Molecular Interaction Fields PDF
324 Pages·2006·7.287 MB·English
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Thanks to the vast progress made in the investigation of biomolecules using NMR during the later 1990s, NMR spectroscopy offers a universal tool for examining the binding of an active substance to its target protein. Its use also benefits the development of drugs in particular. Content: Part I: Basic techniques -- Modern methods for the expression of proteins in isotopically enriched form / Heiko Patzelt ... [et al.] -- Structure calculation using automated techniques / Peter Güntert -- Achieving better sensitivity, less noise and fewer artifacts in NMR spectra / Detlef Moskau and Oliver Zerbe -- Part II: NMR of biomolecules -- NMR strategies for protein assignments / Volker Dötsch -- NMR of membrane-associated peptides and proteins / Reto Bader, Mirjam Lerch, and Oliver Zerbe -- NMR of nucleic acids / Radovan Fiala and Vladimír Sklenář -- Part III: Modern spectroscopic techniques -- Methods for the measurement of angle restraints from scalar, dipolar couplings and from cross-correlated relaxation : application to biomacromolecules / Christian Griesinger -- Orientational restraints / Eva de Alba and Nico Tjandra -- Scalar couplings across hydrogen bonds / Andrew J. Dingley ... [et al.] -- TROSY : transverse relaxation-optimized spectroscopy / Roland Riek -- MAS solid-state NMR of isotopically enriched biological samples / Philip T.F. Williamson, Matthias Ernst, and Beat H. Meier -- Determination of protein dynamics using [superscript 15]N relaxation measurements / David Fushman -- Part IV: Tools for investigation of drug-receptor complexes and for ligand screening -- The determination of equilibrium dissociation constants of protein-ligand complexes by NMR / Gordon C.K. Roberts -- Experiments in NMR-based screening / Carla Marchioro ... [et al.] -- The use of spin labels in NMR-supported lead finding and optimization / Wolfgang Jahnke -- NMR of weakly binding ligands / Marcel J.J. Blommers and Simon Rüdisser -- Isotope filter and editing techniques / Gerd Gemmecker -- Part V: Strategies for drug development using NMR -- Strategies for NMR screening and library design / Christopher A. Lepre -- Strategies for hit finding using NMR / Werner Klaus and Hans Senn. Strategies for drug discovery using NMR / Marcel J.J. Blommers, Andreas Flörsheimer, and Wolfgang Jahnke -- NMR-based drug design : approaches for very large proteins / Maurizio Pellecchia ... [et al.]. Abstract: Thanks to the vast progress made in the investigation of biomolecules using NMR during the later 1990s, NMR spectroscopy offers a universal tool for examining the binding of an active substance to its target protein. Its use also benefits the development of drugs in particular
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