Table Of Content

Varsha Gandhi · Kapil Mehta Rajesh Grover · Sen Pathak Bharat B. Aggarwal Editors Multi-Targeted Approach to Treatment of Cancer Multi-Targeted Approach to Treatment of Cancer ThiSisaFMBlankPage Varsha Gandhi (cid:129) Kapil Mehta (cid:129) Rajesh Grover (cid:129) Sen Pathak (cid:129) Bharat B. Aggarwal Editors Multi-Targeted Approach to Treatment of Cancer Editors VarshaGandhi KapilMehta DepartmentofExperimentalTherapeutics DepartmentofExperimentalTherapeutics UniversityofTexas UniversityofTexas M.D.AndersonCancerCenter M.D.AndersonCancerCenter Houston,Texas,USA Houston,Texas,USA RajeshGrover SenPathak DelhiStateCancerInstitute(East) DepartmentofExperimentalTherapeutics Delhi UniversityofTexas India M.D.AndersonCancerCenter Houston,Texas,USA BharatB.Aggarwal DepartmentofBioimmunotherapy SectionofCytokineResearch UniversityofTexas M.D.AndersonCancerCenter Houston,Texas,USA ISBN978-3-319-12252-6 ISBN978-3-319-12253-3(eBook) DOI10.1007/978-3-319-12253-3 SpringerChamHeidelbergNewYorkDordrechtLondon LibraryofCongressControlNumber:2015930738 ©SpringerInternationalPublishingSwitzerland2015 Thisworkissubjecttocopyright.AllrightsarereservedbythePublisher,whetherthewholeorpart of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation,broadcasting,reproductiononmicrofilmsorinanyotherphysicalway,andtransmissionor informationstorageandretrieval,electronicadaptation,computersoftware,orbysimilarordissimilar methodologynowknownorhereafterdeveloped.Exemptedfromthislegalreservationarebriefexcerpts inconnectionwithreviewsorscholarlyanalysisormaterialsuppliedspecificallyforthepurposeofbeing enteredandexecutedonacomputersystem,forexclusiveusebythepurchaserofthework.Duplication ofthispublicationorpartsthereofispermittedonlyundertheprovisionsoftheCopyrightLawofthe Publisher’s location, in its current version, and permission for use must always be obtained from Springer.PermissionsforusemaybeobtainedthroughRightsLinkattheCopyrightClearanceCenter. ViolationsareliabletoprosecutionundertherespectiveCopyrightLaw. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publicationdoesnotimply,evenintheabsenceofaspecificstatement,thatsuchnamesareexempt fromtherelevantprotectivelawsandregulationsandthereforefreeforgeneraluse. While the advice and information in this book are believed to be true and accurate at the date of publication,neithertheauthorsnortheeditorsnorthepublishercanacceptanylegalresponsibilityfor anyerrorsoromissionsthatmaybemade.Thepublishermakesnowarranty,expressorimplied,with respecttothematerialcontainedherein. Printedonacid-freepaper SpringerispartofSpringerScience+BusinessMedia(www.springer.com) Contents PartI Genetics/Genome/Microenvironment 1 DiversityofChromosomalCharacteristicsAmongMammals:With SpecialReferencetoLaboratoryMouseinCancerResearch. . . . . 3 SenPathak 2 Genome-BasedMulti-targetingofCancer:HypeorHope?. . . . . . 19 ShinjiniSingh,AmitKumarTyagi,SashaRaman,JiaminHuang, LokeshDeb,QaisarManzoor,ArfaaSajid,LiXinYang, JagnyeswarRatha,SahdeoPrasad,andBharatB.Aggarwal 3 ChronicLymphocyticLeukemiaattheGenomicLevel. . . . . . . . . 57 HimaV.VangapanduandVarshaGandhi 4 ApoptosisPathwaysinChronicLymphocyticLeukemia:Roleofthe MicroenvironmentandTherapeuticStrategies. . . . . . . . . . . . . . . . 73 ViralkumarPatel,KumudhaBalakrishnan,andVarshaGandhi 5 Tumor-AssociatedMacrophagesinTumorProgression:From BenchtoBedside. