MRI-guided abdominal radiotherapy

147 Pages·2017·17 MB·English

by  Bjorn Stemkens

Motion management for
MRI-guided abdominal
radiotherapy
Bjorn Stemkens
Colophon
Cover: TheVitruvianmandemonstratingtheradialk-spacetrajectory. Themag-
nifying glass resembles the MRL; clear visualization of internal anatomy leading
to a converging radiation beam.
Design: B. Stemkens, Vitruvian man designed by Freepik.
Motion management for MRI-guided abdominal radiotherapy
PhD thesis, Utrecht University, the Netherlands
All rights reserved. No part of this publication may be reproduced, distributed,
ortransmittedinanyformorbyanymeanswithoutthepriorwrittenpermission
from the author. The copyright of the papers that have been published or have
been accepted for publication has been transferred to the respective journals.
For one project (Chapter 3) funding was provided in part by the Royal Nether-
lands Academy of Arts and Sciences (KNAW) Ter Meulen grant.
Manuscript
Layout: B. Stemkens
Typeset in: LATEX
Printed by: ProefschriftMaken
ISBN: 978-90-393-6849-7
Copyright
(cid:13)cBjorn Stemkens
(cid:13)cElsevier (Chapter 2)
(cid:13)cWiley (Chapters 3 and 6)
(cid:13)cIOP Publishing Ltd (Chapters 4 and 5)
Motion management for
MRI-guided abdominal
radiotherapy
Het controleren van beweging voor MRI-gestuurde
radiotherapie in het abdomen
(met een samenvatting in het Nederlands)
Proefschrift
ter verkrijging van de graad van doctor aan de Universiteit Utrecht op gezag
van de rector magnificus, prof.dr. G.J. van der Zwaan, ingevolge het besluit van
het college voor promoties in het openbaar te verdedingen op 5 oktober 2017 des
middags te 2.30 uur
door
Bjorn Stemkens
geboren op 30 maart 1989 te Helmond
Promotor: Prof.dr.ir. J.J.W. Lagendijk
Copromotoren: Dr.ir. H.N. Tijssen
Dr.ir. C.A.T. van den Berg
Financial support for publication of this thesis was kindly provided by Philips,
Modus Medical Devices Inc., Elekta and Chipsoft.
For those about to rock, we salute you!

Contents
List of Acronyms ix
1 General introduction 1
2 Optimizing4D-MRIdatasamplingforrespiratorymotionana-
lysis of pancreatic tumors 13
3 Adaptivebulk-motionexclusionforimprovedrobustnessofab-
dominal MR imaging 25
4 Image-driven, model-based 3D abdominal motion estimation
for MR-guided radiotherapy 41
5 Dose accumulation in free-breathing MR-guided renal-cell car-
cinoma SBRT 65
6 Maximizing SNR in simultaneous multi-slice body imaging 83
7 Summary and Discussion 101
8 Samenvatting 113
Bibliography 117
List of Publications 129
Acknowledgements 133
Curriculum vitae 137
vii

List of Acronyms
bSSFP balanced Steady-State Free Precession
CAIPIRINHA ControlledAliasingInParallelImagingResultsInHigher
Acceleration
CBCT Cone-Beam Computed Tomography
CS Compressed Sensing
CT Computed Tomography
CTV Clinical Target Volume
DCE Dynamic Contrast Enhanced
DVF Deformable Vector Field
DWI Diffusion Weighted Imaging
EBRT External Beam Radiation Therapy
ED Electron Density
EPID Electronic Portal Imaging Device
FFT Fast Fourier Transform
FID Free-Induction Decay
FOV Field-Of-View
g-factor Geometry factor
GLM General Linear Model
GRAPPA Generalized Autocalibrating Partially Parallel Acquisi-
tions
GTV Gross Tumor Volume
IGRT Image-Guided Radiation Therapy
IMRT Intensity Modulated Radiation Therapy
ITV Internal Target Volume
kV kilo Voltage
Linac Linear Accelerator
LISS Linearly Increasing Slice Shifts
MLC Multi-Leaf Collimator
MRI Magnetic Resonance Imaging
MRL Magnetic Resonance Linear Accelerator
MS Multi-Slice
MV Mega Voltage
NUFFT Non-Uniform Fast Fourier Transform
OAR Organ At Risk
PET Positron Emission Tomography
ix
PI Parallel Imaging
PSA Power Spectrum Analysis
PTV Planning Target Volume
RF Radio Frequency
SBRT Stereotactic Body Radiation Therapy
SENSE Sensitivity Encoding
SMASH Simultaneous Acquisition of Spatial Harmonics
SMS Simultaneous Multi-Slice
SNR Signal-to-Noise Ratio
SOS Stack-Of-Stars
SPECT Single-Photon Emission Computed Tomography
TCP Tumor Control Probability
TSE Turbo Spin Echo
TV Total Variation
VMAT Volumetric Arc Therapy