Molecular Imaging Probes for Cancer Research PDF
Preview Molecular Imaging Probes for Cancer Research
m o c c. cientifinly. MOLECULAR IMAGING so orlduse PROBES FOR CANCER w.wnal wnloaded from ww10/02/14. For perso RESEARCH Doon h G searcOUR ReB er AS cR anT CS or OF s fY beT ProRSI g E nV agiNI mU ar Iby ul c e ol M 7605hc.9789814293679-tp.indd 1 20/6/12 2:18 PM TThhiiss ppaaggee iinntteennttiioonnaallllyy lleefftt bbllaannkk m o c c. entifiy. cinl so orlduse w.wnal wnloaded from ww10/02/14. For perso Doon h G searcOUR ReB er AS cR anT CS or OF s fY beT ProRSI g E nV agiNI mU ar Iby ul c e ol M m o c c. entifiy. cinl so orlduse w.wnal wnloaded from ww10/02/14. For perso MPROOLBECEUS LFAORR I MCAANGCINEGR Doon h G searcOUR RESEARCH ReB er AS cR anT CS or OF s fY edited by beT ProRSI Xiaoyuan Chen g E nV agiNI National Institutes of Health, USA mU ar Iby ul c e ol M World Scientific NEW JERSEY • LONDON • SINGAPORE • BEIJING • SHANGHAI • HONG KONG • TAIPEI • CHENNAI 7605hc.9789814293679-tp.indd 2 20/6/12 2:18 PM Published by World Scientific Publishing Co. Pte. Ltd. 5 Toh Tuck Link, Singapore 596224 USA office: 27 Warren Street, Suite 401-402, Hackensack, NJ 07601 UK office: 57 Shelton Street, Covent Garden, London WC2H 9HE m o c c. entifiy. BAr citaitsahlo Lguiber raercyo rCd afotar ltohgius ibnogo-kin i-sP auvbaliilcaabtlieo nfr oDma ttahe British Library. cinl so orlduse w.wnal wnloaded from ww10/02/14. For perso Doon h G searcOUR MOLECULAR IMAGING PROBES FOR CANCER RESEARCH er ReASB Copyright © 2012 by World Scientific Publishing Co. Pte. Ltd. ancTR All rights reserved. This book, or parts thereof, may not be reproduced in any form or by any means, electronic s for CY OF S oorr mtoe bceh ainnivceanlt,e idn,c wluidthinogu tp whorittotecno ppyeirnmg,i srseicoonr dfrionmg othr ea Pnyu binlifsohremr.ation storage and retrieval system now known beT ProRSI g E nV agiNI mU ar Iby ul c e ol M For photocopying of material in this volume, please pay a copying fee through the Copyright Clearance Center, Inc., 222 Rosewood Drive, Danvers, MA 01923, USA. In this case permission to photocopy is not required from the publisher. ISBN 978-981-4293-67-9 Typeset by Stallion Press Email: [email protected] Printed in Singapore. Xiaoling - Molecular Imaging Probes.pmd 1 6/21/2012, 5:21 PM b1158_FM.qxd 6/19/2012 1:42 PM Page v b1158 Molecular Imaging Probes for Cancer Research Contents m o c c. entifiy. cinl so orlduse List of Contributors ix w.wnal Preface xv Downloaded from wwon 10/02/14. For perso SCehsaspiotenr I1: FRIunantmrdoaadsmuacmetinyot naP ltaso u olCfm aMunrcouelgre acBnuiloalrogIymaging 31 h G ResearcBOUR Chapter 2 CMroaliegc uSl.a Lr eIvminaging Instrumentation 29 er AS ancTR Chapter 3 Molecular Imaging Data Analysis 97 CS or OF F. Habte s fY beT Chapter 4 General Principles of Molecular Imaging Probe Design 129 g ProERSI Shuanglong Liu, Jelena Levi and Zhen Cheng nV agiNI mU ar Iby Session II: Radionuclide Probes forCancerResearch 149 ul c e ol Chapter 5 PETChemistry 151 M Lixin Lang and Xiaoyuan Chen Chapter 6 Multimeric Cyclic RGD Peptides Useful for Development 165 of Integrin α β -Targeted SPECTRadiotracers v 3 Sudipta Chakraborty and Shuang Liu Chapter 7 PETand SPECTImaging of Tumor Metabolism 197 Timothy R. DeGrado Chapter 8 PETand SPECTImaging of Tumor Proliferation 219 Zhanhong Wu and Fouad Kandeel v b1158_FM.qxd 6/19/2012 1:42 PM Page vi b1158 Molecular Imaging Probes for Cancer Research vi Contents Chapter 9 Molecular Imaging of Apoptosis in Cancer 257 Gang Niu and Xiaoyuan Chen Chapter 10 Non-Invasive Imaging of Hypoxia — Challenges 285 and Opportunities C.J. Koch and S.M. Evans Chapter 11 SPECTand PETImaging of Multidrug Resistance 315 Anton G.T. Terwisscha van Scheltinga, Wouter B. Nagengast, Thijs H. Oude Munnink, m o Geke A.P. Hospers, Adrienne H. Brouwers, c c. cientifinly. Canadr oElileisna Pb.e tShc hGr.