Table Of Content

Nanomedicine and Nanotoxicology Josimar O. Eloy Juliana Palma Abriata Juliana Maldonado Marchetti Editors Nanocarriers for Drug Delivery Concepts and Applications Nanomedicine and Nanotoxicology Series Editor V. Zucolotto, Institute of Physics São Carlos, University of São Paulo, São Carlos, São Paulo, Brazil More information about this series at http://www.springer.com/series/10620 Josimar O. Eloy Juliana Palma Abriata (cid:129) (cid:129) Juliana Maldonado Marchetti Editors Nanocarriers for Drug Delivery Concepts and Applications 123 Editors Josimar O.Eloy Juliana Palma Abriata Faculty of Pharmacy, Odontology and Department ofPharmaceutical Sciences Nursing, Department ofPharmacy Schoolof Pharmaceutical Sciences Federal University of Ceará University of SãoPaulo Fortaleza, Ceará,Brazil RibeirãoPreto, Brazil Juliana MaldonadoMarchetti Department ofPharmaceutical Sciences Schoolof Pharmaceutical Sciences University of SãoPaulo RibeirãoPreto, Brazil ISSN 2194-0452 ISSN 2194-0460 (electronic) Nanomedicine andNanotoxicology ISBN978-3-030-63388-2 ISBN978-3-030-63389-9 (eBook) https://doi.org/10.1007/978-3-030-63389-9 ©TheEditor(s)(ifapplicable)andTheAuthor(s),underexclusivelicensetoSpringerNature SwitzerlandAG2021 Thisworkissubjecttocopyright.AllrightsaresolelyandexclusivelylicensedbythePublisher,whether thewholeorpartofthematerialisconcerned,specificallytherightsoftranslation,reprinting,reuseof illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmissionorinformationstorageandretrieval,electronicadaptation,computersoftware,orbysimilar ordissimilarmethodologynowknownorhereafterdeveloped. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publicationdoesnotimply,evenintheabsenceofaspecificstatement,thatsuchnamesareexemptfrom therelevantprotectivelawsandregulationsandthereforefreeforgeneraluse. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained hereinorforanyerrorsoromissionsthatmayhavebeenmade.Thepublisherremainsneutralwithregard tojurisdictionalclaimsinpublishedmapsandinstitutionalaffiliations. ThisSpringerimprintispublishedbytheregisteredcompanySpringerNatureSwitzerlandAG Theregisteredcompanyaddressis:Gewerbestrasse11,6330Cham,Switzerland Preface This is the first edition of Nanocarriers for Drug Delivery, a book following a partnership between editors from the University of São Paulo and Federal UniversityofCeará,inBrazil,withcontributedchaptersfromrenownedresearchers onpharmaceuticalnanotechnologyfromavarietyofuniversitiesinBrazilandother countries. We invited researchers from major universities who have been working withusovertheyears;therefore,thisbookbringstheeffortsofaverycohesiveand unified team. Nanotechnology has undergone fast development in the pharmaceutical field, and currently a variety of drugs have been formulated in nanostructured delivery systems for treatment/diagnosis of a variety of diseases, with many advantages, including reduced side effects, controlled drug release and improved pharmacoki- netics. However, books covering more basic aspects of pharmaceutical nanotech- nologyarescarce;therefore,wedecidedtoeditabookthatnotonlyreviewsrecent innovations, but also addresses more basic and conceptual issues, for a didactic comprehension of the covered topics. The book covers basic aspects of the different nanoparticles currently available, includingthetypeofmaterials,lipid,polymericandinorganicstructures,synthesis strategies, as well as the main physicochemical characterization techniques. Also, we address herein recent applications for both treatmentand diagnosis of diseases, includingcancer,highlightinginvitroandinvivofindings,andclinicalevaluation. Furthermore, we highlight the main barriers for drug delivery which can benefit from nanoencapsulation: the topical and oral routes. The main innovations in the field, such as gene therapy, functionalization of nanoparticles with a variety of moieties,includingmonoclonalantibodiesforselectivedelivery,andphotodynamic therapy, are discussed with very recent examples. Finally, we covered toxicology and regulatory aspects, therefore, providing a thorough overview of nanoparticles for medical applications. Therefore, we covered a very wide field of nanotechnology for medical applications, which is advantageous from those who need a more complete understating of nanotechnology tools for drug delivery. v vi Preface Nanocarriers for Drug Delivery should interest researchers working with drug delivery systems and nanotechnology. We particularly aim to reach undergraduate and graduate students in the pharmaceutical sciences field, considering that our book addresses basic concepts and specific applications of drug nanocarriers. Furthermore, formulation scientists from pharmaceutical industry could take advantage of the issues discussed in the book. We hope that readers can find valuableinformationinthebookandbeinspiredtoworkinthewonderfulworldof pharmaceutical nanotechnology. Fortaleza, Brazil Josimar O. Eloy Ribeirão Preto, Brazil Juliana Palma Abriata Ribeirão Preto, Brazil Juliana Maldonado Marchetti Contents Polymeric Nanoparticles. