Modulation by covalent modification

534 Pages·1985·53.981 MB·English

by  Shmuel Shaltiel, P Boon Chock

CURRENT TOPICS IN
Cellular Regulation
Volume 27 — 1985
Modulation by
Covalent
Modification
edited by
Shmuel Shaltiel · P. Boon Chock
Department of Chemical Immunology Laboratory of Biochemistry
The Weizmann Institute of Science National Heart, Lung, and Blood Institute
Rehovot, Israel National Institutes of Health
Bethesda, Maryland
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Contributors
Numbers in parentheses indicate the pages on which the authors' contributions begin.
ANNE-MARIE ADACHI (419), Department of Medical Biochemistry, The Uni­
versity of Calgary, Calgary, Alberta T2N 1N4, Canada
KAZUO ADACHI1 (419), Department of Medical Biochemistry, The Univer­
sity of Calgary, Calgary, Alberta T2N 1N4, Canada
ROBERT S. ADELSTEIN (51), Laboratory of Molecular Cardiology, National
Heart, Lung, and Blood Institute, National Institutes of Health, Be-
thesda, Maryland 20205
EYTAN ALHANATY (267), Department of Chemical Immunology, The Weiz-
mann Institute of Science, Rehovot, Israel
WAYNE B. ANDERSON (455), Laboratory of Tumor Immunology and Biol­
ogy, National Cancer Institute, Bethesda, Maryland 20205
JUAN J. ARAGÓN (411), Departamento de Enzimología, Instituto de Investi­
gaciones Biomédicas del CSIC, Facultad de Medicina de la Universi­
dad Autónoma, 28029 Madrid, Spain
BERNARD M. BABIOR (327), Blood Research Laboratory and the Depart­
ment of Medicine, Tufts-New England Medical Center, Boston, Mas­
sachusetts 02111
LISA M. BALLOU (183), Department of Biochemistry, University of Wash­
ington, Seattle, Washington 98195
RICHARD W. BOND (373), Department of Biochemistry, University of Illi­
nois, Urbana, Illinois 61801
LISARDO BoscÁ (411), Departamento de Enzimología, Instituto de Investi­
gaciones Biomédicas del CSIC, Facultad de Medicina de la Universi­
dad Autónoma, 28029 Madrid, Spain
H. N. BRAMSON (133), Laboratory ofBioorganic Chemistry and Biochem­
istry, The Rockefeller University, New York, New York 10021
1 Present address: Department of Biochemistry, The University of Saskatchewan, Saska­
toon, Saskatchewan S7N 0W0, Canada.
ix
X CONTRIBUTORS
RAPHAEL BUENO (215), Department of Biology, Massachusetts Institute of
Technology, Cambridge, Massachusetts 02139
MARCELLA CAMICI (233), Institute of Biochemistry, Biophysics and Ge­
netics, University of Pisa, Pisa, Italy
JIN-HONG CHANG (509), Institute of Botany, Academia Sínica, NanKang,
Taipei, Taiwan, Republic of China
VINCENT CHAU (447), Department of Biochemistry and Molecular Biology,
University of Florida, Gainesville, Florida 32610
CHING-SAN CHEN (509), Institute of Botany, Academia Sínica, NanKang,
Taipei, Taiwan, Republic of China
WEI-MEI CHING2 (497), Laboratory of Biochemistry, National Heart,
Lung, and Blood Institute, National Institutes of Health, Bethesda,
Maryland 20205
P. B. CHOCK (3), Laboratory of Biochemistry, National Heart, Lung, and
Blood Institute, National Institutes of Health, Bethesda, Maryland
20205
PHILIP COHEN (23), Department of Biochemistry, University of Dundee,
Dundee DD1 4HN, Scotland
ZAHI DAMUNI (41), Clayton Foundation Biochemical Institute and Depart­
ment of Chemistry, The University of Texas at Austin, Austin, Texas
78712
CESAR DE HARO (63), Centro de Biología Molecular, CSIC-Universidad
Autónoma, Madrid 28049, Spain
ANTONIO G. DE HERREROS (63), Centro de Biología Molecular, CSIC-Uni­
versidad Autónoma, Madrid 28049, Spain
PAUL DOAN (447), Department of Biochemistry and Molecular Biology,
University of Florida, Gainesville, Florida 32610
NOBUYOSHI ESAKI (487), Laboratory ofMicrobial Biochemistry, Institute
for Chemical Research, Kyoto University, Uji, Kyoto-Fu 611, Japan
EDMOND H. FISCHER (183), Department of Biochemistry, University of
Washington, Seattle, Washington 98195
L. FLOHÉ (473), Grünenthal GmbH, Center of Research, D-5100 Aachen,
Federal Republic of Germany
JEAN FRANÇOIS (399), Laboratoire de Chimie Physiologique, Université
Catholique de Louvain and International Institute of Cellular and
Molecular Pathology, B-1200 Brussels, Belgium
D. C. FRY (133), Department of Physiological Chemistry, Johns Hopkins
University School of Medicine, Baltimore, Maryland 21205
2 Present address: Food and Drug Administration, Office of Biologies, Research and
Review, Division of Blood and Blood Products, Bethesda, Maryland 20205.
