperienceinresearchandeducation,withfocusareasincludingthedevelopment,
scale-up, technology transfer and launching of pharmaceutical products, both for
domestic and international markets. He has published more than 300 research and
reviewpapers,12bookchaptersand9books.
Nanotechnology-Based Phytotherapeutics:
Current Status and Challenges
Md Abul Barkat, Harshita, Sabya Sachi Das, Sarwar Beg,
and Farhan J. Ahmad
Abstract
Nanotechnology has the potential to overcome numerous shortcomings
associated with conventional phytotherapeutics. Notable steps have been taken
towardsthereinforcementofnanophytomedicineinthetreatmentofavarietyof
illnesses with high specificity, sensitivity, and efficiency. It also improves and
overcomes the biopharmaceutical challenges involved with phytomedicine.
Phytomedicine/herbal medicine has been practiced and used by humans for
thousands of years because of their healing potential. The faith and assumption
that the medicines from the herbal origin are much more reliable and safer than
syntheticdrugs haveearned demandinrecent yearsandmanagedatremendous
growthofphytopharmaceuticals.Foroptimizedandbetteracceptabilityofherbal
medicine over synthetic medicine, the equivalent robust scientific and clinical
approachesshouldbeapplied.Also,thereisanurgentneedtodevelopavalidated
therapeutic,safety,andtoxicityprofileassociatedwithherbalmedicinetoavoid
anypotentialsideeffects.Inthecontemporarychapter,weendeavoredtoprovide
a short overview of application of nanotechnology approaches in the develop-
ment of herbal-based remedy as well as also highlight the current situation and
prospects.
M.A.Barkat·Harshita(*)
DepartmentofPharmaceutics,CollegeofPharmacy,UniversityofHafrAl-Batin,HafrAl-Batin,
SaudiArabia
S.S.Das
DepartmentofPharmaceuticalSciencesandTechnology,BIT,Mesra,Ranchi,Jharkhand,India
S.Beg·F.J.Ahmad
DepartmentofPharmaceutics,SchoolofPharmaceuticalEducationandResearch,JamiaHamdard,
NewDelhi,Delhi,India
#SpringerNatureSingaporePteLtd.2020 1
S.Begetal.(eds.),Nanophytomedicine,
https://doi.org/10.1007/978-981-15-4909-0_1
2 M.A.Barkatetal.
Keywords
Nanotechnology·Phytotherapeutics·Biopharmaceutical·Herbalmedicine·
Phytomedicine·Clinical
1 Introduction
Nanotechnologyincludesasetofmethodsandapproacheswhichutilizematerialsor
excipients at the nanoscale range to develop products with the novel, distinct, and
enhanced physicochemical and pharmacological activities. Nanotechnology-based
approachesortechniquesareinvolvedinnumerousextentsofknowledgetoendorse
improvements in the nanomedicine field, thus offer a pronounced and impending
application in the healthcare system and so have provided new approaches for the
enhancementoftherapeutics[1,2].Significantattentionhasbeenfocusedinthepast
few years over the development and formulation of herbal drugs based novel drug
delivery system (NDDS). Moreover, these herbal drugs conjugated novel
nanocarriers should preferably accomplish two requisites. Firstly, they should
deliver the therapeutically active moieties to the body at a perquisite rate and as
pertheraterequiredbythebody,throughouttreatment.Secondly,theyshouldtarget
the active moieties to the targeted sites (cells or tissues) of the body. As per the
reports, conventional dosage forms such as prolonged-release dosage forms are
incapabletomeettheseidealconditions[3].
As per World Health Organization (WHO), the definition of herbal medicine
could be justified as the practice of medicine which involves herbs, herbal
ingredients, herbal formulations, and fabricated herbal extracts, which mainly
comprises therapeutically active phytoconstituents isolated from the plant’s parts
orplantextracts,oreventheircombinations[4].Generally,theseherbalconstituents
areisolatedfromtheplantpartsincludingroots,stems,leaves,flowers,seeds,orthe
by-products (gums, resins, and many more) [5]. As per the literature and reported
studies,almost50,000plantspecieshavebeenshowedtohavemedicinalactivities
[6]. About 80% of today’s world’s populations particularly in the developing
countries, herbal medicines are still the first choice remedy for the management of
avarietyofillnessandsoitplaysavitalroleintoday'shealthwellness[7–9].More-
over, both the physicians and the patients have preferred herbal medicines or
phytomedicines due to their impending therapeutic effects and less adverse effects
ascomparedtootherconventionalmedicines[10,11],alsothephytomedicineshave
beenabletoenhancethebioavailability[12].Phytomedicinebasedtherapycouldbe
efficientlyusedtopreventandtreatvariousmalignanciesastheyaremainlyfocused
onthenaturallyoccurringchemicalentitiesfromvariousplantparts.Alsoascompared
tochemotherapy,theyhavesignificantlyenhancedthehealthconditionsofillpeople,
withreduced adverse effects [13].Unfortunately,inearlier days, due tosomeofthe
reasons such as lack of scientific rationalization and processing complications,
phytomedicines were not considered for the development of novel drug delivery
systems or formulations. To overcome these issues, modern phytopharmaceutical