öEd. edr,e MVrairejsolijn N. Lub-de Hooge so orlduse Chapter 12 PETand SPECTImaging of Tumor Vasculature 341 Downloaded from www.won 10/02/14. For personal SCehcatpiotenr I1I3I: KPSNhEaaoiT hnCra-hinRaedran dS SaiP. onYEndaC ugXTchilaoiRdoueeybp uiPoarrnto eCbr ehGse enfnoer ICmaangcienrgResearch 347137 h G ResearcBOUR Chapter 14 QCh. eSmhaisot,r yY .oMf .O Ypatnigca al nIdm Bag.Gin.g X Pinrogbes 419 er AS ancTR Chapter 15 Fluorescent Dye Conjugates for Optical Imaging 451 CS or OF of Cancer s fY Hao Hong, Yunan Yang and Weibo Cai beT g ProERSI Chapter 16 Quantum Dot Conjugates for Optical Imaging 483 nV agiNI of Cancer mU ar Iby Zibo Li and Peter S. Conti ul ec Chapter 17 Activatable Optical Probes for Cancer Imaging 519 ol M Seulki Lee and Xiaoyuan Chen Chapter 18 Raman Imaging Probes for Cancer Research 545 Sangyeop Lee, Sang Wook Son, Chil-Hwan Oh, Soon Young Shin, Young Han Lee and Jaebum Choo Chapter 19 Photoacoustic Imaging Probes for Cancer Research 567 Shai Ashkenazi Chapter 20 Basic Principles of Magnetic Resonance Imaging 581 Hui Mao b1158_FM.qxd 6/19/2012 1:42 PM Page vii b1158 Molecular Imaging Probes for Cancer Research Contents vii Chapter 21 T1-Weighted MR Contrast Agents for Cancer Research 611 Claire Corot, Philippe Robert, Sébastien Ballet, Walter Gonzalez, Jean-Marc Idee, Isabelle Raynal and Marc Port Chapter 22 T2 Weighted MR Contrast Agents for Cancer 659 Research Gabriella Baio and Carlo Emanuele Neumaier Chapter 23 CESTand PARACESTMRI Contrast Agents for 689 m o Imaging Cancer Biomarkers c c. entifiy. Vipul R. Sheth and Mark D. Pagel scionl Chapter 24 MRI Reporter Genes for Cancer Research 715 orlduse Bistra Iordanova and Eric T. Ahrens w.wnal wnloaded from ww10/02/14. For perso CChhaapptteerr 2256 CfUUoallrttr rrtlaahosse ooE Tuumnnreaddan tMPumreeoeldbeni etaN sot eeffudo Sm rD oIalrmiiuedagr gT aaiunnnmgdd oTGGruseamnbero irDe Vlelaalis vBceuarliyaoture 776393 Doon Hilary Hancock and Victor Frenkel h G searcOUR Chapter 27 X-ray Computed Tomography Principles and 795 er ReASB Contrast Agents ancTR Edward E. Graves and Magdalena Bazalova CS or OF s fY Session IV: Multimodality Imaging in CancerResearch 829 beT ProRSI Chapter 28 Multimodality Instrumentation 831 g E nV Jie Tian agiNI mU ar Iby Chapter 29 Multifunctional Probes for Multimodality Imaging 863 cul of Cancer e Mol Gang Liu, Xiaoyuan Chen and Hua Ai Chapter 30 Imaging Cell Trafficking in Cancer Research 905 L. Ottobrini, C. Martelli and G. Lucignani Session V: Applications of MolecularCancerImaging 949 Probes Chapter 31 Molecular Imaging in Early Detection of Cancer 951 Xin Lin, Jin Xie and Xiaoyuan Chen Chapter 32 PETand SPECTin Cancer Theragnostics 979 Silvana Del Vecchio b1158_FM.qxd 6/19/2012 1:42 PM Page viii b1158 Molecular Imaging Probes for Cancer Research viii Contents Chapter 33 Molecular Imaging in Cancer Drug Development 1015 C. Andrew Boswell, Daniela Bumbaca, Cinthia V. Pastuskovas, Eduardo E. Mundo, Ben Q. Shen, Richard A.D. Carano, Jan Marik, Simon P. Williams, Frank-Peter Theil, Paul J. Fielder, Nicholas van Bruggen and Leslie A. Khawli Chapter 34 