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Access to the eBook is limited to the first individual who redeems the PIN, located on the inside cover of this book, at expertconsult.inkling.com and may not be transferred to another party by resale, lending, or other means. i MYOCARDIAL INFARCTION A Companion to Braunwald’s Heart Disease This page intentionally left blank MYOCARDIAL INFARCTION A Companion to Braunwald’s Heart Disease David A. Morrow, MD, MPH Professor of Medicine, Harvard Medical School Director, Levine Cardiac Intensive Care Unit Cardiovascular Division, Brigham and Women’s Hospital Director, TIMI Biomarker Program Senior Investigator, TIMI Study Group Boston, Massachusetts 3251 Riverport Lane St. Louis, Missouri 63043 MYOCARDIAL INFARCTION: A COMPANION TO BRAUNWALD’S HEART DISEASE, 1e ISBN: 978-0-323-35943-6 Copyright © 2017 by Elsevier Inc. All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publisher’s permissions policies, and our arrangements with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency can be found at our website: www.elsevier.com/permissions. This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein). Notices Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary. Practitioners and researchers must always rely on their own experience and knowledge in evaluat- ing and using any information, methods, compounds, or experiments described herein. In using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility. With respect to any drug or pharmaceutical products identified, readers are advised to check the most current information provided (i) on procedures featured or (ii) by the manufacturer of each product to be administered, to verify the recommended dose or formula, the method and duration of administration, and contraindications. It is the responsibility of practitioners, relying on their own experience and knowledge of their patients, to make diagnoses, to determine dosages and the best treatment for each individual patient, and to take all appropriate safety precautions. To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors assume any liability for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein. Library of Congress Cataloging-in-Publication Data Names: Morrow, David A. (David Andrew), editor. Title: Myocardial infarction : a companion to Braunwald’s heart disease / [edited by] David A. Morrow. Other titles: Myocardial infarction (Morrow) | Complemented by (work): Braunwald’s heart disease. Description: 1e. | St. Louis, Missouri : Elsevier, [2017] | Complemented by: Braunwald’s heart disease. | Includes bibliographical references and index. Identifiers: LCCN 2016021702 | ISBN 9780323359436 (hardcover : alk. paper) Subjects: | MESH: Myocardial Infarction Classification: LCC RC685.I6 | NLM WG 310 | DDC 616.1/237--dc23 LC record available at https://lccn.loc. gov/2016021702 Executive Content Strategist: Dolores Meloni Senior Content Development Specialist: Anne Snyder Publishing Services Manager: Catherine Jackson Senior Project Manager: Clay S. Broeker Design Direction: Renee Duenow Printed in China Last digit is the print number: 9 8 7 6 5 4 3 2 1 To Samantha, Sarah, and Becca This page intentionally left blank Contributors Antonio Abbate, MD, PhD Erin A. Bohula, MD, DPhil James C. Roberts, Esquire Professor of Cardiology TIMI Study Group and Division of Cardiology VCU Pauley Heart Center Brigham and Women’s Hospital Virginia Commonwealth University Harvard Medical School Richmond, Virginia Boston, Massachusetts Dominick J. Angiolillo, MD, PhD Roberto Bolli, MD Professor of Medicine Chief, Division of Cardiovascular Medicine Medical Director, Cardiovascular Research Director, Institute of Molecular Cardiology Director, Interventional Cardiology Fellowship Program Executive Vice Chair, Department of Medicine Division of Cardiology University of Louisville University of Florida College of Medicine—Jacksonville Louisville, Kentucky Jacksonville, Florida Marc P. Bonaca, MD, MPH Nandan S. Anavekar, MBBCh, FACC Associate Physician Associate Professor of Medicine Division of Cardiovascular Medicine Department of Cardiovascular Diseases Brigham and Women’s Hospital Department of Radiology Instructor, Harvard Medical School Mayo Clinic Investigator, TIMI Study Group Rochester, Minnesota Boston, Massachusetts Paul W. Armstrong, MD Jason S. Bradfield, MD, FACC, FHRS Distinguished University Professor of Medicine Assistant Professor of Medicine Founding Director, Canadian VIGOUR Centre Director, Specialized Program for Ventricular Tachycardia University of Alberta UCLA Cardiac Arrhythmia Center Edmonton, Alberta, Canada David Geffen