Molecular biology of Alzheimer's disease : genes and mechanisms involved in amyloid generation PDF
Preview Molecular biology of Alzheimer's disease : genes and mechanisms involved in amyloid generation
MOLECULAR BIOLOGY OF ALZHEIMER’S DISEASE MOLECULAR BIOLOGY OF ALZHEIMER’S DISEASE Genes and Mechanisms Involved in Amyloid Generation Edited by CHRISTIAN HAASS Central Institute of Mental Health University of Mannheim Germany harwood academic publishers Australia • Canada • China • France • Germany • India • Japan Luxembourg • Malaysia • The Netherlands • Russia • Singapore Switzerland This edition published in the Taylor & Francis e-Library, 2005. “To purchase your own copy of this or any of Taylor & Francis or Routledge’s collection of thousands of eBooks please go to www.eBookstore.tandf.co.uk.” Copyright © 1998 OPA (Overseas Publishers Association) N.V. Published by license under the Harwood Academic Publishers imprint, part of The Gordon and Breach Publishing Group. All rights reserved. No part of this book may be reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying and recording, or by any information storage or retrieval system, without permission in writing from the publisher. Printed in Singapore. Amsteldijk 166 1st Floor 1079 LH Amsterdam The Netherlands British Library Cataloguing in Publication Data The molecular biology of Alzheimer’s disease 1. Alzheimer’s disease—Molecular aspects I. Haass, Christian 616.8′31′042 ISBN 0-203-30361-X Master e-book ISBN ISBN 0-203-34395-6 (Adobe eReader Format) ISBN: 90-5702-381-4 (Print Edition) CONTENTS Contributors vi Introduction x A Pathology of Alzheimer’s Disease 1. Amyloid Morphology and Pathology of Alzheimer’s Disease 2 Haruyasu Yamaguchi 2. The Tau Proteins in Alzheimer’s Disease 15 Roland Brandt and Jochen Eidenmüller B The Genetics of Familial Alzheimer’s Disease 3. Mutations in Three Genes are Associated with Early Onset Alzheimer’s Disease 44 Paul E.Fraser and Peter H.St George-Hyslop C Molecular and Cellular Biology of the β-Amyloid Precursor Protein and Amyloid β- Peptide 4. The Biological Activities and Function of the Amyloid Precursor Protein of 70 Alzheimer’s Disease Gerd Multhaup, Colin L.Masters, Konrad Beyreuther and Roberto Cappai 5. Proteolytic Processing of the β-Amyloid Precursor Protein 90 Martin Citron and Dennis J.Selkoe 6. Biosynthesis of APP and Aβ: Multiple Pathways for the Generation of Intracellular Aβ 105 David G.Cook, Mark S.Forman, Abraham S.C.Chyung, Robert W.Doms and Virginia M.-Y.Lee 7. The Cell Biology of Amyloid Precursor Protein 128 Bart De Strooper and Fred Van Leuven 8. The Role of Amyloid β-Peptide Terminating at Amino Acid 42 in Early Onset 147 Alzheimer’s Disease Steven G.Younkin v 9. The Biophysics of Amyloid β-Protein Fibrillogenesis 156 David B.Teplow D The Presenilin Genes 10. The Molecular Biology of Presenilin 1 185 Gopal Thinakaran and Sangram S.Sisodia 11. Molecular Biology of Presenilin 2 199 Wilma Wasco 12. Presenilin Proteins and their Role in Development and Notch Signaling 210 Ralf Baumeister and Christian Haass 13. The Processing of the Amyloid-Precursor-Protein (APP) in Presenilin-1 Deficient 226 Neurons Paul Saftig, Dieter Hartmann, Wim Annaert, Kathleen Craessaerts, Fred Van Leuven and Bart De Strooper 14. Presenilins and their Role in Apoptosis 239 Benjamin Wolozin and James Palacino 15. The Phosphorylation of Presenilin Proteins 269 Jochen Walter and Christian Haass E Role of Risk Factors in Alzheimer’s Disease 16. APOE and its Role in Late Onset Alzheimer’s Disease 281 G.William Rebeck F Transgenic Models for Alzheimer’s Disease 17. Transgenic Animal Models in the Development of Therapeutic Strategies for 298 Alzheimer’s Disease Matthias Staufenbiel and Bernd Sommer 18. Presenilins in Transgenic Mice 317 Karen Duff Index 321 vi CONTRIBUTORS Wim Annaert and Experimental Genetics Group Center for Neurologic Diseases Vlaams Interuniversitair Instituut Brigham and Women’s Hospital and voor Biotechnologie (VIB) Harvard Medical School Campus Gasthuisberg Boston, MA 02115 K.U.Leuven USA B-3000 Leuven David G.Cook Belgium Department of Pathology and Laboratory Ralf Baumeister Medicine Genzentrum University of Pennsylvania Medical Center Ludwig-Maximilians-Universität München Abramson Research Center Feodor-Lynen-Strasse 25 Room 806 81377 München 34th and Civic Center Boulevard