Molecular Mechanisms Influencing Aggressive Behaviours (Novartis Foundation Symposia) PDF
Preview Molecular Mechanisms Influencing Aggressive Behaviours (Novartis Foundation Symposia)
Novartis Foundation Symposium 268 MOLECULAR MECHANISMS INFLUENCING AGGRESSIVE BEHAVIOURS 2005 MOLECULAR MECHANISMS INFLUENCING AGGRESSIVE BEHAVIOURS TheNovartisFoundationisaninternationalscienti¢candeducational charity(UKRegisteredCharityNo.313574).KnownuntilSeptember1997 astheCibaFoundation,itwasestablishedin1947bytheCIBAcompany ofBasle,whichmergedwithSandozin1996,toformNovartis.The FoundationoperatesindependentlyinLondonunderEnglishtrust law.Itwasformallyopenedon22June1949. TheFoundationpromotesthestudyandgeneralknowledgeof scienceandinparticularencouragesinternationalco-operationin scienti¢cresearch.Tothisend,itorganizesinternationally acclaimedmeetings(typicallyeightsymposiaandalliedopen meetingsand15^20discussionmeetingseachyear)andpublishes eightbooksperyearfeaturingthepresentedpapersanddiscussions fromthesymposia.Althoughprimarilyanoperationalratherthan agrant-makingfoundation,itawardsbursariestoyoungscientists toattendthesymposiaandafterwardsworkwithoneoftheother participants. TheFoundation’sheadquartersat41PortlandPlace,LondonW1B1BN, providelibraryfacilities,opentograduatesinscienceandallieddisciplines. Mediarelationsarefosteredbyregularpressconferencesandbyarticles preparedbytheFoundation’sScienceWriterinResidence.TheFoundation o¡ersaccommodationandmeetingfacilitiestovisitingscientistsandtheir societies. InformationonallFoundationactivitiescanbefoundat http://www.novartisfound.org.uk Novartis Foundation Symposium 268 MOLECULAR MECHANISMS INFLUENCING AGGRESSIVE BEHAVIOURS 2005 Copyright&NovartisFoundation2005 Publishedin2005byJohnWiley&SonsLtd, TheAtrium,SouthernGate, ChichesterPO198SQ,UK National 01243779777 International(+44)1243779777 e-mail(forordersandcustomerserviceenquiries):[email protected] VisitourHomePageonhttp://eu.wiley.com AllRightsReserved.Nopartofthisbookmaybereproduced,storedinaretrieval systemortransmittedinanyformorbyanymeans,electronic,mechanical,photocopying, recording,scanningorotherwise,exceptunderthetermsoftheCopyright,Designsand PatentsAct1988orunderthetermsofalicenceissuedbytheCopyrightLicensingAgencyLtd, 90TottenhamCourtRoad,LondonW1T4LP,UK,withoutthepermissioninwriting ofthePublisher.RequeststothePublishershouldbeaddressedtothePermissionsDepartment, JohnWiley&SonsLtd,TheAtrium,SouthernGate,Chichester,WestSussexPO198SQ, England,[email protected],orfaxedto(+44)1243770620. Thispublicationisdesignedtoprovideaccurateandauthoritativeinformationinregardto thesubjectmattercovered.ItissoldontheunderstandingthatthePublisherisnotengaged inrenderingprofessionalservices.Ifprofessionaladviceorotherexpertassistanceis required,theservicesofacompetentprofessionalshouldbesought. OtherWileyEditorialO⁄ces JohnWiley&SonsInc.,111RiverStreet,Hoboken,NJ07030,USA Jossey-Bass,989MarketStreet,SanFrancisco,CA94103-1741,USA Wiley-VCHVerlagGmbH,Boschstr.12,D-69469Weinheim,Germany JohnWiley&SonsAustraliaLtd,33ParkRoad,Milton,Queensland4064,Australia JohnWiley&Sons(Asia)PteLtd,2ClementiLoop#02-01,JinXingDistripark,Singapore 129809 JohnWiley&SonsCanadaLtd,22WorcesterRoad,Etobicoke,Ontario,CanadaM9W1L1 Wileyalsopublishesitsbooksinavarietyofelectronicformats.Somecontentthatappears inprintmaynotbeavailableinelectronicbooks. NovartisFoundationSymposium268 viii+264pages,22¢gures,5tables BritishLibraryCataloguinginPublicationData AcataloguerecordforthisbookisavailablefromtheBritishLibrary ISBN-13 978-0-470-01068-6 ISBN-10 0-470-01068-1 Typesetin101(cid:1) on121(cid:1) ptGaramondbyDobbieTypesettingLimited,Tavistock,Devon. 