CONTRIBUTORS XI
SABYASACHI GANGULY3 (83), Department of Molecular Pharmacology, Al­
bert Einstein College of Medicine, Bronx, New York 10461
DONITA GARLAND (145), Laboratory of Vision Research, National Eye In­
stitute, National Institutes of Health, Bethesda, Maryland 20205
PATRICK M. GILLEVET (447), Department of Biochemistry and Molecular
Biology, University of Florida, Gainesville, Florida 32610
STEFANIA GINI (233), Institute of Biochemistry, Biophysics and Genetics,
University of Pisa, Pisa, Italy
RAYUDU GOPALAKRISHNA4 (455), Laboratory of Tumor Immunology and
Biology, National Cancer Institute, Bethesda, Maryland 20205
LUISA GREGORI (447), Department of Biochemistry and Molecular Biology,
University of Florida, Gainesville, Florida 32610
MICHAEL J. GRIFFITH5 (361), Departments of Biochemistry, Medicine, and
Pathology and Dental Research Center, University of North Carolina
at Chapel Hill, Chapel Hill, North Carolina 27514
SANTIAGO GRISOLÍA (387), Instituto de Investigaciones Citológicas de la
Caja de Ahorros de Valencia, 46010 Valencia, Spain
MARIS G. N. HARTMANIS6 (479), Department of Biochemistry and Biotech­
nology, Royal Institute of Technology, S-100 44 Stockholm, Sweden
OSAMU HAYAISHI (253), Osaka Medical College, Takatsuki, Osaka 569,
Japan
BRIAN A. HEMMINGS (117), Friedrich Miescher-Institut, CH-4002 Basel,
Switzerland
JOSE HERNANDEZ-YAGO (387), Instituto de Investigaciones Citológicas de la
Caja de Ahorros de Valencia, 46010 Valencia, Spain
MATTHIAS VON HERRATH (317), Biochemisches Institut, Universität Frei­
burg im Breisgau, D-7800 Freiburg im Breisgau, Federal Republic of
Germany
ROMAN HERRERA (83), Department of Molecular Pharmacology, Albert
Einstein College of Medicine, Bronx, New York 10461
HENRI-GÉRY HERS (399), Laboratoire de Chimie Physiologique, Université
Catholique de Louvain and International Institute of Cellular and
Molecular Pathology, B-1200 Brussels, Belgium
3 Present address: Program in Molecular Biology and Virology, Memorial Sloan-Ketter-
ing Cancer Center, 1275 York Avenue, New York, New York 10021.
4 Present address: Department of Pathology, UCLA School of Medicine, Los Angeles,
California 90024.
5 Present address: Hyland Therapeutics Division, Travenol Laboratories, Inc., 444 W.
Glenoaks Boulevard, Glendale, California 91202.
6 Present address: Laboratory of Biochemistry, National Heart, Lung, and Blood Insti­
tute, National Institutes of Health, Bethesda, Maryland 20205.
