Myocardial and Skeletal Muscle Bioenergetics

663 Pages·1986·18.234 MB·English

by  Samuel P. Bessman (auth.), Nachman Brautbar (eds.)

MYOCARDLAL AND
SKELETAL MUSCLE
BIOENERGETICS
ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY
Editorial Board:
NATHAN BACK, State University of New York at Buffalo
NICHOLAS R. DI LUZIO, Tulane University School of Medicine
EPHRAIM KA TCHALSKI-KA TZIR, The Weizmann Institute of Science
DAVID KRITCHEVSKY, Wistar Institute
ABEL LA1THA, Rockland Research Institute
RODOLFO PAOLETTI, University of Milan
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MYOCARDIAL AND
SKELETAL MUSCLE
BIOENERGETICS
Edited by
Nachman Brautbar
University of Southern California School of Medicine
and Hollywood Presbyterian Medical Center
Los Angeles, California
PLENUM PRESS • NEW YORK AND LONDON
Library of Congress Cataloging in Publication Data
International Congress on Myocardial and Cellular Bioenergetics and Compartmenta
tion (2nd: 1984: University of Southern California)
Myocardial and skeletal muscle bioenergetics.
(Advances in experimental medicine and biology; v. 194)
"Proceedings of the Second International Congress on Myocardial and Cellular
Bioenergetics and Compartmentation, held February 16-18, 1984 at the University of
Southern California, Los Angeles, California" - T.p. verso.
Includes bibliographies and index.
1. Muscles-Congresses. 2. Heart-Muscle-Congresses. 3. Bioenergetics. 4. Cell
compartmentation. 5. Tissue respiration. I. Brautbar, Nachman. II. Title: III. Series.
[DNLM: 1. Cell Compartmentation-congresses. 2. Energy Metabolism-congresses.
3. Energy Transfer-drug effects-congresses. 4. Myocardium-metabolism-con
gresses. WI AD559 v.194/WG 280 1594 1984m]
QP321.I525 1984 599'.01852 86-4883
ISBN-13: 978-1-4684-5109-2 e-ISBN-13: 978-1-4684-5107-8
DOl: 10.1007/978-1-4684-5107-8
Proceedings of the Second International Congress on Myocardial and Cellular
Bioenergetics and Compartmentation, held February 16-18, 1984,
at the University of Southern California, Los Angeles, California
© 1986 Plenum Press, New York
Softcover reprint of the hardcover 1s t edition 1986
A Division of Plenum Publishing Corporation
233 Spring Street, New York, N.Y. 10013
All rights reserved
No part of this book may be reproduced, stored in a retrieval system, or transmitted
in any form or by any means, electronic, mechanical, photocopying, microfilming,
recording, or otherwise, without written permission from the Publisher
To my parents, wife, and children who supported me and stood
behind me at all times
PREFACE
I am pI eased to present to the readers the Proceedings of the
Second International Congress on Myocardial and Cellular Bioenerge
tics and Compartmentation which was held in Los Angeles during
February 16-18, 1984.
I would I ike to express my deep appreciation to all those who
have encouraged us to hold the Second International Congress. This
endeavor could not have been possible without the generous finan
cial support of the following: The American Society for Magnesium
Research, The University of Southern California Department of Con
tinuing Medical Education, Alpha Therapeutics, ALSEB Scientific
Products, The American Physiological Society, Ciba-Geigy Corpora
tion, Victor Gura, M.D., Merck Sharp and Dohme, Phosphoenergetics,
Stuart Pharmaceuticals, and the Upjohn Company.
A note of special thanks goes to Samuel Bessman, M.D., who has
been a source of constant support and encouragement for this Con
gress and for my research endeavors.
Nachman Brautbar
vii
CONTENTS
I. HICROCOMPARTHENTATION AND ENERGY TRANSPORT:
The Physiological Significance of the Creatine Phosphate
Shuttle . . . . . . . . .. . ........ .
S. P. Bessman
Organization of the Mitochondrial Matrix 13
P. A. Srere and B. Sumegi
The Time Course of ATP Cleavage by Contracting
Amphibian and Mammalian Skeletal Muscles 27
E. Homsher
Isozymes of Creatine Kinase in Mammalian Myocardial
Cell Culture • . . . • • • . . . . . • . . . 41
M. W. Seraydarian and T. Yamada
Microcompartmentation at the Mitochondrial Surface:
Its Function in Metabolic Regulation •• 55
D. Brdiczka, G. Knoll, I. Riesinger, U. Weiler,
G. Klug, R. Benz, and J. Krause
The Effect of Inorganic Phosphate on Mitochondrial
Creatine Kinase . • . • . . . . . . . . . . . 71
N. Hall and M. DeLuca
Hormonal Regulation of Creatine Kinase BB 83
A. M. Kaye, N.A. Reiss, Y. Weisman, I.
Binderman, and D. Somjen
Compartmentation of Adenine Nucleotides and
Phosphocreatine Shuttle in Cardiac Cells:
Some New Evidence • • • . • • •• •.••.• 103
v.
A. Saks, A. V. Kuznetsov, Z. A. Huchua,
and V. V. Kupriyanov
ix
Compartmentation of Hormone Action in Adul t
Mammalian Cardiomyocytes • • • 117
I. L. O. Buxton and L. L. Brunton