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 99 MariaRosariaGaldieroandAlbertoMantovani 6 RoleofOsteopontininTumorMicroenvironment:ANewParadigm inCancerTherapy. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 113 RameshButti,PompomGhosh,KumarV.S.Totakura, RadharaniN.NagaVenkata,RamakrishnaNimma,andGopalC.Kundu PartII TumorGrowth/Progression 7 TG2:PlayerThatDictatestheRulesinCancerProgression. . . . . . 129 KapilMehtaandSantoshKumar v vi Contents 8 RoleofSurfactantsinRegulationofCancerGrowth. . . . . . . . . . . 137 AbdelfattahM.Badawi,DinaA.Ismail,SaharAhmed,Ammona Mohamad,MonaDardir,DaliaE.Mohamed,AshganIbrahem, NahlaA.Mansour,andAbeerAshmawy 9 HumanAlbuminome:ReflectionsofNeoplasticTransformationand CancerDetectionThroughAlbumin-AssociatedBiomarkers. . . . . 151 GaganjotSinghKalsey PartIII CancerinIndiaandApproaches 10 IntegratedCancerScreeningStrategiesinIndia. . . . . . . . . . . . . . . 167 RaviMehrotraandRoopaHariprasad 11 GallBladderCancer:WhatNeedstoBeDoneinIndia?. . . . . . . . 179 VinayK.Kapoor 12 CurrentTreatmentforGallbladderCancer. . . . . . . . . . . . . . . . . . 189 M.A.Ansari,P.Gupta,andV.K.Shukla 13 PrevalenceofGastrointestinalCancersinIndia. . . . . . . . . . . . . . . 217 SatyavatiRana PartIV TargetsandTherapeutics 14 PersonalizedTherapeuticStrategiesforEpithelialOvarian Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 235 NeetaSingh,SeemaPatel,andRajarshiKar 15 TumorAngiogenesisandNovelVascularEndothelialReceptor (VEGFR)-SpecificSmallMoleculeInhibitors. . . . . . . . . . . . . . . . . 245 AppuRathinavelu 16 TargetingMitochondria:APowerhouseApproachtoCancer Treatment. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 263 NavneetAgnihotri,IshaRani,andSandeepKumar 17 DesigningofTumor-TargetedHuRsiRNANanoparticleasa TherapeuticforLungCancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 277 RanganayakiMuralidharan,AnishBabu,KantheshBasalingappa, MeghnaMehta,AnupamaMunshi,andRajagopalRamesh 18 TherapeuticAnticancerApproachesTargetingTelomeraseand Telomeres. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 295 DeekshaPal,UjjawalSharma,andRajendraPrasad 19 RoleofInositolTriphosphateReceptorinCancerandIts TargetingThroughAutophagy. . . . . . . . . . . . . . . . . . . . . . . . . . . . 311 AruSingh,MeghaChagtoo,BandanaChakravarti, andMadanM.Godbole Contents vii 20 DNATopoisomeraseII:PromisingTargetforAnticancer Drugs. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 323 ParamjeetKaur,VarinderKaur,andSatwinderjeetKaur 21 ChemopreventiveandAnticancerEfficacyofSilibininAgainst ColorectalCancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 339 SushilKumar,KomalRaina,andRajeshAgarwal 22 IntegratingTraditionalKoreanMedicineintoModern CancerCare. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 351 SeongWooYoon 23 SeizingCancerCompletelyThroughSpecificAblatingCancerStem Cell:TheRoyalRoadtoChemoquiescence. . . . . . . . . . . . . . . . . . . 365 JongMinPark,NapapanKangwan,EunHeeKim,MiKyungChung, YoungminHan,SungHunKwon,ChangIlKwon,andKiBaikHahm 24 CervicalCancerStemCellsandTheirAssociationwithHuman Papillomavirus:AreTheyReadyasAnticancerTargets?. . . . . . . . 377 KanchanVishnoi,AbhishekTyagi,SukhMahendraSingh, BhudevC.Das,andAlokC.Bharti 25 IntegrativeOncology:ScientificResearchinSupportofPatients: Useful,Possible,Valid. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 401 MassimoBonucci ThiSisaFMBlankPage Contributors RajeshAgarwal DepartmentofPharmaceuticalSciences,SkaggsSchoolofPhar- macyandPharmaceuticalSciences,SanDiego,CA,USA University of Colorado Cancer Center, University of Colorado Anschutz Medical Campus,Aurora,CO,USA Bharat B. Aggarwal Department of Bioimmunotherapy, Section of Cytokine Research, University of Texas, M.D. Anderson Cancer Center, Houston, Texas USA NavneetAgnihotri DepartmentofBiochemistry,PunjabUniversity,Chandigarh, India Sahar Ahmed Applied Surfactant Laboratory, Department of Petrochemicals, EgyptianPetroleumResearchInstitute,Cairo,Egypt M. A. Ansari Department of General Surgery, Institute of Medical Sciences, BanarasHinduUniversity,Varanasi,India Abeer Ashmawy Tumor Biology Department, National Cancer Institute, Cairo, Egypt Anish Babu Department of Pathology, University of Oklahoma Health Sciences Center,OklahomaCity,OK,USA StephensonCancerCenter,UniversityofOklahomaHealthSciencesCenter,Okla- homaCity,OK,USA Abdelfattah M. Badawi Applied Surfactant Laboratory, Department of Petro- chemicals,EgyptianPetroleumResearchInstitute,NasrCityCairo,Egypt Kumudha Balakrishnan Departments of Experimental Therapeutics, The Uni- versityofTexasM.D.AndersonCancerCenter,Houston,TX,USA Kanthesh Basalingappa Stephenson Cancer Center, University of Oklahoma HealthSciencesCenter,OklahomaCity,OK,USA ix

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In this book, clinicians and basic scientists from USA, India, and other countries discuss the rationales and clinical experiences with targeted approaches to treat, prevent, or manage cancer. Cancer is a hyperproliferative disorder that is regulated by multiple genes and multiple cell signaling pat
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Varsha Gandhi · Kapil Mehta Rajesh Grover · Sen Pathak Bharat B. Aggarwal Editors Multi-Targeted Approach to Treatment of Cancer Multi-Targeted Approach to Treatment of Cancer ThiSisaFMBlankPage Varsha Gandhi (cid:129) Kapil Mehta (cid:129) Rajesh Grover (cid:129) Sen Pathak (cid:129) Bharat B. Aggarwal Editors Multi-Targeted Approach to Treatment of Cancer Editors VarshaGandhi KapilMehta DepartmentofExperimentalTherapeutics DepartmentofExperimentalTherapeutics UniversityofTexas UniversityofTexas M.D.AndersonCancerCenter M.D.AndersonCancerCenter Houston,Texas,USA Houston,Texas,USA RajeshGrover SenPathak DelhiStateCancerInstitute(East) DepartmentofExperimentalTherapeutics Delhi UniversityofTexas India M.D.AndersonCancerCenter Houston,Texas,USA BharatB.Aggarwal DepartmentofBioimmunotherapy SectionofCytokineResearch UniversityofTexas M.D.AndersonCancerCenter Houston,Texas,USA ISBN978-3-319-12252-6 ISBN978-3-319-12253-3(eBook) DOI10.1007/978-3-319-12253-3 SpringerChamHeidelbergNewYorkDordrechtLondon LibraryofCongressControlNumber:2015930738 ©SpringerInternationalPublishingSwitzerland2015 Thisworkissubjecttocopyright.AllrightsarereservedbythePublisher,whetherthewholeorpart of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation,broadcasting,reproductiononmicrofilmsorinanyotherphysicalway,andtransmissionor informationstorageandretrieval,electronicadaptation,computersoftware,orbysimilarordissimilar methodologynowknownorhereafterdeveloped.Exemptedfromthislegalreservationarebriefexcerpts inconnectionwithreviewsorscholarlyanalysisormaterialsuppliedspecificallyforthepurposeofbeing enteredandexecutedonacomputersystem,forexclusiveusebythepurchaserofthework.Duplication ofthispublicationorpartsthereofispermittedonlyundertheprovisionsoftheCopyrightLawofthe Publisher’s location, in its current version, and permission for use must always be obtained from Springer.PermissionsforusemaybeobtainedthroughRightsLinkattheCopyrightClearanceCenter. ViolationsareliabletoprosecutionundertherespectiveCopyrightLaw. