Table Of Content

Mutation Research, 250 (1991) 503-505 © 1991 Elsevier Science Publishers B.V. All rights reserved 0027-5107 /91 /$03.50 Contents Volume 250 (1991) Editorial introduction F.H. Sobels (The Netherlands) Research Papers Endogenous mutagens and the causes of aging and cancer B.N. Ames and L.S. Gold (U.S.A.) Dietary modulation of DNA damage in human M.G. Simic and D.S. Bergtold (U.S.A.) Implications of newly recognized relationships between mutagenicity, genotoxicity and carcinogenicity of molecules H.S. Rosenkranz, Y. Ping Zhang and G. Klopman (U.S.A.) The significance of deletions in spontaneous and induced mutations associated with movement of transposable DNA elements: possible implications for evolution and cancer D.G. MacPhee (Australia) Comparison of spontaneous and ultraviolet-induced mutagenesis on naked SV40 DNA and SV40 virus F. Bourre, A. Lichtenberger and A. Sarasin (France) Mechanisms of spontaneous mutation in DNA repair-proficient Escherichia coli J.A. Halliday and B.W. Glickman (Canada) Protective effects of sodium selenite on killing and mutation by N-methyl-N ’-nitro-N-nitrosoguanidine in E. coli M. Sato, T. Nunoshiba, H. Nishioka, T. Yagi and H. Takebe (Japan) The metabolic activation of 4-nitro-o-phenylenediamine by chlorophyll-containing plant extracts: The relationship between mutagenicity and antimutagenicity J.M. Gentile and G.J. Gentile (U.S.A.) Prevention by N-acetylcysteine of benzo[ a}pyrene clastogenicity and DNA adducts in rats S. De Flora, F. D’Agostini, A. Izzotti and R. Balansky (Italy) Role of antioxidants in protecting cellular DNA from damage by oxidative stress E.A.L. Martins, L.S. Chubatsu and R. Meneghini (Brazil) Carcinogen metabolism and DNA adducts in human lung tissues as affected by tobacco smoking or metabolic phenotype: a case—control study on lung cancer patients H. Bartsch, S. Petruzzelli, S. De Flora, E. Hietanen, A.-M. Camus, M. Castegnaro, O. Geneste, A. Camoirano, R. Saracci and C. Giuntini (France, Italy, Finland) The non-genotoxicity to rodents of the potent rodent bladder carcinogens o-anisidine and p-cresidine J. Ashby, P.A. Lefevre, H. Tinwell, G. Brunborg, P. Schmezer, B. Pool-Zobel, R. Shannu-Wilson, J.A. Holme, E.J. Soderlund, D. Gulati and J.P. Wojciechowski (Great Britain, Germany, Norway, U.S.A.) Bulky adducts detected by - P-postlabeling in DNA modified by oxidative damage in vitro. Comparison with rat lung I-compounds K. Randerath, P.-F. Yang, T.F. Danna, R. Reddy, W.P. Watson and E. Randerath (U.S.A., Great Britain) Comparative direct-acting mutagenicity of 1- and 2-nitropyrene: Evidence for 2-nitropyrene mutagenesis by both guanine and adenine adducts S. Yu, R.H. Heflich, L.S. Von Tungeln, K. El-Bayoumy, F.F. Kadlubar and P.P. Fu (U.S.A.) DNA sequence dependence of guanine-O® alkylation by the N-nitroso carcinogens N-methyl- and N-ethyl-N- nitrosourea K. Sendowski and M.F. Rajewsky (F.R.G.) Formation of 2-nitro-3-methylimidazo[4,5-/ }quinoline, a directly mutagenic product, by near-ultraviolet irradiation of a mixture of 2-amino-3-methylimidazo[4,5-/ }quinoline and N-nitrosodimethylamine S. Arimoto and H. Hayatsu (Japan) Mutagen formation on nitrite treatment of indole compounds derived from indole-glucosinolate C. Sasagawa and T. Matsushima (Japan) The fidelity of DNA synthesis by the catalytic subunit of yeast DNA polymerase a alone and with accessory proteins T.A. Kunkel, J.D. Roberts and A. Sugino (U.S.A.) New mutations in cloned Escherichia coli umuDC genes: Novel phenotypes of strains carrying a umuC/25 plasmid L. Marsh, T. Nohmi, S. Hinton and G.C. Walker (U.S.A., Japan) 504 Mutagenic DNA repair in Escherichia coli, XX. Overproduction of UmuD’ protein results in suppression of the umuC36 mutation in excision defective bacteria H. Bates, B.A. Bridges and R. Woodgate (Great Britain, U.S.A.) DNA repair in the fission yeast, Schizosaccharomyces pombe A.R. Lehmann, A.M. Carr, F.Z. Watts and J.M. Murray (Great Britain) Widespread adaptive response against environmental methylating agents in microorganisms B. Sedgwick and P. Vaughan (Great Britain) Hierarchies of DNA repair in mammalian cells: biological consequences L.H.F. Mullenders, H. Vrieling, J. Venema and A.A. Van Zeeland (The Netherlands) Genotoxic effects of ethylene oxide and propylene oxide: a comparative study E. Agurell, H. Cederberg, L. Ehrenberg, K. Lindahl-Kiessling, U. Rannug and M. Térnqvist (Sweden) The