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Marcela Tavares Luiz, Juliana Palma Abriata, Giovanni Loureiro Raspantini, and Juliana Maldonado Marchetti Lipid Nanocarriers. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19 Mariza A. Miranda, Margarete M. de Araujo, Alexandre R. Gaspari, Leticia B. Silva, Ivana P. S. Carvalho, Jacqueline C. L. Campos, and Priscyla D. Marcato Inorganic Nanoparticles for Biomedical Applications. . . . . . . . . . . . . . . 49 Paula M. P. Lins, Laís Ribovski, Isabella Sampaio, Olavo A. Santos, Valtencir Zucolotto, and Juliana Cancino-Bernardi Colloidal Disperse Systems: Microemulsions and Nanoemulsions. . . . . . 73 AndreiaAscenso,SandraSimões,JoanaMarto,HelenaMargaridaRibeiro, and António José Almeida Physicochemical Characterization of Drug Nanocarrriers . . . . . . . . . . . 83 Giovanni Loureiro Raspantini, Marcela Tavares Luiz, Melanie Tavares, and Eduardo Ricci-Junior Targeting of Drug Nanocarriers. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 107 Josimar O. Eloy, Raquel Petrilli, and Robert J. Lee Nanocarriers for Oral Drug Delivery. . . . . . . . . . . . . . . . . . . . . . . . . . . 127 Beatriz Stringhetti Ferreira Cury, Andréia Bagliotti Meneguin, Fabíola Garavello Prezotti, Fernanda Isadora Boni, and Valeria Maria de Oliveira Cardoso Nanocarriers of Drugs for Topical Delivery. . . . . . . . . . . . . . . . . . . . . . 153 Maria Teresa Junqueira Garcia, Luciana Biagini Lopes, Gislaine Ribeiro Pereira, and Newton Andréo-Filho vii viii Contents Recent Advances in Nanocarriers Used for Selective Gene Silencing Therapy. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 183 Fabíola Silva Garcia Praça, Lívia Neves Borgheti-Cardoso, Margarete Moreno de Araújo, and Maria Vitória Lopes Badra Bentley Nanocarriers for the Diagnosis and Treatment of Cancer . . . . . . . . . . . 223 Bruno Fonseca-Santos, Patrícia Bento da Silva, Josimar O. Eloy, and Marlus Chorilli Nanosystems Comprising Biocompatible Polymers for the Delivery of Photoactive Compounds in Biomedical Applications . . . . . . . . . . . . . 253 Antonio Claudio Tedesco, Fernando Lucas Primo, and Raquel Petrilli Toxicology of Nanoparticles . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 289 PatríciaMazurekiCampos,JulianaPalmaAbriata,andPriscylaD.Marcato Regulation of Nanotechnology-Based Products Subject to Health Regulations: Application of Quality by Design (QbD) and Quality Risk Management (QRM) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 319 André Luís Dias, Natália Noronha Ferreira, Leonardo Miziara Barboza Ferreira, Liliane Neves Pedreiro, Aline Martins dos Santos, and Maria Palmira Daflon Gremião About the Editors Prof. Josimar O. Eloy, Ph.D. graduated in pharmacy and biochemistry, with master´s and PhD degrees in pharmaceutical sciences by the Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Brazil. He completed an undergraduate internship at the Universidad Nacional Autonoma de México (Mexico) and an internship at the Universidad Complutense de Madrid (Spain).Hewasavisitingscholarfor1yearatTheOhioStateUniversity,USA.He completed a postdoc at Universidade Estadual Paulista (UNESP), Brazil. He has experience in the veterinary pharmaceutical industry in formulation development. Currently, he is Professor at the Federal University of Ceará (UFC), in Fortaleza, Brazil,working intheareaofpharmaceuticaltechnology andnanotechnology.His researchworkhasfocusedondevelopment,characterization(drugquantificationby HPLC, particle size by dynamic light scattering, in vitro release studies, calori- metric analysis, DSC and TGA, X-ray diffractometry, infrared spectroscopy, scanning and transmission electron microscopy) and evaluation of drug delivery systems for the treatment of diseases, especially cancer. His current research involves the strategy of functionalization of drug nanocarriers for targeting, evaluated in models in vitro (cytotoxicity and cell uptake by flow cytometry and confocalmicroscopy)andinvivo,usingxenograftmodelsinmiceforbreastcancer and prostate cancer. He is a permanent member of post-graduation course in pharmaceutical sciences at Federal University of Ceará. JulianaPalmaAbriata,Ph.D. graduatedinpharmaceuticalsciencesatUniversity of Ribeirao Preto (UNAERP). She received her master´s degree, as well as developed her doctoral research in pharmaceutical sciences by the School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Brazil. She wasaguestPhDstudentatCollegeofPharmacy,TheOhioStateUniversity,USA, under supervision of Dr Robert Lee. She has publications in drug delivery field. Currently, she is a postdoc student at School of Pharmaceutical Sciences of Ribeirao Preto, Sao Paulo, Brazil. During this time, she worked with development andcharacterizationofdrugdeliverysystemstoChagasdiseaseandovariancancer treatment. Her research work has focused on development, characterization (drug ix