Table Of Content

NANOBIOANALYTICAL APPROACHES TO MEDICAL DIAGNOSTICS This page intentionally left blank Woodhead Publishing Series in Biomaterials NANOBIOANALYTICAL APPROACHES TO MEDICAL DIAGNOSTICS Edited by PAWAN KUMAR MAURYA DepartmentofBiochemistry,CentralUniversityofHaryana, Mahendergarh, Haryana, India PRANJAL CHANDRA LaboratoryofBio-PhysioSensorsandNanobioengineering, SchoolofBiochemicalEngineering,IndianInstituteof Technology(BHU),Varanasi An imprint of Elsevier WoodheadPublishingisanimprintofElsevier 50HampshireStreet,5thFloor,Cambridge,MA02139,UnitedStates TheBoulevard,LangfordLane,Kidlington,OX51GB,UnitedKingdom Copyright©2022ElsevierLtd.Allrightsreserved. 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Practitionersandresearchersmustalwaysrelyontheirownexperienceandknowledgeinevaluating andusinganyinformation,methods,compounds,orexperimentsdescribedherein.Inusingsuch informationormethodstheyshouldbemindfuloftheirownsafetyandthesafetyofothers,including partiesforwhomtheyhaveaprofessionalresponsibility. Tothefullestextentofthelaw,neitherthePublishernortheauthors,contributors,oreditors,assume anyliabilityforanyinjuryand/ordamagetopersonsorpropertyasamatterofproductsliability, negligenceorotherwise,orfromanyuseoroperationofanymethods,products,instructions,orideas containedinthematerialherein. ISBN:978-0-323-85147-3(print) ISBN:978-0-323-85165-7(online) ForinformationonallWoodheadpublications visitourwebsiteathttps://www.elsevier.com/books-and-journals Publisher:MatthewDeans AcquisitionsEditor:SabrinaWebber EditorialProjectManager:IsabellaC.Silva ProductionProjectManager:ManjuThirumalaivasan CoverDesigner:MarkRogers TypesetbySTRAIVE,India Contents Contributors xi Preface xv 1. Prospects of fluidic forcemicroscopy and related biosensors for medical applications 1 TamásGerecsei,BeatrixP(cid:1)eter,RitaUngai-Salánki,SándorKurunczi, InnaSz(cid:1)ekács,BálintSzabó,andRobertHorvath 1.1 Atomicforcemicroscopy 1 1.2 CellbiologywithAFM 2 1.3 Fluidicforcemicroscopy 4 1.4 Single-cellforcespectroscopybyFluidFM 5 1.5 BacterialadhesionmeasuredbyFluidFM 6 1.6 Eukaryoticcelladhesion 8 1.7 Additionalfluidicforcemicroscopyfunctions 12 1.8 Measurementsbycomputer-controlled micropipette 15 1.9 Label-freebiosensorsforcelladhesionanalysis 18 1.10 Summary 22 Acknowledgments 23 References 23 2. Point ofcarediagnostics for cancer:Recent trendsand challenges 29 HemaniDara,MukundMali,HrushikeshAher,PrafullaKumarPatil, BichismitaSahu,andNehaArya 2.1 Introduction 29 2.2 Roleofbiomarkersinthedetectionofcancer 30 2.3 Point-of-carediagnosticsforcancer 40 2.4 Conclusionandfutureperspectives 57 Acknowledgments 57 References 58 v vi Contents 3. Bioelectrochemical methodsin biomolecular analysis 65 RituparnaAddy,AnkitYadav,ManojKumar,UbhatAli,AnkenapallyAnjali, VijayKumarGarlapati,SudipaBhadra,andSurajbhanSevda 3.1 Introduction 65 3.2 Typesofbioelectrochemicalmethodsforbimolecularanalysis: Workingmechanism 67 3.3 Applicationofbioelectrochemicalsystembased biosensor 71 3.4 Bioelectrochemicalmethodsforcellanalysis 85 3.5 Bioelectrochemicalmethodsforcellanalysis 91 3.6 Bioelectrochemicalmethodsforcellculturefabricationandcell stimulation 93 3.7 Prospectiveandfuturetrends 93 References 94 4. Electrochemical nano-aptasensor as potential diagnostic device for thrombin 105 WeiJuenLiew,ChitraPadmakumariKurup,MohammadRizwan, andMinhazUddinAhmed 4.1 Introduction 105 4.2 Aptasensor 106 4.3 Thrombin 116 4.4 Applicationofelectrochemicalaptasensorsin