Description:Myomas are the most common benign tumor in women of reproductive age, affecting 20-50% of this population and they are the single most common indication for hysterectomy. Recent research on the cellular and molecular biology of myomas enabled us to better understand the pathogenesis and pathophysiology of this tumor. On the clinical arena, novel methods of conservative treatment approaches for myomas have been developed to allow many women to keep their reproductive capacity. This issue covers both recent advances in the understanding of the biology of myomas, and discuss the standard and new options for the treatment of myomas.