Modulation of Oxidative Stress in Heart Disease

679 Pages·2019·16.969 MB·English

by  Sajal Chakraborti, Naranjan S. Dhalla, Madhu Dikshit, Nirmal K. Ganguly

Sajal Chakraborti · Naranjan S. Dhalla 
Madhu Dikshit · Nirmal K. Ganguly
Editors
Modulation
of Oxidative
Stress in
Heart Disease
Modulation of Oxidative Stress in Heart
Disease
Sajal Chakraborti • Naranjan S. Dhalla
Madhu Dikshit • Nirmal K. Ganguly
Editors
Modulation of Oxidative
Stress in Heart Disease
Editors
Sajal Chakraborti Naranjan S. Dhalla
Department of Biochemistry and Biophysics Institute of Cardiovascular Science
University of Kalyani St. Boniface Hospital Research Centre
Kalyani, West Bengal, India Winnipeg, MB, Canada
Madhu Dikshit Nirmal K. Ganguly
Translational Health Science and Translational Health Science and
Technology Institute Technology Institute
Faridabad, Haryana, India Faridabad, Haryana, India
ISBN 978-981-13-8945-0 ISBN 978-981-13-8946-7 (eBook)
https://doi.org/10.1007/978-981-13-8946-7
© Springer Nature Singapore Pte Ltd. 2019
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Prof. Sibaji Raha Prof. Dipak Kumar Kar
This book is dedicated to Prof. Sibaji Raha
(Coordinator of the participation of India at the
International Facility for Antiproton and Ion
Research, Germany, and Former Director, Bose
Institute, Kolkata, India) and Prof. Dipak Kumar Kar
(Vice Chancellor, Sidho Kanho Birsha University,
West Bengal, and Former Pro-vice Chancellor,
Calcutta University, Kolkata, India) for their
exceptional contributions and outstanding leadership
in scientific administration and management in India.
We wish them good health and success in their long
fruitful activities.
Preface
“Day by day thou art making me worthy of the
simple great gifts that thou gaveast to me unasked-
This sky and the lights, this body and the life and the mind-
saving me from perils of overmuch desire ……
day by day thou art making me worthy of thy full acceptance
…...saving me from perils of weak uncertain desire”
Rabindranath Tagore (Gitanjali: Songs of Offering)
This book describes multidisciplinary approach and demonstrates biochemical
mechanisms associated with dysregulation of redox signaling that leads to manifes-
tation of heart diseases. It bridges the gap between fundamental and translational
research on the modulatory role of oxidants in different types of heart diseases. It
also discusses the spatial and temporal aspects of oxidative stress in cardiovascular
system, which are immensely important for development of better strategies for
treating heart diseases.
This book contains 28 chapters, which are divided into three subsections. Dr.
Craig McLachlan, Dr. Ruhul Abid, Dr. Hasan Sayyad, Dr. Nitish Mahapatra, Dr.
Sagartirtha Sarkar, and Dr. Angsuman Bagchi narrate different aspects of ROS-
mediated heart diseases in general; while Dr. Sachin Kumar summarizes modula-
tion of ROS by nitric oxide in neutrophils. Dr. Parimala Narne, Dr. Vijay Kutala, and
Dr. Sudhiranjan Gupta in their chapters enumerate novel insights on the impact of
epigenetic factors and miRNA in oxidative stress-induced heart diseases. In the sub-
section on the pathophysiology of oxidative stress, Dr. Bodh Jugdutt, Dr. Nevena
Jeremic, Dr. Suvro Chatterjee, and Dr. Shyamal Goswami provide notable informa-
tion on oxidative stress-induced heart failure and cardiac remodeling in oxidant-
induced heart diseases; while Dr. Vinu Wilson discusses about the role of oxidative
stress in pulmonary hypertension. Dr. Maria Baez eloquently states oxidative stress-
induced biomarkers, while Dr. Antonio Bernad describes the role of oxidative stress
in cardiac progenitor cell fate determinations. To address therapeutic interventions
and pertaining issues in oxidative stress-induced heart diseases, Dr. Gemma Figtree,
Dr. Parames Sil, Dr. Mark Ziolo, Dr. Emmanual Douzinas, Dr. Yiannakoulou, Dr.
