Molecular Umbrellas and Human Serum Albumin as Novel Drug Delivery Vehicles

78 Pages·2009·8.2 MB·English

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Outline
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Introduction to Drug Delivery
•
Delivery methods
•
Examples
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Novel concepts of drug carriers
•
Molecular Umbrellas (MU)
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Concept, chemistry
–
Permeability
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MU bioconjugation and drug delivery
•
Human Serum Albumin (HSA)
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Biochemical and chemical characteristics
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HSA bioconjugation and drug delivery
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Conclusion
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Relevance of Drug Delivery
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Drug synthesis is execution of a synthetic scheme
•
Drug delivery complements drug synthesis by
bridging chemistry of synthesis to the biochemistry
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•
It involves numerous aspects to formulate a drug,
like:
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Solubility
–
Toxicity
–
Efficacy
•
It’s a package deal…
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Ideal Drug Delivery Process
Formulation Absorption Distribution Metabolism
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Ideal Mail Delivery Process
Receiving Processing Delivering
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Mail Delivery Process
Receiving Processing Delivering
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Mail Delivery Process
Receiving Processing Delivering
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Mail Delivery Process
Receiving Processing Delivering
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Mail Delivery Process
Receiving Processing Delivering
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Aspects of Drug Delivery
•
The ability to specifically formulate drugs to
achieve better absorption, distribution,
metabolism and excretion (ADME) properties
•
Drugs can be delivered as free molecules or
bound to carriers
•
Pharmacologically active compounds usually
delivered combined to a carrier
Silverman, R. B. The Organic Chemistry of Drug Design and Drug Action; 2nd ed.; Elsevier Academic Press, 2004.
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