Function of Creatine Kinase Localization in Muscle
Contraction • • • • • • • • • • 129
S. Koons and R. Cooke
Isotope Labeling Ratios: A Tool for the Exploration
of Me ta bol ic Compartments • • • • • • • • • • • • • • • 139
J. K. Kelleher and R. T. Mallet
The Mitochondrial Creatine Phosphokinase is
Associated with Inner Membrane Cardiolipin •••••• 151
M. Muller, D. Cheneval and E. Carafoli
A Role for Mitochondria in Myocardial Adenosine
Production • • • • • • • • • • • • • • • • • 157
R. D. Bukoski, H. V. Sparks and L. M. Mela-Riker
II. RESPIRATION CONTROL - CELLULAR AND ORGAN LEVEL:
Aspects of Heart Respiratory Control by the Mito-
chondrial Isozyme of Creatine Kinase •••• 169
W. E. Jacobus, K. M. Vandegaer and R. W. Moreadith
Control of Respiration in Intact Muscle • • • • • • 193
M. Mahler
Energy Compartmentation and Active Transport in
Proximal Kidney Tubules. • • • • • • • • ••••• 213
L. J. Mandel, S. P. Soltoff and P. C. Brazy
The Oxygen Dependence of Cellular Energy Metabolism • • • • • 229
D. F. Wilson and M. Erecinska
Regulation of Mitochondrial Respiration in Liver • • • 241
A. J. Verhoeven, C. W. T. van Roermund,
P. J. A. M. Plomp, R. J. A. Wanders, A. K. Groen
and J. M. Tager
Quantitation of Fluxes in the Gluconeogenic,
Glycolytic, and Pentose Phosphate Pathways in
Isolated Rat Hepatocytes: Energetic
Considerations ••••••• • • • • • • • • • 255
J. J. Blum and M. S. Rabkin
x
Why is There a Delay in the Increased Oxygen Consumption
During the Rest-Work Transition in Skeletal
Muscle? • . • . • • • • • • • • • • • • • • • • • . • . • 271
R. J. Connett
III. MYOCARDIAL PRESERVATION, ISCHmrrA: CELLULAR MECHANISMS
Compartmentation and Functional Mechanisms in
Myocardia I F ai I ure and Myocardial Infarction .••••• 283
R. J. Bing, Y. Sasaki, M. Chemnitius and W. Burger
Myocardial Protection of Hypertrophied Hearts
by Administration of Cardioplegia According
to Regional Myocardial Temperature ••••••••• 297
G. Gorlach, H. H. ScheId, F. Polzuweit,
J. Mulch, W. Schaper, and F. W. Hehrlein
Heart Myocytes as Models of the Cellular Response
to Ischemia • • • • • • • • • •• ••••• 303
G. P. Brierley, W. C. Wenger and R. A. Altschuld
Biologic Basis for Limitation of Infarct Size • • • • • • • • • 315
K. A. Reimer and R. B. Jennings
Mitochondrial Transmembrane Proton Electrochemical
Potential, Di- and Tricarboxylate Distribution
and the Poise of the Malate-Aspartate Cycle in
the Intact Myocardium • • • • • • • • • • • •• • ••• 331
R. A. Kauppinen, J. K. Hiltunen and I. E. Hassinen
Sarcomere Length-tension Relationship in Toad
Atrioventricular Pacemaker: Length Dependent
Activation • • • • • • 343
J. R. Lopez and D. Lea
Myocardial Acidosis and the Mitigation of Tissue ATP
Dep I etion in Ischemic Cardiac Musc Ie: The
Role of the Mitochondrial ATPase •••••••••••• 355
W. Rouslin
Vascular Metabolism and Energetics • • • • • • • • • • • • • • 375
R. J. Paul, R. M. Lynch and J. M. Krisanda
Myocardial Glutamate Dehydrogenase Activity ••••••••• 389
H. G. McDaniel and R. L. Jenkins
xi
Long Term Model for Evaluation of Myocardial
Metabolic Recovery Following Global Ischemia •••••• 401
J. St. Cyr, H. Ward, J. Kriett, D. Alyono,
S. Einzig, R. Bianco, R. Anderson, and J. Foker
The Effect of Reperfusion and Streptokinase on Ischemic
Myocardium Serum Creatine Kinase Activity, MM
Subtypes and Myocardial Blood Flow ••••••••••• 415
J. Mickelson, C. J. Carlson, B. Emilson and E. Rapaport
Post-contracture Reperfusion: Effect of Elevated
Potassium and Verapamil. • • • • • • •••• 427
S. B. Digerness, W. G. Tracy, N. F. Andrews
and J. W. Kirklin
Ultrastructure of the Human Myocardium after Intermittent
Ischemia Compared to Cardioplegia. • ••.•••.• 439
G. Gorlach, H. H. Scheld, J. Mulch, J. Schaper,
and F. W. Hehrlein
IV. PATHOPHYSIOLOGY OF ENERGY COMPAR'l'MENTATION:
Cell ular Injury in Phosphate Depletion: Patho-
genesis and Mechanisms in the Myocardium ••••• 451
N. Brautbar
Diabetes Mell i tus and Hypothyroidism Induce Changes
in Myosin Isoenzyme Distribution in the Rat
Heart - Do Alterations in Fuel Flux Mediate
These Changes? ••••••••••••••••••••• 469
W. H. Dillmann
Glycerol Kinase Deficiency: Compartmental Considerations
Regarding Pathogenesis and Clinical Heterogeneity •••• 481
E. R. B. McCabe, and W. K. Seltzer
Phosphorylated Nucleotides and Glycolytic Intermediates
in Diabetic and Non-diabetic Rat uterus in Late
Pregnancy . . . . . . . . . . . . . . . . . . . . . . . . 495
I. Zaidise, P. J. Geiger, D. Boehme and S. P. Bessman
Effect of Calcium Antagonists on Vasopressin Induced
Changes in Myocardial and Renal Pyridine Nucleo-
tides in the Intact Rat •••••••••••••••.• 503
D. DiPette, R. Townsend, J. Guntipalli,
K. Simpson, A. Rogers and E. Bourke
xii