School of Medicine at UCLA Los Angeles, California Kevin R. Bainey, MD, MSc, FRCPC Assistant Professor of Medicine Eugene Braunwald, MD, MD(Hon), ScD(Hon), FRCP Interventional Cardiologist Distinguished Hersey Professor of Medicine Director, Interventional Cardiology Fellowship Program Harvard Medical School Associate Faculty, Canadian VIGOUR Centre Founding Chairman, TIMI Study Group University of Alberta/Mazankowski Alberta Heart Institute Brigham and Women’s Hospital Edmonton, Alberta, Canada Boston, Massachusetts Jacob F. Bentzon, MD, PhD Una Buckley, MD Professor Electrophysiology Fellow Centro Nacional de Investigaciones Cardiovasculares UCLA Cardiac Arrhythmia Center Carlos III (CNIC) David Geffen School of Medicine at UCLA Madrid, Spain Los Angeles, California Associate Professor Department of Clinical Medicine Edward T. Carreras, MD Aarhus University Fellow Aarhus, Denmark Division of Cardiovascular Medicine Brigham and Women’s Hospital Deepak L. Bhatt, MD, MPH, FACC, FAHA, FSCAI, FESC Harvard Medical School Executive Director, Interventional Cardiovascular Programs Boston, Massachusetts Heart and Vascular Center, Brigham and Women’s Hospital Senior Investigator, TIMI Study Group Professor of Medicine, Harvard Medical School Boston, Massachusetts vii viii Guillaume Cayla, MD, PhD Francesco Franchi, MD Professor of Cardiology Assistant Professor of Medicine Department of Cardiology CHU Nimes Division of Cardiology s r o Nimes University Hospital University of Florida College of Medicine-Jacksonville t u University of Montpellier Jacksonville, Florida b ri Member of the ACTION Study Group t n o Nimes, France J. Michael Gaziano, MD, MPH C Chief, Division of Aging, Brigham and Women’s Hospital Jean Philippe Collet, MD, PhD Scientific Director, Massachusetts Veterans Epidemiology Professor of Cardiovascular Medicine Research and Information Center UPMC (PARIS 6) Veterans Administration Boston Healthcare System ACTION Study Group Professor of Medicine Institut de Cardiologie Harvard Medical School Pitié-Salpêtrière University Hospital Boston, Massachusetts Paris, France Thomas A. Gaziano, MD, MSc Jeremiah P. Depta, MD, MPHS, FACC Assistant Professor Director of the Advanced Valvular and Structural Heart Harvard Medical School Disease Program Cardiovascular Medicine Division Sands-Constellation Heart Institute Brigham and Women’s Hospital Rochester General Hospital Boston, Massachusetts Rochester, New York Shahab Ghafghazi, MD Marcelo F. Di Carli, MD Assistant Professor of Medicine Assistant Professor of Radiology and Medicine Division of Cardiovascular Medicine and Institute of Harvard Medical School Molecular Cardiology Chief, Division of Nuclear Medicine and Molecular Imaging Department of Medicine Director, Noninvasive Cardiovascular Imaging Program University of Louisville Brigham and Women’s Hospital Louisville, Kentucky Boston, Massachusetts Christopher B. Granger, MD Jacob A. Doll, MD Professor of Medicine Division of Cardiology Division of Cardiovascular Diseases Duke University Medical Center Duke University Medical Center Durham, North Carolina Durham, North Carolina Anique Ducharme, MD, MSc John D. Grizzard, MD Professor of Medicine Associate Professor Université de Montréal Departments of Radiology and Internal Medicine Director, Heart Failure Clinic Charles L. Baird Professor of Non-Invasive Cardiovascular Montreal Heart Institute Imaging Montreal, Quebec, Canada VCU Health Systems Richmond, Virginia Erling Falk, MD, PhD Professor Sharon L. Hale, BS Department of Clinical Medicine Assistant Editor Aarhus University Journal of Cardiovascular Drugs and Therapy Department of Cardiology Huntington Medical Research Institutes Aarhus University Hospital Pasadena, California Aarhus, Denmark Timothy D. Henry, MD James C. Fang, MD Director Professor of Medicine Division of Cardiology Division of Cardiovascular Diseases Cedars-Sinai Heart Institute University of Utah Los Angeles, California Salt Lake City, Utah Udo Hoffmann, MD, MPH Keith A. A. Fox, MBChB, FRCP, FESC, FACC Professor of Radiology Professor of Cardiology Chief, Division of Cardiovascular Imaging Consultant Cardiologist Department of Radiology University of Edinburgh Massachusetts General Hospital and Harvard Medical Edinburgh, Scotland, United Kingdom School Boston, Massachusetts

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Get the tools and knowledge you need for effective diagnosis, evaluation, and management of patients with acute myocardial infarction. Myocardial Infarction: A Companion to Braunwald's Heart Disease, by David A. Morrow, MD, is a comprehensive, hands-on resource that provides practical guidance from