Xll CONTRIBUTORS
JODI HIRSCHMAN (201), Department of Bacteriology, University of Califor­
nia, Davis, Davis, California 95616
HELMUT HOLZER7 (317), GSF-Abteilung für Enzymchemie, D-8042 Neu­
herberg, Federal Republic of Germany
B. L. HORECKER8 (293), Roche Institute of Molecular Biology, Roche Re­
search Center, Nutley, New Jersey 07110
CHARLES Y. HUANG (437), Laboratory of Biochemistry, National Heart,
Lung, and Blood Institute, National Institutes of Health, Bethesda,
Maryland 20205
S. R. JURGENSEN (3), Laboratory of Biochemistry, National Heart, Lung,
and Blood Institute, National Institutes of Health, Bethesda, Mary­
land 20205
E. T. KAISER (133), Laboratory ofBioorganic Chemistry and Biochemistry,
The Rockefeller University, New York, New York 10021
NOBUHIKO KATUNUMA (345), Department of Enzyme Chemistry, Institute
for Enzyme Research, School of Medicine, The University of Toku-
shima, Tokushima, Japan
MARITA M. KING9 (437), Laboratory of Biochemistry, National Heart,
Lung, and Blood Institute, National Institutes of Health, Bethesda,
Maryland 20205
HENRY S. KINGDON10 (361), Departments of Biochemistry, Medicine, and
Pathology and Dental Research Center, University of North Carolina
at Chapel Hill, Chapel Hill, North Carolina 27514
ERWIN KNECHT (387), Instituto de Investigaciones Citológicas de la Caja de
Ahorros de Valencia, 46010 Valencia, Spain
RONALD A. KOHANSKI (279), Department of Biological Chemistry, The
Johns Hopkins University School of Medicine, Baltimore, Maryland
21205
EIKI KOMINAMI (345), Department of Enzyme Chemistry, Institute for En­
zyme Research, School of Medicine, The University of Tokushima,
Tokushima, Japan
HAJIME KOMURA (253), Suntory Institute for Bioorganic Research, Shima-
moto-cho, Mishima-gun, Osaka 618, Japan
7 Present address: Biochemisches Institut, Universität Freiburg im Breisgau, Freiburg im
Breisgau, Federal Republic of Germany.
8 Present address: Cornell University Graduate School of Medical Sciences, 1300 York
Avenue, New York, New York 10021.
9 Present address: Department of Chemistry, Ohio State University, Columbus, Ohio
43210.
10 Present address: Hyland Therapeutics Division, Travenol Laboratories, Inc., 444 W.
Glenoaks Boulevard, Glendale, California 91202.
CONTRIBUTORS Xlll
JA HYUN KOO11 (221), Section on Metabolic Regulation, Laboratory of
Biochemistry, National Heart, Lung, and Blood Institute, National
Institutes of Health, Bethesda, Maryland 20205
D. E. KOSHLAND, JR. (13), Department of Biochemistry, University of Cali­
fornia, Berkeley, Berkeley, California 94720
SYDNEY KUSTU (201), Department of Bacteriology, University of Califor­
nia, Davis, Davis, California 95616
D. C. LAPORTE12 (13), Department of Biochemistry, University of Califor­
nia, Berkeley, Berkeley, California 94720
M. DANIEL LANE (279), Department of Biological Chemistry, The Johns
Hopkins University School of Medicine, Baltimore, Maryland 21205
RODNEY L. LEVINE (305), Laboratory of Biochemistry, National Heart,
Lung, and Blood Institute, National Institutes of Health, Bethesda,
Maryland 20205
FRITZ LIPMANN (193), The Rockefeller University, New York, New York
10021
MING-CHEH LIU (193), The Rockefeller University, New York, New York
10021
ROGER L. LUNDBLAD (361), Departments of Biochemistry, Medicine, and
Pathology and Dental Research Center, University of North Carolina
at Chapel Hill, Chapel Hill, North Carolina 27514
F. MACHICAO (95), Institut für Klinische Chemie und Forschergruppe Dia­
betes, Krankenhaus München-Schwabing, 8000 Munich, Federal Re­
public of Germany
BORIS M AGASANIK (215), Department of Biology, Massachusetts Institute of
Technology, Cambridge, Massachusetts 02139
TODD M. MARTENSEN (171), Laboratory of Biochemistry, National Heart,
Lung, and Blood Institute, National Institutes of Health, Bethesda,
Maryland 20205
MARÍA J. MAZÓN (159), Instituto de Enzimología del C.S.LC, Facultad de
Medicina de la Universidad Autónoma, Madrid 34, Spain
JOHN C. MEEKS (201), Department of Bacteriology, University of Califor­
nia, Davis, Davis, California 95616
E. MELLONI (293), Institute of Biological Chemistry, University of Genoa,
Genoa, Italy
MARGARET L. MERRYFIELD (41), Clayton Foundation Biochemical Institute
and Department of Chemistry, The University of Texas at Austin,
Austin, Texas 78712
11 Present address: Department of Biochemistry, College of Medicine, Hanyang Univer­
sity, Seoul, Korea.
