Description:A knowledgeable, experienced group of experts, willing to disagree, discuss the rationale and practice of monoamine oxidase inhibitor (MAOI) therapy. The goal is to provide a discussion pertinent to clinical practice. The moderator offered participation to researchers and clinicians highly experienced in MAOI therapy. Before the colloquy, all participants received a list of probable questions. Due to a lack of familiarity, physicians resist prescribing MAOI therapy—arguably the most effective treatment for mood and anxiety disorders, especially atypical depression. The dietary restrictions are humble compared to the risk of mood disorder. In any depression treatment algorithm, consider the early implementation of MAOI therapy. [Psychiatr Ann. 2014;44(12):577–586.]