influence of solvent stress on MMS-induced genetic change in Saccharomyces cerevisiae F.K. Zimmermann and A. Rohlfs (F.R.G.) Utilization of the specific-locus assay in the ad-3 region of two-component heterokaryons of Neurospora for risk assessment of environmental chemicals F.J. De Serres (U.S.A.) Effects of chemical and physical agents on recombination events in cells of the germ line of male and female Drosophila melanogaster F.E. Wiirgler (Switzerland) Variation of spontaneous and induced mitotic recombination in different Drosophila populations: a pilot study on the effects of polyaromatic hydrocarbons in six newly constructed tester strains E.W. Vogel, M.J.M. Nivard and J.A. Zijlstra (The Netherlands, Switzerland) Adaptive response of human lymphocytes for the repair of radon-induced chromosomal damage S. Wolff, R. Jostes, F.T. Cross, T.E. Hui, V. Afzal and J.K. Wiencke (U.S.A.) Revell revisited J.R.K. Savage and A.N. Harvey (U.K.) DNA polymerase 6 mediates increase in exchange production by X-radiation in human lymphocytes moving from Gp to G, M.A Bender and R.C. Moore (U.S.A., Australia) Effect of pH shifts on radiosensitivity of human lymphocytes irradiated in the G, stage A. Bosi, A. Micheli, S. Pietrosanti and G. Olivieri (Italy) Variations of chromosome radiation sensitivity in fetal and adult mice during gestation M. Ricoul and B. Dutrillaux (France) Determination of the chromosomal site for the human radiosensitive ataxia telangiectasia gene by chromosome transfer Y. Ejima, M. Oshimura and M.S. Sasaki (Japan) Mitotic recombination in mammalian cells in vivo A.A. Morley (Australia) Mutations and epimutations in mammalian cells R. Holliday (Australia) Reduction to homozygosity is the predominant spontaneous mutational event in cultured human lymphoblastoid cells D.K. Klinedinst and N.R. Drinkwater (U.S.A.) Mutation induction by okadaic acid, a protein phosphatase inhibitor, in CHL cells, but not in S. typhimurium S. Aonuma, T. Ushijima, M. Nakayasu, H. Shima, T. Sugimura and M. Nagao (Japan) In vivo ionizing irradiations produce deletions in the Aprt gene of human T-lymphocytes J.A. Nicklas, J.P. O’Neill, T.C. Hunter, M.T. Falta, M.J. Lippert, D. Jacobson-Kram, J.R. Williams and R.J. Albertini (U.S.A.) Effect of O°-alkylguanine-DNA alkyltransferase on the frequency and spectrum of mutations induced by N-methyl- N’-nitro-N-nitrosoguanidine in the HPRT gene of diploid human fibroblasts L.L. Lukash, J. Boldt, A.E. Pegg, M.E. Dolan, V.M. Maher and J.J. McCormick (U.S.A.) Cell-cycle dependent mutation of human lymphoblasts: Bromodeoxyuridine and butyl methanesulfonate H. Hoppe IV, K.M. Call, P.-M. Leong and W.G. Thilly (U.S.A.) High somatic mutation frequencies in a LacZ transgene integrated on the mouse X-chromosome J.A. Gossen, W.J.F. De Leeuw, A. Verwest, P.H.M. Lohman and J. Vijg (The Netherlands) Mouse dominant lethal and bone marrow micronucleus studies on methyl vinyl sulfone and divinyl sulfone M.D. Shelby, G.A. Gutierrez-Espeleta, W.M. Generoso and A.F. McFee (U.S.A.) Developmental response of zygotes exposed to similar mutagens W.M. Generoso, A.G. Shourbaji, W.W. Piegorsch and J.B. Bishop (U.S.A.) Induction of specific-locus and dominant lethal mutations in male mice by 1-methyl-1-nitrosourea (MNU) U.H. Ehling and A. Neuhduser-Klaus (F.R.G.) Use of in vivo genetic toxicity data for risk assessment M.S. Legator and J.B. Ward Jr. (U.S.A.) Chromosome aberrations (CA), sister-chromatid exchanges (SCE) and mitogen-induced blastogenesis in cultured peripheral lymphocytes from 48 control individuals sampled 8 times over 2 years D. Anderson, A.J. Francis, P. Godbert, P.C. Jenkinson and K.R. Butterworth (Great Britain) Lymphocyte proliferation kinetics and genotoxic findings in a pilot study on individuals chronically exposed to arsenic in Mexico P. Ostrosky-Wegman, M.E. Gonsebatt, R. Montero, L. Vega, H. Barba, J. Espinosa, A. Palao, C. Cortinas, G. Garcia-Vargas, L.M. del Razo and M. Cebrian (Mexico) Biological and chemical monitoring of occupational exposure to ethylene oxide A.D. Tates, T. Grummt, M. Térnqvist, P.B. Farmer, F.J. Van Dam, H. Van Mossel, H.M. Schoemaker, S. Osterman-Golkar, C. Uebel, Y.S. Tang, A.H. Zwinderman, A.T. Natarajan and L. Ehrenberg (The Netherlands, F.R.G., Sweden, U.K.) Mutation Research and the literature of genetic toxicology. Another milestone J.S. Wassom and E.S. Von Halle (U.S.A.) Contents, Vol. 250 (1991)