12 Present address: Department of Biochemistry, University of Minnesota, Minneapolis,
Minnesota 55455.
XIV CONTRIBUTORS
A. S. MiLDVAN (133), Department of Physiological Chemistry, Johns Hop­
kins University School of Medicine, Baltimore, Maryland 21205
DOUGALD M. MONROE (361), Departments of Biochemistry, Medicine, and
Pathology and Dental Research Center, University of North Carolina
at Chapel Hill, Chapel Hill, North Carolina 27514
JOEL MOSS (243), Laboratory of Cellular Metabolism, National Heart,
Lung, and Blood Institute, National Institutes of Health, Bethesda,
Maryland 20205
UMBERTO MURA (233), Institute of Biochemistry, Biophysics and Genetics,
University of Pisa, Pisa, Italy
KOJI NAKANISHI (253), Suntory Institute for Bioorganic Research, Shima-
moto-cho, Mishima-gun, Osaka 618, Japan
CLAUDIA M. NOYES (361), Departments of Biochemistry, Medicine, and
Pathology and Dental Research Center, University of North Carolina
at Chapel Hill, Chapel Hill, North Carolina 27514
SEVERO OCHOA (63), Roche Institute of Molecular Biology, Roche Research
Center, Nutley, New Jersey 07110
JUN OKA (253), The National Institute of Nutrition, Shinjuku-ku, Tokyo
162, Japan
CYNTHIA N. OLIVER (335), Laboratory of Biochemistry, National Heart,
Lung, and Blood Institute, National Institutes of Health, Bethesda,
Maryland 20205
CATHERINE J. PALLEN (419), Department of Medical Biochemistry, The
University of Calgary, Calgary, Alberta T2N 1N4, Canada
SANG CHUL PARK13 (221), Section on Metabolic Regulation, Laboratory of
Biochemistry, National Heart, Lung, and Blood Institute, National
Institutes of Health, Bethesda, Maryland 20205
LILLI M. PETRUZZELLI (83), Department of Molecular Pharmacology, Al­
bert Einstein College of Medicine, Bronx, New York 10461
GABRIELE POHLIG (317), Biochemisches Institut, Universität Freiburg im
Breisgau, D-7800 Freiburg im Breisgau, Federal Republic of
Germany
S. PoNTREMOLi (293), Institute of Biological Chemistry, University of
Genoa, Genoa, Italy
DANIEL L. PURICH14 (107), Department of Chemistry, University of Cali­
fornia, Santa Barbara, Santa Barbara, California 93106
LESTER J. REED (41), Clayton Foundation Biochemical Institute and De-
13 Present address: Department of Biochemistry, College of Medicine, Seoul National
University, Seoul, Korea.
14 Present address: Department of Biochemistry and Molecular Biology, University of
Florida, Gainesville, Florida 32610.
CONTRIBUTORS XV
partment of Chemistry, The University of Texas at Austin, Austin,
Texas 78712
SUE GOO RHEE (3, 221), Section on Metabolic Regulation, Laboratory of
Biochemistry, National Heart, Lung, and Blood Institute, National
Institutes of Health, Bethesda, Maryland 20205
GABRIELE V. RONNETT (279), Department of Biological Chemistry, The
Johns Hopkins University School of Medicine, Baltimore, Maryland
21205
ORA M. ROSEN15 (83), Department of Molecular Pharmacology, Albert
Einstein College of Medicine, Bronx, New York 10461
SIMON ROSENZWEIG (373), Department of Biochemistry, University of Illi­
nois, Urbana, Illinois 61801
P. R. ROSEVEAR (133), Department of Physiological Chemistry, Johns Hop­
kins University School of Medicine, Baltimore, Maryland 21205
MARKE. RUPPEN (373), Department of Biochemistry, University of Illinois,
Urbana, Illinois 61801
ROBIN M. SCAIFE (107), Department of Chemistry, University of Califor­
nia, Santa Barbara, Santa Barbara, California 93106
WERNER SCHÄFER (317), Biochemisches Institut, Universität Freiburg im
Breisgau, D-7800 Freiburg im Breisgau, Federal Republic of Ger­
many
EMILE VAN SCHAFTINGEN (399), Laboratoire de Chimie Physiologique, Uni­
versité Catholique de Louvain and International Institute of Cellular
and Molecular Pathology, B-1200 Brussels, Belgium
HILARY SCHMEEDA16 (267), Department of Chemical Immunology, The
Weizmann Institute of Science, Rehovot, Israel
JAMES R. SELLERS (51), Laboratory of Molecular Cardiology, National
Heart, Lung, and Blood Institute, National Institutes of Health, Be­
thesda, Maryland 20205
EMILY SHACTER17 (3), Laboratory of Biochemistry, National Heart, Lung,
and Blood Institute, National Institutes of Health, Bethesda, Mary­
land 20205
SHMUEL SHALTIEL (267), Department of Chemical Immunology, The Weiz­
mann Institute of Science, Rehovot, Israel
RAJENDRA K. SHARMA (419), Department of Medical Biochemistry, The
University of Calgary, Calgary, Alberta T2N 1N4, Canada
15 Present address: Program in Molecular Biology and Virology, Memorial Sloan-Ketter-
ing Cancer Center, 1275 York Avenue, New York, New York 10021.