2 2 PrintedandboundinGreatBritainbyT.J.InternationalLtd,Padstow,Cornwall. Thisbookisprintedonacid-freepaperresponsiblymanufacturedfromsustainableforestry, inwhichatleasttwotreesareplantedforeachoneusedforpaperproduction. Contents SymposiumonMolecularmechanismsin£uencingaggressivebehaviours,heldattheNovartis Foundation,London,20^22July2004 Editors:GregoryBock(Organizer)andJamieGoode ThismeetingwasbasedonaproposalmadebyDonaldPfa¡,BarryKeverneandRandyNelson DonaldPfa¡ Introduction 1 RobertJ.BlanchardandD.CarolineBlanchard Somesuggestionsforrevitalizing aggressionresearch 4 Discussion 13 RobinLovell-Badge Aggressivebehaviour:contributionsfromgenesonthe Ychromosome 20 Discussion 33 DianeM.Robins Androgenreceptorandmolecularmechanismsofmale-speci¢c geneexpression 42 Discussion 53 EdwardS.Brodkin Quantitativetraitlocusanalysisofaggressivebehavioursin mice 57 Discussion 69 DonaldPfa¡,ElenaCholerisandSonokoOgawa Genesforsexhormone receptorscontrollingmouseaggression 78 Discussion 89 GeneraldiscussionI 96 CatherineDulac Moleculararchitectureofpheromonesensinginmammals 100 Discussion 107 Klaus-PeterLesch Serotonergicgeneinactivationinmice:modelsforanxietyand aggression? 111 Discussion 140 v vi CONTENTS RandyJ.Nelson E¡ectsofnitricoxideontheHPAaxisandaggression 147 Discussion 160 GeneraldiscussionII 167 BerendOlivier Serotonergicmechanismsinaggression 171 Discussion 183 CraigF.Ferris Vasopressin/oxytocinandaggression 190 Discussion 198 ManuelaMartinezandConcepcio¤nBlasco-Ros Typologyofhumanaggression anditsbiologicalcontrol 201 Discussion 208 StephenJ.Suomi Aggressionandsocialbehaviourinrhesusmonkeys 216 Discussion 222 IanW.Craig TheroleofmonoamineoxidaseA(MAOA)intheaetiologyof antisocialbehaviour:theimportanceofgene^environmentinteractions 227 Discussion 237 Finaldiscussion 242 Indexofcontributors 254 Subjectindex 256 Participants D.CarolineBlanchard UniversityofHawaii,DepartmentofPsychology, CollegeofSocialSciences,Gartley110,2430CampusRoad,Honolulu, HI96822,USA RobertJ.Blanchard UniversityofHawaii,DepartmentofPsychology,College ofSocialSciences,Gartley110,2430CampusRoad,Honolulu,HI96822,USA Bj˛rnBrembs InstitutfˇrNeurobiologie,FUBerlin,K˛nigin-Luise-Str. 28/30,D-14195Berlin,Germany EdwardS.Brodkin UniversityofPennsylvaniaSchoolofMedicine,Centerfor NeurobiologyandBehavior,415CurieBoulevard,Room111,Philadelphia, PA19104-6140,USA IanCraig POBox82,SGDPResearchCentre,InstituteofPsychiatry, DeCrespignyPark,DenmarkHill,LondonSE58AF,UK CatherineDulac DepartmentofMolecularandCellularBiology, HarvardUniversity,16DivinityAvenue,Cambridge,MA02138,USA CraigFerris DepartmentofPsychiatry,UniversityofMassachusettsMedical School,55LakeAvenueNorth,Worcester,Massachusetts01655,USA StephenGammie 1117WestJohnsonSt,ZoologyResearchBuilding, Room213,DepartmentofZoology,UniversityofWisconsin,Madison, WI 53706,USA RobertHinde StJohn’sCollege,CambridgeCB21TP,UK BarryKeverne Sub-DepartmentofAnimalBehaviour,Universityof Cambridge,HighStreet,Madingley,CambridgeCB38AA,UK JaapKoolhaas DepartmentofAnimalPhysiology,UniversityofGroningen, P.O.Box14,9750AAHaren,TheNetherlands vii viii PARTICIPANTS Klaus-PeterLesch KlinikundPoliklinikfˇrPsychiatrieundPsychotherapie, Universit(cid:1)tWˇrzburg,D-97080Wˇrzburg,Germany RobinLovell-Badge TheNationalInstituteforMedicalResearch, TheRidgeway,MillHill,LondonNW71AA,UK StephenManuck BehavioralPhysiologyLaboratory,Departmentof Psychology,UniversityofPittsburgh,506OldEngineeringHall,Pittsburgh, PA15260,USA ManuelaMartinez DepartmentofPsychobiology,FacultyofPsychology, UniversityofValencia,Avda.BlascoIba•ez21,46010,Valencia,Spain RandyNelson DepartmentsofPsychologyandNeuroscience,09Townshend Hall,TheOhioStateUniversity,Columbus,OH 43210,USA BerendOlivier DepartmentofPsychopharmacology,UtrechtInstitutefor PharmaceuticalSciences,UtrechtUniversity,Sorbonnelaan16,3584CA, Utrecht,TheNetherlands DonaldPfa¡ (Chair) NeurobiologyandBehavior,TheRockefellerUniversity, Box275,1230YorkAvenue,NewYork,NY10021-6399,USA DianeM.Robins DepartmentofHumanGenetics,UniversityofMichigan, 4909Buhl,1241E.CatherineSt,AnnArbor,MI48109-0618,USA DavidSkuse BehaviouralandBrainSciencesUnit,InstituteofChildHealth, 30GuilfordStreet,LondonWC1N1EH,UK StephenSuomi NationalInstituteofChildHealthandHumanDevelopment, 31CenterDrive,Bethesda,MD20892,USA BrianTrainor(NovartisFoundationBursar) BauerCenterforGenomicsResearch, HarvardUniversity,7DivinityAvenue,Cambridge,MA02138,USA
Description:The list of books you might like
