Nanopharmaceuticals. Principles and Applications Volume 1 PDF
Preview Nanopharmaceuticals. Principles and Applications Volume 1
Environmental Chemistry for a Sustainable World 46 Vinod Kumar Yata Shivendu Ranjan Nandita Dasgupta Eric Lichtfouse Editors Nano- pharmaceuticals: Principles and Applications Vol.1 Environmental Chemistry for a Sustainable World Volume 46 Series Editors Eric Lichtfouse, Aix-Marseille University, CNRS, IRD, INRA, Coll France, CEREGE, Aix-en-Provence, France Jan Schwarzbauer, RWTH Aachen University, Aachen, Germany Didier Robert, CNRS, European Laboratory for Catalysis and Surface Sciences, Saint-Avold, France Other Publications by the Editors Books Environmental Chemistry http://www.springer.com/978-3-540-22860-8 Organic Contaminants in Riverine and Groundwater Systems http://www.springer.com/978-3-540-31169-0 Sustainable Agriculture Volume 1: http://www.springer.com/978-90-481-2665-1 Volume 2: http://www.springer.com/978-94-007-0393-3 Book series Environmental Chemistry for a Sustainable World http://www.springer.com/series/11480 Sustainable Agriculture Reviews http://www.springer.com/series/8380 Journals Environmental Chemistry Letters http://www.springer.com/10311 More information about this series at http://www.springer.com/series/11480 Vinod Kumar Yata • Shivendu Ranjan Nandita Dasgupta • Eric Lichtfouse Editors Nanopharmaceuticals: Principles and Applications Vol. 1 Editors Vinod Kumar Yata Shivendu Ranjan Animal Biotechnology Centre Faculty of Engineering and Built National Dairy Research Institute Environment Karnal, India University of Johannesburg Johannesburg, South Africa Nandita Dasgupta Department of Biotechnology Eric Lichtfouse Institute of Engineering and Technology CNRS, IRD, INRAE, Coll Lucknow, Uttar Pradesh, India France, CEREGE Aix-Marseille University Aix-en-Provence, France ISSN 2213-7114 ISSN 2213-7122 (electronic) Environmental Chemistry for a Sustainable World ISBN 978-3-030-44924-7 ISBN 978-3-030-44925-4 (eBook) https://doi.org/10.1007/978-3-030-44925-4 © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2021 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG. The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland Preface Nanomaterials have a special place in pharmaceutical industry due to their size and ease of penetrability into the mammalian cells. The integration of pharmaceutical drugs and therapeutic biomolecules with nanomaterials will lead to the develop- ment of novel nanopharmaceuticals for enhanced therapeutic applications. This book, Nanopharmaceuticals: Principles and Applications, is intended to provide a regular update on applications of nanopharmaceuticals along with general fundamentals. Chapter 1 presents the comprehensive description of basic principles, method- ologies, similarities and differences of liposomes and phytosomes. It also focuses on implications of these nanocarriers in CNS disorder and presents the various con- cepts of brain delivery in great detail. Chapter 2 begins with the detailed classification of nanoinonized drug particles, polymeric nanoparticles and hydrophobic nanoparticles. This is followed by a description of applications of polymeric nanoparticles. It concludes with the bio- logical, technical and study-design challenges of nanopharmaceuticals. Chapter 3 is dedicated to supermagentic iron oxide nanoparticles for the diagno- sis of brain, breast, gastric, ovarian, liver, colorectal, lung and pancreatic cancers. It begins with brief introduction to magnetic resonance imaging and ends with future prospective of iron oxide nanoparticles in cancer detection. Chapter 4 tackles the DNA nanostructures and its applications in bimolecular delivery. It also focuses on detailed description of smart DNA nanostructures and briefly discusses “computational sequence design for DNA nanostructures” at the end of the chapter. Chapter 5 includes the toxicity and application of different types of ionic liquids for humans and environment and also describes characteristics, applications and regulatory gaps of nanoparticle-ionic liquid combined systems. Chapter 6 gives a brief introduction about the skin delivery and a detailed discus- sion about the different types of nanocarriers such as micelles, microemulsions, nanoemulsions