Srinivas Gopala, Dr. Surekha Rani, and Dr. Biaus Samanta made extraordinary
effort. They focused on different therapeutic implications in modulating oxidative
stress-induced heart diseases. Each chapter of this book is profoundly useful for the
researchers to identify targets for drug development and to address different types
vii
viii Preface
of heart diseases. In fact, these are the flowers of the spring. So, let “hundreds of
flowers blossom and hundreds schools of thought contend.”
The goal of this book is to provide some glimpses of the role of oxidative stress
in heart diseases along with the current understanding of their prevention and thera-
peutics. We have tried to keep this book concise, informative, and readable. Putting
together all the articles, we believe that the book will be helpful to the postgraduate
students and biomedical researchers.
Our sincere gratitude goes to all contributors for their considerable energy, time,
and effort to accomplish a complete chapter, which generates no quid pro quo ben-
efit. We are thankful to Mr. G. Senthil Kumar, Dr. Madhurima Kahali, and Mr.
Daniel Ignatius Jagadisan (Springer Nature) for their cooperation and support dur-
ing the preparation of this book.
Kalyani, West Bengal, India Sajal Chakraborti
Contents
Part I R egulation of Oxidative Stress
1 Modulation of Oxidative Stress in Heart Disease
by Uncoupling Proteins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
Zakaria A. Almsherqi, Bernita Yeo Hui Li, Yuling Zhou,
and Craig S. McLachlan
2 Oxidant-Dependent and Oxidant- Independent Proangiogenic
and Vasomotor Signaling in Coronary Vascular Endothelium . . . . . . . 23
Sarah Aldosari, Maan Awad, May Z. Gao, Isabella G. McCormack,
Frank W. Sellke, and Md. Ruhul Abid
3 Modulation of miRNA in Oxidative Stress-Induced
Cardiac Remodeling . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 63
Sudhiranjan Gupta
4 Myocardial Oxidative Stress and Metabolic Diseases . . . . . . . . . . . . . . 81
Hassan I. H. El-Sayyad
5 Impact of Genetic and Epigenetic Factors on the Oxidative
Stress in Cardiovascular Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 107
Shiva Krishna Katkam, Bobbala Indumathi,
Shaik Mohammad Naushad, and Vijay Kumar Kutala
6 Role of Monoamine Oxidases in Heart Diseases . . . . . . . . . . . . . . . . . . 129
Vinayak Gupta, Vikas Arige, and Nitish R. Mahapatra
7 Key Cellular Effectors in ROS-Mediated Cardiac Diseases . . . . . . . . . 151
Ratul Datta Chaudhuri, Santanu Rana, Kaberi Datta,
and Sagartirtha Sarkar
8 Reactive Oxygen Species Generation in Neutrophils:
Modulation by Nitric Oxide . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 197
Sachin Kumar and Madhu Dikshit
ix
x Contents
9 Heat Shock Proteins and Their Associated Oxidative
Stress-Induced Heart Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 215
Sangeeta Mitra, Rakhi Dasgupta, and Angshuman Bagchi
10 Modulation of Oxidative Stress in Cardiovascular Diseases . . . . . . . . . 237
Jay C. Jha, Madhura Bose, and Karin Jandeleit-Dahm
Part II P athophysiology of Oxidative Stress
11 Oxidative Stress and Heart Failure . . . . . . . . . . . . . . . . . . . . . . . . . . . . 257
Bodh I. Jugdutt and Bernadine A. Jugdutt
12 Oxidative Stress in Metabolic Syndrome: Experimental