thrombindetection 122 4.5 Conclusionsandfutureoutlook 134 Conflictofinterest 134 Acknowledgments 134 References 135 5. Antibiotics and analytical methods used for their determination 143 O.I.Guliy,B.D.Zaitsev,andI.A.Borodina 5.1 Introduction 143 5.2 Antibacterialdrugsandtheextentoftheiruse 144 5.3 Conclusion 168 Acknowledgments 170 Conflictofinterest 170 References 170 Contents vii 6. Integration of microfluidics with biosensing technology for noncommunicable disease diagnosis 179 SyazanaAbdullahLim,AfiqahNabihahAhmad,RoslynnaRosli, andSitiNoorfatimahSafar 6.1 Introduction 179 6.2 Biosensortechnology 183 6.3 Microfluidicstechnology 184 6.4 Microfluidics-basedbiosensors 189 6.5 Communicationtechnology 197 6.6 Conclusion 202 References 202 7. Role andimplication of nanomaterials in clinical diagnostics 209 JuhiShah,StutiBhagat,andSanjaySingh 7.1 Introduction 209 7.2 Nanomaterialsinbioimagingbaseddiagnostics 210 7.3 Nanodevices 219 7.4 Nano-biosensors 227 7.5 Lateralflowassay 239 7.6 Safetyconcernsandlimitationsofusingnanoparticle 243 7.7 Conclusionandfutureprospects 244 Acknowledgments 244 References 245 8. Nano-materials in biochemical analysis 255 SomuYadavandPawanKumarMaurya 8.1 Introduction 255 8.2 Classificationofnanoparticles 256 8.3 Synthesisofnanoparticles 258 8.4 Functionalizationofnanomaterialsforbiochemicalapplications 260 8.5 Biochemicalapplicationsofnanoparticles 261 8.6 Conclusionandfutureprospects 278 References 279 9. Lignocellulose-based nanomaterials for diagnostic and therapeutic applications 285 HemansiandJitendraKumarSaini 9.1 Introduction 285 viii Contents 9.2 Lignocelluloseanditscomposition 287 9.3 Nanoparticlesfromlignocellulose 287 9.4 BiomedicalapplicationsofLCBnanomaterials 294 9.5 Conclusionandfutureprospects 296 References 298 10. Bioanalytical approaches in detection of free radicals andRONS 303 AdityaArya 10.1 Introduction 303 10.2 OverviewofROSdetectionmethods 305 10.3 Conventionalexvivobioanalyticalmethods 306 10.4 Conventionalinvivomethods 311 10.5 Advancemethodsforradical/RNOSdetection 314 10.6 Conclusion 316 References 316 11. Nano-biosensors for biochemical analysis 319 NimitShah,AshishBadiye,NeetiKapoor,andRiteshK.Shukla 11.1 Introduction 319 11.2 Biosensors 322 11.3 AuNP-basedbiosensors 325 11.4 Carbonnanotubebasedbiosensors 327 11.5 Quantumdotsbasedbiosensors 328 11.6 Nanoparticlesinanalyticalbiochemistry 328 11.7 Nanoparticlesinbioassays 336 11.8 Applications 337 11.9 Conclusionandfutureperspectives 338 Acknowledgments 339 References 339 12. Nanobiomaterials inbiomedicine: Designing approaches andcritical concepts 345 PallabiBanerjeeandImteyazQamar 12.1 Introduction 345 12.2 Nanomaterialsandit’sapplicationsinnanomedicine 346 12.3 Nanoparticlesusedindrugdeliverysystem 351 12.4 Conclusion 357 References 358 Contents ix 13. Erythrocytes modelfor oxidative stress analysis 363 VikramDalalandSagarikaBiswas 5.1 Oxidativestress 363 5.2 Oxidativestressanddiseases 367 5.3 Oxidativestressandautoimmunediseases 371 5.4 Oxidativestressandrheumatoidarthritis 374 5.5 Oxidativestressanderythrocytes 377 5.6 Conclusion 379 Acknowledgment 381 Authorscontributions 381 References 381 14. Lipid film based biosensors:A protectiontool for the public health 391 Georgia-ParaskeviNikoleli 14.1 Introduction 391 14.2 Constructionoflipidfilmbasednanosensors 392 14.3 Applicationsoflipidfilmbasedbiosensorsinclinicalanalysisforthe protectionofpublichealth 396 14.4 Conclusion 400 References 401 Index 405