and polymeric and lipid-based nanoparticles. It also covers the safety issues, clinical benefits, ecotoxicity and regulatory framework of nanopharmaceuticals. v vi Preface Chapter 7 consists of two parts: the first part deals with detailed classification of swelling, responsive, mechanical behaviour of synthetic gels, and the second part discusses the therapeutic, diagnostic and biosensor applications of gel-based nano- pharmaceuticals. This chapter also deals with the challenges of nanogels in above- mentioned applications. Chapter 8 focuses on microfluidics-based lab-on-chip technologies for drug screening applications. It also provides detailed description of microfabrication techniques apart from cell- and organ-based drug screening techniques. Chapter 9 presents innovative and insightful information on synthesis of carbon, metal nanoparticles and semiconductor nanocrystals. It also describes the surface functionalization and targeting capabilities of nanoparticles in detail. All the chapters in this book address the impact of nanoformulations on thera- peutic and/or diagnostic purposes. Each chapter provides the basic principles to state-of-the-art developments of nanopharmaceuticals with extensive references. Karnal, India Vinod Kumar Yata Johannesburg, South Africa Shivendu Ranjan Lucknow, India Nandita Dasgupta Aix-en-Provence, France Eric Lichtfouse Contents 1 Liposomes vs Phytosomes: Principles, Methodologies, and Therapeutic Applications with Emphasis on CNS Disorders . . . . 1 Hafsa Ahmad, Abhishek Arya, Satish Agrawal, and Anil Kumar Dwivedi 2 Applications of Nanopharmaceuticals in Delivery and Targeting . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73 Mohamed Abbas Ibrahim and Ahmed A. H. Abdellatif 3 Applications of Iron Oxide Nanoparticles in the Magnetic Resonance Imaging for the Cancer Diagnosis . . . . . . 115 Kanwal Akhtar, Yasir Javed, Muhammad Imran Akhtar, and Naveed A. Shad 4 DNA-Based Nanopharmaceuticals . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 159 V. Dilna, Chinnu Sabu, and K. Pramod 5 An Overview on Ionic Liquids: A New Frontier for Nanopharmaceuticals . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 181 Tânia Santos de Almeida, Rita Caparica, Ana Júlio, and Catarina Pinto Reis 6 Therapeutic Implications of Nanopharmaceuticals in Skin Delivery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 205 Ana Henriques Mota, Ana Santos-Rebelo, António José Almeida, and Catarina Pinto Reis 7 Biomimetic and Synthetic Gels for Nanopharmaceutical Applications. . . . . . . . . . . . . . . . . . . . . . . . . . . 273 Busra Yildiz, Sezer Ozenler, Muge Yucel, Umit Hakan Yildiz, and Ahu Arslan Yildiz vii viii Contents 8 On-Chip Drug Screening Technologies for Nanopharmaceutical and Nanomedicine Applications . . . . . . . . . . 311 Rabia Onbas, Rumeysa Bilginer, and Ahu Arslan Yildiz 9 Synthesis of Some Bioactive Nanomaterials and Applications of Various Nanoconjugates for Targeted Therapeutic Applications . . . . . . . . . . . . . . . . . . . . . . . . . . 347 Sabyasachi Chakrabortty, Sunil Kumar Vimal, and Sanjib Bhattacharya Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 377 About the Editors Dr. Vinod Kumar Yata is an Interdisciplinary Researcher working in the National Dairy Research Institute, Karnal, India. Previously, he worked as an Assistant Professor in the Department of Biotechnology, Dr. B.R. Ambedkar National Institute of Technology Jalandhar, Punjab, India. He received his PhD in Biotechnology from Indian Institute of Technology Guwahati. He specializes in interdisciplinary research which includes nanotechnology, microfluidics, biotechnology, cancer biol- ogy, and bioinformatics. He has developed a microfluidic device for the separation of live and motile spermatozoa from cattle semen samples. He opened up a new avenue to prodrug enzyme therapy by introducing the nanocarriers for the delivery of non-mammalian prodrug-activating enzymes. He elucidated the structural fea- tures and binding interactions of several biomolecules by in silico methods. He has published several research papers in peer-reviewed international journals and pre- sented papers in several international conferences. ix
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