Multiple Origins of Sex Differences in Brain: Neuroendocrine Functions and their Pathologies PDF
Preview Multiple Origins of Sex Differences in Brain: Neuroendocrine Functions and their Pathologies
Research and Perspectives in Endocrine Interactions For furthervolumes: http://www.springer.com/series/5241 . Donald W. Pfaff (cid:129) Yves Christen Editors Multiple Origins of Sex Differences in Brain Neuroendocrine Functions and their Pathologies Editors DonaldW.Pfaff YvesChristen LaboratoryofNeurobiologyandBehavior FondationIpsenpourla TheRockefellerUniversity RechercheTherapeutique, NewYork France USA ISSN1861-2253 ISBN978-3-642-33720-8 ISBN978-3-642-33721-5(eBook) DOI10.1007/978-3-642-33721-5 SpringerHeidelbergNewYorkDordrechtLondon LibraryofCongressControlNumber:2012955940 #Springer-VerlagBerlinHeidelberg2013 Thisworkissubjecttocopyright.AllrightsarereservedbythePublisher,whetherthewholeorpart of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation,broadcasting,reproductiononmicrofilmsorinanyotherphysicalway,andtransmissionor informationstorageandretrieval,electronicadaptation,computersoftware,orbysimilarordissimilar methodologynowknownorhereafterdeveloped.Exemptedfromthislegalreservationarebriefexcerpts inconnectionwithreviewsorscholarlyanalysisormaterialsuppliedspecificallyforthepurposeofbeing enteredandexecutedonacomputersystem,forexclusiveusebythepurchaserofthework.Duplication ofthispublicationorpartsthereofispermittedonlyundertheprovisionsoftheCopyrightLawofthe Publisher’s location, in its current version, and permission for use must always be obtained from Springer.PermissionsforusemaybeobtainedthroughRightsLinkattheCopyrightClearanceCenter. ViolationsareliabletoprosecutionundertherespectiveCopyrightLaw. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publicationdoesnotimply,evenintheabsenceofaspecificstatement,thatsuchnamesareexempt fromtherelevantprotectivelawsandregulationsandthereforefreeforgeneraluse. While the advice and information in this book are believed to be true and accurate at the date of publication,neithertheauthorsnortheeditorsnorthepublishercanacceptanylegalresponsibilityfor anyerrorsoromissionsthatmaybemade.Thepublishermakesnowarranty,expressorimplied,with respecttothematerialcontainedherein. Printedonacid-freepaper SpringerispartofSpringerScience+BusinessMedia(www.springer.com) Foreword Multiple Origins of Sex Differences in Brain. Neuroendocrine Functions and their Pathologies Intheoreticalterms,sexdifferencesinbrainsandbehaviorsoflaboratoryanimals offer the possibility of fascinating scientific studies on a range of molecular phenomena such as genomic imprinting, DNA methylation, chromatin protein modification,non-codingDNA,potentiallyresultinginimportantneuroanatomical and neurochemical sex differences in the brain. Such sex differences could arise consequent to exposures to testosterone early in development, or to other effects deriving from the Y chromosome. However, this general subject has been treated with much hyperbole. Historically, sex differences were assumed to be present wheretheydidnotreallyexist,e.g.withrespecttomathematics,executiveleader- ship,etc.etc.Underwhatcircumstancesdowereallycareaboutsexdifferencesin brain and behavior? These circumstances concern human maladies whose diagnoses are much different between boys and girls, or between women and men.Prominentexamplesdiscussedinthisvolumeincludeautism,attentiondeficit hyperactivitydisordersandcongenitaladrenalhyperplasia.Infact,infantboysare more susceptible than infant girls to a variety of disorders that arise early in development. This volume then ends with a consideration of effects of estrogenic hormonesontheinjuredbrain,andtheirrolesasprotectiveagents. This volume contains the proceedings of the XIth Colloque Me´decine et Recherche of Fondation Ipsen held in Paris, on December 3, 2011 which bring togethercliniciansandbasicscientistsworkinginendocrinologyandneuroscience. DonaldPfaff(TheRockefellerUniversity,NewYork,USA) YvesChristen(FondationIPSEN,Paris,France) v . Acknowledgments TheeditorswishtoexpresstheirgratitudetoMrsMaryLynnGageforhereditorial assistance,MrsSoniaLeCornec,AstriddeGe´rard,Ce´lineMaffre,andJacqueline Mervailliefortheorganizationofthemeeting. vii . Contents Hormone-DependentChromatinModificationsRelated toSexuallyDifferentiatedBehaviors. . . . . . . . . . . . . . . . . . . . . . . . . . . 1 KhatunaGagnidzeandDonaldW.Pfaff ImportanceofGenomicImprintingintheEvolution andDevelopmentoftheMaternalBrain. . . . . . . . . . . . . . . . . . . . . . . . 21 BarryE.Keverne GenomicImprintingintheAdultandDevelopingBrain. . . . . . . . . . . . 35 CatherineDulacandGreggChristopher TheSynapse:DifferencesBetweenMenandWomen. . . . . . . . . . . . . . . 43 JavierDeFelipeandLidiaAlonso-Nanclares GonadalHormoneInfluencesonHumanNeurobehavioral Development:OutcomesandMechanisms. . . . . . . . . . . . . . . . . . . . . . . 59 MelissaHines CongenitalAdrenalHyperplasia:Neuroendocrine,Behavioral andCognitiveImplications. . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . .. 71 PhyllisW.Speiser GeneticVariationWithinSerotoninGenes,Hormones, andAggression. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 81 FrancescaDucci,LauraBevilacqua,PaolaLandi,andDavidGoldman MultipleOriginsofSexDifferencesinAttentionDeficit HyperactivityDisorder. . . . . .. . . . . . . . . .. . . . . . . . . .. . . . . . . . . .. . 103 JamesM.Swanson,KimberlyD.Lakes,TimL.Wigal, andNoraD.Volkow FetalTestosteroneinMind:ImplicationsforAutism. . . . . . . . . . . . . . . 123 BonnieAuyeungandSimonBaron-Cohen ix
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