Germany Philadelphia, PA 19104 USA Konrad Beyreuther ZMBH-Center of Molecular Biology Abraham S.C.Chyung University of Heidelberg Department of Pathology and Laboratory Im Neuenheimer Feld 282 Medicine 69120 Heidelberg Third Floor Maloney Germany HUP Philadelphia, PA 19104 Roland Brandt USA Department of Neurology University of Heidelberg Kathleen Craessaerts Im Neuenheimer Feld 345 Experimental Genetics Group 69120 Heidelberg Vlaams Interuniversitair Instituut Germany voor Biotechnologie (VIB) Campus Gasthuisberg Roberto Cappai K.U.Leuven Department of Pathology B-3000 Leuven University of Melbourne and the Mental Belgium Health Research Institute of Victoria Parkville, Vic 3052 Bart De Strooper Australia Experimental Genetics Group Vlaams Interuniversitair Instituut Martin Citron voor Biotechnologie (VIB) Amgen Inc Campus Gasthuisberg Department 238, Mailstop 5–1-C K.U.Leuven 1840 DeHavilland B-3000 Leuven Thousand Oaks, CA 91320 Belgium USA vii Robert W.Doms Department of Molecular Biology J5 Department of Pathology and Laboratory 68159 Mannheim Medicine Germany University of Pennsylvania Medical Center Dieter Hartmann Abramson Research Center Anatomisches Institut Room 806 Universität Kiel 34th and Civic Center Boulevard Kiel Philadelphia, PA 19104 Germany USA Virginia M.-Y.Lee Karen Duff Department of Pathology and Laboratory Mayo Clinic Jacksonville Medicine 4500 San Pablo Road Third Floor Maloney Jacksonville, FL 32224 HUP USA Philadelphia, PA 19104 Jochen Eidenmüller USA Department of Neurology Fred Van Leuven University of Heidelberg Experimental Genetics Group Im Neuenheimer Feld 345 Vlaams Interuniversitair Instituut 69120 Heidelberg voor Biotechnologie (VIB) Germany Campus Gasthuisberg Mark S.Forman K.U.Leuven Department of Pathology and Laboratory B-3000 Leuven Medicine Belgium Third Floor Maloney Colin L.Masters HUP Department of Pathology Philadelphia, PA 19104 University of Melbourne and the Mental USA Health Research Institute of Victoria Paul E.Fraser Parkville, Vic 3052 Centre for Research in Neurodegenerative Australia Diseases Gerd Multhaup Departments of Medical Biophysics ZMBH-Center of Molecular Biology and Medicine University of Heidelberg University of Toronto Im Neuenheimer Feld 282 Toronto Hospital 69120 Heidelberg 6 Queen’s Park Crescent Germany Toronto, ON M5S 3H2 Canada James Palacino Department of Pharmacology Christian Haass Bldg. 102, Rm. 3634 Central Institute of Mental Health Loyola University Medical Center viii 2160 South First Avenue Departments of Medical Biophysics Maywood, IL 60513 and Medicine USA University of Toronto Toronto Hospital G.William Rebeck 6 Queen’s Park Crescent Alzheimer’s Research Center Toronto, ON M5S3H2 Massachusetts General Hospital Canada 149 13th Street Charlestown, MA 02114 Matthias Staufenbiel USA Nervous System Research Novartis Pharma AG Paul Saftig S-356.8.06 Zentrum Biochemie und Molekulare 4002 Basel Zellbiologie Switzerland Abteilung Biochemie II Universität Göttingen David B.Teplow Göttingen Center for Neurologic Diseases Germany Brigham and Women’s Hospital and Harvard Medical School Dennis J.Selkoe Boston, MA 02115 Center for Neurologic Diseases USA Brigham and Women’s Hospital and Harvard Medical School Gopal Thinakaran Boston, MA 02115 Department of Pathology USA The Johns Hopkins University School of Medicine Sangram S.Sisodia 558 Ross Building Department of Pathology and Neuroscience 720 Rutland Avenue The Johns Hopkins University School Baltimore, MD 21205 of Medicine USA 558 Ross Building 720 Rutland Avenue Jochen Walter Baltimore, MD 21205 Central Institute of Mental Health USA Department of Molecular Biology J5 68159 Mannheim Bernd Sommer Germany Nervous System Research Novartis Pharma AG Wilma Wasco S-356.8.06 Genetics and Aging Unit 4002 Basel Massachusetts General Hospital East Switzerland Building 149, 13th Street Charlestown, MA 02129–9142 Peter H.St George-Hyslop USA Centre for Research in Neurodegenerative Diseases Benjamin Wolozin ix Department of Pharmacology Bldg. 102, Rm. 3634 Loyola University Medical Center 2160 South First Avenue May wood, IL 60513 USA Haruyasu Yamaguchi Gunma University School of Health Sciences 3–39–15 Showa-Machi Maebashi, Gunma 371 Japan Steven G.Younkin Mayo Clinic Jacksonville 4500 San Pablo Road Jacksonville, FL32224 USA
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