Table Of Content

MOLECULAR ASPECTS OF MEDICINE VOLUME 12 Editors-in-Chief H. BAUM King’s College (KQC), University of London, England S. DI MAURO College of Physicians and Surgeons of Columbia University, New York 10032, USA © PERGAMON PRESS OXFORD - NEW YORK - SEOUL - TOKYO MOLECULAR ASPECTS OF MEDICINE An Interdisciplinary Review Journal Editor-in-Chief H. Baum, Department of Biochemistry, King’s College London, Kensington Campus, Campden Hill Road, Kensington, London W8 7AH, England Associate Editor S. Di Mauro, Department of Neurology, College of Physicians and Surgeons of Columbia University, New York 10032, U.S.A. Advisory Board E. Carafoli (Zurich) E. Shafrir (Jerusa/em) A. W. Linnane (Me/bourne) G. M. Lenoir (Lyon) T. J. Peters (London) Y. Yazaki (Tokyo) Subscription Rates Published bi-monthly. Annual Institutional Subscription Rate (1992): £230.00 (US$415.00). Two-year Institutional Rate (1992/93): £437.00 (US$788.50). Sterling prices are definitive. US dollar prices are quoted for convenience only, and are subject to exchange rate fluctuation. Prices include postage and insurance and are subject to change without notice. Subscription rates for Japan are available on request. Single back volumes and parts are available. Subscription enquiries from customers in North America should be sent to: Pergamon Press Inc., 395 Saw Mill River Road, Elmsford, NY 10523, U.S.A., and for the remainder of the world to: Pergamon Press plc, Headington Hill Hall, Oxford OX3 OBW, England. Back issues of all previously published volumes are available direct from Pergamon Press offices. Molecular Aspects of Medicine is published bimonthly. At the end of the year Subscribers will receive, free, the annual subject index. © 1992 Pergamon Press plc Publishing/Advertising Offices Pergamon Press plc, Pergamon Press Inc., Headington Hill Hall, 395 Saw Mill River Road, Oxford OX3 OBW, England. Elmsford, NY 10523, U.S.A. CONTENTS MOLECULAR AND CELLULAR BIOLOGY OF CYSTIC FIBROSIS M. A. McPherson and R. L. Dormer FREE RADICALS AND THE IMMUNE RESPONSE J. Lunec (Editor) DYSTROPHIN AND DISEASE E. P. Hoffman and L. Schwartz MODERN METHODS OF PROMOTING DRUG ABSORPTION THROUGH THE SKIN B. W. Barry AIDS: THE PATHOGENESIS OF HIV INFECTION A. G. Dalgleish (Editor) MOLECULAR INSIGHTS INTO RHEUMATOID ARTHRITIS D. L. Scott, D. A. Willoughby and D. R. Blake MOLECULAR BASIS OF NEW APPROACHES TO THE THERAPY OF RHEUMATOID ARTHRITIS D. Westmacott, D. Bradshaw, M. K. H. Kumar, E. J. Lewis, E. J. Murray, J. S. Nixon and A. D. Sedgwick SUBJECT INDEX CONTENTS OF PREVIOUS VOLUMES LIST OF CONTRIBUTORS BARRY, B. W., Postgraduate Studies in Pharmaceutical Technology, The School of Pharmacy, University of Bradford, Bradford BD7 1DP, U.K. BLAKE, D. R., The Departments of Rheumatology and Experimental Pathology, St. Bartholomew’s Hospital Medical College, Charterhouse Square, London, U.K. The London Hospital Medical College, Whitechapel Road, London, U.K. BRADSHAW, D., Department of Anti-inflammatory Biology, Roche Products Limited, P.O. Box 8, Welwyn Garden City, Hertfordshire AL7 3AY, U.K. DALGLEISH, A. G., Department of Oncology, St. George’s Hospital, Tooting, London SW17 ORE, U.K. DORMER, R. L., Department of Medical Biochemistry, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, U.K. HOFFMAN, E. P., Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine and Department of Human Genetics, University of Pittsburgh School of Public Health, Biomedical Science Tower, W1211, Pittsburgh, PA 15261, U.S.A. KUMAR, M. K. H., Department of Anti-inflammatory Biology, Roche Products Limited, P.O. Box 8, Welwyn Garden City, Hertfordshire AL7 3AY, U.K. LEWIS, E. J., Department of Anti-inflammatory Biology, Roche Products Limited, P.O. Box 8, Welwyn Garden City, Hertfordshire AL7 3AY, U.K. LUNEC, J., Wolfson Research Laboratories, Department of Clinical Chemistry, Queen Elizabeth Medical Centre, Edgbaston, Birmingham B15 2TH, U.K. McPHERSON, M. A., Department of Medical Biochemistry, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, U.K. MURRAY, E. J., Department of Anti-inflammatory Biology, Roche Products Limited, P.O. Box 8, Welwyn Garden City, Hertfordshire AL7 3AY, U.K. NIXON, J. S., Department of Anti-inflammatory Biology, Roche Products Limited, P.O. Box 8, Welwyn Garden City, Hertfordshire AL7 3AY, U.K. SEDGWICK, A. D., Department of Anti-inflammatory Biology, Roche Products Limited, P.O. Box 8, Welwyn Garden City, Hertfordshire AL7 3AY, U.K. SCHWARTZ, L., Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, and Department of Human Genetics, University of Pittsburgh School of Public Health, Biomedical Science Tower, W1211, Pittsburgh, PA 15261, U.S.A. SCOTT, D. L., The Departments of Rheumatology and Experimental Pathology, St. Bartholomew’s Hospital Medical College, Charterhouse Square, London, U.K. The London Hospital Medical College, Whitechapel Road, London, U.K. 1V List of Contributors WESTMACOTT, D., Department of Anti-inflammatory Biology, Roche Products Limited, P.O. Box 8, Welwyn Garden City, Hertfordshire AL7 3AY, U.K. WILLOUGHBY, D. A., The Departments of Rheumatology and Experimental Pathology, St. Bartholomew’s Hospital Medical College, Charterhouse Square, London, U.K.; The London Hospital Medical College, Whitechapel Road, London, U.K.