16 Present address: Department of Biochemistry, The Hebrew University; Hadassah
Medical School, Jerusalem, Israel.
17 Present address: Laboratory of Genetics, National Cancer Institute, National Insti­
tutes of Health, Bethesda, Maryland 20205.
xvi CONTRIBUTORS
TRACY L. SIMPSON (279), Department of Biological Chemistry, The Johns
Hopkins University School of Medicine, Baltimore, Maryland 21205
MARK X. SLIWKOWSKI (479), Laboratory of Biochemistry, National Heart,
Lung, and Blood Institute, National Institutes of Health, Bethesda,
Maryland 20205
KENJI SODA (487), Laboratory of Microbial Biochemistry, Institute for
Chemical Research, Kyoto University, Uji, Kyoto-Fu 611, Japan
ALBERTO SOLS (411), Departamento de Enzimologia, Instituto de Inves­
tigaciones Biomédicas del CSIC, Facultad de Medicina de la Universi­
dad Autónoma, 28029 Madrid, Spain
LAUREL STADTMAUER (83), Department of 'Molecular Pharmacology, Albert
Einstein College of Medicine, Bronx, New York 10461
ROBERT L. SWITZER (373), Department of Biochemistry, University of Illi­
nois, Urbana, Illinois 61801
HIDEHIKO TANAKA (487), Laboratory of Microbial Biochemistry, Institute
for Chemical Research, Kyoto University, Uji, Kyoto-Fu 611, Japan
MIRIAM TAUBER-FINKELSTEIN (267), Department of Chemical Immunology,
The Weizmann Institute of Science, Rehovot, Israel
LIN TSAI (497), Laboratory of Biochemistry, National Heart, Lung, and
Blood Institute, National Institutes of Health, Bethesda, Maryland
20205
KUNIHIRO UEDA (253), Department of Medical Chemistry, Kyoto Univer­
sity Faculty of Medicine, Yoshida, Sakyo-ku, Kyoto 606, Japan
MARTHA VAUGHAN (243), Laboratory of Cellular Metabolism, National
Heart, Lung, and Blood Institute, National Institutes of Health, Be­
thesda, Maryland 20205
EMMA VILLA-MORUZZI (183), Institute of General Pathology, University of
Pisa, Pisa, Italy
K. WALSH (13), Department of Biochemistry, University of California,
Berkeley, Berkeley, California 94720
JERRY H. WANG (419), Department of Medical Biochemistry, The Univer­
sity of Calgary, Calgary, Alberta T2N 1N4, Canada
TUAN-NAN WEN (509), Institute of Botany, Academia Sínica, NanKang,
Taipei, Taiwan, Republic of China
O. H. WIELAND (95), Institut für Klinische Chemie und Forschergruppe
Diabetes, Krankenhaus München-Schwabing, 8000 Munich, Federal
Republic of Germany
ARTHUR J. WITTWER18 (497), Laboratory of Biochemistry, National Heart,
Lung, and Blood Institute, National Institutes of Health, Bethesda,
Maryland 20205
18 Present address: Monsanto Company, 800 N. Lindbergh Boulevard, St. Louis, Mis­
souri 63167.