Model of Biomarkers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 313
María del Carmen Baez, Mariana Tarán, Mónica Moya,
and María de la Paz Scribano Parada
13 Oxidative Stress as a Critical Determinant of Adult
Cardiac Progenitor Cell-Fate Decisions . . . . . . . . . . . . . . . . . . . . . . . . . 339
Diego Herrero, Susana Cañón, Guillermo Albericio, Susana Aguilar,
Rosa María Carmona, Adrián Holguín, and Antonio Bernad
14 Role of Oxidative Stress in Hyperhomocysteinemia-Induced
Heart Diseases . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 365
Nevena Jeremic, Jovana Bradic, Anica Petkovic, and Gregory Weber
15 Nitrosative Stress and Cardiogenesis: Cardiac Remodelling
Perturbs Embryonic Metabolome . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 377
Pavitra Kumar, Lakshmikirupa Sundaresan, and Suvro Chatterjee
16 Oxidative Stress in Pulmonary Artery Hypertension . . . . . . . . . . . . . . 393
Vinu Wilson and Subir Kumar Maulik
17 Free Radicals and Reactive Oxygen Species
in Cardiovascular Pathophysiology: An Overview . . . . . . . . . . . . . . . . 403
Shyamal K. Goswami
18 Epigenetic Basis of Oxidative Stress in Diabetic Coronary
Atherosclerosis: A Shift in Focus from Genetic Prerogative . . . . . . . . . 419
Parimala Narne
19 Role of Oxidative Stress, Mitochondrial Dysfunction,
and Autophagy in Cardiovascular Disease: Its Pathogenesis
and Amelioration by Different Small Natural Molecules . . . . . . . . . . . 457
Sharmistha Chatterjee, Uday Hossain, and Parames C. Sil
20 Parkin Protein: The Missing Link Between Cardiovascular
and Parkinson’s Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 489
Angshuman Bagchi
Contents xi
Part III Prevention and Therapeutics
21 New Technologies in Drug Development Provide New Hope
in Targeting of Dysregulated Redox Signalling
in Cardiovascular Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 505
Soloman Saleh, Kristen Bubb, and Gemma A. Figtree
22 An Exercise Mimetic That Targets Nitroso-Redox
Balance as a Therapeutic for Heart Disease . . . . . . . . . . . . . . . . . . . . . . 533
Vikram Shettigar and Mark T. Ziolo
23 Myocardial Injury Secondary to Intestinal
Ischemia/Reperfusion or Microbiota Disturbance:
Preventive and Therapeutic Concerns . . . . . . . . . . . . . . . . . . . . . . . . . . 555
Emmanuel E. Douzinas and Aikaterini Apeiranthitis
24 Multi-target Approach for Oxidative Stress Modulation
by Aspirin, Salicylates and Other NSAIDs:
Clinical Implications in Atherosclerosis . . . . . . . . . . . . . . . . . . . . . . . . . 565
Eugenia Yiannakopoulou
25 The Evolving Concept of Mitochondrial Dynamics
in Heart: Interventional Opportunities. . . . . . . . . . . . . . . . . . . . . . . . . 579
Ashok Sivasailam, Mahalaxmi Ganjoo, Varghese T. Panicker,
Vivek V. Pillai, and Srinivas Gopala
26 Pharmacogenetic Implications of Statin Therapy
on Oxidative Stress in Coronary Artery Disease . . . . . . . . . . . . . . . . . 629
Nivas Shyamala and Surekha Rani Hanumanth
27 Basic Mechanisms of Ischemia/Reperfusion Injury Leading
to Cellular and Tissue Damage: Therapeutic Implications . . . . . . . . . . 645
Emmanuel E. Douzinas and Aikaterini Apeiranthitis
28 Targeting Mitochondria for Therapy of Cardiovascular Disease . . . . . 671
Biaus Samanta, Satabdi Banerjee, Suman K. Nandy,
and Sajal Chakraborti