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publicationdoesnotimply,evenintheabsenceofaspecificstatement,thatsuchnamesareexempt fromtherelevantprotectivelawsandregulationsandthereforefreeforgeneraluse. While the advice and information in this book are believed to be true and accurate at the date of publication,neithertheauthorsnortheeditorsnorthepublishercanacceptanylegalresponsibilityfor anyerrorsoromissionsthatmaybemade.Thepublishermakesnowarranty,expressorimplied,with respecttothematerialcontainedherein. Printedonacid-freepaper SpringerispartofSpringerScience+BusinessMedia(www.springer.com) Contents PartI Genetics/Genome/Microenvironment 1 DiversityofChromosomalCharacteristicsAmongMammals:With SpecialReferencetoLaboratoryMouseinCancerResearch. . . . . 3 SenPathak 2 Genome-BasedMulti-targetingofCancer:HypeorHope?. . . . . . 19 ShinjiniSingh,AmitKumarTyagi,SashaRaman,JiaminHuang, LokeshDeb,QaisarManzoor,ArfaaSajid,LiXinYang, JagnyeswarRatha,SahdeoPrasad,andBharatB.Aggarwal 3 ChronicLymphocyticLeukemiaattheGenomicLevel. . . . . . . . . 57 HimaV.VangapanduandVarshaGandhi 4 ApoptosisPathwaysinChronicLymphocyticLeukemia:Roleofthe MicroenvironmentandTherapeuticStrategies. . . . . . . . . . . . . . . . 73 ViralkumarPatel,KumudhaBalakrishnan,andVarshaGandhi 5 Tumor-AssociatedMacrophagesinTumorProgression:From BenchtoBedside. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 99 MariaRosariaGaldieroandAlbertoMantovani 6 RoleofOsteopontininTumorMicroenvironment:ANewParadigm inCancerTherapy. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 113 RameshButti,PompomGhosh,KumarV.S.Totakura, RadharaniN.NagaVenkata,RamakrishnaNimma,andGopalC.Kundu PartII TumorGrowth/Progression 7 TG2:PlayerThatDictatestheRulesinCancerProgression. . . . . . 129 KapilMehtaandSantoshKumar v vi Contents 8 RoleofSurfactantsinRegulationofCancerGrowth. . . . . . . . . . . 137 AbdelfattahM.Badawi,DinaA.Ismail,SaharAhmed,Ammona Mohamad,MonaDardir,DaliaE.Mohamed,AshganIbrahem, NahlaA.Mansour,andAbeerAshmawy 9 HumanAlbuminome:ReflectionsofNeoplasticTransformationand CancerDetectionThroughAlbumin-AssociatedBiomarkers. . . . . 151 GaganjotSinghKalsey PartIII CancerinIndiaandApproaches 10 IntegratedCancerScreeningStrategiesinIndia. . . . . . . . . . . . . . . 167 RaviMehrotraandRoopaHariprasad 11 GallBladderCancer:WhatNeedstoBeDoneinIndia?. . . . . . . . 179 VinayK.Kapoor 12 CurrentTreatmentforGallbladderCancer. . . . . . . . . . . . . . . . . . 189 M.A.Ansari,P.Gupta,andV.K.Shukla 13 PrevalenceofGastrointestinalCancersinIndia. . . . . . . . . . . . . . . 217 SatyavatiRana PartIV TargetsandTherapeutics 14 PersonalizedTherapeuticStrategiesforEpithelialOvarian Cancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 235 NeetaSingh,SeemaPatel,andRajarshiKar 15 TumorAngiogenesisandNovelVascularEndothelialReceptor (VEGFR)-SpecificSmallMoleculeInhibitors. . . . . . . . . . . . . . . . . 245 AppuRathinavelu 16 TargetingMitochondria:APowerhouseApproachtoCancer Treatment. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 263 NavneetAgnihotri,IshaRani,andSandeepKumar 17 DesigningofTumor-TargetedHuRsiRNANanoparticleasa TherapeuticforLungCancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 277 RanganayakiMuralidharan,AnishBabu,KantheshBasalingappa, MeghnaMehta,AnupamaMunshi,andRajagopalRamesh 18 TherapeuticAnticancerApproachesTargetingTelomeraseand Telomeres. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 295 DeekshaPal,UjjawalSharma,andRajendraPrasad 19 RoleofInositolTriphosphateReceptorinCancerandIts TargetingThroughAutophagy. . . . . . . . . . . . . . . . . . . . . . . . . . . . 311 AruSingh,MeghaChagtoo,BandanaChakravarti, andMadanM.Godbole Contents vii 20 DNATopoisomeraseII:PromisingTargetforAnticancer Drugs. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 323 ParamjeetKaur,VarinderKaur,andSatwinderjeetKaur 21 ChemopreventiveandAnticancerEfficacyofSilibininAgainst ColorectalCancer. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 339 SushilKumar,KomalRaina,andRajeshAgarwal 22 IntegratingTraditionalKoreanMedicineintoModern CancerCare. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 351 SeongWooYoon 23 SeizingCancerCompletelyThroughSpecificAblatingCancerStem Cell:TheRoyalRoadtoChemoquiescence. . . . . . . . . . . . . . . . . . . 365 JongMinPark,NapapanKangwan,EunHeeKim,MiKyungChung, YoungminHan,SungHunKwon,ChangIlKwon,andKiBaikHahm 24 CervicalCancerStemCellsandTheirAssociationwithHuman Papillomavirus:AreTheyReadyasAnticancerTargets?. . . . . . . . 377 KanchanVishnoi,AbhishekTyagi,SukhMahendraSingh, BhudevC.Das,andAlokC.Bharti 25 IntegrativeOncology:ScientificResearchinSupportofPatients: Useful,Possible,Valid. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 401 MassimoBonucci ThiSisaFMBlankPage Contributors RajeshAgarwal DepartmentofPharmaceuticalSciences,SkaggsSchoolofPhar- macyandPharmaceuticalSciences,SanDiego,CA,USA University of Colorado Cancer Center, University of Colorado Anschutz Medical Campus,Aurora,CO,USA Bharat B. Aggarwal Department of Bioimmunotherapy, Section of Cytokine Research, University of Texas, M.D. Anderson Cancer Center, Houston, Texas USA NavneetAgnihotri DepartmentofBiochemistry,PunjabUniversity,Chandigarh, India Sahar Ahmed Applied Surfactant Laboratory, Department of Petrochemicals, EgyptianPetroleumResearchInstitute,Cairo,Egypt M. A. Ansari Department of General Surgery, Institute of Medical Sciences, BanarasHinduUniversity,Varanasi,India Abeer Ashmawy Tumor Biology Department, National Cancer Institute, Cairo, Egypt Anish Babu Department of Pathology, University of Oklahoma Health Sciences Center,OklahomaCity,OK,USA StephensonCancerCenter,UniversityofOklahomaHealthSciencesCenter,Okla- homaCity,OK,USA Abdelfattah M. Badawi Applied Surfactant Laboratory, Department of Petro- chemicals,EgyptianPetroleumResearchInstitute,NasrCityCairo,Egypt Kumudha Balakrishnan Departments of Experimental Therapeutics, The Uni- versityofTexasM.D.AndersonCancerCenter,Houston,TX,USA Kanthesh Basalingappa Stephenson Cancer Center, University of Oklahoma HealthSciencesCenter,OklahomaCity,OK,USA ix

Description:
In this book, clinicians and basic scientists from USA, India, and other countries discuss the rationales and clinical experiences with targeted approaches to treat, prevent, or manage cancer. Cancer is a hyperproliferative disorder that is regulated by multiple genes and multiple cell signaling pat
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