Clinical Translation of Molecular Imaging Probes 1041 Steve Y. Cho and Martin G. Pomper m o c.c Index 1067 entifiy. cinl so orlduse w.wnal wnloaded from ww10/02/14. For perso Doon h G searcOUR ReB er AS cR anT CS or OF s fY beT ProRSI g E nV agiNI mU ar Iby ul c e ol M b1158_FM.qxd 6/19/2012 1:42 PM Page ix b1158 Molecular Imaging Probes for Cancer Research List of Contributors m o c c. entifiy. cinl so orlduse Eric T. Ahrens, Department of Biological Sciences, Carnegie Mellon University, w.wnal Pittsburgh, PA, USA wnloaded from ww10/02/14. For perso HUShnuaiavi eArAsiis,t yh,Nk Ceanhtieaonzngia,d l uD,E Cenphgaiinnrtaemereinntg oRf esBeaiorcmhe dCiceanlt erE nfgoirn eBeiroinmga,t eUrianlisv, erSsiictyh uaonf Doon Minnesota, Minneapolis, MN, USA h G searcOUR Gabriella Baio, Department of Diagnostic Imaging, National Cancer Institute, ReB Genoa, Italy er AS cR CanST Sébastien Ballet, Guerbet Research, BP57400, 95943 Roissy CDG, France or OF bes fTY Magdalena Bazalova, Department of Radiation Oncology, Stanford University, ProRSI Stanford, CA, USA g E nV agiNI C. Andrew Boswell, Pharmacokinetic and Pharmacodynamic Sciences, mU ar Iby Genentech, Inc., South San Francisco, CA, USA ul c e ol Adrienne H. Brouwers, Department of Nuclear Medicine and Molecular M Imaging, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands Daniela Bumbaca, Pharmacokinetic and Pharmacodynamic Sciences, Genentech, Inc., South San Francisco, CA, USA Weibo Cai, Departments of Radiology and Medical Physics, School of Medicine and Public Health, University of Wisconsin – Madison, Madison, Wisconsin, USA Richard A.D. Carano, Biomedical Imaging, Genentech, Inc., South San Francisco, CA, USA ix b1158_FM.qxd 6/19/2012 1:42 PM Page x b1158 Molecular Imaging Probes for Cancer Research x Contributors Sudipta Chakraborty, School of Health Sciences, Purdue University, West Lafayette, IN, USA Kai Chen, Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, USA Xiaoyuan Chen, Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD, USA m o c entific.y. ZSthaennfo Crdh, eCnAg,, DUeSpAartment of Radiology, Stanford University School of Medicine, cinl so orlduse Steve Y. Cho, Department of Radiology, Johns Hopkins University, Baltimore, wnloaded from www.w10/02/14. For personal MJSPaoeDetuebt,rh uU mKSS.o A CrCehaoonot,i ,D Mepoalretmcuelnatr oIfm Baigoinnagn oC Eenntgeirn e(eMriInCg),, HDaenpyaarntgm Uennti voefr sRitay,d Aionlosagny,, h DoG on University of Southern California, Los Angeles, CA, USA searcOUR Claire Corot, Guerbet Research, BP57400, 95943 Roissy CDG, France ReB er AS ancTR Timothy R. DeGrado, Molecular Imaging Research Program, Mayo Clinic, CS or OF Rochester, USA. s fY ProbeRSIT Silvana Del Vecchio, Department of Biomorphological and Functional Sciences, g E University “Federico II”, Naples, Italy nV agiNI mU Elisabeth G.E. de Vries, Department of Medical Oncology, University of ular Iby Groningen and University Medical Center Groningen, Groningen, The Netherlands c e ol M S.M. Evans, Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA Paul J. Fielder, Pharmacokinetic and Pharmacodynamic Sciences, Genentech, Inc., South San Francisco, CA, USA Victor Frenkel, Department of Biomedical Engineering, Catholic University of America, Washinton, DC, USA WalterGonzalez, Guerbet Research, BP57400, 95943 Roissy CDG, France Edward E. Graves, Department of Radiation Oncology, Stanford University, Stanford, CA, USA
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