NA+H+ EXCHANGE PDF
Preview NA+H+ EXCHANGE
Na+/H+ Exchange Editor Sergio Grinstein, Ph.D. Associate Professor Department of Cell Biology The Hospital for Sick Children and Department of Biochemistry University of Toronto Toronto, Canada Boca Raton London New York CRC Press is an imprint of the Taylor & Francis Group, an informa business First published 1988 by CRC Press Taylor & Francis Group 6000 Broken Sound Parkway NW, Suite 300 Boca Raton, FL 33487-2742 Reissued 2018 by CRC Press © 1988 by CRC Press, Inc. CRC Press is an imprint of Taylor & Francis Group, an Informa business No claim to original U.S. Government works This book contains information obtained from authentic and highly regarded sources. Reasonable efforts have been made to publish reliable data and information, but the author and publisher cannot assume responsibility for the validity of all materials or the consequences of their use. 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CCC is a not-for-profit organization that provides licenses and registration for a variety of users. For organizations that have been granted a photocopy license by the CCC, a separate system of payment has been ar- ranged. Trademark Notice: Product or corporate names may be trademarks or registered trademarks, and are used only for identification and explanation without intent to infringe. Library of Congress Cataloging-in-Publication Data Na+ /H+ exchange/editor, Sergio Grinstein. p. cm. Bibliography: p. Includes index. ISBN 0-8493-4701-7 1. Ion exchange—Research—Methodology. 2. Sodium ions—Research- -Methodology. 3. Hydrogen ions—Research—Methodology. 4. Cellular control mechanisms—Research—Methodology. I. Grinstein, Sergio. 1950- . QH604.5.N3 1988 574.87’5—dc19 87-27840 A Library of Congress record exists under LC control number: 87027840 Publisher’s Note The publisher has gone to great lengths to ensure the quality of this reprint but points out that some imperfections in the original copies may be apparent. Disclaimer The publisher has made every effort to trace copyright holders and welcomes correspondence from those they have been unable to contact. ISBN 13: 978-1-315-89578-9 (hbk) ISBN 13: 978-1-351-07488-9 (ebk) Visit the Taylor & Francis Web site at http://www.taylorandfrancis.com and the CRC Press Web site at http://www.crcpress.com PREFACE Na+fH+ exchange was first discovered in 1976. The field lay donnant until the early 1980s, when an explosion in interest and knowledge occurred. Since then, the number of publications dealing directly or indirectly with Na+ fH+ exchange has increased exponen- tially. The reasons behind this interest are not only the ubiquity of the exchanger, but the realization that, unlike other transport systems, it is involved in a variety of cellular functions. Na+fH+ exchange seems to be central to pH regulation, to transepithelial salt transport in "leaky" epithelia, and to the control of cellular volume. Activation of Na+fH+ exchange has also been proposed as a signal for cellular proliferation and differentiation. In addition, the activity of the exchanger appears to be modulated by a bewildering array of biological agents, including honnones, growth factors, tumor-promoting agents, and chemotactic fac- tors. What detennines the primary function of the exchanger in a particular cell type is largely unknown, but strict controls and/or interactions with other transport systems, such as the CI-/HCO) exchanger, must exist. To this date, some individual aspects of the function of the Na +/ H+ exchanger (or antiport) have been reviewed, but a comprehensive, up-to-date treatise of its structure, function, and regulation was not available. It is the purpose of this volume to provide a succinct summary of our present knowledge of the physiology, biochemistry, and phannacology of Na+fH+ exchange. Sergio Grinstein May, 1987 ACKNOWLEDGMENTS I want to express my gratitude to all the authors that contributed to this volume (particularly those who submitted their chapters before the deadline!). I thank Toni Smith for expert secretarial assistance. Her arm-twisting ensured timely delivery of some of the chapters. S. G. is the recipient of a Medical Research Council of Canada Scientist Award. THE EDITOR Sergio Grinstein, Ph.D., is an Associate Professor at the Department of Cell Biology of the Hospital for Sick Children in Toronto and holds a cross-appointment at the Department of Biochemistry of the University of Toronto. Dr. Grinstein received his Ph.D. at the Polytechnical Institute of Mexico City and trained as a post-doctoral fellow in Canada and Switzerland. Dr. Grinstein is a member of the American Physiological Society, the Society of General Physiologists, and the Biophysical Society. His research interests are in the areas of ion transport and signal transduction across biological membranes. He has published over 100 articles and has made presentations at more than 20 scientific meetings. Dr. Grinstein is currently an Associate Editor for the American Journal of Physiology. CONTRIBUTORS Pascal Barbry David Epel, Ph.D. Center for Biochemistry Professor of Biological Sciences University of Nice Hopkins Marine Station C.N.R.S. Stanford University Nice, France Pacific Grove, California Martine Bassilana, Ph.D. Leon G. Fine, M.D. Permanent Investigator Professor of Medicine and Department of Biology Chief of the Division of Nephrology Atomic Energy Commission Department of Medicine C.N.R.S. University of California at Los Angeles Villefranche, France School of Medicine Los Angeles, California Dale J. Benos, Ph.D. Professor Department of Physiology and Arthur L. Finn, M.D. Biophysics Departments of Medicine and University of Alabama Medical Center Physiology Birmingham, Alabama University of North Carolina School of Medicine A. J. Bierman Chapel Hill, North Carolina Hubrecht Laboratory Institute for Developmental Biology Arlette Franchi Utrecht, Netherlands Center for Biochemistry University of Nice W. F. Boron C.N.R.S. Department of Cellular and Molecular Nice, France Physiology Yale University School of Medicine New Haven, Connecticut Christian Frelin Center for Biochemistry Peter M. Cala, Ph.D. University of Nice Associate Professor C.N.R.S. Department of Human Physiology Nice, France University of California School of Medicine Federico Garcia-Romeo, D.Sc. Davis, California Director of Research Laboratoire Jean Maetz Evelyne Damiano-Forano, Ph.D. Department of Biology Permanent Investigator C.E.A. Department of Microbiology Villefranche Sur Mer, France I.N.R.A. Clermont-Ferrand, France Robert J, Gillies, Ph.D. Siegfried W. de Laat Assistant Professor Hubrecht Laboratory Department of Biochemistry Institute for Developmental Biology Colorado State University Utrecht, Netherlands Fort Collins, Colorado Sergio Grinstein, Ph.D. Alain E. Lagarde, Ph.D., D.Sc. Associate Professor Senior Research Scientist Department of Cell Biology Department of Cancer and Cell Biology Hospital for Sick Children Mt. Sinai Hospital Research Institute Toronto, Ontario, Canada Toronto, Ontario, Canada Robert Gunther Michel Lazdunski Adjunct Assistant Professor of Medicine Center for Biochemistry Division of Nephrology University of Nice Department of Medicine C.N.R.S. University of California at Los Angeles Nice, France School of Medicine Gerard Leblanc, Ph.D., D.Sc. Los Angeles, California Permanent Investigator Department of Biology Ron Jacob, Ph.D. Atomic Energy Commission Department of Cellular Pharmacology Villefranche, France Smith, Kline & French Research, Ltd. Welwyn, Hertfordshire, England Melvyn Lieberman, Ph.D. Professor Thierry Jean Department of Physiology Center for Biochemistry Duke University Medical Center University of Nice Durham, North Carolina C.N.R.S. Nice, France Thaddeus Molski, B.A. Research Assistant James L. KinseDa, Ph.D. Department of Physiology Research Physiologist University of Connecticut Health Center Regulatory Mechanisms Section Farmington, Connecticut National Institute of Aging National Institutes of Health Marshall H. Montrose, Ph.D. Baltimore, Maryland Postdoctoral Fellow Physiology Institute Amira Knp, Ph.D. University of Zurich Associate Professor Zurich, Switzerland Department of Biochemistry and Pediatrics W. H. Moolenaar, Ph.D. University of Toronto The Netherlands Cancer Institute Toronto, Ontario, Canada Department of Cellular Biochemistry Amsterdam, Netherlands Ira Kurtz Assistant Professor of Medicine Rene Motais, D.Sc. Division of Nephrology Professor Department of Medicine Laboratoire Jean Maetz University of California at Los Angeles Department of Biology School of Medicine C.E.A. Los Angeles, California Villefranche Sur Mer, France Heini Murer, Ph.D. Robert W. Putnam, Ph.D Professor of Physiology Assistant Professor Physiology Institute Department of Physiology and University of Zurich Biophysics Zurich, Switzerland Wright State University School of Medicine N. L. Nakhoul Dayton, Ohio Department of Cellular and Molecular Physiology Philip M. Rosoff, M.D. Yale University School of Medicine New Haven, Connecticut Assistant Professor Department of Pediatrics and Physiology Edward P. Nord, M.D. Tufts University School of Medicine Assistant Professor of Medicine Boston, Massachusetts Division of Nephrology Department of Medicine John M. Russell, Ph.D. University of California at Los Angeles School of Medicine Professor Los Angeles, California Department of Physiology and Biophysics Linda S. Okerlund, B.S. University of Texas Medical Branch Research Assistant Galveston, Texas Department of Biochemistry Colorado State University Bertram Sacktor, Ph.D. Fort Collins, Colorado Chief of the Laboratory of Biological Chemistry John C. Parker, M.D. National Institute of Aging Professor Gerontology Research Center Department of Medicine National Institutes of Health University of North Carolina School of Baltimore, Maryland Medicine Chapel Hill, North Carolina Claude Sardet David Piwnica-Worms, M.D., Ph.D. Center for Biochemistry Instructor University of Nice Department of Radiology C.N.R.S. Harvard Medical School Nice, France Boston, Massachusetts Ramadan I. Sha'afi, Ph.D. Allan S. Pollock, M.D. Professor Assistant Professor Department of Physiology Department of Medicine University of Connecticut Health Center University of California Farmington, Connecticut San Francisco, California Jacques Pouyssegur, D.Sc., Ph.D. Richard Vaughan-Jones Center for Biochemistry Lecturer University of Nice Laboratory of Physiology C.N.R.S. Oxford University Nice, France Oxford, England Paul Vigne Mitchel L. Villereal, Ph.D. Center for Biochemistry Associate Professor University of Nice Department of Pharmacological and C.N.R.S. Physiological Sciences Nice, France University of Chicago Chicago, Illinois David Warnock, M.D. Professor Department of Medicine and Pharmacology University of California San Francisco, California
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